When you can’t tolerate any disruptions to your daily analytical work, the Thermo Scientific™ Vanquish™ Core HPLC systems empower your operators to continually deliver exceptional results. Transferring methods to the Vanquish Core system is simple and seamless, regardless of your current HPLC setup.
Built upon the innovative Vanquish platform, the Vanquish Core HPLC systems provide exceptional analytical precision, detector sensitivity, and operational simplicity to enable unprecedented reliability and robustness. Designed specifically for routine analysis laboratories, the Vanquish Core HPLC systems provide:
Thermo Scientific Vanquish Core HPLC System.
On-time delivery of your results is critical. The Vanquish Core HPLC system enables your laboratory to maximize productivity through novel intelligence features, ensuring exceptional instrument reliability.
An optimally-functioning injection valve is critical to deliver precise and accurate quantitative results on an HPLC system. The Vanquish Core HPLC system uses innovative long-life injection valves, reducing cost of ownership, minimizing unexpected downtime, and increasing overall confidence in your results.
In today’s connected and globalized world, instrument reliability is measured through the ability to deliver the right results in every lab, on every instrument, operated by any user in laboratories across the globe. The Vanquish Core HPLC system ensures that your labs deliver consistency, no matter where they are.
Thermo Scientific Vanquish Core HPLC System: Test sites of a Vanquish Core round robin test using eight different instruments with individual samples, users, and columns. Each analysis passed the specified SST criteria highlighting the reliability of the instrument and the ease of use for each user resulting in successful SST.
Thermo Scientific Vanquish Core HPLC System: Results of a global round robin test showing that all eight data sets consistently surpass the SST criteria of resolution above 1.5 and excellent peak area reproducibility.
Regardless of your current software infrastructure, you can take advantage of the latest chromatographic innovations. The Vanquish Core HPLC system pairs perfectly with Chromeleon CDS to take advantage of its unrivaled ease-of-use, reliability, and performance.
The Vanquish Core HPLC system supports you in minimizing both out-of-specification results and deviations from your Standard Operating Procedures (SOPs).
Thermo Scientific Vanquish Core HPLC System: The Vanquish Core HPLC system virtually eliminates potential causes of out-of-specification (OoS) results due to industry-leading system intelligence.
In today’s analytical laboratory environment, your scientific personnel have limited time for in-depth familiarization with new instrumentation. An LC system should seamlessly fit into your existing workflows and processes without requiring extra training or expertise. The Vanquish Core HPLC system brings ease of use to a new level, enabling every user to deliver exceptional results, independent of user experience.
Thermo Scientific Vanquish Core UHPLC System: Vanquish Solvent Monitor manages your eluent and waste levels for highest confidence during analysis.
The Vanquish Solvent Monitor enables Vanquish HPLC and UHPLC systems to accurately and automatically measure the liquid levels in each individual solvent channel and waste container.
Deep integration of the Vanquish Solvent Monitor into the Vanquish Core system provides direct viewing of solvent and waste volumes within Chromeleon CDS and directly on the module itself.
Run large sample sets with confidence, avoid lost time, and eliminate procedural deviations by monitoring mobile phase levels; prevent hazardous spills by monitoring waste levels.
The interactive Vanquish User Interface allows operators to intuitively, immediately, and intelligently monitor the current system status:
When you need to improve your lab’s productivity while maintaining existing workflows, you need a system that has the flexibility to precisely replicate your current methods. The Vanquish Core HPLC system is designed to mimic other HPLC systems to transfer normal-phase and reversed-phase methods easily while boosting productivity and ease of operation.
Thermo Scientific Vanquish Core HPLC System: With the Vanquish Core HPLC system, the instrument gradient delay volume can be seamlessly adjusted in order to match legacy HPLC instruments. In this example the gradient delay volume was increased by a simple software command (Idle Volume=200 μL) in the instrument method to best match the Agilent ® 1260 Infinity LC system.
Transferring analytical HPLC methods can be challenging if you do not have the right instrumental tools at hand. The reason for that is that the success of method transfer is not only determined by a single instrumental parameter such as the gradient delay volume of the HPLC system. In fact, the system dispersion and the column thermostatting technology also play a major role. The Vanquish Core HPLC system is the only instrument that can cover all of these parameters to allow for the easiest method transfer.
Thermo Scientific Vanquish Core HPLC System: Replicate your methods.In addition to gradient delay volume, matching the column thermostatting mode and overall system dispersion are critical to ensure your method is successfully transferred from one system to another. Vanquish Core offers two column thermostatting options to change to the column thermostatting principle of your legacy HPLC instrument with a single mouse click.
Thermo Scientific Vanquish Core HPLC System: High organic sample solvents can cause peak shape distortions on modern HPLC instruments. Vanquish Core HPLC systems conduct sandwich injections to be able to inject high organic samples while keeping the chromatographic efficiency.
Furthermore, modern HPLC instruments offer lower system dispersion, which benefits overall separation power but might lead to undesirable peak shapes when samples with high organic content are injected. The Vanquish Core HPLC system uses custom injection programs to do a simple in-needle dilution to the sample and enable you to run your method as usual while benefiting from improved separation power.
Thermo Scientific Vanquish Core HPLC System Method Transfer kit for Vanquish Core HPLC system. In combination with the Vanquish Split Samplers metering device, the gradient delay volume can be adjusted on a microliter scale over a wide range. Audit trail tracking of the settings and full qualification ensure regulatory compliance.
Choosing the right detection technology is key to revealing all the components of interest in your sample. The Vanquish Core HPLC systems offer a wide range of detection capabilities that can be easily integrated and combined to fit your methods.
The industry-leading Thermo Scientific™ Vanquish™ diode array detectors offer excellent signal-to-noise performance and the widest linear range, exceeding that of variable wavelength detectors. Based on diode array detection technology, the multiple wavelength detector offers a cost-effective solution for simultaneously acquiring up to eight UV-Vis wavelength channels.
Thermo Scientific Vanquish Core HPLC System: Concentration vs. peak height plot of nevirapine with data points that were considered for calibration (black) and data points that were eliminated from calibration due to curve decline (red). Linear calibration with permitted offset and no weighting.Fluorescence detection enables high sensitivity and selectivity.
Thermo Scientific Vanquish Core HPLC System: FLD chromatogram of the four aflatoxins: G2, G1, B2 and B1 at a concentration of 0.9 μg/kg for G2 and B2 and 2.9 μg/kg for G1 and B1.
UV-Vis detection with excellent sensitivity and linearity is a cost- effective and powerful solution for quantitative compound analysis.
Isocratic separations with refractive index detection offers cost-effective, universal detection for routine analysis.
The Thermo Scientific™ Vanquish™ charged aerosol detector is powerful, uniform, and universal; able to detect virtually any large and small molecule with sub-nanogram-level sensitivity, even those that lack a chromophore or that poorly ionize. The flexibility and performance of charged aerosol detection is ideal for analytical R&D, while its simplicity and reproducibility benefit manufacturing QA/QC applications.
Thermo Scientific Vanquish Core HPLC System: Unlike mass spectrometry and UV, the CAD is able to measure all analytes in the sample. Mass spectrometry (MS) requires the analyte to form gas phase ions while response by a UV detector depends upon the nature of the chromophore.Mass spectrometry gives access to valuable data no other technology can deliver. The easy to use Thermo Scientific™ ISQ™ EM single quadrupole mass spectrometer or the Thermo Scientific™ ISQ™ EC single quadrupole mass spectrometer integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.
LC-MS quantification is a widely used technology in many application fields, including food safety and environmental monitoring. In conjunction with the Thermo Scientific mass spectrometer portfolio, Vanquish Core delivers a great solution for ultra-sensitive detection. For control of your LC-MS setup you can choose between the feature-rich Thermo Scientific™ Xcalibur™ software, the powerful Thermo Scientific™ TraceFinder™ software or the compliant-ready Chromeleon CDS control.
Thermo Scientific Vanquish Core HPLC System: Innovating for you.Use the Vanquish Solvent Monitor to increase your regulatory compliance, productivity, and safety of your laboratory. That device guarantees that your HPLC systems will never run dry and the waste will not spill over, reducing loss of valuable measurement time and sample material.
With the Vanquish User Interface, you are the master of your LC instrument. The display always shows you the key parameters of your instrument such as flow and pressure and guides you in a visual step-by-step video tutorial through key maintenance tasks.
Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitates multiple detector technologies. The Vanquish Core systems have been built to utilize a wide range of analytical detectors, including mass spectrometry (MS), diode array detection (DAD), multi wavelength detection (MWD), charged aerosol detection (CAD), variable wavelength detection (VWD), refractive index detection (RID), and fluorescence detection (FLD).
The Vanquish autosampler has the option to add the Vanquish Loader to connect the LC or LC-MS system to the sample preparation robotics, allowing the complete analysis of the sample from preparation to reporting without human intervention.
Superior retention time precision and accuracy, as well as enhanced column protection.
Vanquish Core provides proprietary optimized normal-phase and reversed-phase valves. The valves used in the Vanquish Core HPLC systems are designed to meet the reliability needs to make HPLC run robustly and routinely. The reversed-phase valves are long-life and follow a no maintenance philosophy reducing your overall cost of ownership.
Utilizes tool-free Viper Fingertight Fittings with near-zero dead volume operation and ergonomic design.
Modules can be repaired without de-stacking; each unit has handles for ease of maneuvers; light bars on the front of the system indicate system status; and the entire system supports tool-free maintenance.
The built-in drawer stores accessories, related documents, or any other useful material for the system.
The tunable gradient delay volume and multiple thermostatting options allow you to precisely replicate your legacy HPLC methods.
Support under Chromeleon CDS feature release and long-term support versions, Waters Empower and Agilent OpenLab CDS.
Thermo Scientific LC portfolio overview.
