<p><strong>Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.</p><p>In their study,<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en"><strong>Dr. Hana Cahová</strong></a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.</p><p>The work was significantly shaped by <strong>Valentina Serianni from Hana Cahová’s team</strong>, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by <strong>Jana Škerlová</strong>, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.</p><p>Hana Cahová adds: <i>“We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by<strong> Dr. Tomáš Kouba</strong>, one of the authors of the study. <i>“Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,”</i> he explains.</p><p>Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en"><strong>cryo-EM center</strong></a><strong> </strong>that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5"><strong>Molecular insight into 5′ RNA capping with Np<sub>n</sub>Ns by bacterial RNA polymerase</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p>Nat. Chem. Biol. 21 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from <i>Thermus</i> <i>thermophilus</i>. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</p></div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

<p><strong>Food adulteration is a phenomenon with a long history that has gained increasing importance in recent years due to the globalization of food supply chains and strong economic pressures. Whether it involves diluting olive oil with cheaper oils, adding sugar to honey, or the hidden use of substitutes in protein supplements, the result is a loss of consumer trust and, in some cases, a potential risk to health. Analytical chemistry plays a key role in this area by providing methods and technologies capable of identifying and quantifying target compounds as well as unwanted impurities in a wide range of food matrices.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg" alt="Watrex: Food Adulteration and How It Is Revealed by Analytical Chemistry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg 245w," sizes="100vw" width="1600" height="900"></p><h4><strong>The Role of Chromatography in Forensic Food Analysis</strong></h4><p>Chromatography, particularly liquid chromatography (HPLC), is one of the most effective analytical tools for separating complex mixtures of molecules. It enables:</p><ul><li>qualitative identification of individual components in a sample,</li><li>quantitative determination of their concentrations,</li><li>detection of impurities and unexpected components that may indicate<br>adulteration.</li></ul><p>In practice, HPLC is often combined with various types of detectors (UV/VIS, DAD, refractive index detectors) or with other techniques (e.g., mass spectrometry) to increase selectivity and sensitivity.</p><h4><strong>Isocratic vs. Gradient Elution</strong></h4><p>In the analysis of food samples, chromatographic methods are selected according to the analytical goal:</p><ul><li><strong>Isocratic HPLC </strong>uses a constant mobile phase composition throughout the analysis. It is simple, robust, and ideal for routine determinations of well-defined target analytes (e.g., sugars or vitamins).</li><li><strong>Gradient HPLC</strong> changes the mobile phase composition during separation, enabling better resolution of complex mixtures with a wide range of polarities (e.g., peptides or phenolic compounds).</li></ul><p>Gradient methods are particularly useful when analytes have very different properties and high separation efficiency is required.</p><h4><strong>Watrex Praha and the Contribution of Modern Systems to Food Analysis</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha, s.r.o.</strong></a> is one of the leading Czech manufacturers and distributors of liquid chromatography systems and instruments, with a long tradition dating back to 1990. The company has successfully transformed from a distributor into a manufacturer of its own HPLC and related technologies, focusing on modular, robust systems suitable even for demanding analytical tasks.</p><p>Their <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=93&amp;search=streamline"><strong>Streamline™ product line</strong></a><strong> </strong>includes several HPLC system concepts suitable for food analysis:</p><ul><li><strong>Isocratic HPLC system</strong> – a simple yet precise configuration with a single pump, column thermostat, and UV/VIS detector; suitable for routine determination of known analytes (e.g., basic carbohydrates, food additives).</li><li><strong>Binary gradient HPLC system</strong> – equipped with two pumps enabling mobile phase gradient formation, which enhances separation performance for complex mixtures<br>(e.g., phenolic profiles of wine, components of aromatic extracts).</li><li><strong>GPC/SEC system (Gel Permeation / Size Exclusion Chromatography)</strong> – a specialized solution for the determination of macromolecules and polymers, also relevant for the analysis of high-molecular-weight components in foods (e.g., polysaccharides).</li></ul><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Watrex_catalog_2024_ba97395f92.pdf"><strong>Product catalogue HERE</strong></a></p></blockquote><p>Thanks to the modular nature of these systems, analysts can easily adapt the configuration to a specific analytical problem, from simple routine analyses to complex characterization of food samples.</p><h4><strong>Practical Examples of Adulteration Revealed by HPLC</strong></h4><ul><li><strong>Detection of olive oil dilution: </strong>HPLC can separate and quantify characteristic triacylglycerols and fatty acids; unusual patterns indicate the presence of cheaper oils.</li><li><strong>Estimation of sugar addition in honey:</strong> Isocratic HPLC with a refractive index detector can determine sugar profiles (glucose, fructose, sucrose), revealing dilution or the addition of sugar syrups.</li><li><strong>Identification of aromatic adulterants in wine:</strong> Gradient HPLC with a PDA detector can reveal phenolic and aromatic profiles that are altered by the addition of synthetic compounds.</li></ul><h4><strong>Conclusion</strong></h4><p>Food adulteration remains a current issue that requires reliable and sensitive analytical methods. Liquid chromatography, and in particular modern HPLC systems, represent one of the most powerful tools for detecting unwanted additives, impurities, and unexpected components in complex food samples. Manufacturers such as <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> provide flexible chromatographic platforms covering a wide range of analytical tasks from simple isocratic to advanced gradient and GPC/SEC applications thereby supporting analysts in ensuring food quality and consumer protection.</p><blockquote><p>Did you find this article interesting? Follow <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> on their social media (<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/company/watrex/?viewAsMember=true"><strong>LinkedIn</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/WatrexPrague"><strong>Facebook</strong></a>) for more engaging topics.</p></blockquote>

Food Adulteration and How It Is Revealed by Analytical Chemistry

<p><strong>Join us for a fascinating conversation with Dr. Subhoja Chakraborty from the University of Central Florida, whose cutting-edge research targets the global challenge of malaria drug resistance. Dr. Chakraborty shares her journey from structure-based drug design during her PhD to her recent collaborative work repurposing human kinase inhibitors as rapid, selective antimalarials against drug-resistant Plasmodium falciparum strains.</strong></p><h4><strong>In this episode, you'll learn:</strong></h4><ul><li>How structure-guided approaches reveal potential drug targets, including cysteine proteases like falcipain-2, and kinases implicated in malaria's complex life cycle.</li><li>The power of repurposing kinase inhibitors originally developed for cancer and other diseases, focusing on compound 12, which blocks hemozoin formation and protein kinase 6—key steps in parasite survival.</li><li>Lab techniques such as affinity, gel filtration, and size exclusion chromatography for recombinant protein purification—and how troubleshooting is crucial for high-yield, stable complexes.</li><li>Advances in mass spectrometry for characterizing protein interactions, validating drug targets, and mapping molecular pathways pivotal to malaria therapeutics.</li><li>Tips and lessons for new researchers facing the challenges of sample preparation, complex protocols, and working as part of a collaborative team.</li></ul><p>Dr. Chakraborty’s insights bridge the gap between basic science and translational drug discovery, offering hope for more effective, targeted malaria treatments in a world where resistance to frontline therapies threatens millions.</p><h4><strong>Referenced Papers:</strong></h4><ul><li>"Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity" (Cell Chemical Biology, 2025)</li><li>"New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain" (BBRC, 2022)</li><li>"Structure-Based Optimization of Protease−Inhibitor Interactions to Enhance Specificity of Human Stefin‑A against Falcipain‑2 from the Plasmodium falciparum 3D7 Strain" (Biochemistry, 2023)</li></ul><p>If you’re a student, scientist, or simply passionate about advances in infectious disease research, this episode offers actionable insights, inspiring advice, and a front-row seat to innovation in combating malaria.</p><h3><strong>Video Transcription</strong></h3><h4><strong>From Structural Biology to Drug Discovery: Chromatography and Mass Spectrometry in Malaria Research</strong></h4><h5><strong>Introduction</strong></h5><p>In this discussion, Subhoja shares insights into her research journey, focusing on malaria drug discovery and the role of modern analytical techniques in biological and biomedical research. The conversation is aimed primarily at undergraduate students and early-career researchers interested in chemistry, biotechnology, and life sciences.</p><h5><strong>Research Focus: Malaria Drug Discovery and Kinase Targets</strong></h5><p>Subhoja is currently involved in malaria drug discovery research at the University of Central Florida, where she has been working since beginning her postdoctoral position two years ago. Her earlier PhD research focused on structure-based drug design in malaria, using a combination of in silico approaches, recombinant protein expression, and X-ray crystallography to determine precise three-dimensional structures of target proteins and their inhibitors.</p><p>This structural perspective provided a foundation for her current work, which centers on drug discovery through compound screening and repurposing. A recent publication from her laboratory explores the use of repurposed mammalian CDK-like kinase inhibitors as potential antimalarial agents. While such kinase inhibitors are well known in cancer and cardiovascular research, their application to malaria targets represents a novel and promising approach.</p><p>Kinases are attractive drug targets because of their central role in cell signaling and growth pathways. By targeting specific kinases involved in different stages of the malaria parasite life cycle—whether asexual growth, gametocytogenesis, or differentiation—it may be possible to significantly inhibit parasite growth and progression.</p><h5><strong>Chromatography in Protein Expression and Purification Workflows</strong></h5><p>Chromatography plays a critical role throughout Subhoja’s research. Her experience spans from basic chromatography techniques during her early training to advanced protein purification workflows using affinity chromatography, gel filtration (size exclusion chromatography), and ion exchange chromatography.</p><p>Recombinant proteins are routinely purified using affinity resins such as nickel or cobalt, followed by further purification to remove contaminants. Fast Protein Liquid Chromatography (FPLC) enables compact, stepwise purification workflows suitable for producing proteins for in vitro assays.</p><p>A recurring challenge in this process is the expression of high-molecular-weight proteins, which often accumulate in insoluble fractions or inclusion bodies. Careful selection of expression vectors, host systems, and induction conditions is therefore essential to maximize yield and solubility.</p><h5><strong>Integrating Size Exclusion Chromatography into the Workflow</strong></h5><p>Size exclusion chromatography (SEC) is typically used after affinity purification to further improve protein purity. Following elution with imidazole or glutathione, desalting is required to prevent buffer components from interfering with downstream assays. This is often achieved using desalting columns such as G-25 or PD-10.</p><p>To remove lower-molecular-weight contaminants, finer SEC media—such as Superdex or Sephacryl columns—are employed. Concentration steps using molecular-weight cut-off filters are then applied to obtain the desired protein concentration for functional studies.</p><p>These iterative purification and troubleshooting steps are a routine part of protein biochemistry and reflect the importance of methodical optimization and careful validation.</p><h5><strong>The Role of Mass Spectrometry in Biomolecular Characterization</strong></h5><p>Mass spectrometry is a key analytical tool in Subhoja’s research pipeline, particularly for target identification and validation. In both malaria and cancer research, MS is used alongside chromatography, immunoprecipitation, and pull-down assays to study protein interactions and molecular recognition events.</p><p>Affinity-based mass spectrometry enables the identification of binding partners and interactors, whether studying proteins, long non-coding RNAs, or protein complexes. Techniques such as native MS, tandem affinity purification, and proximity labeling (e.g., TurboID-based workflows) provide deeper insights into molecular networks and signaling pathways.</p><p>These approaches are essential for understanding how candidate drug targets function within complex biological systems.</p><h5><strong>Sample Preparation Challenges in Biological Research</strong></h5><p>Sample preparation remains one of the most challenging aspects of biological experimentation. Whole-cell lysates contain proteases, nucleases, and other components that can rapidly degrade target molecules. Preventing degradation requires minimizing preparation time, maintaining low temperatures, and using appropriate inhibitor cocktails.</p><p>Reproducibility is also critical: biological experiments require multiple replicates, and variability is often unavoidable. Careful handling, protocol optimization, and continuous troubleshooting are essential to ensure reliable results, whether preparing samples for chromatography, mass spectrometry, sequencing, or immunoprecipitation.</p><h5><strong>Advances in Chromatography and MS for Malaria Research</strong></h5><p>Modern advances in chromatography and mass spectrometry significantly enhance malaria research by enabling precise target identification, quantification, and functional characterization. Drug discovery workflows begin with construct design and recombinant expression, followed by purification and interaction studies.</p><p>In malaria research, stage-specific parasite biology requires careful extraction and analysis of proteins from different life cycle stages. Tandem affinity MS, immunoprecipitation, and in vivo validation studies help confirm target relevance and therapeutic potential.</p><p>Recent work on repurposed kinase inhibitors has shown promising results, including inhibition of hemozoin formation—a key detoxification pathway for the malaria parasite—highlighting the potential of such compounds for further development.</p><h5><strong>Malaria, Drug Resistance, and Global Impact</strong></h5><p>Malaria remains a major global health burden, with over 600,000 deaths annually and widespread drug resistance complicating treatment. Artemisinin resistance, particularly associated with mutations in the K13 propeller domain, has driven the search for new targets and therapies.</p><p>During her PhD, Subhoja focused on falcipain-2, a cysteine protease involved in hemoglobin degradation within the parasite. This pathway is critical for parasite survival and has emerged as a promising drug target. Her work revealed that falcipain-2 operates within a larger protein complex responsible for hemoglobin processing and amino acid release.</p><p>Understanding these molecular mechanisms is essential for developing robust, stage-specific antimalarial strategies.</p><h5><strong>Advice for Early-Career Researchers</strong></h5><p>For researchers just starting out, Subhoja emphasizes the importance of hands-on experience. Working directly with cells, lysates, and analytical tools is essential for truly understanding experimental systems. Failure is an inherent part of research, and perseverance is key.</p><p>Motivation, teamwork, careful sample handling, and thorough preparation all contribute to long-term success. Reading extensively, critically evaluating one’s own work, and appreciating incremental progress are vital aspects of a sustainable research career.</p><p>Every successful experiment—no matter how small—represents meaningful progress and contributes to the broader goals of science and medicine.</p><h5><strong>Closing Remarks</strong></h5><p>The discussion highlights how interdisciplinary approaches combining chromatography, mass spectrometry, structural biology, and biochemistry are driving advances in malaria drug discovery. Through careful experimental design, analytical rigor, and collaborative teamwork, researchers can address complex biological challenges and contribute to global health solutions.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

Article

Product

Video

Scientists

Food

Interview

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Watrex Praha

KNAUER AZURA 1240 bar UHPLC System

High-end solution for most challenging tasks. Ideally suited for quality control tasks with high sample throughput.

<p><strong>High-end solution for most challenging tasks.&nbsp;Ideally suited for quality control tasks with high sample throughput. This solution is recommended whenever lowest detection limits, highest analysis speed and resolution or most accurate flow delivery is needed.</strong></p><div><div><ul><li>Developed with innovative technology and decades of continuous improvements <strong>the AZURA®&nbsp;UHPLC 1240 bar systems enter&nbsp;a new level of performance and durability</strong></li><li><strong>Covers ultra high pressure applications</strong> due&nbsp;to&nbsp;working conditions in the range of&nbsp;<strong>0.1–5.0&nbsp;ml/min at up to 1240&nbsp;bar&nbsp;</strong></li><li>This system is made for&nbsp;high resolution <strong>UHPLC columns packed with smallest particles &lt; 2 µm</strong> or <strong>core shell materials</strong>, while any other HPLC or UHPLC column can also be used&nbsp;</li><li><strong>Perfect partner for MS/MS coupling</strong> due to very precise and accurate delivery also in the low flow rate range</li><li>Typical applications include food, pharmaceutical and environmental analyses with high throughput</li></ul></div></div><div><div><p>Choose this system whenever highest performance and speed is needed!</p><p><strong>If your applications do not require such a high back pressure and resolution, then you should take a look at the KNAUER AZURA HPLC systems. These can be operated at up to 862 bar.</strong></p></div></div><h3><strong>Specifications</strong></h3><ul><li><strong>Back pressure range:</strong> 1240 bar max.</li><li><strong>Flow rate range:</strong> 0.001–5 ml/min</li><li><strong>Available pump systems:</strong> Binary HPG</li><li><strong>Special pump features:</strong> Active pulsation compensation, RFID for automatic pump head detection, Integrated pressure sensor, Leak management, Piston seal wash, Purge valve (automatic)</li><li><strong>Injection options:</strong> Autosampler, Liquid handler</li><li><strong>Injection volume range:</strong> 0.1 µl–5000 µl depending on sample loop</li><li><strong>Sample capacity:</strong> 108 standard HPLC vials (1.5 ml) or up to 768 positions when equipped with microtiter plates, with liquid handler up to 390 HPLC vials</li><li><strong>Column thermostatting range: </strong>5–85 °C</li><li><strong>Eluent preheating:</strong> Optional cartridge for eluent pre-heating</li><li><strong>Column switching options:</strong> Optional switching between up to 8 columns</li><li><strong>Choice of detectors:</strong> DAD 190–700 nm, DAD 190–1000 nm, RID, UVD, MWD, FLD, ELSD, MS</li><li><strong>Choice of software packages:</strong> ClarityChrom® CDS, OpenLAB® CDS EZChrom Edition, Mobile Control, Chromeleon™ 7.2</li></ul><h3><strong>System components</strong></h3><div><div><p>An AZURA UHPLC system adapts to your application requirements. The highly modular system design allows you to choose the best suited components for your specific task.</p></div></div><h4><strong>Eluent delivery</strong></h4><h5><strong>Binary high-pressure gradient (HPG) pump system</strong></h5><p>The new <strong>AZURA®&nbsp;P 8.1L UHPLC pump</strong> is specially designed for ultra-fast and high-resolution applications.&nbsp;It features a 2-channel internal degassing unit, a 2x2 channel solvent selection valve, and a low dwell-volume eluent mixer.</p><p>The adaptive pulsation compensation of the pump is independent of flow rate, backpressure, and eluent type through real-time eluent compressibility monitoring and variable piston stroke. Together with the ultra-precise piston movement thanks to KNAUER’s proprietary advanced piston drive technology, this results in outstanding flow reproducibility at any working conditions.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_Binary_high_pressure_gradient_HPG_pump_system_b94a8018c7.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - Binary high-pressure gradient (HPG) pump system" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_Binary_high_pressure_gradient_HPG_pump_system_b94a8018c7.jpg 245w," sizes="100vw" width="1280" height="550"></p><h4><strong>Sample Injection</strong></h4><h5><strong>Autosampler 1240 bar</strong></h5><p>The&nbsp;<strong>autosampler AZURA AS 6.1L 1240&nbsp;bar</strong> can inject from up to 768 positions when equipped with microtiter plates or from up to 108 standard 2 ml sample vials. It&nbsp;is equipped with an ILD<sup>TM</sup> valve, consisting of a rotor-stator combination with a central port for depressurizing the sample loop before receiving the sample. This way, the sample is not diluted with solvent. A Cooling/heating option (4–40 °C) is optionally available.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_autosampler_AZURA_AS_6_1_L_1240_bar_ff1ac03e70.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - autosampler AZURA AS 6.1L 1240&nbsp;bar" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_autosampler_AZURA_AS_6_1_L_1240_bar_ff1ac03e70.jpg 245w," sizes="100vw" width="1280" height="780"></p><h5><strong>Liquid handler&nbsp;</strong></h5><p>The <strong>Liquid handler LH 8.1 </strong>offers automatic sample preparation to speed up your workflow. No sample loss and high precision injection of small and large sample volumes are provided. High-throughput with up to 4 robotic coolers with&nbsp;max. of 24 racks for up to 390 HPLC vials or well plates. Washing station with two different wash solvents minimizes carry-over. Flexibility of modules and functions according to your needs.</p><h4><strong>Column selection and thermostat</strong></h4><h5><strong>Column thermostat</strong></h5><p>The <strong>forced air column thermostat</strong><i> </i><strong>AZURA CT 2.1</strong> is capable of heating or cooling from 5 to 85 °C. The powerful fan and robust peltier element keep the column at a very stable temperature, thus allowing reproducible analysis results.&nbsp;Optional eluent preheating cartridges can be installed.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_Educational_HPLC_System_Column_selection_and_thermostat_567c35ab61.jpg" alt="Knauer: KNAUER AZURA Educational HPLC System - Column selection and thermostat" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_Educational_HPLC_System_Column_selection_and_thermostat_567c35ab61.jpg 245w," sizes="100vw" width="1700" height="881"></p><h5><strong>Column switching valves</strong></h5><p><strong>KNAUER valves V&nbsp;4.1</strong>&nbsp;and the <strong>KNAUER valve drive VU 4.1&nbsp;</strong>are designed for a wide range of chromatographic applications. Flexibility is provided by choice of different materials and sizes as well as drivers for various software packages.</p><h4><strong>Detection</strong></h4><h5><strong>Diode array detectors (DAD or PDA)</strong></h5><p>The AZURA Diode array detectors (DAD)&nbsp;are high-end diode array detectors with a wavelength range from 190–1000 nm for the <strong>AZURA DAD 6.1L</strong> and 190–700 nm for the <strong>AZURA DAD 2.1L</strong>. The intelligent temperature management of both devices enables fast operational readiness after startup. It also minimizes baseline drift. Due to the frontally accessible deuterium and halogen lamp, the device is easy to service.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_DAD_6_1_L_Diode_array_detectors_DAD_or_PDA_919e55c936.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - AZURA DAD 6.1L Diode array detectors (DAD or PDA)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_DAD_6_1_L_Diode_array_detectors_DAD_or_PDA_919e55c936.jpg 245w," sizes="100vw" width="1280" height="387"></p><h5><strong>Mass Detector for MS/MS</strong></h5><p>The <strong>SCIEX Triple Quad™ 4500 MS/MS</strong> system offers superior quantitative performance with high sensitivity combined with excellent robustness and long-term stability. Designed for food, environmental, forensic and clinical research, this MS/MS system enables test development for even the most demanding applications.</p><ul><li>Workhorse triple quad mass spectrometer for dependable everyday use&nbsp;</li><li>High sensitivity for food and environmental contaminant screening and target quantitation</li><li>High scan speed for reliable quantitation of sharp UHPLC peaks</li><li>Simple and fast data processing powered by SCIEX OS software</li></ul><h5><strong>Variable or multiple wavelength detectors (MWD or VWD)</strong></h5><p>The <strong>AZURA MWD 2.1L</strong> is an 8 channel, sensitive multiwavelength detector combining high performance with easy handling at an affordable price. The newly developed optical unit and intelligent temperature management ensure for maximum sensitivity combined with minimal baseline drift.&nbsp;</p><h5><strong>UV/VIS detectors with single variable wavelength</strong></h5><p>The UV/VIS Detector <strong>AZURA UVD 2.1L</strong> is a competitively priced HPLC spectrophotometer for routine HPLC applications including fast LC methods.&nbsp;It comes with an installed deuterium lamp which covers a wavelength range from 190 to 750 nm.&nbsp;Due to a smart design the flow cell is easily accessible and can be changed very quickly.&nbsp;</p><h5><strong>Refractive index detection (RI)</strong></h5><p>The <strong>AZURA RID 2.1L</strong> is a sensitive and competitively priced differential refractometer. It is suitable for detecting compounds with little or no UV activity such as alcohols, sugars, lipids or polymers.&nbsp;The intelligently designed optical unit with advanced temperature control ensures high sensitivity, fast baseline stabilization, and excellent reproducibility. The wide linear dynamic range, its low internal volume of 43 µl from the inlet to the flow cell and 10 ml/min maximum flow rate make the AZURA RID 2.1L the perfect choice for most laboratory tasks.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_RID_2_1_L_Refractive_index_detection_RI_8cd15bf26d.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - AZURA RID 2.1L Refractive index detection (RI)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_RID_2_1_L_Refractive_index_detection_RI_8cd15bf26d.jpg 245w," sizes="100vw" width="1280" height="387"></p><h5><strong>Fluorescence detection (FLD)</strong></h5><p>The fluorescence detectors <strong>RF-20A </strong>and <strong>RF-20Axs</strong> provide&nbsp;world-class sensitivity, excellent maintainability and diverse validation / support functions. They&nbsp;support&nbsp;a wide range of applications in the wavelength range of 200 to 750 nm for the RF-20Axs and 200 to 650 nm for the RF-20A from conventional analysis to high-performance analysis.</p><h5><strong>Evaporative light scattering detection (ELSD)&nbsp;</strong></h5><p>As an universal detector, an <strong>ELSD </strong>offers numerous possibilities for detecting substances that have few or no chromophores. Since the eluents are evaporated, the use of non-UV-compatible solvents poses no problems and the ELSD is gradient compatible. KNAUER offers different models for different application tasks.</p><h4><strong>Software solutions</strong></h4><h5><strong>Mobile Control</strong></h5><p>The Mobile Control is an intuitive and cost-effective software solution for controlling and monitoring your AZURA devices and systems. The clear system overview provides instant information on key parameters and system status. Adjust and operate single devices or even whole systems with a few fingertips.&nbsp;The well-structured block programming assists you to clearly and quickly automate device control. A smart user management makes the Mobile Control safe. Device parameters can only be changed by authorized operators.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_Educational_HPLC_System_Mobile_Control_software_2052b3ed77.jpg" alt="Knauer: KNAUER AZURA Educational HPLC System - Mobile Control software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_Educational_HPLC_System_Mobile_Control_software_2052b3ed77.jpg 241w," sizes="100vw" width="1280" height="830"></p><h5><strong>ClarityChrom® CDS</strong></h5><p>ClarityChrom is an easy-to-use chromatography data system for workstations. The optional control extensions for GC, PDA and GPC allow to use the software for a wide range of applications.</p><h5><strong>OpenLAB® CDS EZChrom Edition</strong></h5><p>Basic Workstation license, includes System Suitability, Fraction Collector Control and Software Maintenance Agreement</p><h5><strong>Chromeleon™ 7.2</strong></h5><p>Thermo Scientific™ Dionex™ Chromeleon™ is one of the most wide-spread chromatography data systems. Its intuitive handling benefits laboratory workflow and the highly developed algorithms simplify data processing. It offers a broad range of third-party drivers and can be easily used with existing HPLC systems. KNAUER offers drivers for a lot of its devices.&nbsp;</p>

KNAUER ULDC system AZURA 862 (BP and DAD)

ULDC system AZURA 862 with binary HPG pump and 3D diode array detector. ULDC (ultra low dispersion chromatography) system proposal.

<p><strong>The new ULDC (ultra low dispersion chromatography)&nbsp;system&nbsp;meets the enormous requirements that are essential to minimize extra column volume and thus peak dispersion.</strong></p><ul><li><strong>Ultra low dispersion volume</strong> due to optimized injection, flow and detection components</li><li>Conventional method (also gradient) can directly be transfered to ULDC system without any adaptations</li><li><strong>Sharper early-eluting peaks</strong> generate better sensitivities and resolution</li></ul><h4><strong>Eluent delivery</strong></h4><p>The Pump&nbsp;P6.1L with a HPG configuration features a solvent <strong>selection valve to set up to 4 solvents</strong> to the system of which two can be blended simultaneously. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_High_pressure_gradient_HPLC_pump_AZURA_P_6_1_L_High_Pressure_Pump_with_10_ml_pump_head_stainless_steel_b7d7d07d6c.jpg" alt="Knauer: High pressure gradient HPLC pump - AZURA P 6.1L High Pressure Pump with 10 ml pump head, stainless steel" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_High_pressure_gradient_HPLC_pump_AZURA_P_6_1_L_High_Pressure_Pump_with_10_ml_pump_head_stainless_steel_b7d7d07d6c.jpg 245w," sizes="100vw" width="1280" height="627"></p><h4><strong>Sample Injection</strong></h4><p>The Autosampler 6.1L can inject <strong>0.1 – 5000 µl</strong> to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of <strong>up to 768 samples or 108 vials</strong>.</p><h4><strong>Column thermostating</strong></h4><p>The Column thermostat&nbsp;CT 2.1&nbsp;is suitable for column <strong>thermostatization above and below room temperature</strong>. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.</p><h4><strong>Chromatography data system</strong></h4><p><strong>KNAUER ClarityChrom®</strong> is a powerful, yet easy-to-use chromatography software for instrument control, data acquisition and data processing. It is an economical solution compared to other more complex chromatography software while still offering <strong>FDA 21 CFR Part 11 compliance</strong>.</p><h4><strong>Detection&nbsp;</strong></h4><p>The detector<strong>&nbsp;DAD 2.1L features</strong> a novel light path and flow cell architecture with improved handling and excellent performance. This Diode array detector can be used in the wavelength range of 190-700 nm.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_DAD_6_1_L_Diode_array_detectors_DAD_or_PDA_919e55c936.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - AZURA DAD 6.1L Diode array detectors (DAD or PDA)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_DAD_6_1_L_Diode_array_detectors_DAD_or_PDA_919e55c936.jpg 245w," sizes="100vw" width="1280" height="387"></p><h4><strong>This AZURA ULDC system can be customized with several detectors:</strong></h4><ul><li><strong>The diode array detector DAD 6.1L</strong> covers all conceivable applications with a spectral range of 190-1000 nm. With its novel light path and optimized flow cells, it is one of the most powerful devices on the market.</li><li><strong>The detector&nbsp;MWD 2.1L</strong> is an 8 channel, sensitive multiwavelength detector combining high performance with easy handling at an affordable price. This multiwavelength detector can be used in the wavelength range of 190-700 nm.</li><li><strong>The&nbsp;variable single wavelength UV/VIS detector&nbsp;UVD 2.1L</strong> comes with an installed deuterium lamp which covers a wavelength range from 190 to 750 nm. It is a competitively priced detector for routine HPLC applications including fast LC <span style="font-size:12px;">methods</span>.</li></ul><p>Customized configurations like combinations of several detectors are also available. Every AZURA 862 HPLC system can easily be upgraded to ULDC and it is not necessary to purchase a UHPLC system with higher back pressure capabilities.</p><h3><strong>Key Features</strong></h3><div><div><div><ul><li>Ultra sharp peaks</li><li>Maximum separation power</li><li>Ultra low extra column volume</li><li>Better performance than HPLC</li></ul><h3><strong>Technical Data</strong></h3><h4><strong>Analytical system</strong></h4><ul><li><strong>Application area:</strong> UHPLC, HPLC</li><li><strong>Pump system:</strong> Gradient</li><li><strong>Gradient:</strong> Binary HPG</li><li><strong>Injection: </strong>Autosampler</li><li><strong>Detector: </strong>Diode array detection DAD</li><li><strong>Software: </strong>ClarityChrom, Mobile Control</li><li><strong>Pressure: </strong>862 bar</li><li><strong>Column thermostat: </strong>Yes</li></ul><h3><strong>Included components</strong></h3><h4><strong>AZURA Eluent tray E 2.1L</strong></h4><p>AZURA® Eluent tray E 2.1L for AZURA® devices with a capacity of 6 x 1 l bottles or 4 x 2.5 l bottles or 2 x 5 l bottles, (delivery without bottles)</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_AZURA_Eluent_tray_E_2_1_L_Eluent_tray_for_up_to_6_x_1000_ml_bottles_delivery_without_bottles_or_4_x_2_5_l_bottles_or_2_x_5_l_bottles_or_1_x_10_l_bottle_da9c964bad.jpg" alt="Knauer: AZURA Eluent tray E 2.1L - Eluent tray for up to 6 x 1000 ml bottles, (delivery without bottles), or 4 x 2.5 l bottles, or 2 x 5 l bottles, or 1 x 10 l bottle" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_AZURA_Eluent_tray_E_2_1_L_Eluent_tray_for_up_to_6_x_1000_ml_bottles_delivery_without_bottles_or_4_x_2_5_l_bottles_or_2_x_5_l_bottles_or_1_x_10_l_bottle_da9c964bad.jpg 245w," sizes="100vw" width="1280" height="540"></p><h4><strong>Set of eluent supply bottles for HPG and LPG systems incl. bottle for piston backflushing</strong></h4><p>Set of 4 eluent bottles 1000 ml, 1 bottle 250 ml for piston backflushing, incl. closed caps, GL45 use with AZURA tubing kit</p><h4><strong>High pressure gradient HPLC pump</strong></h4><p>AZURA® Pump P 6.1L (HPG), with 10 ml pump head (stainless steel), degasser and mixer (400 µl)</p><ul><li>Max. flow rate : 10 ml/min</li><li>Pump head materials : Stainless Steel &nbsp;Gradient : High pressure gradient (binary)</li><li>Pump features : Active pulsation compensation, RFID for automatic pump head detection, Integrated pressure sensor, Purge valve (manual), Leak management, Piston seal wash</li><li>Maximum delivery pressure [MPa] : 86 MPa</li></ul><h4><strong>Fast and versatile analytical HPLC autosampler</strong></h4><p>AZURA® Autosampler AS 6.1L analytical HPLC autosampler, 862 bar</p><ul><li>Maximum back pressure: 862 bar</li><li>Sample loop: 100 µl</li><li>Sample tray cooling: None</li><li>Autosampler Flow Path: Analytical</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_autosampler_AZURA_AS_6_1_L_1240_bar_ff1ac03e70.jpg" alt="Knauer KNAUER AZURA 1240 bar UHPLC System - autosampler AZURA AS 6.1L 1240&nbsp;bar" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_autosampler_AZURA_AS_6_1_L_1240_bar_ff1ac03e70.jpg 245w," sizes="100vw" width="1280" height="780"></p><h4><strong>Column thermostat for up to 8 HPLC columns</strong></h4><p>Column thermostat AZURA CT 2.1 for constant temperatures and reproducible results</p><ul><li>Temperature range : 5–85 °C</li></ul><h4><strong>Basic Diode Array Detector for Liquid Chromatography and Process Technology</strong></h4><p>AZURA® Detector DAD 2.1L Diode array detector DAD 2.1L without flow cell 190 - 700 nm, incl. test cell</p><ul><li>Detector type: Diode array detector</li><li>Detection channels: 8 (Digital)/4 (Analog)</li><li>Wavelength range: 190 - 700 nm</li><li>Number of diodes: 256</li><li>Linearity: &gt; 2.0 AU at 274 nm (ASTM E1657-98)</li></ul><h4><strong>Standard KNAUER LightGuide UV Flow Cell Cartridge</strong></h4><p>10 mm path length, 2µl, 1/16", 50 bar, LightGuide Flow cell cartridge for AZURA® Detector DAD/MWD</p><ul><li>Flow cell type: Analytical UV flow cell</li><li>Path length: 10 mm</li><li>Capillary connection: 1/16''</li><li>Max. flow rate: 5 ml/min</li><li>Flow cell volume: 2 µl</li></ul><h4><strong>Start-Up Kit with flexible, precut capillaries for analytical UHPLC and ULDC systems with 1/16" connections</strong></h4><p>Set of precut capillaries, fittings, connectors and adapters</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Start_Up_Kit_with_flexible_precut_capillaries_for_analytical_UHPLC_and_ULDC_systems_with_1_16_connections_3e479ace7e.jpg" alt="Knauer: Start-Up Kit with flexible, precut capillaries for analytical UHPLC and ULDC systems with 1-16 connections" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Start_Up_Kit_with_flexible_precut_capillaries_for_analytical_UHPLC_and_ULDC_systems_with_1_16_connections_3e479ace7e.jpg 245w," sizes="100vw" width="1280" height="435"></p><h4><strong>Tool kit AZURA</strong></h4><p>Tool Kit AZURA® for systems with PEEK or pre-cut capillary kits</p><h4><strong>8-port GBit switch for connection of AZURA devices with a PC</strong></h4><p>8-port LAN GBit switch NetGear GS108GE, 8x RJ-45, GBit, Auto MDI-X, power plug UK, US or AUS</p><h4><strong>ClarityChrom 9.1.0 - Workstation, autosampler control included</strong></h4><p>ClarityChrom® single instrument license for one time base</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Clarity_Chrom_Workstation_7ed6c2cb72.jpg" alt="Knauer: ClarityChrom Workstation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Clarity_Chrom_Workstation_7ed6c2cb72.jpg 245w," sizes="100vw" width="839" height="495"></p><h4><strong>ClarityChrom 9.1.0 - PDA extension</strong></h4><p>ClarityChrom® option for PDA data processing</p><h4><strong>Eluent waste kit for AZURA Analytical systems</strong></h4><p>Eluent waste kit for all AZURA Analytical systems, incl. filter, waste can and cap.</p></div></div></div>

ECOM ECS06 Gradient Analytical System

Highly effective HPLC system with a UV-VIS detector, a column oven, an analytical pump, a gradient box, and an autosampler with/without cooling and heating, 40 MPa (5801 psi).

<div style="display:block;" aria-labelledby="tab_item-0"><p><strong>Highly effective HPLC system with a UV-VIS detector, a column oven, an analytical pump, a gradient box, and an autosampler with/without cooling and heating, 40 MPa (5801 psi).</strong></p><p>The detector with eight channels in the range of 200-800 nm and a very low noise level also offers high-speed scanning <strong>up to 100 Hz</strong>. The units are communicated through <strong>RS232</strong> or Ethernet (LAN). An additional PC A/D converter card is not required for this system. The system contains an autosampler and Clarity software. All units are supported in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity software</strong></a> from installation.</p><p>A wireless mouse and keyboard set (P/N: EPC-0028), a PC (P/N: EPC-0026), and a computer monitor (P/N: EPC-0027) can be purchased with the system.</p><h3><strong>Main parts</strong></h3><h5><strong>ECDA2800 UV-VIS PDA DETECTOR</strong></h5><p>Analytical Diode Array Detector measures at eight wavelengths simultaneously or performs a full scan with a speed of up to 100 Hz. 3D support in Clarity SW. Noise level ±5 x 10-6 AU. Four analog outputs. Two special mathematical channels are available. AD 05 analytical cell is included.</p><h5><strong>ECO2080L COLUMN OVEN WITH HEATING AND COOLING</strong></h5><p>This column oven allows precise temperature stabilization in the range of 0-80°C. A big compartment room can accommodate up to 3 columns with lengths up to 30 cm. Peltier technology offers the possibility of heating and cooling independently from room temperature.</p><h5><strong>ECP2010 ANALYTICAL HPLC PUMP</strong></h5><p>This isocratic pump works with Gradient Box ECB2004B as a quaternary gradient pump. The flow rate range is 0.001-10.00 ml/min and the pressure limit is 40 MPa. Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.</p><h5><strong>ECB2004B GRADIENT BOX WITH DEGASSER</strong></h5><p>The box is suited for handling liquids in ECOM gradient systems. It accommodates a container for solvent bottles, a built-in high-efficiency vacuum degasser, and a four-way gradient valve. Up to four solvent lines may be degassed simultaneously by one unit. A four-way gradient valve is controlled from the pump ECP2010.</p><h5><strong>AUTOSAMPLER AS96</strong></h5><p>A reliable and precise autosampler for a wide range of applications in HPLC and LC-MS in variants with or without a cooling and heating module. State-of-the-art injection technology with fast injection and wash cycles. For 2x48 vials, max. pressure 40 MPa (5801 psi)</p><h5><strong>CLARITY CHROMATOGRAPHY SOFTWARE</strong></h5><p>This system is fully controlled by Clarity Chromatography software, which is also a part of delivery. Clarity software complies with CFR21GLP requirements.</p><h3>SYSTEM CONTAINS&nbsp;</h3><p><strong>Pcs / Description (P/N)</strong></p><ul><li>1x / ECDA2800 Analytical UV-VIS PDA Detector (ANW0000X)</li><li>1x /&nbsp;ECB2004B Gradient box with degasser (ABA0000X)</li><li>1x / ECP2010 Analytical HPLC pump (ACA0000X)</li><li>1x / ECO2080L Column oven with heating and cooling (AOA00004)</li><li>1x / Autosampler AS96 for 2x48 vials, 40 MPa, with or without heating and cooling module (ASA97010/ASA97000)</li><li>1x / Clarity – Station for 1 instrument (AP000C50)</li><li>1x / Clarity module for HPLC control (AP000A24)</li><li>1x / Clarity SW module for AS controlvAP000A26)</li><li>1x / Module for PDA data Clarity SW (AP000A29)</li><li>1x / Accessories for analyt. system series 2000 (ASA00180)</li><li>1x / Accessories for autosampler (ASA96180)</li></ul><p>Note: Column and computer not included. PC system has to be equipped for handling 3 serial RS232 or 1 Ethernet port at least. Please, check also <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity software</strong></a> requirements..</p><h3>Configuration options</h3><ul><li><strong>ASA0600X</strong> - Gradient analytical system - incl. autosampler <strong>without cooling and heating</strong>, up to 40 MPa (5801 psi)</li><li><strong>ASA06C0X</strong> - Gradient analytical system – incl. autosampler <strong>with cooling and heating</strong>, up to 40 MPa (5801 psi)</li></ul></div>

ECOM ECS07 Gradient Analytical System

Highly effective HPLC system with a UV-VIS detector, a column oven, an analytical pump (60 MPa, 8702 psi), a gradient box, and an autosampler.

<div style="display:block;" aria-labelledby="tab_item-0"><p><strong>Highly effective HPLC system with a UV-VIS detector, a column oven, an analytical pump, a gradient box, and an autosampler with/without cooling and heating, 60 MPa (8702 psi).</strong></p><p>The detector with eight channels in the range of 200-800 nm and a very low noise level also offers high-speed scanning <strong>up to 100 Hz</strong>. The units are communicated through <strong>RS232</strong> or <strong>Ethernet (LAN)</strong>. An additional PC A/D converter card is not required for this system. The system contains an autosampler and Clarity software. All units are supported in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity software</strong></a> from installation.</p><p>A wireless mouse and keyboard set (P/N: EPC-0028), a PC (P/N: EPC-0026), and a computer monitor (P/N: EPC-0027) can be purchased with the system.</p><h3><strong>Main parts</strong></h3><h5><strong>ECDA2800 UV-VIS PDA DETECTOR</strong></h5><p>Analytical Diode Array Detector measures at eight wavelengths simultaneously or performs a full scan with a speed of up to 100 Hz. 3D support in Clarity SW. Noise level ±5 x 10-6 AU. Four analog outputs. Two special mathematical channels are available. AD 05 analytical cell is included.</p><h5><strong>ECO2080L COLUMN OVEN WITH HEATING AND COOLING</strong></h5><p>This column oven allows precise temperature stabilization in the range of 0-80°C. A big compartment room can accommodate up to 3 columns with lengths up to 30 cm. Peltier technology offers the possibility of heating and cooling independently from room temperature.&nbsp;</p><h5><strong>ECP2010H ANALYTICAL HPLC PUMP</strong></h5><p>This isocratic pump works with Gradient Box ECB2004B as a <strong>quaternary gradient pump</strong>. The flow rate range is <strong>0.001-10.00 ml/min</strong> and the pressure limit is <strong>60 MPa</strong>. Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.</p><h5><strong>ECB2004B GRADIENT BOX WITH DEGASSER</strong></h5><p>The box is suited for handling liquids in ECOM gradient systems. It accommodates a container for solvent bottles, a built-in high-efficiency vacuum degasser, and a four-way gradient valve. Up to four solvent lines may be degassed simultaneously by one unit. A four-way gradient valve is controlled from the pump ECP2010.</p><h5><strong>AUTOSAMPLER AS96</strong></h5><p>A reliable and precise autosampler for a wide range of applications in HPLC and LC-MS in <strong>variants with or without a cooling and heating module</strong>. State-of-the-art injection technology with fast injection and wash cycles. Max. pressure <strong>60 MPa.</strong></p><h5><strong>CLARITY CHROMATOGRAPHY SOFTWARE</strong></h5><p>This system is fully controlled by Clarity Chromatography software, which is also a part of delivery. Clarity software complies with CFR21GLP requirements.</p><h3>SYSTEM CONTAINS&nbsp;</h3><p><strong>Pcs / Description (P/N)</strong></p><ul><li>1x / ECDA2800 Analytical UV-VIS PDA Detector (ANW0000X)</li><li>1x /&nbsp;ECB2004B Gradient box with degasser (ABA0000X)</li><li>1x / ECP2010H Analytical HPLC pump (ACF0000X)</li><li>1x / ECO2080L Column oven with heating and cooling (AOA00004)</li><li>1x / Autosampler AS96 for 2x48 vials, 60 MPa, with or without heating and cooling module (ASA96000/ASA96010)</li><li>1x / Clarity – Station for 1 instrument (AP000C50)</li><li>1x / Clarity module for HPLC control (AP000A24)</li><li>1x / Clarity SW module for AS controlvAP000A26)</li><li>1x / Module for PDA data Clarity SW (AP000A29)</li><li>1x / Accessories for analyt. system series 2000 (ASA00180)</li><li>1x / Accessories for autosampler (ASA96180)</li></ul><p>Note: Column and computer not included. PC system has to be equipped for handling 3 serial RS232 or 1 Ethernet port at least. Please, check also <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity software</strong></a> requirements..</p><h3>Configuration options</h3><ul><li><strong>ASA0700X</strong> - Gradient analytical system - incl. autosampler <strong>without cooling and heating</strong>, up to 60 MPa.</li><li><strong>ASA07C0X </strong>- Gradient analytical system – incl. autosampler <strong>with cooling and heating</strong>, up to 60 MPa.</li></ul></div>

Waters ACQUITY PREMIER UPLC System

Get the highest limits of detection, more consistent results, and better recovery, so you can see what you couldn’t before.

<p class="cke-user_style-important"><strong>Redefining separation science. Again.</strong></p><p data-pm-slice="1 3 []"><strong>The most significant innovation in separation science since we introduced UPLC™ in 2004, the ACQUITY™ Premier Solution reduces variability associated with metal-sensitive analytes - without time-consuming tasks like system and column passivation. By giving you greater confidence in your results, minimizing your risk, and increasing efficiency, you will have more time to generate meaningful data and focus on your next scientific breakthrough.</strong></p><h5><strong>With the ACQUITY Premier Solution you can:</strong></h5><ul data-spread="false"><li>Increase confidence in every result</li><li>Minimize risk of undetected analytes</li><li>Get to the right answer – faster</li></ul><h3><span><strong>Stop looking and start seeing</strong></span></h3><p data-pm-slice="1 3 []"><span>The ACQUITY Premier Solution enables your lab to make informed decisions and reduce risk with stronger analytical capabilities to detect more of your sample components from the very beginning. Get the highest limits of detection, more consistent results, and better recovery, so you can see what you couldn’t before.</span></p><h5><span><strong>The ACQUITY Premier Solution can help you:</strong></span></h5><ul data-spread="false"><li>Decrease time-to-result</li><li>Reduce time on method development</li><li>Increase overall efficiency in the laboratory</li></ul><figure class="image"><img style="aspect-ratio:1148/1223;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_2_50afcbba6d.jpg" alt="Waters ACQUITY PREMIER Solution: The ACQUITY Premier Solution consists of the ACQUITY Premier System, ACQUITY Premier Columns, and QuanRecovery™ Vials and Plates with MaxPeak™ HPS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_2_50afcbba6d.jpg 147w," sizes="100vw" width="1148" height="1223"></figure><h3><span><strong>MaxPeak High Performance Surfaces Technology</strong></span></h3><p>The ACQUITY Premier Solution is designed with MaxPeak High Performance Surfaces (HPS) Technology, which offers improvements in separation and detection of metal-sensitive analytes. By mitigating non-specific binding, the ACQUITY Premier Solution provides:</p><ul data-spread="false"><li>Dramatic improvements in RP and HILIC applications for organic acids, organophosphates, oligonucleotides, peptides, glycans, and phospholipids</li><li>Increased sensitivity reducing risk of undetected analytes</li><li>Increased efficiency by eliminating time-consuming system and column passivation</li><li>Greater reproducibility and increased confidence in results</li></ul><figure class="image"><img style="aspect-ratio:1183/1177;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_3_ca85533e85.jpg" alt="Waters ACQUITY PREMIER Solution: ACQUITY Premier Solution performance without time-consuming passivation – analysis of insulin receptor – doubly phosphorylated peptide (TRDIpYETDpYYRK)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_3_ca85533e85.jpg 157w," sizes="100vw" width="1183" height="1177"></figure><h3><strong>Holistic solutions for optimal performance</strong></h3><p>A true measure of excellence for Waters is in orchestrating consistent instrument and chemistry optimization, enabling you to fine-tune your system to your specific analytical need, rapidly change between applications, and consistently maintain a high level of confidence in every result.</p><p>The outcome is better quality data faster and improved system-to-system and column-to-column reproducibility, allowing methods to be transferred between analysts, instruments, and laboratories.</p><figure class="image"><img style="aspect-ratio:1534/1271;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4e1b9e6b60.jpg" alt="Waters ACQUITY PREMIER Solution: The ACQUITY Premier Solution significantly reduces analyte/surface interaction of sensitive compounds for improved chromatographic performance in RPLC/MS-based separations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4e1b9e6b60.jpg 188w," sizes="100vw" width="1534" height="1271"></figure><h3><span><strong>Improve spectral quality and analyte identification</strong></span></h3><p><span>Obtaining high-quality mass spectrometry spectra is central to structural elucidation and analyte identification. The process of obtaining these spectra is often confounded by spectral overlap from closely eluting analytes or poor-quality MS signal due to low peak concentration. MaxPeak HPS Technology eliminates secondary interactions from metals, reducing chromatographic peak tailing. The result is more gaussian peaks, reduced chromatographic coelution, and superior spectral quality.</span></p><figure class="image"><img style="aspect-ratio:1291/1172;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg" alt="Waters ACQUITY PREMIER Solution: Improve spectral quality and analyte identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg 171w," sizes="100vw" width="1291" height="1172"></figure><h3><span><strong>Global Services: Committed to your success</strong></span></h3><p data-pm-slice="1 1 []"><span>As part of the ACQUITY Premier experience, one of our applications specialists will work with you to ensure you are getting everything you need from your system. We have a flexible range of support plans to ensure you get the most out of your system:</span></p><h4><span><strong>FlexChoice™ MySystem Coverage&nbsp;</strong></span></h4><p><span>Choose the support you need – no more, no less. The Waters service team offers personalized and flexible support, maintenance, and service options to meet your unique lab requirements.</span></p><h4><span><strong>Compliance Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Simplify your process of validating, qualifying, and record-keeping with consulting services to help meet your regulatory guidelines.</span></p><h4><span><strong>Professional Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Waters comprehensive suite of consultative services, software applications, and analytical business tools guide you on your path to increased efficiencies and lower costs.</span></p><h4><span><strong>FlexUp™ Technology Renewal Program</strong></span></h4><p data-pm-slice="1 1 []"><span>Benefit from ongoing seamless upgrades to our latest LC and mass spec instrumentation and software and eliminate the issues associated with older instrumentation.</span></p><p><span>*Coming soon to all regions.</span></p><h3><span><strong>Informatics: Get more from your data for more trusted decisions</strong></span></h3><p><span>Capture, manage, integrate, and analyze your LC and MS data with our informatics platforms, improving discovery and manufacturing, quality and integrity, and reducing time to market. Easily and seamlessly conduct scientific searches, integrate networks, manage compliance, and streamline operations.</span></p><h4><span><strong>Empower™ Chromatography Data System</strong></span></h4><p data-pm-slice="1 1 []"><span>Your entire laboratory operates better with Empower Software, which makes it easier than ever to run samples and produce meaningful results, all while ensuring adherence to strict compliance requirements.</span></p><h4><span><strong>MassLynx™ Software</strong></span></h4><p data-pm-slice="1 1 []"><span>Increase laboratory productivity with Waters MassLynx™ Software, which simplifies interaction with and improves your MS system with an intuitive interface, intelligent instrument control, and software features built around the focus of your analysis - the sample.</span></p><h4><span><strong>Unifi™</strong></span></h4><p data-pm-slice="1 1 []"><span>Merges LC and high-performance MS data into a single solution, providing organizations with the flexibility to deploy UNIFI-based systems within regulated and non-regulated laboratory environments.</span><br><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg" alt="Waters ACQUITY PREMIER Solution " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Thermo Scientific Vanquish Tandem LC Systems

The Thermo Scientific Vanquish Tandem LC Systems increase throughput and maximize detector output by using a second pump and intelligent column switching to eliminate the time required for column equilibration in a gradient elution. 

<h3><strong>Optimize your productivity</strong></h3><p><strong>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;</strong></p><p>At the same time, <strong>advancements and innovations</strong> are needed to improve <strong>operational efficiency</strong> and <strong>performance</strong>. How do you accomplish this? It’s easy with the <strong>Thermo Scientific™ Vanquish™ High-throughput LC systems</strong> built for <strong>enhanced productivity</strong>. <strong>Vanquish High-throughput LC systems</strong> combine <strong>individual Vanquish components</strong> and <strong>software wizards</strong> to deliver <strong>increased throughput</strong> or <strong>detector utilization</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"></p><h3><strong>Two flow paths for maximized productivity</strong></h3><p>Your laboratory may be facing <strong>increased pressure to improve working efficiency</strong> and deal with <strong>limiting resources</strong>, such as <strong>budget</strong>, <strong>space</strong>, or <strong>manpower</strong>. <strong>Vanquish High-throughput LC systems</strong> are designed to <strong>overcome these limitations</strong> by providing <strong>multiple flow paths</strong> for <strong>parallelization of specific stages of the LC run</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"></p><h4><strong>Unique dual technology</strong></h4><p>The <strong>Vanquish platform</strong> contains <strong>two unique dual modules</strong>. <strong>Vanquish dual pumps</strong> merge <strong>two individual, low pressure mixing pumps</strong> in one housing enabling <strong>separate eluents and gradients</strong> for each pump.</p><p><strong>Vanquish dual split samplers</strong> possess <strong>two independently controlled injection units</strong> including <strong>separate injection valves and injection needles</strong>. Used in <strong>Dual LC and LC-MS workflows only</strong>, this enables <strong>high throughput</strong> and <strong>extensive sample characterization workflows</strong>.</p><h3><strong>Two configurations to best serve your needs</strong></h3><p><strong>Vanquish High-throughput workflows</strong> are configured with <strong>Thermo Scientific™ Vanquish™ Core system</strong>, <strong>Thermo Scientific™ Vanquish™ Flex system</strong> or <strong>Thermo Scientific™ Vanquish™ Horizon system</strong> modules. Both workflows make use of <strong>two pumps</strong> to <strong>increase instrument productivity</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"></p><h4><strong>Vanquish Duo UHPLC Systems</strong></h4><ul><li><strong>Supported systems:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li><strong>Sampler:</strong> Dual split sampler</li><li><strong>Detector:</strong> Two out of the complete detector portfolio</li><li><strong>Software control:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4><strong>Vanquish Tandem LC Systems</strong></h4><ul><li><strong>Supported systems:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li><strong>Sampler:</strong> Split sampler</li><li><strong>Detector:</strong> One out of the complete detector portfolio and/or one mass spectrometer</li><li><strong>Software control:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3><strong>Vanquish Tandem LC systems</strong></h3><div><div><div><div><p><strong>Gradient separations</strong> are commonly used in <strong>LC or LC-MS</strong>. <strong>Column reconditioning</strong>, such as <strong>washing and re-equilibration</strong>, takes time and <strong>reduces your overall sample throughput</strong>. The <strong>Vanquish Tandem LC systems</strong> eliminate these limitations and <strong>improve productivity</strong> by:</p><ul><li><strong>Increasing sample throughput</strong> without modifying a <strong>validated method</strong></li><li><strong>Improving return on investment</strong> by <strong>maximizing mass spectrometer utilization</strong></li><li><strong>Reducing column carry over</strong> through <strong>extended column washing</strong> without <strong>sacrificing throughput</strong></li><li><strong>Simplifying method setup</strong> with <strong>automatic method conversion</strong> from your original <strong>gradient method</strong></li></ul></div></div></div></div><div>&nbsp;</div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_4_a031ad3221.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_4_a031ad3221.jpg 245w," sizes="100vw" width="1749" height="530"></p><h4><strong>Throughput increase using Tandem LC</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_3_6bc55942ed.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Throughput increase by Tandem LC is between 10–80% for most common conditions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_3_6bc55942ed.jpg 245w," sizes="100vw" width="894" height="434"></p><p>The <strong>Vanquish Tandem LC system</strong> splits the analysis between <strong>two pumps</strong> and <strong>two columns</strong>. One pump delivers the <strong>analytical gradient</strong> while the second pump runs the <strong>reconditioning gradient</strong>. This configuration allows you to use <strong>two identical columns</strong> to <strong>run your sequence faster</strong> without <strong>compromising data quality</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_5_d818007fe4.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Reproducible results for the Thermo Scientific™ Vanquish™ Horizon Tandem UHPLC system—Thermo Scientific™ Q Exactive™ HF hybrid quadrupole-Orbitrap™ mass spectrometer showing an overlay of five total ion current chromatograms. The sample shown is digested Infliximab using the Thermo Scientific™ SMART ™ Digest Kit." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_5_d818007fe4.jpg 245w," sizes="100vw" width="1123" height="499"></p><h4><strong>Simply upgrade your method</strong></h4><p>Implementing <strong>Tandem LC-MS</strong> into your workflow is easy with <strong>compliance-ready Chromeleon software</strong> for LC or LC-MS users and <strong>Thermo Scientific Standard Instrument Integration (SII)</strong> for <strong>Thermo Scientific Xcalibur software</strong> for LC-MS users.</p><p>A <strong>simple dedicated instrument method wizard</strong> enables you to <strong>create new methods without the need for additional training</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_0c7f310b1e.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_0c7f310b1e.jpg 193w," sizes="100vw" width="353" height="285"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_2_47128950b2.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Chromeleon CDS and SII for Xcalibur guides users through the implementation of a Tandem LC or LC-MS method with automatic system volume considerations and gradient formation of the reconditioning pump." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_2_47128950b2.jpg 160w," sizes="100vw" width="361" height="353"></p><h3><strong>Thermo Scientific LC portfolio overview</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660"></p>

Waters ACQUITY UPLC H-Class PLUS System

Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution.

<div><div><h4><strong>Performance that advances your lab</strong></h4></div></div><div><div><p><strong>Whether your goal is to rapidly develop new methods or to routinely analyze large numbers of incoming samples, the ACQUITY UPLC H-Class PLUS System can help you decrease the time to result, while increasing the depth and quality of information received from your sample analysis.</strong></p><p>With the ACQUITY UPLC H-Class PLUS System, you can improve laboratory productivity by transitioning methods to UPLC/UHPLC technology, improve the characterization of your most complex samples through enhanced resolution and leverage advanced tools to simplify and streamline your method development workflow.</p><div><div><div><div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution. The system provides on-demand solvent blending and support for any analytical LC column, making it an ideal choice for modernizing existing or developing new methods." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div><ul><li><strong>Get the flexibility of multi-solvent blending</strong> - Blend up to nine solvents with integrated solvent-select valve with the Quaternary Solvent Manager&nbsp;</li><li><strong>Deliver precise and accurate binary solvent blending</strong> - Blend up to four solvents with integrated solvent-select valve with the Binary Solvent Manager</li><li><strong>Get high-precision injections with direct inject sampling&nbsp;</strong>- The needle-in-flow path design ensures an accurate needle seal at high pressure</li><li><strong>Get accurate temperature control across the entire column</strong> - Configurable for 1 to 6 columns with active preheating</li><li><strong>Automate the formulation of mobile phases</strong> - Significantly reduce the time you spend in the prep lab with&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"> Auto•Blend Plus </a>Technology</li><li><strong>Transfer methods more easily</strong> - Easily adjust for system volume differences when transferring methods from an alternative LC system without alteration to the method table using Gradient SmartStart </li><li><strong>Wide software support</strong> – ACQUITY UPLC H-Class PLUS System is supported by  <strong>Empower, MassLynx, UNIFI</strong>, and several 3rd party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Improving laboratory productivity by transitioning methods to UPLC technology.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: A highly reliable and robust LC-MS system without any compromise in speed, resolution, or sensitivity, especially in everyday settings. The ACQUITY H-Class PLUS Binary System combines an optimized flow path resistant to clogging, stable high-pressure gradient formation, and support for sub-2-µm to 5-µm particle columns to deliver the ideal choice for reproducible everyday LC-MS analyses with any tandem quad or Q-ToF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div><div><div><h3><strong>Discover the UPLC difference</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS System</strong> is the next evolution of ultra-performance instrumentation, providing the <strong>high resolution</strong> of a <strong>quaternary or binary liquid chromatography (LC) system</strong>.</p><p>Achieving <strong>true UPLC performance</strong> requires that system dispersion (or extra-column band spread) be matched to the peak widths associated with narrow bore columns packed with <strong>sub-2-μm particles</strong>. While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the <strong>sharp peaks of UPLC performance</strong> and the <strong>ACQUITY UPLC H-Class PLUS System</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Comparison of the same method with the same column on a low-dispersion ACQUITY UPLC H-Class PLUS System versus a higher-dispersion UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg 245w," sizes="100vw" width="1024" height="555"></p></div></div><div><div><h3><strong>Take your methods to the next level</strong></h3><p>Leverage the benefits of <strong>UPLC technology</strong> to improve your existing <strong>HPLC methods</strong>. By scaling your methods to UPLC, your laboratory will benefit from the combination of <strong>increased resolution, sensitivity, and speed</strong> that comes with modern small particle chemistries.</p><p>Designed to accommodate all of your LC method needs, the <strong>ACQUITY UPLC H-Class PLUS System</strong> is ideally suited to <strong>future-proof your laboratory</strong>, enabling the support of existing HPLC methods now, and provide <strong>significant productivity and cost benefit</strong> when utilized for UPLC methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: The USP analysis of diclazuril and organic impurities was scaled from HPLC to UHPLC to UPLC. The UPLC method resulted in a 4x reduction in run time and a 10x reduction in solvent consumption resulting in improved sample throughput and reduced cost per analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg 245w," sizes="100vw" width="1024" height="613"></p></div></div><div><div><h3><strong>Discover the best method for the best results</strong></h3><p>Get the <strong>versatility</strong> to discover the best set of chromatographic conditions for your sample, providing a <strong>more robust method</strong>. The flexibility of the <strong>ACQUITY UPLC H-Class PLUS Quaternary System</strong> allows you to <strong>automatically screen important method parameters</strong>, including:</p><ul><li>Up to <strong>six columns</strong> in independently temperature-controlled compartments</li><li>pH and ionic strength with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"><strong>Auto•Blend Plus</strong></a><strong> Technology</strong></li><li><strong>Optional and integrated solvent selection valve</strong> expands access to six additional mobile phase lines&nbsp;</li><li><strong>11 unique gradient profiles</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: (A) Auto·Blend Plus method gradient table for trastuzumab pH optimization. (B) pH optimization on trastuzumab charge variants separation. Gradient: 20 mM MES buffer, 50–155 mM NaCl in 15 min." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg 245w," sizes="100vw" width="1024" height="622"></p></div></div><div><div><h3><strong>Deliver greater speed and precision for routine analyses</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> combines the <strong>proven reliability and performance</strong> of the H-Class PLUS System with the <strong>precision and lowest system volume</strong> offered by our <strong>high-pressure mixing binary solvent manager</strong>, allowing you to:</p><ul><li>Accommodate the <strong>most challenging sample matrices</strong></li><li>Tackle applications with <strong>long shallow gradients</strong></li><li><strong>Improve the throughput</strong> of your methods</li></ul><p><strong>Combine </strong>the capabilities of the <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> with <strong>Waters </strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Tandem-Quadrupole-%28-Triple-Quadrupole-%29-Mass-Spectrometry/nav.htm?cid=134656172"><strong>Tandem quadruple technology</strong></a><strong> </strong>for routine quantitative UPLC-MS/MS applications, so you can confidently quantify and trace components in the most complex of samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Direct transfer without a gradient delay offers the opportunity for method improvement with the analysis time going from 5 minutes to 3 minutes representing a 40% reduction in runtime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg 245w," sizes="100vw" width="1024" height="600"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 15,000 psi</li><li><strong>pH range</strong>: 1–12.5 (<i><span>For specific test conditions, contact your Waters sales representative)</span></i></li><li><strong>Operating flow rate range</strong>: Up to 2.2 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: ≤0.002% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary, Quaternary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 6 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications</strong> <strong>(QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div></div></div></div></div>

Waters ACQUITY UPLC I-Class PLUS System

With the ACQUITY UPLC I-Class PLUS System, your lab can achieve highly efficient, rapid separations from ultra-low dispersion and delay volume.

<div><div><h4><strong>Complex chromatography challenges, solved</strong></h4></div></div><div><div><p><strong>Looking for answers to the most complex scientific challenges is what you do, and the scientific tools you deploy and the information they provide can make all the difference. With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS System provides new possibilities for maximizing the resolution and sensitivity of your methods, enhancing the characterization of your samples, and improving productivity to advance the science of your laboratory.</strong></p><div><div><div><div><p>With the <strong>ACQUITY UPLC I-Class PLUS System</strong>, your lab can achieve <strong>highly efficient, rapid separations</strong> from <strong>ultra-low dispersion and delay volume</strong>. The system enables your lab to get <strong>narrow, ultra-efficient peaks</strong>, enhancing the <strong>sensitivity of any mass spectrometer</strong> and simplifying the characterization of the most complex sample.</p><ul><li><strong>Achieve precise and accurate binary solvent blending</strong> with the Binary Solvent Manager, ideal for up to four solvents with integrated solvent-select valve</li><li><strong>Get sample injection versatility</strong>, depending upon your application with the flow-through needle and fixed loop injector options</li><li><strong>Manage ultra-low carryover</strong> through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers</li><li><strong>Get accurate temperature control</strong> across the entire column, configurable for 1 to 2 columns with active preheating</li><li><strong>Improve the performance of any mass spectrometer</strong> with the highest chromatographic resolution which minimizes interference from co-elutions</li><li><strong>Minimize the time and cost</strong> associated with annual qualification with the Waters Empower-based automated system qualification tool (SQT)</li><li><strong>Supported by Empower, Masslynx, UNIFI</strong>, and several third-party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p><strong>Enhance the characterization of your samples</strong>, while <strong>improving productivity</strong> to advance the science of your laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: ACQUITY UPLC I-Class PLUS System FTN-H PDA angled." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_9b05f209f6.jpg 245w," sizes="100vw" width="1024" height="637"></p><div><div><div><div><h3><strong>Get a clearer picture of your sample</strong></h3><p>Get improved resolution through <strong>reduced system dispersion</strong> with the <strong>ACQUITY UPLC I-Class PLUS System</strong>, providing separations that can amplify your research.</p><p><strong>Shorten analysis times</strong>, <strong>reduce solvent usage</strong>, and <strong>speed access to the data</strong> you need for critical decisions. Designed to fit into your existing LC workflow, the ACQUITY UPLC I-Class PLUS System provides a <strong>clear view into what lies within the sample</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_2_c2d3e9e7d9.jpg 245w," sizes="100vw" width="1024" height="595"></p></div></div></div></div></div></div></div></div><div><div><h3><strong>An inlet that improves the performance of any MS</strong></h3><p>The ACQUITY UPLC I-Class PLUS System is designed specifically for the <strong>rapid pace of laboratories</strong> on the <strong>cutting edge of research</strong> where <strong>LC-MS plays a critical role</strong>.</p><p><strong>With the ACQUITY UPLC I-Class PLUS System, your lab will:</strong></p><ul><li><strong>Improve resolution and ionization efficiency</strong> with narrow peak widths, enhancing <strong>mass spectrometry sensitivity</strong></li><li><strong>Enhance sensitivity</strong> through <strong>industry-leading carryover performance</strong></li><li><strong>Improve sample characterization</strong> through <strong>selective isolation</strong> with multidimensional UPLC configurations</li><li><strong>Achieve exceptionally fast analysis times</strong> with <strong>ultra-low delay volume</strong></li><li><strong>Achieve ultimate peak capacity</strong> with <strong>CORTECS Columns</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_3_d8d5bb46be.jpg 182w," sizes="100vw" width="1024" height="878"></p></div></div><div><div><h3><strong>Achieve ultimate peak capacity with CORTECS Columns</strong></h3><p>When paired with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/columns/cortecs-columns.html"><strong>CORTECS 1.6 µm solid-core columns</strong></a>, the ACQUITY UPLC I-Class PLUS System enables scientists to achieve new levels of resolution, sensitivity, and chromatographic performance. With <strong>CORTECS Columns</strong> and the ACQUITY UPLC I-Class PLUS System, you can increase resolution for even your toughest samples and get the flexibility and power you need to rapidly separate a wide array of compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg" alt="Waters ACQUITY UPLC I-Class PLUS System: By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_I_Class_PLUS_System_4_2dfd32bd0d.jpg 210w," sizes="100vw" width="1024" height="761"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 18,000 psi</li><li><strong>pH Range</strong>*: 1–12.5</li><li><strong>Operating flow rate range</strong>: Up to 2.0 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: &lt;0.001% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 2 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications (QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div>

Waters ACQUITY Arc LC System

The ACQUITY™ Arc™ System is an all-in-one platform for HPLC and UHPLC, designed for robust method development and seamless transfer between modern LC systems, addressing a wide range of analytical challenges.

<p class="cke-user_style-important"><strong>Built upon a foundation of reliability</strong></p><p data-pm-slice="1 1 []"><strong>The method development process is changing. New regulations, software and analytical technologies are rapidly changing how methods are designed, transferred, and monitored over their lifecycle. An all-in-one platform for HPLC and UHPLC separations, the ACQUITY™ Arc™ System is designed to meet the spectrum of challenges you face from robust method development to seamless transfer between any modern LC systems.</strong></p><p data-pm-slice="1 1 []">With the <strong>ACQUITY Arc System</strong>, you can experience true plug-and-play method compatibility for HPLC and UHPLC separations. Significant productivity gains can be realized by deploying a single LC platform that allows for the efficient transfer, adjustment, and improvement of methods from any LC platform without compromise in method integrity.</p><figure class="image"><img style="aspect-ratio:768/886;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_63246061ea.jpg" alt="Waters ACQUITY Arc System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_63246061ea.jpg 136w," sizes="100vw" width="768" height="886"></figure><p data-pm-slice="1 1 []">Laboratory-driven organizations have relied on Waters for over 60 years to deliver reliable, robust, and reproducible solutions to ensure confidence in their analytical results. With over 100,000 LC systems installed, we understand the significant impact the right technology has on your business, and the implications it has on characterizing the quality and safety of your products.</p><p data-pm-slice="1 1 []">Methods with greater agility, robustness, and capacity for change can help you reduce regulatory burden, risk of failure and costs. Visit <a disabled="true">www.methods.waters.com</a> to learn more about how method life cycle management (MLCM) connects your method today to your method tomorrow.</p><h3><strong>Designed for discovery to routine QC applications</strong></h3><p>The <strong>ACQUITY Arc System</strong> is the only available LC system with regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument. With unrivaled column capacity and Arc Multi-flow path™ technology, the<strong> ACQUITY Arc System</strong> allows you to generate new methods and modernize legacy HPLC methods faster than ever before.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Comprehensive detector portfolio</strong></h4><p>High-performance analytical detectors designed to maximize HPLC and UHPLC performance, delivering exceptional sensitivity and linearity for your assays.</p><p>Photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, and mass detection, including the ACQUITY QDa™ Detector.</p><h4><strong>Gradient SmartStart</strong></h4><p>Automatically manage gradient start time and pre-injection steps to maximize sample throughput. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.</p><h4><strong>Quaternary solvent management</strong></h4><p>Precise and accurate blending of up to four solvents with automated solvent compressibility compensation. Increase solvent flexibility with an optional, integrated solvent select valve, providing access to six additional solvents.</p><h4><strong>Negligible carryover</strong></h4><p>Advanced flow-through needle design minimizes carryover by continuously cleansing the needle during run. User-configurable wash settings provide flexibility to address even the most complex sample matrices.</p><h4><strong>Thermal management options</strong></h4><p>Column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm, with a temperature range of 4 °C to 90 °C. Integrated column selection valve options provide unattended, fast column changeover.</p><h4><strong>Auto•Blend™ Plus Technology</strong></h4><p>Program gradients directly in terms of pH and ionic strength to minimize manual mobile phase preparation, reduce potential for human error, and accelerate method robustness testing for chromatographic methods.</p><h4><strong>Arc Multi-flow path technology</strong></h4><p>Delivers plug-and-play method compatibility with HPLC or UHPLC methods with the flip of a switch.</p><p>Easily replicate or improve established methods by simply selecting between Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention.</p><h4><strong>Column Technology</strong></h4><p>Industry-leading selectivity choices to meet the needs of virtually every LC application.</p><h4><strong>Laboratory Informatics</strong></h4><p>Software control within your existing Empower™ or MassLynx™ infrastructure.</p><h3><strong>Replicate your established methods</strong></h3><p data-pm-slice="1 1 []">The <strong>ACQUITY Arc System</strong>, enabled by unique Arc Multi-flow path technology, easily accepts and replicates methods from any HPLC platform, without compromise.&nbsp;</p><p data-pm-slice="1 1 []">Whether you are trying to replicate an out-of-date HPLC method, transfer methods across the organization, or to contract partners, the <strong>ACQUITY Arc System</strong> gives you ultimate flexibility to reproduce, modernize, and transfer existing methods with ease and greater cost efficiency, while preserving the integrity of your methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg" alt="Waters ACQUITY Arc System: Analysis run on a Vendor X LC system and replicated on the ACQUITY Arc System. Conditions: 15 to 35% B in 3 min, 35 to 95% B in 2 min; Mobile phase A: 0.1% HCOOH in H 2 O, mobile phase B: 0.1% HCOOH in ACN; Flow rate = 2.0 mL/min; Column: XSelect™ CSH C 18 , 4.6 x 150 mm, 5 μm; Temp. = 30 °C; UV@ 260 nm; 10.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg 245w," sizes="100vw" width="1099" height="596"></p><p>Upgrade your laboratory with a versatile, modern LC system that delivers HPLC and UHPLC method compatibility at the flip of a switch.</p><h3><strong>Modernize your methods</strong></h3><p>The United States Pharmacopeia (USP) is championing pharmacopeial harmonization and modernization efforts, and international organizations are following suit. As a result, the USP is encouraging the modernization of older compendial methods to ensure they are fit for purpose.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg" alt="Waters ACQUITY Arc System: Quetiapine fumarate system suitability solution analyzed on the ACQUITY Arc System using HPLC, UHPLC, and UPLC™ column/method conditions for the quetiapine impurity method. Peak identification: (1) quetiapine related compound G, (2) quetiapine related compound B, (3) quetiapine desethoxy, and (4) quetiapine." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg 245w," sizes="100vw" width="1092" height="678"></p><p>Revisions to these guidelines give you more flexibility to modify your existing pharmacopeial methods with modern techniques and technologies, and in some cases avoid revalidation. The <strong>ACQUITY Arc System</strong>, featuring the Waters Columns Calculator, allows you to confidently scale your gradient methods from a 3.5 μm to a 2.5 μm particle, decreasing run times, lowering solvent consumption, and increasing sample throughput.</p><h3><span><strong>Save time. Reduce cost.</strong></span></h3><p data-pm-slice="1 1 []">With the right column, the <strong>ACQUITY Arc System</strong> is the ideal solution to accommodate methods from any LC platform.&nbsp;</p><p data-pm-slice="1 1 []">From concept to production, the transition your product takes through the product development cycle often requires rigorous LC assays to properly characterize and assess its readiness to advance to the next stage. These LC assays are often adapted to accommodate the technology available from one stage to the next, in some cases requiring an adjustment from a smaller particle size (sub-2-μm) to a larger particle size (2.5 μm–5 μm).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System enables the support of HPLC and UHPLC methods on a single platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg 173w," sizes="100vw" width="959" height="860"></p><p>The <strong>ACQUITY Arc System</strong> provides the flexibility to maximize productivity through efficient and rapid 2.5 μm–2.7 μm UHPLC separations, or to accommodate larger 3.0 μm–5 μm HPLC particles.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg" alt="Waters ACQUITY Arc System: Save time. Reduce cost." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg 245w," sizes="100vw" width="1683" height="469"></p><h3><span><strong>Mitigate your risk</strong></span></h3><p data-pm-slice="1 1 []">With an expanded range of column manager options enabling up to 15-column switching from 4 °C to 90 °C, the <strong>ACQUITY Arc System</strong> will help you significantly reduce the time spent generating robust methods. Equipped with the plug-and-play ACQUITY QDa Mass Detector, the <strong>ACQUITY Arc System</strong> tracks peaks in your method and reveals hidden coelutions of similar analytes, ensuring you have complete confidence in the reliability and reproducibility of your method now and far into the future.</p><h4><strong>Thermal management options</strong></h4><p data-pm-slice="1 1 []">Active and passive pre-heating options available, with up to 15-column switching from 4 °C to 90 °C. Automated monitoring and tracking of column usage with eCord™ technology available with active pre-heating options.</p><h4><strong>Quaternary solvent management</strong></h4><p data-pm-slice="1 1 []">Accelerate your method development with precise and accurate blending of up to four solvents. Increase solvent flexibility with an optional solvent select valve, providing access to six additional solvents.</p><h4><strong>Auto•Blend Plus Technology</strong></h4><p data-pm-slice="1 1 []">Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</p><h4><strong>Comprehensive detector portfolio</strong></h4><p>Diverse portfolio of detectors for method development, method transfer, and routine use.</p><h4><strong>ACQUITY QDa Detector</strong></h4><p>Mass detection built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no adjustments, it easily integrates with your<strong> ACQUITY Arc System.</strong></p><h5><strong>Support</strong></h5><p data-start="0" data-end="175">Empower eLearning modules to help train your lab on Empower 3 and Method Validation. Applications support that’s customized based on your method development needs.</p><h5><strong>Consumables</strong></h5><p data-start="177" data-end="410" data-is-last-node="">Industry-leading selectivity choices to meet the needs of virtually every LC application. Quality Control (QC) Reference Material benchmarks your <strong>ACQUITY Arc System </strong>and enables perfect resolution. Certified clean vials.</p><h5><strong>Laboratory Informatics</strong></h5><p>Software control within your existing Empower or MassLynx infrastructure. Empower 3 Method Validation Manager allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</p><h3><span><strong>Develop methods that stand the test of time</strong></span></h3><p>Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.</p><p>The <strong>ACQUITY Arc System</strong> is fully compatible with the ACQUITY Arc, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram, leaving nothing to chance.</p><ul><li>Confirm the identity of peaks in a separation without injecting standards.</li><li>Identify new peaks in a separation with molecular weight information.&nbsp;</li><li>Detect unresolved peaks and determine if a peak is homogeneously pure.</li><li>Easily track peaks as method conditions are changed.</li></ul><p data-start="272" data-end="600">Using Empower 3 Software and its Custom Calculations and Custom Reporting functions enables you to quickly and automatically evaluate chromatographic data. Configurable reports allow you to choose optimal conditions based on metrics rather than judgment, ensuring a comprehensive assessment of data and best method conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_7_e7ef959203.jpg" alt="Waters ACQUITY Arc System: Method transfer of USP Assay for Fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. Conditions: Mobile phase: 20:80 acetonitrile/ water; Flow rate = 0.5 mL/min; Column: XSelect HSS T3, 4.6 x 150 mm, 3.5 μm; UV@ 260 nm; 20.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_7_e7ef959203.jpg 224w," sizes="100vw" width="939" height="654"></p><h3><strong>Streamline your workflow</strong></h3><div><div data-message-author-role="assistant" data-message-id="7b732be9-0a45-45fb-b585-70a90c1a74d6" dir="auto" data-message-model-slug="gpt-4o"><div><div><p data-start="602" data-end="827">How would you benefit from increased assay consistency between analysts and from lab to lab? What would you gain by accelerating your robustness testing prior to transferring methods to QA/QC?</p><p data-start="829" data-end="1392" data-is-last-node="">Auto•Blend Plus Technology is a novel software tool that extends traditional quaternary solvent blending to permit gradient programming directly in units of pH and ionic strength, providing the ability to vary composition in even the smallest increments of pH (even those differing by 0.1 pH units or less).&nbsp;</p><p data-start="829" data-end="1392" data-is-last-node="">With Auto•Blend Plus, the cumbersome and error-prone approach of manually preparing several pre-mixed mobile phases can now be eliminated with on-demand mobile phase creation, providing significant time savings and improved productivity to the laboratory.</p></div></div></div></div>

Waters Alliance HPLC System

 With its proven performance history, the Alliance HPLC is the industry’s analytical HPLC system of choice, ideally suited for methods development and routine analysis.

<div><div><h4><strong>Reliably achieve quality, compliant data. Every time, in every lab.</strong></h4></div></div><div><div><p><strong>Liquid chromatography (LC) systems must deliver unequivocal results that give you confidence in your scientific and business decisions. Waters LC commitment continues to succeed with the latest Alliance HPLC System – trusted by scientists worldwide for the data to drive informed decisions.</strong></p><div><div><div><div><p>Building on <strong>industry-standard performance and reliability</strong>, the <strong>Alliance HPLC System</strong> provides the <strong>capabilities to meet today’s business challenges</strong>. With its <strong>proven performance history</strong>, the Alliance HPLC is the <strong>industry’s analytical HPLC system of choice</strong>, ideally suited for <strong>methods development and routine analysis</strong>.</p><ul><li>Time-tested, dependable, and robust workhorse for your HPLC separations</li><li>Integrated solvent and sample management with consistent system-to-system performance and high reproducibility</li><li>Simplify your daily LC system start-up with advanced software functionality</li></ul><h5><strong>Recommended Use</strong></h5><p>For standard HPLC workflows where <strong>consistency and compliance</strong> are the highest priorities.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_1_6b63ab6d62/Waters-Alliance-HPLC-System-1.jpg" alt="Waters Alliance HPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_1_6b63ab6d62/thumbnail_Waters-Alliance-HPLC-System-1.jpg 147w," sizes="100vw" width="908" height="961"></p><div><div><h3><strong>Excellence through the years</strong></h3><p>The consistency of the Alliance HPLC System gives you <strong>exceptional confidence in your analytical results</strong>, day-to-day and year-to-year. Get <strong>accurate and reproducible results</strong> with <strong>Waters flagship HPLC technology</strong>, which provides <strong>consistent and reliable performance</strong>. Whether your Alliance HPLC System is newly manufactured, or you're working on one that is several years old, the Alliance HPLC System is a <strong>time-tested, dependable,</strong> and <strong>robust </strong>workhorse for your HPLC separations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_dfafc334c1.jpg" alt="Waters Alliance HPLC System: Comparison of the separation of carbamates using two different Alliance HPLC Systems, manufactured 7 years apart. The results are equivalent." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_dfafc334c1.jpg 245w," sizes="100vw" width="1024" height="532"></p></div></div><div><div><h3><strong>Performance that exceeds your method requirements</strong></h3><p>The <strong>Alliance HPLC System</strong> ensures the <strong>reliability of your results</strong> via <strong>high injection precision</strong> and <strong>repeatable and accurate flow rates</strong>, resulting in <strong>easy peak identification</strong>, <strong>precise quantification</strong>, and <strong>exceptional retention time repeatability</strong>.</p><p>The integrated solvent delivery system features <strong>quaternary blending with a fixed delay volume</strong> for <strong>consistent and predictable results</strong>, regardless of system back pressure. The sample managers’ <strong>flexible injection capabilities</strong> cover a wide injection volume range (up to 2 mL) with <strong>excellent carryover performance</strong>, typically <strong>below 0.005%</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_2_6dab43c365.jpg" alt="Waters Alliance HPLC System: USP method for Budesonide on the Alliance HPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_2_6dab43c365.jpg 245w," sizes="100vw" width="1024" height="580"></p></div></div><div><div><h3><strong>Advancements in column chemistry and mass detection</strong></h3><p>The <strong>Alliance HPLC</strong> can leverage <strong>smaller particle size column chemistry</strong> to improve your laboratory's efficiency. With <strong>CORTECS 2.7 µm particle size columns</strong>, your lab will benefit from <strong>improvements in resolution</strong> and <strong>faster run times</strong> when transferring from a 5 µm size particle chemistry.</p><p>Further <strong>increase confidence in your data</strong> by adding <strong>mass confirmation with the ACQUITY QDa Detector</strong>, which is <strong>simple to use</strong> and can easily integrate into your existing workflow. <strong>Analysis in Empower 3 Software</strong> combines data from <strong>UV/Vis and mass spectrometry (MS)</strong> peaks to give <strong>mass information to each peak</strong> in the separation.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_3_3711671b2e.jpg" alt="Waters Alliance HPLC System: Mass detection with the ACQUITY QDa Detector with UV detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_3_3711671b2e.jpg 245w," sizes="100vw" width="1024" height="550"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_4_bf40981882.jpg" alt="Waters Alliance HPLC System: Mass detection with the ACQUITY QDa Detector with UV detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_4_bf40981882.jpg 240w," sizes="100vw" width="1024" height="666"></p></div></div><div><div><h3><strong>Features and benefits</strong></h3><ul><li><strong>Quaternary solvent blending. </strong>Support isocratic and gradient applications with 11 unique gradient profile curves and blend up to 4 solvents in any proportion with Auto-Blend Technology. Compatible with solvent types such as reversed-phase, normal-phase, GPC, SEC, and IEX.</li><li><strong>Advanced solvent delivery capabilities. </strong>Serial flow path with pulse-free solvent delivery without the use of dampeners. Online solvent degassing and automated solvent compressibility compensation for accurate flow. Integrated seal wash for robust operation with all solvent types is standard.</li><li><strong>Optional, temperature-controlled environment.</strong> House up to 120 vials in an optional, temperature-controlled environment. Achieve low carryover with active and user programmable needle wash. Variable injection volumes from 0.1 to 100 μL standard, and up to 2 mL optional. Support STAT samples and auto-addition.</li><li><strong>Detection and column options. </strong>Get optional column heating, heating/cooling, or column switching capabilities. Detection capabilities include photodiode array, UV/Vis, fluorescence (FLR), refractive index (RI), evaporative light scattering (ELS), electrochemical, conductivity, and mass detection.</li><li><strong>Intuitive interface and software. </strong>Get instant access to system settings through the large LCD screen with simplified daily set-up with SystemPREP. Supports Empower, MassLynx, and 3<sup>rd</sup> party software packages.</li><li><strong>Compliance-ready. </strong>Supports Waters Empower-based automated system qualification tool (SQT), minimizing the time and cost of annual qualification with standards like GMP, GLP, ISO 17025, and USP &lt;1058&gt;.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_HPLC_System_2_47fe8951d2/Waters-Alliance-HPLC-System-2.jpg" alt="Waters Alliance HPLC System: Alliance HPLC System provides powerful functionality for all your application needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_HPLC_System_2_47fe8951d2/thumbnail_Waters-Alliance-HPLC-System-2.jpg 161w," sizes="100vw" width="903" height="874"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 5,000 psi</li><li><strong>Front panel display</strong>: Easy to use control panel</li><li><strong>Mobile phases</strong>: Up to 4 with Auto-Blend Technology</li><li><strong>Flow rate range</strong>: Up to 10 mL/min</li><li><strong>Sample carryover</strong>: ≤0.0025% (Caffeine) under specified conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Quaternary</li><li><strong>Solvent conditioning</strong>: Vacuum Degas</li><li><strong>Column capacity</strong>: Standard up to 3 columns</li><li><strong>Maximum sample capacity</strong>: 120</li><li><strong>Detector options</strong>:&nbsp;<ul><li>Tunable UV</li><li>Photo Diode Array</li><li>Fluorescence</li><li>Refractive Index</li><li>Evaporative Light Scattering</li><li>Electrochemical</li><li>Conductivity</li><li>Mass Spectrometry</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li></ul></li><li><strong>Physical specifications</strong>:<ul><li><strong>Width:</strong> 45.7 cm (18.0 in.) or 58.4 cm (23.0 in.) with column heater</li><li><strong>Height:</strong> 57.1 cm (22.5 in.)</li><li><strong>Depth:</strong> 57.1 cm (22.5 in.) or 64.8 cm (25.5 in.) with sample heater/cooler</li></ul></li></ul></div></div></div></div></div></div></div></div>

Products from category Liquid chromatographs focused on HPLC - page 2

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