An SPE technical tip focused on identifying the sources of interferences and extra peaks observed after sample extraction.

Although 100% recovery is expected in SPE, values above 100% are sometimes observed. This article explains the most common causes and provides practical guidance on how to identify and resolve them.

A technical guide to troubleshooting low analyte recovery in SPE. Explains relative vs. absolute recovery and provides practical solutions for conditioning, loading, and sorbent selection.

Matrix effects can suppress or enhance analyte signals and compromise accuracy. Learn how sample prep techniques—especially SPE with Strata-X PRO—reduce phospholipid interference and improve LC-MS results.

Practical troubleshooting guide for low recovery in SPE methods. Learn how to identify problems with solvents, flow rate, pH, or sorbent choice step by step.

Over-drying silica-based SPE cartridges during conditioning can reduce analyte retention and recovery. Learn best practices to avoid losses and ensure reproducible results.

Bioanalytical samples often need pretreatment before SPE. Each matrix presents challenges like protein removal, red blood cell lysis, glucuronide hydrolysis, or tissue homogenization.

Solid phase extraction enables clean-up, pre-concentration, and solvent switching. Proper solvent choice and SPE mode are key for effective solid sample preparation.

How much sample can I load onto my SPE device? Is it linked to the concentration of my analyte of interest?

How is normal phase (NP) SPE different from reversed phase (RP) SPE? How do I decide which one to use?