News from LabRulezLCMS Library - Week 16, 2025
Article | Application

News from LabRulezLCMS Library - Week 16, 2025

This week we bring you application notes by Agilent Technologies, Knauer, Shimadzu, Thermo Fisher Scientific and Waters Corporation!
We, 16.4.2025
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News from LabRulezLCMS Library - Week 16, 2025
News from LabRulezLCMS Library - Week 15, 2025
Article | Application

News from LabRulezLCMS Library - Week 15, 2025

This week we bring you application notes by Agilent Technologies, Shimadzu, Thermo Fisher Scientific and Waters Corporation!
We, 9.4.2025
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News from LabRulezLCMS Library - Week 15, 2025
Matrix effect evaluation using multi-component post-column infusion in untargeted hydrophilic interaction liquid chromatography-mass spectrometry plasma metabolomics
Scientific article | Science and research

Matrix effect evaluation using multi-component post-column infusion in untargeted hydrophilic interaction liquid chromatography-mass spectrometry plasma metabolomics

This study evaluates matrix effects in untargeted HILIC-MS plasma metabolomics using post-column infusion, identifying optimal conditions and improving method reliability for metabolite analysis.
Mo, 7.4.2025
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Matrix effect evaluation using multi-component post-column infusion in untargeted hydrophilic interaction liquid chromatography-mass spectrometry plasma metabolomics
News from LabRulezLCMS Library - Week 14, 2025
Article | Application

News from LabRulezLCMS Library - Week 14, 2025

This week we bring you application notes by Agilent Technologies, Mestrelab Research, Shimadzu and Waters Corporation, poster by GC Image / MDCW and technical note by Thermo Fisher Scientific!
We, 2.4.2025
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News from LabRulezLCMS Library - Week 14, 2025
Quantification of Gd species in a tetrameric Gd-based contrast agent using HPLC-ICP-MS
Scientific article | Science and research

Quantification of Gd species in a tetrameric Gd-based contrast agent using HPLC-ICP-MS

This study presents an HPLC-ICP-MS method for precise quantification of Gd complexes in Gadoquatrane, enabling detection of trace by-products to optimize synthesis and drug control strategies.
Mo, 17.3.2025
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Quantification of Gd species in a tetrameric Gd-based contrast agent using HPLC-ICP-MS
Evaluating the potential of hydrophilic interaction liquid chromatography for collagen peptide mapping analysis
Scientific article | Science and research

Evaluating the potential of hydrophilic interaction liquid chromatography for collagen peptide mapping analysis

This study optimizes a HILIC method for collagen peptide mapping, evaluating stationary phases, injection techniques, and MS coupling to enhance peptide separation and hydroxylation analysis.
Mo, 17.3.2025
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Evaluating the potential of hydrophilic interaction liquid chromatography for collagen peptide mapping analysis
Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography
Scientific article | Various

Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography

This study investigates how mobile phases and chromatographic conditions affect siRNA duplex stability, using DSC and chromatography to measure melting temperatures.
Mo, 10.3.2025
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Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography
Remote Deep-Ultraviolet Laser Ablation in Connection with Electrospray Ionization–Atmospheric Pressure Chemical Ionization (rDUVLAESCI): A Novel Dual Ionization Source for Molecular Mass Spectrometry
Scientific article | Science and research

Remote Deep-Ultraviolet Laser Ablation in Connection with Electrospray Ionization–Atmospheric Pressure Chemical Ionization (rDUVLAESCI): A Novel Dual Ionization Source for Molecular Mass Spectrometry

This study introduces a novel remote deep-UV laser ablation dual-ionization source for molecular mass spectrometry and imaging with enhanced spatial resolution.
Tu, 18.2.2025
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Remote Deep-Ultraviolet Laser Ablation in Connection with Electrospray Ionization–Atmospheric Pressure Chemical Ionization (rDUVLAESCI): A Novel Dual Ionization Source for Molecular Mass Spectrometry
Evaluation of ion pairing reversed-phase liquid chromatography for the separation of large RNA molecules
Scientific article | Various

Evaluation of ion pairing reversed-phase liquid chromatography for the separation of large RNA molecules

The goal of this study is to optimize IP-RPLC for separating and characterizing large RNA molecules, enhancing RNA quality attribute analysis for therapeutic development.
Tu, 21.1.2025
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Evaluation of ion pairing reversed-phase liquid chromatography for the separation of large RNA molecules
Understanding the fundamentals of the on-off retention mechanism of oligonucleotides and their application to high throughput analysis
Scientific article | Various

Understanding the fundamentals of the on-off retention mechanism of oligonucleotides and their application to high throughput analysis

The goal of this study is to investigate oligonucleotide elution behavior in IP-RPLC under various mobile phase conditions and develop ultra-fast separation methods for therapeutic oligonucleotides.
Tu, 14.1.2025
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Understanding the fundamentals of the on-off retention mechanism of oligonucleotides and their application to high throughput analysis
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