This study demonstrates Orbitrap-IRMS for full and intramolecular carbon isotope analysis of PFOA, enabling sensitive PFAS source fingerprinting without analyte decomposition.

This study couples LC to ESI-Orbitrap MS for stable isotope analysis using peak homogenization to remove chromatographic isotope effects and amount dependency, achieving precise C, N, and S isotopologue ratios.

Researchers at IOCB Prague have developed new fluorogenic labels that deliver high-contrast fluorescence microscopy, enabling precise visualization of cellular processes without background noise.

Structure-guided libraries and machine learning enable faster discovery of active nucleic acid sequences beyond random mutagenesis.

This study introduces a biochemometric 2D NMR heterocovariance approach to correlate spectral features with bioactivity, enabling targeted discovery of bioactive compounds in complex extracts.

This study reports the first implementation of IR-activated NETD with xenon on a quadrupole-Orbitrap MS, demonstrating improved RNA fragmentation and biopharmaceutical characterization.

This study combines metabolomics, structural analysis, and public omics data to uncover the extensive diversity and global distribution of kurstakin lipopeptides linked to Bacillus biocontrol activity.

This study investigates the synthesis and curing of a furan-based glycidyl amine epoxy resin, revealing improved stiffness and Tg through α-chlorohydrin-driven cross-link formation.

A coumarin-based photocleavable solid support allows visible-light release and nonchromatographic purification of RNA oligonucleotides, including UV-sensitive phosphorothioate backbones.

Benchmarking revealed that the Orbitrap Astral Zoom prototype outperforms the standard Astral MS, sampling more ions per peptide and delivering improved sensitivity and quantitative precision in DIA proteomics.