Low SPE recovery does not have to mean method failure. Learn how fraction collection and analysis can identify analyte losses and guide effective troubleshooting steps.

This week we bring you application notes by KNAUER, Shimadzu, Thermo Fisher Scientific and Waters Corporation and technical note by Agilent Technologies!

Proper drying of the SPE sorbent is a critical step to achieve high sensitivity, good reproducibility, and maximum analyte recovery, especially for complex sample matrices.

EU Drinking Water Directive 2020/2184 sets ultra-low limits for pesticides, PFAS, metals and endocrine disruptors. Learn how SPE and nitrogen evaporation enable LC-MS/MS compliance at ng/L levels.

How the EU’s revised Urban Wastewater Treatment Directive is driving demand for ultra-sensitive LC-MS/MS workflows—and why nitrogen evaporation is critical for reliable micropollutant monitoring.

An SPE technical tip focused on identifying the sources of interferences and extra peaks observed after sample extraction.

Although 100% recovery is expected in SPE, values above 100% are sometimes observed. This article explains the most common causes and provides practical guidance on how to identify and resolve them.

A technical guide to troubleshooting low analyte recovery in SPE. Explains relative vs. absolute recovery and provides practical solutions for conditioning, loading, and sorbent selection.

How can neutral analytes be efficiently concentrated in the presence of ionized acidic or basic contaminants? This SPE tip explains how mixed-mode cartridges improve selectivity and cleanup.

Matrix effects can suppress or enhance analyte signals and compromise accuracy. Learn how sample prep techniques—especially SPE with Strata-X PRO—reduce phospholipid interference and improve LC-MS results.