A coumarin-based photocleavable solid support allows visible-light release and nonchromatographic purification of RNA oligonucleotides, including UV-sensitive phosphorothioate backbones.

5 webinars: accurate mass, biopharma processing, Cary 3500, downstream chromatography, LC productivity, PFAS testing, USP <621>, UV-Vis analysis

This week we bring you application notes by Agilent Technologies, Metrohm, Thermo Fisher Scientific / HPLC and Waters Corporation!

Benchmarking revealed that the Orbitrap Astral Zoom prototype outperforms the standard Astral MS, sampling more ions per peptide and delivering improved sensitivity and quantitative precision in DIA proteomics.

This week we bring you application notes by Agilent Technologies, Metrohm, Shimadzu and Waters Corporation!

A validated QbD-based RP-HPLC method enables robust, stability-indicating impurity analysis of Elexacaftor, supporting process development and quality control in drug manufacturing.

This week we bring you application notes by Agilent Technologies, Shimadzu and Waters Corporation and technical note by Thermo Fisher Scientific!

LC-HRMS screening combined with temporal clustering identified daily domestic discharge patterns in wastewater, enabling improved interpretation of population chemical exposure.

A novel persistence-directed testing approach combined with nontarget GC-MS and LC-HRMS revealed a significant fraction of persistent chemicals in offshore oil platform produced waters.

7 webinars: automated liquid handling, discovery chemistry, GLP-1, HPLC maintenance, LC workflows, SCIEX OS software, SFE/SFC, UV-Vis, workflow automation