Scientists at IOCB Prague reveal a previously unknown mechanism that initiates gene transcription. Using cryo-EM, they uncover how alarmone molecules enable RNA synthesis under stress.

Two outstanding early-career researchers at UCT Prague, Filipa Oliveira and Stella Gonsales, received prestigious GAČR JUNIOR STAR grants for innovative research in materials science and sustainable chemistry.

A practical, end-to-end overview of oligonucleotide manufacturing—from solid-phase synthesis to purification, QC, endotoxin removal, and formulation—highlighting scalable, integrated production workflows.

Eurachem/CITAC VaMPIS guidance introduces validation of measurement procedures that include sampling, using measurement uncertainty to assess fitness for purpose in both in situ and ex situ measurements.

This study demonstrates Orbitrap-IRMS for full and intramolecular carbon isotope analysis of PFOA, enabling sensitive PFAS source fingerprinting without analyte decomposition.

Dwight Stoll explains why chromatography needs big, high-quality retention datasets for AI—how short columns boost throughput, why ratios matter, and why “drifty” phases threaten prediction models.

This study couples LC to ESI-Orbitrap MS for stable isotope analysis using peak homogenization to remove chromatographic isotope effects and amount dependency, achieving precise C, N, and S isotopologue ratios.

Interview with Dr. Eamonn Clark on WRRC water research, fuel-spill impacts, PFAS workflows, and how DIY tools like a homebuilt nitrogen evaporator can expand low-resource labs.

Researchers at IOCB Prague have developed new fluorogenic labels that deliver high-contrast fluorescence microscopy, enabling precise visualization of cellular processes without background noise.

Structure-guided libraries and machine learning enable faster discovery of active nucleic acid sequences beyond random mutagenesis.