Waters Xevo G3 QTof Mass Spectrometer

Complete Coverage for Confident Characterization

The Xevo™ G3 QTof, an analytical workhorse, is designed to characterize and quantify a diverse set of molecules.

ULTIMATE PERFORMANCE

Ensure maximum coverage of analytes and with improved transmission low m/z ions, labile species, while still excelling in traditional biopharmaceutical workflows and addressing emerging needs to characterize new modalities.

CONNECTED PRODUCTIVITY

Harmonize workflows across development, manufacturing and QC by deploying the Xevo G3 QTof and the BioAccord™ System with ACQUITY™ Premier within the waters_connect™ ecosystem.

EXTENDED FLEXIBILITY

Improved quantitative capabilities, with wider inter- and intra-spectrum dynamic range for comprehensive quantitative/qualitative analysis, ideal for screening and targeted applications.

UNQUESTIONED CONFIDENCE

Ensure high quality data with consistent robustness and reproducibility through advances in ion optics, maintaining performance and productivity over a longer time period.

Ultimate Performance

Increase your application coverage

As labs extend their capabilities, more is required from their analytical systems. The Xevo G3 QTof incorporates new technology building blocks that improve a scientists’ ability to characterize:

1. Complex biologics with inclusion of a m/z 16,000 calibration range and tailored informatics.
2. Challenging small molecules with updates to the ion optics and detection system that maximize transmission and dynamic range.

Waters Xevo G3 QTof: The Xevo G3 QTof, equipped with the StepWave™ XS ion guide, efficiently transmits low mz ions, labile species, increasing compound coverage and analytical fidelity.

Connected Productivity

Harmonize your workflows across the pipeline

Harmonizing workflows across development, manufacturing and QC is key to ensuring lab productivity. The Xevo G3 QTof is ideal for characterizing biomolecules and processes before transitioning to dedicated attribute monitoring assays on either the Xevo G3 QTof or BioAccord System with ACQUITY Premier.

The waters_connect Ecosystem offers seamless, compliant-ready workflows to understand and monitor biotherapeutic variation. Systems and users can be connected through waters_connect, with security-controlled access, full data traceability, with the operational efficiency and scalability of networked deployment.

Achieve robust and unbiased performance for analysis of your biotherapeutics with ACQUITY Premier Systems and Columns and an expanding array of informatics tools, including Peptide MAM, INTACT Mass, and CONFIRM Sequence applications.

Waters Xevo G3 QTof: Harmonize your workflows with Xevo G3 QTof, the BioAccord System and tailored informatics.

Delivering Qualitative and Quantitative Performance

Is it detected and how much is detected?

Analytical laboratories are under pressure to maximize system usage, so a flexible multifunctional instrument that can deliver high quality qualitative and quantitative data sets is critical.

The Xevo G3 QTof, has evolved to address those needs, with updates to core technology delivering up to 5 orders of linear dynamic range through application of adaptive intensity control for targeted Tof-MRM analysis.

For untargeted and screening experiments, with up to 4x increase in-spectrum dynamic range, the Xevo G3 QTof is able detect and quantify components of interest in the most challenging of complex matrices.

Waters Xevo G3 QTof: Utilizing Tof-MRM to answer critical questions.

Complete Confidence

High quality reliable data sets every time

Instrument stability and uptime are unquestioned necessities in a fast-paced high-throughput environment. The evolved design of the Xevo G3 QTof has been engineered to deliver consistent robustness and reproducibility, maintaining performance and productivity over a longer time period. With updated ion optics and optimized ion beam conditioning the Xevo G3 QTof is a true analytical workhorse that deliverables high quality data routinely.

Waters Xevo G3 QTof: The Xevo G3 QTof, equipped with the StepWave™ XS ion guide, efficiently transmits low m/z ions, labile species, increasing compound coverage and analytical fidelity.

Unhindered Analytical Capabilities

Extending the reach of characterization

Having an extensive toolkit at your disposal protects against future unknowns and the ever-increasing complexity of samples.

The Xevo G3 QTof is equipped with the universal source architecture, maximizing versatility and minimizing downtown. With options including ESI, ESCi,™ APCI, APGC,™ ASAP,™ UniSpray,™ nanoFlow ESI, and DESI XS* the Xevo G3 QTof can be used for many different applications and molecule types — swap your source not your instrument.

Support of a range of inlets including ACQUITY Premier System, ACQUITY UPLC™ PLUS Series, ACQUITY UPLC M-Class, and ACQUITY 2D-LC* ensures your lab is equipped for the future and can handle challenging and complex samples. 
* For specific configuration requirements consult with your Waters Representative.

The Xevo G3 QTof is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to meet your labs analytical requirements.

waters_connect: The modern, app-based software platform, waters_connect, offers seamless, compliant-ready workflows ensuring data traceability and transferability in a fast paced, highly connected laboratory.

MassLynx: The well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.

Waters Xevo G3 QTof: Sequence coverage map of a 21mer heavily modified oligonucleotide within the CONFIRM Sequence application, displaying all the confirmed fragment ions.