When you need the best analytical tools for the toughest analytical challenges, like producing life-saving medicines or ensuring the quality and safety of our food and environment, the Thermo Scientific™ Vanquish™ Horizon UHPLC system lets you push the boundaries of separation science.
Designed with innovative technology and attention to fine detail, the Vanquish Horizon UHPLC system brings exceptional analytical precision, detector sensitivity, and operational simplicity to enable unmatched robustness and performance. Designed for research labs who need the highest performing UHPLC and LC-MS, the Vanquish Horizon UHPLC system delivers:
Thermo Scientific Vanquish Horizon UHPLC System.In your laboratory, UHPLC is an essential tool to advance your research and prevail against the toughest analytical challenges. The Vanquish Horizon UHPLC system is built with innovative technologies to improve your UHPLC analysis with:
Thermo Scientific Vanquish Horizon UHPLC System: Accelerated peptide mapping utilizing the full power range of the Vanquish Horizon UHPLC system while maintaining 100% sequence coverage using a Thermo Scientific™ Acclaim™ RSLC 120, C18, 2.2 μm column.
In today’s analytical laboratory environment, your scientific personnel have limited time for in-depth familiarization with new instrumentation. An LC system should seamlessly fit into your existing workflows and processes without requiring extra training or expertise. The Vanquish Horizon UHPLC system brings ease of use to a new level, enabling every user to deliver exceptional results, independent of user experience.
Thermo Scientific Vanquish Horizon UHPLC System: Vanquish Solvent Monitor manages your eluent and waste levels for highest confidence during analysis.
The Vanquish Solvent Monitor enables Vanquish HPLC and UHPLC systems to accurately and automatically measure the liquid levels in each individual solvent channel and waste container.
Deep integration of the Vanquish Solvent Monitor into the Vanquish Horizon UHPLC system provides direct viewing of solvent and waste volumes within Chromeleon CDS and directly on the module itself.
Run large sample sets with confidence, avoid lost time, and eliminate procedural deviations by monitoring mobile phase levels; prevent hazardous spills by monitoring waste levels.
Keep up with the ever-increasing sample processing demand by improving productivity and throughput. The Vanquish Horizon UHPLC system can cope with ultra-high throughput analysis with:
Double your throughput, deepen your sample knowledge, and better utilize your bench space with the Thermo Scientific™ Vanquish™ Duo UHPLC systems. Two completely independent flow paths in one system for maximum productivity.
Increase your lab throughput by 30% with the Vanquish Tandem LC systems. Maximize the utilization of your optical detector or mass spectrometer.
Thermo Scientific Vanquish Horizon UHPLC System: High-throughput capabilities.
Increase sample capacity with the Thermo Scientific™ Vanquish™ Charger module for a total capacity of up to nearly 9000 samples while the barcode reader simultaneously manages the complete inventory.
Improve your lab’s quantification capabilities with Thermo Scientific Vanquish Inverse Gradient LC systems, employing the unique and universal Charged Aerosol Detection, to consistently quantify all non-volatile and semi-volatile compounds even when no reference standard is available.
By utilizing a second pump to deliver an inverse gradient, the detector offers:
Thermo Scientific Vanquish Horizon UHPLC System: Improve your quantification.
The isolation of a single compound from a complex mixture can be a major challenge for scientists tasked with in-depth sample characterization. The demands for isolation followed by further investigation can be multifaceted, based on the key area of focus of the drug development process.
The Vanquish Analytical Purification LC Systems support a broad range of applications for both upstream and downstream processes. They match the separation power of the LC systems with compelling fractionation for high-purity and high-yield compound collection. Built with Thermo Scientific Vanquish HPLC and UHPLC system components, they deliver unrivaled performance, robustness, and user-friendliness
Purify by fractionation to:
The analysis of complex samples with difficult-to-resolve analytes or interfering matrixes could be challenging with conventional UHPLC utilizing a single column chemistry. In these cases, the analysis may be improved by employing two-dimensional liquid chromatography to resolve co-eluting peaks and gain confidence in your separation.
Four different Vanquish 2D-LC systems can be configured from Vanquish Horizon modules/components targeting different two-dimensional LC workflows:
Thermo Scientific Vanquish Horizon UHPLC System: Vanquish Online 2D-LC systems.
Analytical precision, for both retention times and peak areas, are critical to obtain reliable qualitative and quantitative analytical results for every application and specifically in 2D-LC applications. The Vanquish Horizon UHPLC system brings this precision to new levels of confidence in your results.
Thermo Scientific Vanquish Horizon UHPLC System: Autosampler linearity for even low injection volumes, here from 100 nL to 1 μL.
During injections, the sample loop at atmospheric pressure is placed in line with the high-pressure flow path, typically resulting in a pressure drop. With regular UHPLC systems, this adversely affects retention time precision and column lifetime.
SmartInject Technology automatically eliminates the pressure drop improving data confidence and reducing cost of ownership.
Thermo Scientific Vanquish Horizon UHPLC System: Significant reduction of pressure drop after injection using SmartInject Technology resulting in improved retention time reproducibility (6 replicates) and enhanced column lifetime.
Regardless of your current software infrastructure, you can take advantage of the latest innovation of the Vanquish Horizon UHPLC system. The Vanquish Horizon system combines perfectly with Chromeleon CDS to take advantage of the unrivaled flexibility, precision and ease-of-use.
Scalable from workstation to global enterprise, Chromleon CDS provides complete instrument control, data acquisition, data processing and data security regardless of whether you work with the most recent feature release, the extended support or the long-term support software version.
Enabling seamless instrument control and method creation for all laboratories currently employing Waters Empower CDS and Agilent OpenLab CDS software.
Thermo Scientific Vanquish Horizon UHPLC System: Network scalability—stand-alone to a global network with secure central data storage.
Mass spectrometry is a prevalent tool in many laboratories. The Vanquish Horizon UHPLC system can be seamlessly coupled to best in class Thermo Scientific triple quadrupole or Thermo Scientific high-resolution accurate mass Orbitrap mass spectrometers. For single point control, your LC-MS system can be controlled completely by Chromeleon CDS.
Thermo Scientific Vanquish Horizon UHPLC System: The Vanquish Horizon UHPLC system with the Thermo Scientific™ Orbitrap Exploris™ 480 mass spectrometer.
Workflow automation is important for many industries in order to increase consistency of results and lab efficiency—particularly during the pandemic where labs must ensure high productivity with the minimum number of onsite personnel. Vanquish HPLC and UHPLC systems can be easily equipped with a Thermo Scientific™ Vanquish™ Loader to fully automate your LC or LC-MS analysis when used in combination with a robotic mover.
Thermo Scientific Vanquish Horizon UHPLC System.
Choosing the right detection technology is key to revealing all the components of interest in your sample. The Vanquish Horizon UHPLC system offers a wide range of detection capabilities that can be easily integrated and combined to fit your methods.
Thermo Scientific Vanquish Diode Array Detector HL with the Thermo Scientific™ LightPipe™ detection technology delivers supreme analyte sensitivity through low baseline noise and longer effective light path by total internal reflection. The Thermo Scientific Vanquish Diode Array Detector FG offers cutting edge detector linearity as well as a smooth and robust LC-MS integration. Based on diode array detection technology, the Multiple Wavelength Detector offers a cost-effective solution for simultaneously acquiring up to eight UV-Vis wavelength channels.
Thermo Scientific Vanquish Horizon UHPLC System: Concentration vs. peak height plot of nevirapine with data points that were considered for calibration (black) and data points that were eliminated from calibration due to curve decline (red). Linear calibration with permitted offset and no weighting.
Fluorescence detection enables high sensitivity and selectivity.
Thermo Scientific Vanquish Horizon UHPLC System: FLD chromatogram of the four aflatoxins: G2, G1, B2 and B1 at a concentration of 0.9 μg/kg for G2 and B2 and 2.9 μg/kg for G1 and B1.
UV-Vis detection with excellent sensitivity and linearity is a cost- effective and powerful solution for quantitative compound analysis.
The Thermo Scientific™ Vanquish™ Charged Aerosol Detectors are powerful and near-universal. They are able to detect all non-volatile and many semi-volatile analytes with uniform response and with sub-nanogram-level, even those that lack a chromophore or that poorly ionize. The flexibility and performance of charged aerosol detection is ideal for analytical R&D, while its simplicity and reproducibility benefit manufacturing QA/QC applications.
Thermo Scientific Vanquish Horizon UHPLC System: Unlike mass spectrometry and UV, the CAD is able to measure all analytes in the sample. Mass spectrometry (MS) requires the analyte to form gas phase ions while response by a UV detector depends upon the nature of the chromophore.
Mass spectrometry gives access to valuable data no other technology can deliver. The easy-to-use Thermo Scientific™ ISQ™ EM single quadrupole mass spectrometer or the Thermo Scientific™ ISQ™ EC single quadrupole mass spectrometer integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility using the ISQ EM. Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.
LC-MS is widely used for quantification purposes in many application fields, including food safety and environmental monitoring. In conjunction with the Thermo Scientific mass spectrometer portfolio, Vanquish Horizon delivers a great solution for ultra-sensitive detection. For control of your LC-MS setup you can choose between the feature-rich Thermo Scientific™ Xcalibur™ software, the powerful Thermo Scientific™ TraceFinder™ software or the compliance-ready Chromeleon CDS control.
Thermo Scientific Vanquish Horizon UHPLC System: Explore the system.Use the Vanquish Solvent Monitor to increase your regulatory compliance, productivity, and safety of your laboratory. That device guarantees that your HPLC systems will never run dry and the waste will not spill over, reducing loss of valuable measurement time and sample material.
With the Vanquish User Interface, you are the master of your LC instrument. The display always shows you the key parameters of your instrument such as flow and pressure and guides you in a visual step-by-step video tutorial through key maintenance tasks.
Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitates multiple detector technologies. The Vanquish Horizon UHPLC systems have been built to utilize a wide range of analytical detectors, including mass spectrometry (MS), diode array detection (DAD), multi wavelength detection (MWD), charged aerosol detection (CAD), variable wavelength detection (VWD), and fluorescence detection (FLD).
The Vanquish autosampler has a default sample capacity of 216 1.5 mL glass vials or 4 well plates. This capacity can be further increased with the Thermo Scientific Vanquish Charger module to a capacity of up to 23 well plates.
The Vanquish autosampler has the option to add the Vanquish Loader to connect the LC or LC-MS system to the sample preparation robotics, allowing the complete analysis of the sample from preparation to reporting without human intervention.
The valves used in the Vanquish Horizon UHPLC system are designed to meet the reliability needs to make UHPLC run robustly and routinely. The valves are long-life and follow a no-maintenance philosophy reducing your overall cost of ownership.
Superior retention time precision and accuracy, as well as enhanced column protection.
Utilizes tool-free Viper Fingertight Fittings with near-zero dead volume operation and ergonomic design.
Modules can be repaired without de-stacking; each unit has handles for ease of maneuvers; light bars on the front of the system indicate system status; and the entire system supports tool-free maintenance.
The built-in drawer stores accessories, related documents, or any other useful material for the system.
The Vanquish Horizon pumping delivers the best retention time precision of the complete portfolio even for the most shallow gradients. Smart algorithms improve flow accuracy and minimize baseline pulsation.
Highest injection precision for even the lowest injection volumes and retention time precision for reliable qualitative and quantitative sample characterization.
Vanquish Horizon UHPLC Systems are, by design, biocompatible to deal with all challenging eluents for biopharmaceutical characterization, increasing data confidence and instrument uptime.
The Vanquish Horizon UHPLC System can scan be operated in various software environments including the latest Chromeleon software feature release, Chromeleon CDS long-term and extended support version, Waters Empower and Agilent OpenLab CDS.
Thermo Scientific LC portfolio overview.
