A facile and eco-friendly simultaneous quantification LC-TQ-MS/MS approach for N-Nitroso Moxifloxacin and di-nitroso pyrrolopiperidine in Moxifloxacin tablets and eye drops
Scientific article | Science and research

A facile and eco-friendly simultaneous quantification LC-TQ-MS/MS approach for N-Nitroso Moxifloxacin and di-nitroso pyrrolopiperidine in Moxifloxacin tablets and eye drops

A rapid, green LC-QqQ-MS/MS method quantifies N-MOX and DNPP in moxifloxacin tablets and eye drops. Validated per ICH, it ensures safety by detecting trace NDSRIs with minimal environmental impact.
Mo, 28.7.2025
LabRulez
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A facile and eco-friendly simultaneous quantification LC-TQ-MS/MS approach for N-Nitroso Moxifloxacin and di-nitroso pyrrolopiperidine in Moxifloxacin tablets and eye drops
A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method
Scientific article | Science and research

A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method

Novel LC-MS/MS and UPLC methods quantify NDSRI in mefenamic acid tablets and suspensions with high sensitivity, accuracy, and eco-friendly evaluation via multiple green metrics.
Mo, 21.7.2025
LabRulez
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A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method
Systematic method optimisation approach for small molecule imaging on the SELECT SERIES MALDI MRT - Drug mapping in fingerprints, a case study
Scientific article | Science and research

Systematic method optimisation approach for small molecule imaging on the SELECT SERIES MALDI MRT - Drug mapping in fingerprints, a case study

MALDI-MSI on SELECT SERIES MALDI-MRT was optimized for fingerprint imaging. The method improves resolution and enables detection of drugs like antipsychotics in latent prints.
Mo, 14.7.2025
LabRulez
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Systematic method optimisation approach for small molecule imaging on the SELECT SERIES MALDI MRT - Drug mapping in fingerprints, a case study
NDMA in macrolides: GC-MS/MS method for its detection and study of its formation
Scientific article | Science and research

NDMA in macrolides: GC-MS/MS method for its detection and study of its formation

This study evaluates the risk of NDMA formation from macrolide antibiotics, highlighting solubility-related analytical challenges and the role of drug form and storage in NDMA levels.
Mo, 7.7.2025
LabRulez
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NDMA in macrolides: GC-MS/MS method for its detection and study of its formation
A unique method of rare-earth recycling can strengthen the raw material independence of Europe and America
Article | Science and research

A unique method of rare-earth recycling can strengthen the raw material independence of Europe and America

Scientists at IOCB Prague created an eco-friendly method to recycle rare earths like neodymium from magnets, offering a sustainable alternative to mining and boosting EU & US raw material security.
We, 2.7.2025
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
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A unique method of rare-earth recycling can strengthen the raw material independence of Europe and America
Development and thorough evaluation of a multi-omics sample preparation workflow for comprehensive LC-MS/MS-based metabolomics, lipidomics and proteomics datasets
Scientific article | Science and research

Development and thorough evaluation of a multi-omics sample preparation workflow for comprehensive LC-MS/MS-based metabolomics, lipidomics and proteomics datasets

This study aimed to develop and compare ten extraction protocols to find the most effective method for generating metabolomics, lipidomics, and proteomics data from postmortem tissue.
Mo, 30.6.2025
LabRulez
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Development and thorough evaluation of a multi-omics sample preparation workflow for comprehensive LC-MS/MS-based metabolomics, lipidomics and proteomics datasets
A novel LC-MS/MS assay for low concentrations of creatinine in sweat and saliva to validate biosensors for continuous monitoring of renal function
Scientific article | Science and research

A novel LC-MS/MS assay for low concentrations of creatinine in sweat and saliva to validate biosensors for continuous monitoring of renal function

This study develops and validates an LC-MS/MS assay to quantify low creatinine levels in sweat and saliva, supporting non-invasive biosensor-based kidney function monitoring during haemodialysis.
Mo, 19.5.2025
LabRulez
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A novel LC-MS/MS assay for low concentrations of creatinine in sweat and saliva to validate biosensors for continuous monitoring of renal function
News from LabRulezLCMS Library - Week 17, 2025
Article | Application

News from LabRulezLCMS Library - Week 17, 2025

This week we bring you application notes by Shimadzu and Waters Corporation, presentation by Agilent Technologies and technical notes by Knauer and Thermo Fisher Scientific!
We, 23.4.2025
LabRulez
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News from LabRulezLCMS Library - Week 17, 2025
Ion exchange chromatography of biotherapeutics: Fundamental principles and advanced approaches
Scientific article | Science and research

Ion exchange chromatography of biotherapeutics: Fundamental principles and advanced approaches

This review outlines IEX fundamentals and explores advanced strategies—like pH gradients, ultra-short columns, and coupling with MS—for characterizing complex biotherapeutics.
Mo, 21.4.2025
LabRulez
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Ion exchange chromatography of biotherapeutics: Fundamental principles and advanced approaches
Waters HPLC Column Coach
Article | Product

Waters HPLC Column Coach

Waters Column Coach is a helpful tool for comparing reversed-phase column selectivity. It uses the Neue Test to assess hydrophobicity and selectivity under consistent, standard conditions.
Th, 17.4.2025
Waters Corporation (Europe)
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Waters HPLC Column Coach
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