Wide-pore SEC columns for rAAV and mRNA were systematically compared. DNACore AAV-SEC and Biozen dSEC-7 offered the best efficiency, guiding optimal gene therapy product characterization.

The review compiles R and Python tools for analyzing lipidomics and metabolomics data, guiding beginners to create publication-ready graphics and enabling robust, reproducible chemometric analysis.

UPCE scientists co-authored a Nature Communications paper presenting best practices in R and Python for statistical processing and visualization of lipidomics and metabolomics data.

This study introduces acrylamide monolith HILIC-MS for intact mAb glycoprofiling, offering high selectivity, baseline separation, and detection of low-abundance glycoforms missed by RPLC-MS.

Ion-pairing HILIC improves impurity profiling of therapeutic oligonucleotides. It resolves deaminated impurities from full-length products, beyond current LC-MS limits.

Cows fed multispecies swards produced milk with more polyunsaturated and bioactive fatty acids than ryegrass systems, suggesting benefits for milk quality and consumer health.

A novel AF4-MALS and Py-GC-MS workflow enables size-resolved polymer analysis of nanoplastics in wastewater. It improves detection, quantification, and offers insights into polymer composition.

Using UPLC-HRMS and SIMCA, 159 NPS standards were analyzed to build classification models. The approach showed strong validation and accurate identification of seized samples, aiding forensic drug analysis.

Using low-cost REIMS with a 450 nm laser, researchers detected pathogen-specific biomarkers in tomato plants, distinguishing infections from Meloidogyne incognita and Pseudomonas syringae.

A ZenoTOF 7600 modified for CID, EAD, and UVPD allowed LC–MS screening of pesticides in juices and wines. About 30 were detected at pg–ng/mL levels, confirmed by multiple dissociation methods.