Whether you are analyzing innovative biotherapeutics or novel chemical medicines, method development with Thermo Scientific™ Vanquish™ Flex™ UHPLC system has never been easier.
More than 30 years of liquid chromatography expertise has led to the Vanquish Flex UHPLC system, bringing exceptional analytical precision, detector sensitivity and operational simplicity to enable unprecedented robustness and flexibility. Designed for the needs of UHPLC and LC-MS scientists, Vanquish Flex UHPLC systems provide:
Thermo Scientific Vanquish FLEX UHPLC System.
In your laboratory, each analytical question brings a new challenge. Vanquish Flex UHPLC systems are an essential analytical tool to help you solve each of these challenges, bringing a choice of technology to move your innovation forward:
Thermo Scientific Vanquish FLEX UHPLC System: Extracted ion chromatogram of a matrix extracted spike (MES) of over 200 pesticide residues in baby food at 10 ng/g.
Whether you run traditional HPLC applications or high-efficiency UHPLC applications; no matter if you analyze small molecules or innovative biopharmaceuticals; the Vanquish Flex UHPLC system can meet your separation requirements. With fully biocompatible fluidics the Vanquish Flex UHPLC systems provide:
Thermo Scientific Vanquish FLEX UHPLC System: Aggregate analysis of bevacizumab using a Thermo Scientific™ MAbPac™ SEC-1 HPLC column (4.0 × 300 mm) allowing over nearly 2000 injections on the same column. Column lifetime is improved by SmartInject Technology.
During injections, the sample loop at atmospheric pressure is placed in line with the high-pressure flow path, typically resulting in a pressure drop. With regular UHPLC systems, this adversely affects retention time precision and column lifetime.
SmartInject Technology automatically eliminates the pressure drop improving data confidence and reduced cost of ownership.
Thermo Scientific Vanquish FLEX UHPLC System: Significant reduction of pressure drop after injection using SmartInject Technology resulting in improved retention time reproducibility (6 replicates) and enhanced column lifetime.Liquid chromatography method development is a time-consuming process, usually requiring expert knowledge. With Thermo Scientific™ Vanquish™ Flex Method Development UHPLC systems your laboratory can significantly accelerate method development by taking advantage of a high degree of automation and utilization of sub-2 μm particle size columns.
Automated method scouting on Vanquish Method Development UHPLC systems provide:
The combination of Chromeleon CDS with ChromSword Chromeleon Connect or S-Matrix ® Fusion QbD ® software provides a complete solution from method development to method validation following Analytical Quality by Design (AQbD) principles. Enabling automated optimization to develop and improve methods faster and more efficiently with tools to make compliance easier.
Thermo Scientific Vanquish FLEX UHPLC System: Automatic scouting of different column chemistries for fastest method development.
Double your throughput, deepen your sample knowledge, and better utilize your bench space with the Thermo Scientific™ Vanquish™ Duo UHPLC systems. Two completely independent flow paths for maximum productivity.
Gain an average of 40% in throughput depending on method conditions with the Vanquish Tandem LC systems. Maximize the utilization of your optical detector or mass spectrometer.
Thermo Scientific Vanquish FLEX UHPLC System: Boost your productivity.In today’s analytical laboratory environment, your scientific personnel have limited time for in-depth familiarization with new instrumentation. An LC system should seamlessly fit into your existing workflows and processes without requiring extra training or expertise. The Vanquish Flex UHPLC system brings ease of use to a new level, enabling every user to deliver exceptional results, independent of user experience.
Thermo Scientific Vanquish FLEX UHPLC System: Vanquish Solvent Monitor manages your eluent and waste levels for highest confidence during analysis.The Vanquish Solvent Monitor enables Vanquish HPLC and UHPLC systems to accurately and automatically measure the liquid levels in each individual solvent channel and waste container.
Deep integration of the Vanquish Solvent Monitor into the Vanquish Flex UHPLC system provides direct viewing of solvent and waste volumes within Chromeleon CDS and directly on the module itself.
Run large sample sets with confidence, avoid lost time, and eliminate procedural deviations by monitoring mobile phase levels; prevent hazardous spills by monitoring waste levels.
The interactive Vanquish User Interface allows operators to intuitively, immediately, and intelligently monitor the current system status:
Regardless of your current software infrastructure, you can take advantage of the latest innovation of the Vanquish Flex UHPLC system. The Vanquish Flex system combines perfectly with Chromeleon CDS to take advantage of the unrivaled flexibility, precision and ease-of-use.
Scalable from workstation to global enterprise, Chromleon CDS provides complete instrument control, data acquisition, data processing and data security regardless of whether you work with the most recent feature release, the extended support or the long-term support software version.
Enabling seamless instrument control and method creation for all laboratories currently employing Waters Empower CDS and Agilent OpenLab CDS software.
Thermo Scientific Vanquish FLEX UHPLC System: Network scalability—stand-alone to a global network with secure central data storage.Mass spectrometry is a prevalent tool in many laboratories. The Vanquish Flex UHPLC system can be seamlessly coupled to best in class Thermo Scientific triple quadrupole or Thermo Scientific high-resolution accurate mass Orbitrap mass spectrometers. For single point control, your LC-MS system can be controlled completely by Chromeleon CDS.
Thermo Scientific Vanquish FLEX UHPLC System: The Vanquish Flex with the Thermo Scientific™ TSQ Quantis™ Triple Quadrupole mass spectrometer.
Workflow automation is important for many industries in order to increase consistency of results and lab efficiency—particularly during the pandemic where labs must ensure high productivity with the minimum number of onsite personnel. Vanquish HPLC and UHPLC systems can be easily equipped with a Thermo Scientific™ Vanquish™ Loader to fully automate your LC or LC-MS analysis when used in combination with a robotic mover.
Thermo Scientific Vanquish FLEX UHPLC System.
Choosing the right detection technology is key to revealing all the components of interest in your sample. The Vanquish Flex UHPLC system offers a wide range of detection capabilities that can be easily integrated and combined to fit your methods.
Thermo Scientific LightPipe ™ Vanquish Diode Array Detector HL delivers you supreme analyte sensitivity by a low baseline noise and low dispersion. The Thermo Scientific Vanquish Diode Array Detector FG offers cutting edge detector linearity as well as a smooth and robust LC-MS integration. Based on diode array detection technology, the multiple wavelength detector offers a cost-effective solution for simultaneously acquiring up to eight UV-Vis wavelength channels.
Thermo Scientific Vanquish FLEX UHPLC System: Concentration vs. peak height plot of nevirapine with data points that were considered for calibration (black) and data points that were eliminated from calibration due to curve decline (red). Linear calibration with permitted offset and no weighting.
Fluorescence detection enables high sensitivity and selectivity.
Thermo Scientific Vanquish FLEX UHPLC System: FLD chromatogram of the four aflatoxins: G2, G1, B2 and B1 at a concentration of 0.9 μg/kg for G2 and B2 and 2.9 μg/kg for G1 and B1.
UV-Vis detection with excellent sensitivity and linearity is a cost- effective and powerful solution for quantitative compound analysis.
The Thermo Scientific™ Vanquish™ Charged Aerosol Detectors are powerful, uniform, and universal; able to detect virtually any large and small molecule with sub-nanogram-level sensitivity, even those that lack a chromophore or that poorly ionize. The flexibility and performance of charged aerosol detection is ideal for analytical R&D, while its simplicity and reproducibility benefit manufacturing QA/QC applications.
Thermo Scientific Vanquish FLEX UHPLC System: Unlike mass spectrometry and UV, the CAD is able to measure all analytes in the sample. Mass spectrometry (MS) requires the analyte to form gas phase ions while response by a UV detector depends upon the nature of the chromophore.
Mass spectrometry gives access to valuable data no other technology can deliver. The easy-to-use Thermo Scientific™ ISQ™ EM single quadrupole mass spectrometer or the Thermo Scientific™ ISQ™ EC single quadrupole mass spectrometer integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.
LC-MS quantification is a widely used technology in many application fields, including food safety and environmental monitoring. In conjunction with the Thermo Scientific mass spectrometer portfolio, Vanquish Flex delivers a great solution for ultra-sensitive detection. For control of your LC-MS setup you can choose between the feature-rich Thermo Scientific™ Xcalibur™ software, the powerful Thermo Scientific™ TraceFinder™ software or the compliance-ready Chromeleon CDS control.
Thermo Scientific Vanquish FLEX UHPLC System: Innovating for you.Use the Vanquish Solvent Monitor to increase your regulatory compliance, productivity, and safety of your laboratory. That device guarantees that your HPLC systems will never run dry and the waste will not spill over, reducing loss of valuable measurement time and sample material.
With the Vanquish User Interface, you are the master of your LC instrument. The display always shows you the key parameters of your instrument such as flow and pressure and guides you in a visual step-by-step video tutorial through key maintenance tasks.
Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitates multiple detector technologies. The Vanquish Flex UHPLC systems have been built to utilize a wide range of analytical detectors, including mass spectrometry (MS), diode array detection (DAD), multi wavelength detection (MWD), charged aerosol detection (CAD), variable wavelength detection (VWD), and fluorescence detection (FLD).
The Vanquish autosampler has a default sample capacity of 216 1.5 mL glass vials or 4 well plates. This capacity can be further increased with the Thermo Scientific Vanquish Charger module to a capacity of up to 23 well plates.
The Vanquish autosampler has the option to add the Vanquish Loader to connect the LC or LC-MS system to the sample preparation robotics, allowing the complete analysis of the sample from preparation to reporting without human intervention.
The valves used in the Vanquish Flex UHPLC system are designed to meet the reliability needs to make UHPLC run robustly and routinely. The valves are long-life and follow a no-maintenance philosophy reducing your overall cost of ownership.
Superior retention time precision and accuracy, as well as enhanced column protection.
Utilizes tool-free Viper Fingertight Fittings with near-zero dead volume operation and ergonomic design.
Modules can be repaired without de-stacking; each unit has handles for ease of maneuvers; light bars on the front of the system indicate system status; and the entire system supports tool-free maintenance.
Highest injection precision for even the lowest injection volumes and retention time precision for reliable qualitative and quantitative sample characterization.
Vanquish Frex UHPLC Systems are, by design, biocompatible to deal with all challenging eluents for biopharmaceutical characterization, increasing data confidence and instrument uptime.
The built-in drawer stores accessories, related documents, or any other useful material for the system.
The Vanquish Flex UHPLC System can scan be operated in various software environments including the latest Chromeleon software feature release, Chromeleon CDS long-term and extended support version, Waters Empower and Agilent OpenLab CDS.
Thermo Scientific LC portfolio overview.
