Welcome to the future of mass spectrometry. , the next generation of mass spectrometry.
With enhanced sensitivity and dynamic range, the standard model is ideal for advanced applications in metabolomics, lipidomics, proteomics, translational research, and structural biology while the BioPharma Edition is tailored for the demanding requirements of the biopharmaceutical industry. Both models offer innovative features that surpass the capabilities of the previous Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer.
Explore the model that best suits your needs and unlock the full potential of your analytical workflows.
Whether you are analyzing small molecules or large biomolecules, the Thermo Scientific Excedion Pro Hybrid Mass Spectrometer provides advanced performance and precision to help you achieve groundbreaking discoveries in your scientific analyses.
Featuring excellent sensitivity and intra scan dynamic range, the innovative Orbitrap Excedion Pro MS goes beyond the capabilities of traditional hybrid or Quadrupole Time-of-Flight (QTOF) MS technologies. Explore the full potential of your research with the cutting-edge technology of the Orbitrap Excedion Pro MS.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Orbitrap Excedion Pro MS shown with OptiSpray technology.
Electron Transfer Dissociation (EASY-ETD) option combined with HCD (Higher-Energy Collisional Dissociation) fragmentation delivers unique EThcD (Electron-Transfer/Higher-Energy Collisional Dissociation) fragmentation data on a hybrid benchtop mass spectrometer.
For increased ion flux and gentle transfer of ions for lower limits of detection for a wider range of molecules, the high-sensitivity atmospheric pressure interface combines high-capacity ion transfer tube and electrodynamic ion funnel, optimized for labile compounds and efficient ion transfer.
MS/MS acquisition rates of up to 70 Hz in the Orbitrap mass analyzer with maximum resolution of 480,000 (FWHM) at m/z 200.
Enhanced dynamic range (eDR) mode enables five orders of magnitude intrascan dynamic range.
Hybrid-DIA combines the sensitivity and specificity of targeted experiments with the unbiased discovery of DIA-based shotgun proteomics in a single experiment.
Unique processing mode powered by Phased Spectrum Deconvolution Method (ΦSDM) improves the acquisition rate of TMTpro 32plex reagents experiments.
Adaptive RT for dynamic adjustment of chromatographic monitoring windows ensures reproducible measurements with sensitivity and specificity for comprehensive coverage of targeted compounds across large sample cohorts.
With the Orbitrap Excedion Pro Mass Spectrometer, you don't just meet your goals; you exceed them! Embrace the future of mass spectrometry and unlock new possibilities in your research and development endeavors. Discover the power of innovation and exceed your expectations with the Orbitrap Excedion Pro MS.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
Optimized for labile compounds — Radio frequency (RF) device optimized for labile compounds efficiently capture ions as they leave the High-Capacity Transfer Tube (HCTT). Automatic tuning results in broad ion transmission curves with reduced ion losses, increasing sensitivity.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
Fast and sensitive alternative fragmentation Electron Transfer Dissociation (ETD) generated from fluoranthene radical anions. The townsend discharge provides extremely stable and robust ionization. Compact size, located entirely within the footprint of the instrument.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
ETD and EThcD fragmentation occur in the ion routing multipole followed by detection in the Orbitrap mass analyzer. The EThcD combination provides b- and y-type and c- and z-type fragment ions in a single Orbitrap spectrum.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
Reduces noise by preventing neutrals and high-velocity clusters from entering the quadrupole mass filter using a double bent design geometry. Axial field along the length of the rods improves ion transfer robustness. To increase duty cycles up to 150%, a pre-accumulation of ions can be modulated with Automatic Gain Control (AGC).
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
To reduce carbon footprint and overall maintenance, Orbitrap Excedion Pro Mass Spectrometers come standard with a single rough dry pump instead of two oil pumps.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
Software solutions across all next-generation Thermo Scientific platforms for ease of use through different systems. Get meaningful results faster with edition-specific application templates that are ready to use and built into the method editor.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
The Thermo Scientific Orbitrap Excedion Pro BioPharma Hybrid Mass Spectrometer addresses the unique challenges of biopharmaceutical research. With enhanced precision, sensitivity, and dynamic range, this advanced instrument excels in the analysis of biotherapeutics/biopharmaceuticals from peptides to advanced bispecifics and everything in between.
Unlock new potential in your biopharmaceutical applications. With cutting-edge technology and innovative features that ensure accurate and reliable results, Orbitrap Excedion Pro BioPharma MS empowers researchers to push the boundaries of biopharmaceutical science.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Orbitrap Excedion Pro BioPharma MS shown with OptaMax Plus ion source.
Extended mass range up to m/z 12,000 with application mode “Intact Protein”.
Adaptive RT for dynamic adjustment of chromatographic monitoring windows ensures reproducible measurements with sensitivity and specificity.
With the Orbitrap Excedion Pro BioPharma Mass Spectrometer, you don't just meet your goals; you exceed them! Embrace the future of mass spectrometry and unlock new possibilities in your research and development endeavors. Discover the power of innovation and exceed your expectations with the Orbitrap Excedion Pro BioPharma MS.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers.
Make groundbreaking discoveries with the Thermo Scientific Orbitrap Excedion Pro Mass Spectrometer, which sets a new standard in analytical performance.
The Orbitrap Excedion Pro BioPharma Mass Spectrometer ensures comprehensive characterization by detecting and quantifying impurities and modifications, performing accurate quantitative analysis, and enhancing top-down, middle-down, and bottom-up capabilities. It streamlines workflows for rapid, high-throughput analysis, significantly reducing time-to-results and increasing productivity.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: UHPLC-HRAM-MS-ddMS2 analysis of NISTmAb tryptic digest peptide mapping experiment, EThcD unambiguously identified the two leucine residues (loss of 43Da from z9 and z12 fragments) and one isoleucine residue (loss of 29Da from z6 fragments) in this 13-amino acids doubly charged peptide with complete sequence coverage. Zoom-in insets show high mass accuracy (<5ppm) achieved for the signature fragments.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Signature fragments (c+57 and z-57) generated by ETD distinguish isoaspartic acid from aspartic acid.b: In a UHPLC-HRAM-MS-ddMS2 analysis of NISTmAb tryptic digest peptide mapping experiment, EThcD achieved high sequence coverage and unambiguously identified isoaspartic acid in a 23-amino acid triply charged deamidated peptide present at a low abundance level (0.18%) with high confidence. The zoom-in insets showed the high mass accuracy (<8 ppm) achieved for both signature fragments (z6-57 and c17+57).
The Orbitrap Excedion Pro Biopharma Mass Spectrometer-based HDX MS offers a comprehensive and novel tool set for the analysis of protein conformation, conformation dynamics, and protein-protein interactions:
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Peptide identification and sequence coverage of Rituximab heavy chain (HC) and light chain (LC) across different on-column injection amounts (300 ng, 700 ng, and 1.5 µg) using a 6-minute gradient. The bar graph represents the number of identified peptides for HC (dark blue) and LC (light blue), while the orange line indicates sequence coverage percentage.
The fast scan speed of the Orbitrap Excedion Pro Biopharma Mass Spectrometer enables precise and high-throughput HDX-MS analysis, facilitating accurate protein-ligand binding screening.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Identification of binding pocket on KRAS G12C upon Adagrasib binding using DIA-HDX. (a) Woods plot. X-axis denotes the residue number, while y-axis shows percentage change in deuteration. Blue bars with error bars indicate experimental data points at 20sec labeling time, representing regions with significant deuteration changes. Dashed lines indicate a threshold for significant changes in deuteration. (b) Structural representation of KRAS G12C in complex with Adagrasib. The protein backbone is depicted in gray, with the G12C mutation region and key structural elements highlighted in blue.
The Orbitrap Excedion Pro Mass Spectrometer is an essential tool for metabolomics research, providing numerous advantages that enhance the analytical capabilities for comprehensive metabolite profiling and targeted metabolite analysis.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: NIST SRM 1950 plasma metabolite extracts, separated using reversed phase and interrogated with iterative data dependent MS2 analysis using AcquireX deep scan workflow. Shown: 2X the number of compounds detected with MS1. Here, a compound refers to a unique m/z and RT-pair, after background subtraction, with isotopes, adducts and in-source fragments coalesced into a single entry. After injections, over 21% more compounds were annotated using mzCloud mass spectral library. Full scan MS1 to generate the precursor inclusion list for the data dependent workflow done with eDR workflow or Orbitrap full scan mode without eDR and results processed using Compound Discoverer 3.4 software.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: When plotting a regression of peak area versus total number of compounds detected in SRM 1950, the eDR scan mode achieves an additional order of magnitude of depth for plasma metabolite identification. This indicates that the greater than 2X gain in compounds are on the low end of the dynamic range without compromising the high-end measurements.
![Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Annotated compound found in plasma only when using eDR scan mode. The mass spectrum on the bottom right indicates that A0 and A1 peaks are measured and can be used to further confidently confirm the molecular formula of the species as C19H40N3O9P [H]+.](https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Orbitrap_Excedion_Pro_Mass_Spectrometers_7_13f04bad71_l.webp)
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Annotated compound found in plasma only when using eDR scan mode. The mass spectrum on the bottom right indicates that A0 and A1 peaks are measured and can be used to further confidently confirm the molecular formula of the species as C19H40N3O9P [H]+.
Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers: Full MS spectrum of Phenylalanine in plasma with only 5% of the precursor being fragmented.
The Orbitrap Excedion Pro MS transforms everyday proteomics into exceptional results.
Unlock the full potential of your Thermo Scientific Orbitrap Excedion Pro Mass Spectrometer with a range of complementary products that will elevate your research capabilities, streamline your processes, and deliver exceptional results in your scientific investigations.
From the precision of Thermo Scientific Vanquish UHPLC Systems and the advanced Thermo Scientific FAIMS Pro Duo Interface to the versatile Thermo Scientific OptaMax Plus and OptiSpray Ion Sources, experience advanced performance and reliability while exceptional software solutions enhance your analytical workflows.
Collaborate more efficiently and gain new insights faster, to get closer to the truth. The web-based Thermo Scientific Ardia Platform, scalable software solution for modern, dynamic, and often cloud-based environments; connects and organizes projects, people, and instruments on a global level.
Deliver efficiency, assurance, and compliance with one enterprise software that supports your chromatography and MS operations throughout your business. Designed to integrate seamlessly with your laboratory and IT infrastructure now and in the future.
Confidently control, acquire, and interrogate data from the Orbitrap Excedion Pro Mass Spectrometers and related instruments using Thermo Scientific Xcalibur Software.
Extend intelligence-driven mass spectrometry through experimental connectivity by integrating independent experiments into an automated workflow that enhances real-time, selective LC-MSn data acquisition for efficient and comprehensive sample and study characterization.
Simplify and streamline your Orbitrap Excedion Pro BioPharma Mass Spectrometer analysis workflows from batch processing to in-depth data analyses with Thermo Scientific BioPharma Finder Software.
Transform your Orbitrap Excedion Pro Mass Spectrometer small molecule data, whether small or large dataset, into actionable insights with Thermo Scientific Compound Discoverer Software.
Transform your Orbitrap Excedion Pro Mass Spectrometer small molecule data, whether small or large dataset, into actionable insights with Thermo Scientific Compound Discoverer Software.
Perform comprehensive analysis of top-down proteomics data with Thermo Scientific ProSightPD Software. Featuring robust proteomic search engines for proteoform characterization, including proteoforms with PTMs or truncations, ProSightPD Software accommodates proteomic data generated by fragmentation techniques present in the Orbitrap Excedion Pro MS.
