How the EU’s revised Urban Wastewater Treatment Directive is driving demand for ultra-sensitive LC-MS/MS workflows—and why nitrogen evaporation is critical for reliable micropollutant monitoring.

An SPE technical tip focused on identifying the sources of interferences and extra peaks observed after sample extraction.

Although 100% recovery is expected in SPE, values above 100% are sometimes observed. This article explains the most common causes and provides practical guidance on how to identify and resolve them.

A technical guide to troubleshooting low analyte recovery in SPE. Explains relative vs. absolute recovery and provides practical solutions for conditioning, loading, and sorbent selection.

How can neutral analytes be efficiently concentrated in the presence of ionized acidic or basic contaminants? This SPE tip explains how mixed-mode cartridges improve selectivity and cleanup.

Matrix effects can suppress or enhance analyte signals and compromise accuracy. Learn how sample prep techniques—especially SPE with Strata-X PRO—reduce phospholipid interference and improve LC-MS results.

Explore how nitrogen blowdown enhances sample prep efficiency in SPE workflows using Waters Oasis, Agilent Bond Elut and Phenomenex Strata, improving analyte recovery, sensitivity and method reliability.

Over-drying silica-based SPE cartridges during conditioning can reduce analyte retention and recovery. Learn best practices to avoid losses and ensure reproducible results.

Bioanalytical samples often need pretreatment before SPE. Each matrix presents challenges like protein removal, red blood cell lysis, glucuronide hydrolysis, or tissue homogenization.

Solid phase extraction enables clean-up, pre-concentration, and solvent switching. Proper solvent choice and SPE mode are key for effective solid sample preparation.