This study introduces a biochemometric 2D NMR heterocovariance approach to correlate spectral features with bioactivity, enabling targeted discovery of bioactive compounds in complex extracts.

This study reports the first implementation of IR-activated NETD with xenon on a quadrupole-Orbitrap MS, demonstrating improved RNA fragmentation and biopharmaceutical characterization.

This study combines metabolomics, structural analysis, and public omics data to uncover the extensive diversity and global distribution of kurstakin lipopeptides linked to Bacillus biocontrol activity.

This study investigates the synthesis and curing of a furan-based glycidyl amine epoxy resin, revealing improved stiffness and Tg through α-chlorohydrin-driven cross-link formation.

A coumarin-based photocleavable solid support allows visible-light release and nonchromatographic purification of RNA oligonucleotides, including UV-sensitive phosphorothioate backbones.

Benchmarking revealed that the Orbitrap Astral Zoom prototype outperforms the standard Astral MS, sampling more ions per peptide and delivering improved sensitivity and quantitative precision in DIA proteomics.

A validated QbD-based RP-HPLC method enables robust, stability-indicating impurity analysis of Elexacaftor, supporting process development and quality control in drug manufacturing.

LC-HRMS screening combined with temporal clustering identified daily domestic discharge patterns in wastewater, enabling improved interpretation of population chemical exposure.

A novel persistence-directed testing approach combined with nontarget GC-MS and LC-HRMS revealed a significant fraction of persistent chemicals in offshore oil platform produced waters.

LC-HRMS detected more prescribed and non-prescribed drugs than immunoassays and would have influenced clinical decisions for 25% of patients, mainly those with opioid-use history.