This study demonstrates Orbitrap-IRMS for full and intramolecular carbon isotope analysis of PFOA, enabling sensitive PFAS source fingerprinting without analyte decomposition.

This study couples LC to ESI-Orbitrap MS for stable isotope analysis using peak homogenization to remove chromatographic isotope effects and amount dependency, achieving precise C, N, and S isotopologue ratios.

A coumarin-based photocleavable solid support allows visible-light release and nonchromatographic purification of RNA oligonucleotides, including UV-sensitive phosphorothioate backbones.

Benchmarking revealed that the Orbitrap Astral Zoom prototype outperforms the standard Astral MS, sampling more ions per peptide and delivering improved sensitivity and quantitative precision in DIA proteomics.

LC-HRMS screening combined with temporal clustering identified daily domestic discharge patterns in wastewater, enabling improved interpretation of population chemical exposure.

A novel persistence-directed testing approach combined with nontarget GC-MS and LC-HRMS revealed a significant fraction of persistent chemicals in offshore oil platform produced waters.

LC-HRMS detected more prescribed and non-prescribed drugs than immunoassays and would have influenced clinical decisions for 25% of patients, mainly those with opioid-use history.

Day 1 in České Budějovice featured an Orbitrap plenary by Alexander Makarov, sessions on exposome, proteomics and structural MS, sponsor talks, flash talks and an evening networking reception.

Regenerating liver redirects ammonia metabolism to fuel de novo pyrimidine synthesis, enabling cell proliferation and tissue repair after hepatectomy through metabolic reprogramming.

A new class of trisubstituted pyridines targets ATP synthase in Acinetobacter baumannii. Four lead compounds showed potent antibacterial effects and synergized with colistin against multidrug-resistant strains.