<p><strong>Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.</p><p>In their study,<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en"><strong>Dr. Hana Cahová</strong></a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.</p><p>The work was significantly shaped by <strong>Valentina Serianni from Hana Cahová’s team</strong>, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by <strong>Jana Škerlová</strong>, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.</p><p>Hana Cahová adds: <i>“We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by<strong> Dr. Tomáš Kouba</strong>, one of the authors of the study. <i>“Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,”</i> he explains.</p><p>Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en"><strong>cryo-EM center</strong></a><strong> </strong>that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5"><strong>Molecular insight into 5′ RNA capping with Np<sub>n</sub>Ns by bacterial RNA polymerase</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p>Nat. Chem. Biol. 21 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from <i>Thermus</i> <i>thermophilus</i>. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</p></div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

<p><strong>Food adulteration is a phenomenon with a long history that has gained increasing importance in recent years due to the globalization of food supply chains and strong economic pressures. Whether it involves diluting olive oil with cheaper oils, adding sugar to honey, or the hidden use of substitutes in protein supplements, the result is a loss of consumer trust and, in some cases, a potential risk to health. Analytical chemistry plays a key role in this area by providing methods and technologies capable of identifying and quantifying target compounds as well as unwanted impurities in a wide range of food matrices.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg" alt="Watrex: Food Adulteration and How It Is Revealed by Analytical Chemistry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg 245w," sizes="100vw" width="1600" height="900"></p><h4><strong>The Role of Chromatography in Forensic Food Analysis</strong></h4><p>Chromatography, particularly liquid chromatography (HPLC), is one of the most effective analytical tools for separating complex mixtures of molecules. It enables:</p><ul><li>qualitative identification of individual components in a sample,</li><li>quantitative determination of their concentrations,</li><li>detection of impurities and unexpected components that may indicate<br>adulteration.</li></ul><p>In practice, HPLC is often combined with various types of detectors (UV/VIS, DAD, refractive index detectors) or with other techniques (e.g., mass spectrometry) to increase selectivity and sensitivity.</p><h4><strong>Isocratic vs. Gradient Elution</strong></h4><p>In the analysis of food samples, chromatographic methods are selected according to the analytical goal:</p><ul><li><strong>Isocratic HPLC </strong>uses a constant mobile phase composition throughout the analysis. It is simple, robust, and ideal for routine determinations of well-defined target analytes (e.g., sugars or vitamins).</li><li><strong>Gradient HPLC</strong> changes the mobile phase composition during separation, enabling better resolution of complex mixtures with a wide range of polarities (e.g., peptides or phenolic compounds).</li></ul><p>Gradient methods are particularly useful when analytes have very different properties and high separation efficiency is required.</p><h4><strong>Watrex Praha and the Contribution of Modern Systems to Food Analysis</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha, s.r.o.</strong></a> is one of the leading Czech manufacturers and distributors of liquid chromatography systems and instruments, with a long tradition dating back to 1990. The company has successfully transformed from a distributor into a manufacturer of its own HPLC and related technologies, focusing on modular, robust systems suitable even for demanding analytical tasks.</p><p>Their <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=93&amp;search=streamline"><strong>Streamline™ product line</strong></a><strong> </strong>includes several HPLC system concepts suitable for food analysis:</p><ul><li><strong>Isocratic HPLC system</strong> – a simple yet precise configuration with a single pump, column thermostat, and UV/VIS detector; suitable for routine determination of known analytes (e.g., basic carbohydrates, food additives).</li><li><strong>Binary gradient HPLC system</strong> – equipped with two pumps enabling mobile phase gradient formation, which enhances separation performance for complex mixtures<br>(e.g., phenolic profiles of wine, components of aromatic extracts).</li><li><strong>GPC/SEC system (Gel Permeation / Size Exclusion Chromatography)</strong> – a specialized solution for the determination of macromolecules and polymers, also relevant for the analysis of high-molecular-weight components in foods (e.g., polysaccharides).</li></ul><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Watrex_catalog_2024_ba97395f92.pdf"><strong>Product catalogue HERE</strong></a></p></blockquote><p>Thanks to the modular nature of these systems, analysts can easily adapt the configuration to a specific analytical problem, from simple routine analyses to complex characterization of food samples.</p><h4><strong>Practical Examples of Adulteration Revealed by HPLC</strong></h4><ul><li><strong>Detection of olive oil dilution: </strong>HPLC can separate and quantify characteristic triacylglycerols and fatty acids; unusual patterns indicate the presence of cheaper oils.</li><li><strong>Estimation of sugar addition in honey:</strong> Isocratic HPLC with a refractive index detector can determine sugar profiles (glucose, fructose, sucrose), revealing dilution or the addition of sugar syrups.</li><li><strong>Identification of aromatic adulterants in wine:</strong> Gradient HPLC with a PDA detector can reveal phenolic and aromatic profiles that are altered by the addition of synthetic compounds.</li></ul><h4><strong>Conclusion</strong></h4><p>Food adulteration remains a current issue that requires reliable and sensitive analytical methods. Liquid chromatography, and in particular modern HPLC systems, represent one of the most powerful tools for detecting unwanted additives, impurities, and unexpected components in complex food samples. Manufacturers such as <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> provide flexible chromatographic platforms covering a wide range of analytical tasks from simple isocratic to advanced gradient and GPC/SEC applications thereby supporting analysts in ensuring food quality and consumer protection.</p><blockquote><p>Did you find this article interesting? Follow <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> on their social media (<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/company/watrex/?viewAsMember=true"><strong>LinkedIn</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/WatrexPrague"><strong>Facebook</strong></a>) for more engaging topics.</p></blockquote>

Food Adulteration and How It Is Revealed by Analytical Chemistry

<p><strong>Join us for a fascinating conversation with Dr. Subhoja Chakraborty from the University of Central Florida, whose cutting-edge research targets the global challenge of malaria drug resistance. Dr. Chakraborty shares her journey from structure-based drug design during her PhD to her recent collaborative work repurposing human kinase inhibitors as rapid, selective antimalarials against drug-resistant Plasmodium falciparum strains.</strong></p><h4><strong>In this episode, you'll learn:</strong></h4><ul><li>How structure-guided approaches reveal potential drug targets, including cysteine proteases like falcipain-2, and kinases implicated in malaria's complex life cycle.</li><li>The power of repurposing kinase inhibitors originally developed for cancer and other diseases, focusing on compound 12, which blocks hemozoin formation and protein kinase 6—key steps in parasite survival.</li><li>Lab techniques such as affinity, gel filtration, and size exclusion chromatography for recombinant protein purification—and how troubleshooting is crucial for high-yield, stable complexes.</li><li>Advances in mass spectrometry for characterizing protein interactions, validating drug targets, and mapping molecular pathways pivotal to malaria therapeutics.</li><li>Tips and lessons for new researchers facing the challenges of sample preparation, complex protocols, and working as part of a collaborative team.</li></ul><p>Dr. Chakraborty’s insights bridge the gap between basic science and translational drug discovery, offering hope for more effective, targeted malaria treatments in a world where resistance to frontline therapies threatens millions.</p><h4><strong>Referenced Papers:</strong></h4><ul><li>"Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity" (Cell Chemical Biology, 2025)</li><li>"New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain" (BBRC, 2022)</li><li>"Structure-Based Optimization of Protease−Inhibitor Interactions to Enhance Specificity of Human Stefin‑A against Falcipain‑2 from the Plasmodium falciparum 3D7 Strain" (Biochemistry, 2023)</li></ul><p>If you’re a student, scientist, or simply passionate about advances in infectious disease research, this episode offers actionable insights, inspiring advice, and a front-row seat to innovation in combating malaria.</p><h3><strong>Video Transcription</strong></h3><h4><strong>From Structural Biology to Drug Discovery: Chromatography and Mass Spectrometry in Malaria Research</strong></h4><h5><strong>Introduction</strong></h5><p>In this discussion, Subhoja shares insights into her research journey, focusing on malaria drug discovery and the role of modern analytical techniques in biological and biomedical research. The conversation is aimed primarily at undergraduate students and early-career researchers interested in chemistry, biotechnology, and life sciences.</p><h5><strong>Research Focus: Malaria Drug Discovery and Kinase Targets</strong></h5><p>Subhoja is currently involved in malaria drug discovery research at the University of Central Florida, where she has been working since beginning her postdoctoral position two years ago. Her earlier PhD research focused on structure-based drug design in malaria, using a combination of in silico approaches, recombinant protein expression, and X-ray crystallography to determine precise three-dimensional structures of target proteins and their inhibitors.</p><p>This structural perspective provided a foundation for her current work, which centers on drug discovery through compound screening and repurposing. A recent publication from her laboratory explores the use of repurposed mammalian CDK-like kinase inhibitors as potential antimalarial agents. While such kinase inhibitors are well known in cancer and cardiovascular research, their application to malaria targets represents a novel and promising approach.</p><p>Kinases are attractive drug targets because of their central role in cell signaling and growth pathways. By targeting specific kinases involved in different stages of the malaria parasite life cycle—whether asexual growth, gametocytogenesis, or differentiation—it may be possible to significantly inhibit parasite growth and progression.</p><h5><strong>Chromatography in Protein Expression and Purification Workflows</strong></h5><p>Chromatography plays a critical role throughout Subhoja’s research. Her experience spans from basic chromatography techniques during her early training to advanced protein purification workflows using affinity chromatography, gel filtration (size exclusion chromatography), and ion exchange chromatography.</p><p>Recombinant proteins are routinely purified using affinity resins such as nickel or cobalt, followed by further purification to remove contaminants. Fast Protein Liquid Chromatography (FPLC) enables compact, stepwise purification workflows suitable for producing proteins for in vitro assays.</p><p>A recurring challenge in this process is the expression of high-molecular-weight proteins, which often accumulate in insoluble fractions or inclusion bodies. Careful selection of expression vectors, host systems, and induction conditions is therefore essential to maximize yield and solubility.</p><h5><strong>Integrating Size Exclusion Chromatography into the Workflow</strong></h5><p>Size exclusion chromatography (SEC) is typically used after affinity purification to further improve protein purity. Following elution with imidazole or glutathione, desalting is required to prevent buffer components from interfering with downstream assays. This is often achieved using desalting columns such as G-25 or PD-10.</p><p>To remove lower-molecular-weight contaminants, finer SEC media—such as Superdex or Sephacryl columns—are employed. Concentration steps using molecular-weight cut-off filters are then applied to obtain the desired protein concentration for functional studies.</p><p>These iterative purification and troubleshooting steps are a routine part of protein biochemistry and reflect the importance of methodical optimization and careful validation.</p><h5><strong>The Role of Mass Spectrometry in Biomolecular Characterization</strong></h5><p>Mass spectrometry is a key analytical tool in Subhoja’s research pipeline, particularly for target identification and validation. In both malaria and cancer research, MS is used alongside chromatography, immunoprecipitation, and pull-down assays to study protein interactions and molecular recognition events.</p><p>Affinity-based mass spectrometry enables the identification of binding partners and interactors, whether studying proteins, long non-coding RNAs, or protein complexes. Techniques such as native MS, tandem affinity purification, and proximity labeling (e.g., TurboID-based workflows) provide deeper insights into molecular networks and signaling pathways.</p><p>These approaches are essential for understanding how candidate drug targets function within complex biological systems.</p><h5><strong>Sample Preparation Challenges in Biological Research</strong></h5><p>Sample preparation remains one of the most challenging aspects of biological experimentation. Whole-cell lysates contain proteases, nucleases, and other components that can rapidly degrade target molecules. Preventing degradation requires minimizing preparation time, maintaining low temperatures, and using appropriate inhibitor cocktails.</p><p>Reproducibility is also critical: biological experiments require multiple replicates, and variability is often unavoidable. Careful handling, protocol optimization, and continuous troubleshooting are essential to ensure reliable results, whether preparing samples for chromatography, mass spectrometry, sequencing, or immunoprecipitation.</p><h5><strong>Advances in Chromatography and MS for Malaria Research</strong></h5><p>Modern advances in chromatography and mass spectrometry significantly enhance malaria research by enabling precise target identification, quantification, and functional characterization. Drug discovery workflows begin with construct design and recombinant expression, followed by purification and interaction studies.</p><p>In malaria research, stage-specific parasite biology requires careful extraction and analysis of proteins from different life cycle stages. Tandem affinity MS, immunoprecipitation, and in vivo validation studies help confirm target relevance and therapeutic potential.</p><p>Recent work on repurposed kinase inhibitors has shown promising results, including inhibition of hemozoin formation—a key detoxification pathway for the malaria parasite—highlighting the potential of such compounds for further development.</p><h5><strong>Malaria, Drug Resistance, and Global Impact</strong></h5><p>Malaria remains a major global health burden, with over 600,000 deaths annually and widespread drug resistance complicating treatment. Artemisinin resistance, particularly associated with mutations in the K13 propeller domain, has driven the search for new targets and therapies.</p><p>During her PhD, Subhoja focused on falcipain-2, a cysteine protease involved in hemoglobin degradation within the parasite. This pathway is critical for parasite survival and has emerged as a promising drug target. Her work revealed that falcipain-2 operates within a larger protein complex responsible for hemoglobin processing and amino acid release.</p><p>Understanding these molecular mechanisms is essential for developing robust, stage-specific antimalarial strategies.</p><h5><strong>Advice for Early-Career Researchers</strong></h5><p>For researchers just starting out, Subhoja emphasizes the importance of hands-on experience. Working directly with cells, lysates, and analytical tools is essential for truly understanding experimental systems. Failure is an inherent part of research, and perseverance is key.</p><p>Motivation, teamwork, careful sample handling, and thorough preparation all contribute to long-term success. Reading extensively, critically evaluating one’s own work, and appreciating incremental progress are vital aspects of a sustainable research career.</p><p>Every successful experiment—no matter how small—represents meaningful progress and contributes to the broader goals of science and medicine.</p><h5><strong>Closing Remarks</strong></h5><p>The discussion highlights how interdisciplinary approaches combining chromatography, mass spectrometry, structural biology, and biochemistry are driving advances in malaria drug discovery. Through careful experimental design, analytical rigor, and collaborative teamwork, researchers can address complex biological challenges and contribute to global health solutions.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

Article

Product

Video

Scientists

Food

Interview

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Watrex Praha

Metrohm

Thermo Fisher Scientific

C&EN

<p><strong>We live in a world of routine, familiarity and comfort. Anything outside of that is scary. It’s not often that we step outside of our comfort zones. Let’s be curious and take a step to the wild side of chromatography with the familiarity that we seek such as HPLC and GC, where we find out more than just counterions. Exploring the world of impurities whether they are organics or metal species, with simple changes and utilizing different detection can help solve many analytical challenges.</strong></p>
<p>Who should attend?</p>
<p>Pharma, Chromatography, MS customers, Lab scientists and Lab managers</p>
<p>What you will learn:</p>
<ul>
<li><strong>The capability of ion chromatography to help solve analytical challenges</strong></li>
<li><strong>How to apply ion chromatography at different stages of drug development</strong></li>
<li><strong>Preventative and troubleshooting drug development with ion chromatography for impurities</strong></li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Wai-Chi Man (Product Marketing Manager, Thermo Fisher Scientific)</p>
</blockquote>
<blockquote>
<p>Wai-Chi has specialized in ion chromatography (IC) since 1989, with over 36 years of experience in analytical chemistry in a wide variety of techniques and industries. Her work at Thermo Fisher Scientific has supported a wide range of customers from various industries, providing IC support in method development, troubleshooting, sample preparation, training, seminars, events, and workshops.</p>
</blockquote>


Thermo Fisher Scientific: How ion chromatography plays a vital role in drug development

How ion chromatography plays a vital role in drug development

How to apply ion chromatography at different stages of drug development. Preventative and troubleshooting drug development.

How ion chromatography plays a role in drug development

<p><strong>Ion Chromatography (IC) is an established and useful analytical tool for pharmaceutical applications. Many times, IC is faster, easier to implement, and offers significant advantages over traditional wet chemistry methods. In fact, the United States Pharmacopeia has modernized a substantial number of monographs to stipulate IC methods for numerous pharmaceutical assays of APIs and analysis of impurities and excipients.</strong></p>
<p>In this webinar, you will hear about recently validated IC methods for various assays and their associated impurities and challenges associated with some magnesium-based OTC products.</p>
<p>We will also review the basics of IC and various sample preparation techniques to overcome difficult sample matrices. A live Q&amp;A session will be hosted at the end of the webinar to address any questions you may have.<br/>Key learning points of this webinar:</p>
<ul>
<li>Understand newly validated IC methods for pharmaceutical applications.</li>
<li>Learn how ion chromatography can be used for fast and reliable salt identification, assay, and impurities. </li>
<li>Learn what strategies are available for automation of sample preparation to deal with difficult sample matrices.</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Linx Waclaski (Product Manager Ion Chromatography, Metrohm USA)</p>
</blockquote>
<blockquote>
<p>Linx Waclaski is the Product Manager for Ion Chromatography at Metrohm USA in Riverview, Florida. He has years of experience in multiple chromatographic techniques, including ion chromatography, gas chromatography, liquid chromatography, and mass spectrometry, with extensive experience in R&amp;D and applications development. His chromatography applications experience extends across environmental, food safety, and life sciences industries. He has an M.S. in Forensic Science from Duquesne University.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Shibu Paul (Product Specialist Ion Chromatography, Metrohm USA)</p>
</blockquote>
<blockquote>
<p>Shibu Paul, Product Specialist for Ion Chromatography at Metrohm USA, has more than 30 years of experience in the food, environmental and instrumentation industries, working in positions from bench chemist to laboratory director. He has a Ph.D. in Environmental Chemistry from Cochin University of Science &amp; Technology, India and an M.B.A. from the University of South Florida.</p>
</blockquote>


Metrohm: Ion Chromatography for Pharmaceutical Applications

Ion Chromatography for Pharmaceutical Applications

Recently validated IC methods for various assays and their associated impurities and challenges associated with some magnesium-based OTC products.

<p><strong>We have an exciting virtual three-day agenda with great speakers from industry experts, workshops, and poster sessions.</strong></p>
<p>Come and listen to industry experts to discover IC in the world of</p>
<ul>
<li>Glycan research</li>
<li>Pesticides</li>
<li>Metabolomics </li>
<li>Pharmaceutical analysis</li>
<li>Industrial processes</li>
<li>Geochemistry</li>
<li>Food and beverage</li>
</ul>
<p><strong>Discover tools, tips, and tricks to get the most out of your IC analysis in our IC workshops.</strong></p>
<p>Registration and the agenda will be available soon - Watch this space.</p>


Thermo Scientific: Global IC Symposium 2023

Global IC Symposium 2023 - Day 1

We have an exciting virtual three-day agenda with great speakers from industry experts, workshops, and poster sessions.

Thermo Scientific Global IC Symposium 2023

<p><strong>This year we invite you to ignite your mind to Be Curious about what Ion chromatography (IC) can do with its versatility in many detections across the IC application spectrum to improve your workflows and solve challenges.</strong></p>
<p>During this three day virtual event, learn from a panel of experts how the latest IC applications are helping colleagues achieve breakthroughs, and walk away with valuable information on how advancements in IC can increase laboratory analytical capabilities. </p>
<p>Although each day is convenient for a specific region, you can attend any session on any day. All sessions and workshops will be available for on-demand viewing after the event concludes.</p>
<h3><strong>Day 1 Agenda | April 18 | North and South America</strong></h3>
<p>Discover IC column development, and where it’s headed with mass spectrometry, as they can be an integral detection for carbohydrate profiling and environmental metabolites characterization. Learn how standalone IC can solve industrial samples and degradation products with comprehensive IC information, all at once.</p>
<h5><strong>11:30 EDT: Opening Plenary: The Past, Present, and Future of IC Column Development</strong></h5>
<ul>
<li>Alexandra Zatirakha (Thermo Fisher Scientific, IC/SP R&amp;D, Sunnyvale)</li>
</ul>
<h5><strong>12:30 EDT: Characterizing Carbohydrate Degradation Products from Bacteroides Thetaiotaomicron to Understand Bacterial Dextran Utilization in the Gut</strong></h5>
<ul>
<li>Neil Rumachik (Thermo Fisher Scientific, IC/SP R&amp;D, Sunnyvale)</li>
<li>Fiona Cuskin (Newcastle University, UK)</li>
</ul>
<h5><strong>1:30 PM EDT: Toward Comprehensive Chemical Characterization of Metabolomic Using Orbitrap Fusion Tribrid Mass Spectrometer Coupled with Ion and Liquid Chromatography Techniques: Dissolved Organic Matter as an Example</strong></h5>
<ul>
<li>Hussain Abdulla (Department of Physical and Environmental Sciences, Texas A&amp;M University-Corpus Christi)</li>
</ul>
<h5><strong>2:30 PM EDT: The Use of Ion Chromatography in the Monitoring of Degradation Products from the Electrochemical Treatment Of Organic Compounds</strong></h5>
<ul>
<li>Emily Tossi (Federal University of Rio Grande do Norte)</li>
</ul>
<h5><strong>3:30 PM EDT: Ion Chromatography as a Tool for Industrial Problem Solving</strong></h5>
<ul>
<li>Isaac Negrete and Stephen Fosdick (Dow)</li>
</ul>
<h5><strong>4:30 PM EDT: Workshop: Everything, Everywhere, All at Once IC!</strong></h5>
<ul>
<li>Kelly Femrite (IC/SP Product Support, Sunnyvale)</li>
<li>Carl Fisher (IC/SP Product Marketing, Sunnyvale)</li>
<li>Criss Corchard-Keeler (Service Marketing Manager, CMD/MOL Thermo Fisher Scientific)</li>
</ul>


Thermo Fisher Scientific: IC Symposium 2023

IC Symposium 2023 - Day 1

Join us for the 2023 Global IC Symposium! North and South America

<p><strong>This year we invite you to ignite your mind to Be Curious about what Ion chromatography (IC) can do with its versatility in many detections across the IC application spectrum to improve your workflows and solve challenges.</strong></p>
<p>During this three day virtual event, learn from a panel of experts how the latest IC applications are helping colleagues achieve breakthroughs, and walk away with valuable information on how advancements in IC can increase laboratory analytical capabilities. </p>
<p>Although each day is convenient for a specific region, you can attend any session on any day. All sessions and workshops will be available for on-demand viewing after the event concludes.</p>
<h3><strong>Day 2 Agenda | April 19 | Europe and Africa</strong></h3>
<p>Untap the versatility of ion chromatography with challenging analytes such as chlorate, sulfite, cationic polar pesticides, and glycoprotein sialic acid in tricky matrices while optimizing your workflow.</p>
<h5><strong>9:00 AM CET: Opening Plenary: Untapped Potential in Ion Chromatography for Resolving Analytical Challenges</strong></h5>
<ul>
<li>Detlef Jensen (Thermo Fisher Scientific, IC Expert)</li>
</ul>
<h5><strong>11:00 AM CET: Determination of Chlorate in Agar Samples Using Ion Chromatography</strong></h5>
<ul>
<li>Flavio Zanetti (Biopolife Srl, Trieste, Italy)</li>
</ul>
<h5><strong>12:00 PM CET: Determination of Sulphur Dioxide in Foods by Ion Chromatography</strong></h5>
<ul>
<li>Noel Finn (Public Analyst Laboratory, St. Finbarr’s Hospital, Douglas Road, Cork)</li>
</ul>
<h5><strong>1:00 PM CET: 30 min Lunch</strong></h5>
<h5><strong>1:30 PM CET: Analysis of Polar Cationic Pesticides by IC-MS</strong></h5>
<ul>
<li>Anatte Margalit (DAFM)</li>
</ul>
<h5><strong>2:30 PM CET: Determination of Glycoprotein Sialic Acid Composition Using HPAE-PAD in Dual Eluent Generation Cartridge Mode</strong></h5>
<ul>
<li>Jingli Hu (Thermo Fisher Scientific, IC/SP Applications, Sunnyvale)</li>
</ul>
<h5><strong>3:30 PM CET: Optimizing Your IC Workflow Using Chromeleon CDS</strong></h5>
<ul>
<li>Dan Talbot (Thermo Fisher Scientific, IC/SP Senior, Application Sales Support, UK &amp; Ireland)</li>
</ul>


IC Symposium 2023 - Day 2

Join us for the 2023 Global IC Symposium! Europe and Africa

<p><strong>This year we invite you to ignite your mind to Be Curious about what Ion chromatography (IC) can do with its versatility in many detections across the IC application spectrum to improve your workflows and solve challenges.</strong></p>
<p>During this three day virtual event, learn from a panel of experts how the latest IC applications are helping colleagues achieve breakthroughs, and walk away with valuable information on how advancements in IC can increase laboratory analytical capabilities. </p>
<p>Although each day is convenient for a specific region, you can attend any session on any day. All sessions and workshops will be available for on-demand viewing after the event concludes.</p>
<h3><strong>Day 3 Agenda | April 20 | Asia Pacific</strong></h3>
<p>Expand the world of electrochemistry applications and IC hyphenation with high-resolution mass spectrometry and understand how Inductively Coupled Plasma Spectrometry can speciate isotopes while simplifying Pharmacopeia QC analysis and keeping your IC in top-notch condition.</p>
<h5><strong>11:00 AM SGT: Opening Plenary: Electrochemical Detection and Its Application in Ion Chromatography</strong></h5>
<ul>
<li>Yan Liu (Thermo Fisher Scientific, IC/SP R&amp;D, Sunnyvale)</li>
</ul>
<h5><strong>12:00 PM SGT: Application of Anion Chromatography Coupled High-Resolution Mass Spectrometry to Increase Cellular Metabolite Coverage</strong></h5>
<ul>
<li>Vinzenz Hofferek (McConville Lab, Department of Biochemistry and Pharmacology)</li>
</ul>
<h5><strong>1:00 PM SGT: Analysis of Anhydrosugars and Xylooligosaccharides by Ion Chromatography with Electrospray Lithium Cationisation-Triple Quadrupole Tandem Mass Spectrometry</strong></h5>
<ul>
<li>Dr. Estrella Sanz Rodriguez (Natural Products Analysis, Australian Centre for Research on Separation Science (ACROSS), University of Tasmania)</li>
</ul>
<h5><strong>2:00 PM SGT: You Gotta Keep ‘Em Separated: Novel IC Applications for Subsequent Isotopic Analyses by Rapid and/or Hyphenated Techniques</strong></h5>
<ul>
<li>Dr. Brandon Mahan (College of Science and Engineering, James Cook University)</li>
<li>Grace Manestar (IsoTropics PhD Candidate)</li>
</ul>
<h5><strong>3:00 PM SGT: Use of Ion Chromatography in Pharmaceutical Quality Control</strong></h5>
<ul>
<li>Catherine Frankis and Stella Planou (Reading Scientific Services Ltd., Reading Science Centre, Whiteknights Campus)</li>
</ul>
<h5><strong>4:00 PM SGT: Tips on Keeping Your Ion Chromatography in Top-Notch Condition</strong></h5>
<ul>
<li>Ryan Ong (Thermo Fisher Scientific, IC/SP Application Sales Support, Singapore)</li>
</ul>


IC Symposium 2023 - Day 3

Join us for the 2023 Global IC Symposium! Day 3 | Asia Pacific.

<p><strong>This meeting covers the latest trends and techniques to meet current water and environmental testing demands for emerging contaminants and evolving regulations. Our guest speakers from the water industry and environmental research and testing laboratories will share their expertise on their latest work, analytical workflows, and automation.</strong></p>
<p>Join us and discover valuable insights to maximise testing productivity and instrument uptime, simplify workflows and standardise data workup.</p>
<h3><strong>June 27 (Day 1) Emerging contaminants</strong></h3>
<p>This session will explore PFAS, microplastics, untargeted screening, automation and sample preparation.</p>
<p>Attend the whole day or selected presentations only.</p>
<h5><strong>10:00</strong> Online access opens (Streaming begins 09:30 BST/10:30 CEST)</h5>
<h5><strong>10:30 Opening of the event, welcome and introduction</strong></h5>
<ul>
<li>Presenter: Jeff Stubbs (Thermo Fisher Scientific)</li>
</ul>
<h5><strong>10:50 Screening of unknowns using Thermo Scientific Orbitrap MS and Thermo Scientific Compound Discoverer software</strong></h5>
<ul>
<li>Presenter: Janine Elliot (Scottish Environment Protection Agency)</li>
</ul>
<h5><strong>11:20 Biotoxins, seafood safety and mass spectrometry</strong></h5>
<ul>
<li>Presenter: Ben Maskrey (Centre of Environment, Fisheries and Aquaculture Science)</li>
</ul>
<h5><strong>11:50 Determination of microplastics with pyrolysis and GC-MS</strong></h5>
<ul>
<li>Presenter: Dr. Michael Soll (Frontier Lab Europe)</li>
</ul>
<h5><strong>12:20</strong> Break</h5>
<h5><strong>12:40 What combustion ion chromatography sum parameter analysis can do for the analysis of PFAS</strong></h5>
<ul>
<li>Presenter: Dr. Lewis Mark (A1-envirosciences Limited)</li>
</ul>
<h5><strong>13:10 Use of Thermo Scientific Exploris 120 Orbitrap HRAM-LC-MS for the analysis of 47 PFAS compounds in UK waters</strong></h5>
<ul>
<li>Presenter: John Quick (ALS Environmental Ltd.)</li>
</ul>
<h5><strong>13:40 Workshop - new untargeted PFAS analysis workflow capabilities within Compound Discoverer software</strong></h5>
<ul>
<li>Presenter: Frans Schoutsen (Thermo Fisher Scientific)</li>
</ul>
<h5><strong>14:10</strong> Break</h5>
<h5><strong>15:10 Starting your voyage into PFAS? Tools and protocols to succeed</strong></h5>
<ul>
<li>Presenter: Ed George (Thermo Fisher Scientific)</li>
</ul>
<h5><strong>16:10 Workshop - new approaches in performing automation by GC (and LC)</strong></h5>
<ul>
<li>Presenter: Dan Carrier (Thermo Fisher Scientific)</li>
</ul>
<h5><strong>16:30</strong> Closing of the live streaming event</h5>


Thermo Scientific: Water & Environmental Analysis User Meeting - Day 1

Water & Environmental Analysis User Meeting - Day 1

Streaming live from our Demo Centre in Hemel Hempstead | Join the complete event or the presentations of your choice only.

<p><strong>This meeting covers the latest trends and techniques to meet current water and environmental testing demands for emerging contaminants and evolving regulations. Our guest speakers from the water industry and environmental research and testing laboratories will share their expertise on their latest work, analytical workflows, and automation.</strong></p>
<p>Join us and discover valuable insights to maximise testing productivity and instrument uptime, simplify workflows and standardise data workup.</p>
<h3><strong>June 28 (Day 2) – Evolving regulations</strong></h3>
<p>This session will explore disinfection by-products, haloacetic acids, heavy metals, volatiles/semi-volatiles analysis.</p>
<p>Attend the whole day or selected presentations only.</p>
<h5><strong>10:00</strong> Online access opens (Streaming begins 09:30 BST/10:30 CEST)</h5>
<h5><strong>10:30 Opening of the event, welcome and introduction</strong></h5>
<ul>
<li>Presenter: Ed George (Thermo Fisher Scientific)</li>
</ul>
<h5><strong>10:50 Beyond compliance - use of the Orbitrap Exploris 120 HRAM-LC-MS for the monitoring of catchments</strong></h5>
<ul>
<li>Presenter: Mark Collins (Northern Ireland Water)</li>
</ul>
<h5><strong>11:20 Utilizing IC-MS/MS for the analysis of halo acetic acids and disinfection by products in drinking water</strong></h5>
<ul>
<li>Presenter: Chris Pegg (Anglian Water)</li>
</ul>
<h5><strong>11:50 GC-MS analysis of environmental samples using automated sample preparation</strong></h5>
<ul>
<li>Presenter: John Quick (ALS Environmental Ltd.)</li>
</ul>
<h5><strong>12:20</strong> Break</h5>
<h5><strong>12:40 Development of an ion chromatography method with EC and MS detection for the analysis of bromide and the disinfection by products bromate, chlorate and chlorite</strong></h5>
<ul>
<li>Presenter: Joseph Scott (Affinity Water)</li>
</ul>
<h5><strong>13:10 High throughput nutrients analysis - developing methodologies for environmental and wastewater matrices</strong></h5>
<ul>
<li>Presenter: Red Godwin (Thermo Fisher Scientific)</li>
</ul>
<h5><strong>13:40 Performing the analysis of trace metals in environmental samples via ICP and ICP-MS</strong></h5>
<ul>
<li>Presenter: Trudy McMurray (Northern Ireland Environment Agency)</li>
</ul>
<h5><strong>14:15</strong> Closing of the live streaming event</h5>


Thermo Scientific: Water & Environmental Analysis User Meeting - Day 2

Water & Environmental Analysis User Meeting - Day 2

<p><strong>EPA Draft Method 1621 represents a shift in thinking in how we screen for PFAS and other fluorinated compounds in the environment, giving a better picture of the full scope of contamination. The method uses combustion ion chromatography (CIC) to determine adsorbable organic fluorine (AOF) in water samples, a non-targeted sum parameter defined by the method itself.</strong></p>
<p>In this webinar, Amelia Paolantonio, from Enthalpy Analytical, will show attendees how she was able to successfully implement this method in her lab. Webinar participants will gain valuable insights into best practices for the method and things to watch out for, such as the importance of cleanliness. Dr. Jay Gandhi, from Metrohm USA, will discuss how to execute a total solution for your fluorine analysis to help you comply with Draft Method 1621.  </p>
<p>Key Learning Objectives:</p>
<ul>
<li><p><strong>Learn about EPA Draft Method 1621 and its requirements</strong></p>
</li>
<li><p><strong>Find out the challenges of executing this method and the strategies to overcome them</strong></p>
</li>
<li><p><strong>Learn how to implement a total solution for complying with the method</strong></p>
</li>
</ul>
<p>Who Should Attend:</p>
<ul>
<li><p><strong>Environmental lab technicians, analysts, lab managers, and lab directors</strong></p>
</li>
<li><p><strong>Those interested in learning about new monitoring technologies for PFAS and fluorinated compounds</strong></p>
</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Amelia Paolantonio (Senior Scientist, Enthalpy Analytical)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Dr. Jay Gandhi (Vertical Markets Manager, Metrohm USA)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Catherine Dold (Health &amp; Environment Writer, C&amp;EN Media Group)</p>
</blockquote>


C&EN: The Changing PFAS Landscape: Insights Into EPA Draft Method 1621

The Changing PFAS Landscape: Insights Into EPA Draft Method 1621

EPA Draft Method 1621 represents a shift in thinking in how we screen for PFAS and other fluorinated compounds in the environment

Insights Into EPA Draft Method 1621

<p><strong>Discrete analyzers are robust, easy-to-use, and provide parallel measurement of multiple analytes in as fast as 10 minutes. Compared to traditional wet chemistry techniques, they provide equivalent or better data quality while speeding up the determination process significantly. Adding this automation to one’s laboratory workflow significantly reduces the amount of reagent used and analysts’ bench time. Ion chromatography (IC) is a well-established analytical method that expands the breadth of water analyses by offering distinct capabilities that include ultra-trace level determinations for a broad spectrum of analytes.  Thermo Scientific Dionex IC Systems can be tailored to meet specific anion and cation analysis needs providing direct determination of multiple analytes in a single run and the ability to handle challenging sample matrices.</strong></p>
<p>In this webinar, Timothy Traynor, Technical Specialist at Pace Analytical will present comprehensive water analysis workflows utilizing integrated discrete analyzers and Dionex IC systems and discuss their complementary benefits that offer high sensitivity, flexibility, and sample throughput, helping laboratories in Pace’s network to reduce overall cost per test and increase laboratory productivity.</p>
<p>Gary He, Product Marketing Manager, will also discuss the recent advances of Thermo Scientific Gallery Aqua Master Discrete Analyzers that enable more automation and better U.S. EPA compliance.</p>
<p>Dr. Carl Fisher, Product Marketing Manager, will conclude the session by providing a high-level overview of the tailored Thermo Scientific IC solutions that are integral to comprehensive water analysis.</p>
<blockquote>
<p><strong>Presenter:</strong> Timothy Traynor (Technical Specialist, Pace Analytical)</p>
</blockquote>
<blockquote>
<p>Timothy Traynor has been a Technical Specialist in Pace’s IDEA Lab since 2019. Prior to his current role, Traynor has worked as a Chemist and a Metals Analyst at Pace, and a Chemist at the North Dakota Department of Health, among others. Traynor has a bachelor’s degree in Chemistry from Concordia College and a master’s degree in Theology from Saint John’s University.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Gary He (Product Marketing Manager - Gallery Discrete Analyzers, Thermo Fisher Scientific)</p>
</blockquote>
<blockquote>
<p>Currently serving as the Product Marketing Manager for the Gallery discrete analyzers within Thermo Fisher Scientific, Gary is responsible for leading the marketing programs to drive sustainable technology adoption in established applications such as water, nutrient, agricultural, food and beverage analyses, and in new adjacent applications, such as enzyme analysis for food and beverage, animal nutrition, grain processing, home care detergent, and biopharma.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Carl Fisher (Product Marketing Manager - Ion Chromatography, Thermo Fisher Scientific)</p>
</blockquote>
<blockquote>
<p>In his current role, Carl is the Product Marketing Manager focusing on environmental applications for ion chromatography and sample preparation products . Prior to this, he spent several years as an analytical chemist as a member of the Applications Laboratory team, producing technical and application notes.</p>
</blockquote>


Thermo Scientific: Expanding the breadth of water contaminant determinations with ion chromatography and discrete analysis

Expanding the breadth of water contaminant determinations with ion chromatography and discrete analysis

IC Systems can be tailored to meet anion and cation analysis needs providing direct determination of multiple analytes in a single and challenging matrices.

LCMS webinars focusing on IC - page 5