Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry
Scientific article | Science and research

Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry

This study presents a sensitive LC-HRMS method for sequence verification and impurity profiling of RNA-based therapeutics.
Mo, 1.6.2026
LabRulez
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Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry
From the Road to the Field: Decoding Chemical Transformation in Aging Tire and Artificial Turf Crumb Rubber
Scientific article | Science and research

From the Road to the Field: Decoding Chemical Transformation in Aging Tire and Artificial Turf Crumb Rubber

This study investigates chemical aging of tire and turf crumb rubber, identifying hundreds of transformation products and potential aging markers.
Mo, 25.5.2026
LabRulez
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From the Road to the Field: Decoding Chemical Transformation in Aging Tire and Artificial Turf Crumb Rubber
A Novel Compact Multi-Reflecting Time-of-Flight Mass Spectrometer
Scientific article | Science and research

A Novel Compact Multi-Reflecting Time-of-Flight Mass Spectrometer

This study introduces a compact multi-reflecting TOF mass spectrometer combining high resolution, fast acquisition, and broad dynamic range for LC-MS/MS.
Mo, 18.5.2026
LabRulez
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A Novel Compact Multi-Reflecting Time-of-Flight Mass Spectrometer
Cerebrospinal Fluid Proteome Reveals Dysregulation of Lysosomal and Axonal Proteins in Neurosyphilis
Scientific article | Science and research

Cerebrospinal Fluid Proteome Reveals Dysregulation of Lysosomal and Axonal Proteins in Neurosyphilis

LC–MS/MS proteomics of cerebrospinal fluid reveals lysosomal and axonal pathway disruptions and potential biomarkers in neurosyphilis.
Mo, 11.5.2026
LabRulez
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Cerebrospinal Fluid Proteome Reveals Dysregulation of Lysosomal and Axonal Proteins in Neurosyphilis
New blood biomarkers reveal how faithfully diabetes patients take metformin
Article | Science and research

New blood biomarkers reveal how faithfully diabetes patients take metformin

Researchers from the Institute of Physiology CAS identified novel blood biomarkers that objectively reveal whether patients with type 2 diabetes take metformin as prescribed.
Fr, 8.5.2026
Czech Academy of Sciences
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New blood biomarkers reveal how faithfully diabetes patients take metformin
Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections
Article | Science and research

Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections

New androstane-based steroid derivatives can significantly improve antibiotic efficacy against multidrug-resistant Staphylococcus aureus, offering a promising strategy to overcome efflux-mediated resistance.
Fr, 8.5.2026
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
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Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections
Regarding Emitter Positioning for Nanoflow Electrospray Ionization with a High-Capacity Inlet Capillary
Scientific article | Science and research

Regarding Emitter Positioning for Nanoflow Electrospray Ionization with a High-Capacity Inlet Capillary

This study shows nanoflow ESI-MS signal intensity is robust within 1–2 mm of optimal emitter position, improving proteomics workflow stability.
Mo, 4.5.2026
LabRulez
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Regarding Emitter Positioning for Nanoflow Electrospray Ionization with a High-Capacity Inlet Capillary
From Chemistry to Functionality - HPLC–DAD/LC–MS/MS Characterization of Bee Product-Enriched Prunus spinosa L. Kombucha with In Vitro Antidiabetic Activity and Bioaccessibility
Scientific article | Science and research

From Chemistry to Functionality - HPLC–DAD/LC–MS/MS Characterization of Bee Product-Enriched Prunus spinosa L. Kombucha with In Vitro Antidiabetic Activity and Bioaccessibility

This study characterizes bee product–enriched blackthorn kombucha, revealing improved bioactive content, antioxidant capacity, and antidiabetic activity.
Mo, 27.4.2026
LabRulez
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From Chemistry to Functionality - HPLC–DAD/LC–MS/MS Characterization of Bee Product-Enriched Prunus spinosa L. Kombucha with In Vitro Antidiabetic Activity and Bioaccessibility
LCMS-Net: Deep Learning for Raw High Resolution Mass Spectrometry Data Applied to Forensic Cause-of-Death Screening
Scientific article | Science and research

LCMS-Net: Deep Learning for Raw High Resolution Mass Spectrometry Data Applied to Forensic Cause-of-Death Screening

LCMS-Net is an end-to-end deep learning model for raw LC-HRMS data, improving accuracy, reducing preprocessing, and minimizing batch effects in metabolomics.
Mo, 20.4.2026
LabRulez
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LCMS-Net: Deep Learning for Raw High Resolution Mass Spectrometry Data Applied to Forensic Cause-of-Death Screening
Characterization of Asian lacquers by atmospheric solids analysis probe high resolution tandem mass spectrometry coupled with cyclic ion mobility separation
Scientific article | Science and research

Characterization of Asian lacquers by atmospheric solids analysis probe high resolution tandem mass spectrometry coupled with cyclic ion mobility separation

This study uses ASAP-IMS-HRMS to characterize and classify Asian lacquers by origin, detecting phenols, pigments, and resins in historical samples.
Mo, 13.4.2026
LabRulez
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Characterization of Asian lacquers by atmospheric solids analysis probe high resolution tandem mass spectrometry coupled with cyclic ion mobility separation
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