Mass Spectrometry Imaging with Trapped Ion Mobility Spectrometry Enables Spatially Resolved Chondroitin, Dermatan, and Hyaluronan Glycosaminoglycan Oligosaccharide Analysis In Situ
Scientific article | Science and research

Mass Spectrometry Imaging with Trapped Ion Mobility Spectrometry Enables Spatially Resolved Chondroitin, Dermatan, and Hyaluronan Glycosaminoglycan Oligosaccharide Analysis In Situ

This study introduces an MSI-TIMS method to identify and spatially resolve GAG oligosaccharides and their sulfation states directly from retinal tissue sections.
Mo, 14.4.2025
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Mass Spectrometry Imaging with Trapped Ion Mobility Spectrometry Enables Spatially Resolved Chondroitin, Dermatan, and Hyaluronan Glycosaminoglycan Oligosaccharide Analysis In Situ
Comparison of carrier gases for the separation and quantification of mineral oil hydrocarbon (MOH) fractions using online coupled high performance liquid chromatography-gas chromatography-flame ionisation detection
Scientific article | Science and research

Comparison of carrier gases for the separation and quantification of mineral oil hydrocarbon (MOH) fractions using online coupled high performance liquid chromatography-gas chromatography-flame ionisation detection

This study evaluates hydrogen, helium, and nitrogen as carrier gases in HPLC-GC-FID for MOH analysis in food, showing nitrogen as a suitable and effective alternative despite some peak broadening.
Mo, 14.4.2025
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Comparison of carrier gases for the separation and quantification of mineral oil hydrocarbon (MOH) fractions using online coupled high performance liquid chromatography-gas chromatography-flame ionisation detection
Matrix effect evaluation using multi-component post-column infusion in untargeted hydrophilic interaction liquid chromatography-mass spectrometry plasma metabolomics
Scientific article | Science and research

Matrix effect evaluation using multi-component post-column infusion in untargeted hydrophilic interaction liquid chromatography-mass spectrometry plasma metabolomics

This study evaluates matrix effects in untargeted HILIC-MS plasma metabolomics using post-column infusion, identifying optimal conditions and improving method reliability for metabolite analysis.
Mo, 7.4.2025
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Matrix effect evaluation using multi-component post-column infusion in untargeted hydrophilic interaction liquid chromatography-mass spectrometry plasma metabolomics
Hydrophilic interaction liquid chromatography: An efficient tool for assessing thorium interaction with phosphorylated biomimetic peptides
Scientific article | Science and research

Hydrophilic interaction liquid chromatography: An efficient tool for assessing thorium interaction with phosphorylated biomimetic peptides

This study uses HILIC-MS to explore how thorium interacts with phosphorylated biomimetic peptides, revealing its affinity and selectivity versus uranium for toxicity modeling.
Mo, 31.3.2025
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Hydrophilic interaction liquid chromatography: An efficient tool for assessing thorium interaction with phosphorylated biomimetic peptides
Modeling indirectly detected analyte peaks in ion-pair reversed-phase chromatography
Scientific article | Science and research

Modeling indirectly detected analyte peaks in ion-pair reversed-phase chromatography

This study models indirect detection using co- and counter-ion probes in chromatography. New isotherm models accurately predicted elution and sensitivity, with errors mostly under 4.72%.
Mo, 24.3.2025
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Modeling indirectly detected analyte peaks in ion-pair reversed-phase chromatography
Quantification of Gd species in a tetrameric Gd-based contrast agent using HPLC-ICP-MS
Scientific article | Science and research

Quantification of Gd species in a tetrameric Gd-based contrast agent using HPLC-ICP-MS

This study presents an HPLC-ICP-MS method for precise quantification of Gd complexes in Gadoquatrane, enabling detection of trace by-products to optimize synthesis and drug control strategies.
Mo, 17.3.2025
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Quantification of Gd species in a tetrameric Gd-based contrast agent using HPLC-ICP-MS
Evaluating the potential of hydrophilic interaction liquid chromatography for collagen peptide mapping analysis
Scientific article | Science and research

Evaluating the potential of hydrophilic interaction liquid chromatography for collagen peptide mapping analysis

This study optimizes a HILIC method for collagen peptide mapping, evaluating stationary phases, injection techniques, and MS coupling to enhance peptide separation and hydroxylation analysis.
Mo, 17.3.2025
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Evaluating the potential of hydrophilic interaction liquid chromatography for collagen peptide mapping analysis
High-throughput mercury speciation analysis of breast milk using HPLC-ICP-MS
Scientific article | Health

High-throughput mercury speciation analysis of breast milk using HPLC-ICP-MS

This study developed an HPLC-ICP-MS method to quantify Hg²⁺ and MeHg⁺ in breast milk, evaluating collection methods, total mercury correlation, and elemental associations in samples over a 4-month study.
Mo, 10.3.2025
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High-throughput mercury speciation analysis of breast milk using HPLC-ICP-MS
Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography
Scientific article | Various

Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography

This study investigates how mobile phases and chromatographic conditions affect siRNA duplex stability, using DSC and chromatography to measure melting temperatures.
Mo, 10.3.2025
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Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography
Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography
Scientific article | Various

Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography

This study identifies ion release from borosilicate glass bottles as a cause of poor HILIC retention time repeatability and proposes PFA bottles as a solution.
Mo, 3.3.2025
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Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography
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