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Manufacturer

Phenomenex

Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories. From drug discovery and pharmaceutical development to disease diagnosis, food safety to environmental analysis, Phenomenex chromatography solutions accelerate science and help researchers improve global health and well-being.

Distributor

Phenomenex

(310) 212-0555 USA

SPE sample preparation

Phenomenex Clarity OTX Clean-UpRapid 15-minute clean-up of biological samples using Clarity OTX SPE enables efficient isolation of RNA- and DNA-based therapeutics without LLE, optimized for LC-MS bioanalysis.

Features

Phenomenex Clarity OTX Clean-Up

15 Minute Clean Up from Biological Samples

Isolate RNA and DNA-based therapeutics / metabolites from biological fluids and tissues in less time with Clarity OTX solid phase extraction (SPE) and buffer products.

No liquid-liquid extraction (LLE) required required
>80 % typical extraction recoveries
Optimized for LC-MS bioanalysis

General Extraction
Common Extraction Procedure (~180 minutes)
General Extraction

Common Extraction Procedure (~180 minutes)

Phenomenex: Clarity OTX Clean-Up: Common Extraction Procedure (~180 minutes)

Suitable for Most Oligo Therapeutics & Samples

Oligo types / Sample Types

DNA: Plasma
Aptamers: Serum
RNAi/siRNA: Urine
Thioates: Tears
Lipid-conjugates: Saliva
Liposome encapsulated: Tissue

Extraction Protocol

Sample Pre-Treatment

Tissue:
- Proteinase K digestion or homogenize
- Mix 1-to-1 with Lysis-Loading buffer
Biological Fluids: Mix 1-to-1 with Lysis-Loading buffer

Phenomenex: Clarity OTX Clean-Up: Extraction Protocol

Manufacturer

Phenomenex

Distributor

Phenomenex

(310) 212-0555 USA

www.phenomenex.com

[email protected]

News

Article | Academy

SPE Troubleshooting: Understanding and Resolving Low Recovery in Solid Phase Extraction

Low SPE recovery does not have to mean method failure. Learn how fraction collection and analysis can identify analyte losses and guide effective troubleshooting steps.

Phenomenex

Article | Academy

Improving Oligonucleotide Conjugate Recovery with Clarity XRO

Improve oligonucleotide recovery with Clarity™ XRO. Learn how optimized lysis, SPE conditions, and elution strategies enhance reproducibility and performance in complex biological samples.

Phenomenex