<div><p><strong>Purifying the target protein is crucial for investigating its specific properties and interactions with biomolecules like DNA, RNA, and other proteins. A range of purification strategies is available, and the optimal approach depends on factors such as the required scale, throughput, and downstream application. In many cases, the process must be fine-tuned through empirical optimization to achieve the desired purity and yield.</strong></p></div><div><div><div><div><h3><strong>What is Protein Purification?</strong></h3><p>Protein purification is a critical process in biotechnology and life sciences, aimed at isolating a specific protein from complex biological mixtures such as cell lysates or tissue extracts. The goal is to obtain a highly purified protein sample, free from contaminants like other proteins, nucleic acids, and lipids, to enable accurate analysis of its structure, function, and interactions.</p><p>This process is especially vital in biotechnological areas inside immunology and microbiology. In <strong>immunology</strong>, it underpins the production of vaccines, therapeutic antibodies, and diagnostic assays by enabling the isolation of key immune proteins and antibodies. It also supports the investigation of cell signaling and immune response mechanisms. In <strong>microbiology</strong>, purified proteins are essential for studying pathogens, identifying disease-related antigens, and driving drug discovery efforts. Ultimately, protein purification is fundamental to the development of targeted vaccines, innovative diagnostics, and effective therapeutic strategies.</p></div></div></div></div><div><div><div><div><h3><strong>Types of Protein Purification Methods</strong></h3></div></div></div></div><div><p>There are several types of protein purification methods, each chosen based on the protein’s characteristics such as size, charge, solubility, and binding affinity. Below are some commonly used methods:</p></div><div><div><div><div><h4><strong>Non-Chromatographic Approaches</strong></h4></div></div><div><p>Non-chromatographic approaches use simpler physicochemical principles—such as solubility, molecular size, or diffusional properties—to separate and purify proteins. These techniques are often employed as initial purification or concentration steps before further refinement.</p><h5><strong>Precipitation Techniques</strong></h5><p>Protein precipitation is a widely used approach in purification workflows, typically relying on one of three main methods:</p><ul><li><strong>Organic solvent precipitation</strong> involves adding solvents like ethanol or acetone to lower the solution's dielectric constant. This promotes protein–protein interactions, reducing solubility and leading to aggregation and precipitation.</li><li><strong>Isoelectric point precipitation </strong>exploits the pH at which a protein carries no net charge. At this point, solubility is minimized, causing the protein to precipitate from solution.</li><li><strong>Nonionic polymer precipitation</strong> uses polymers such as dextran, polyethylene glycol (PEG), or NPEP to alter the solution’s physical properties. These agents create crowding effects that promote protein aggregation without directly binding to the proteins.</li></ul><h5><strong>Dialysis</strong></h5><p>Dialysis involves placing a protein solution inside a semi-permeable membrane that allows water and ions to pass while the protein remains inside, facilitating buffer exchange.This method is commonly used during protein expression and purification workflows for buffer exchange, desalting, and removal of unwanted small molecules such as imidazole, urea, or ammonium sulfate. The process helps maintain protein stability and activity by gradually equilibrating the sample with the desired buffer conditions.</p><h5><strong>Immunocapture (Magnetic Bead-Based Purification</strong></h5><p>Immunocapture uses antibodies immobilized on solid supports like magnetic beads to selectively bind and isolate a target protein. This method is highly specific and particularly useful for low-abundance targets or small-scale prep, such as:</p><ul><li>Pulling down proteins from complex mixtures</li><li>Capturing tagged recombinant proteins (e.g., FLAG, HA, or His tags)</li><li>Enrichment before western blotting, MS, or ELISA</li></ul><p>Magnetic beads offer speed, ease of use, and minimal sample loss, making them ideal for lab-scale workflows.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/products/biozenspe-sample-preparation-products/biozen-magbeads">Biozen MagBeads</a> provide a fast and efficient method for purifying, isolating, and cleaning up monoclonal antibodies (mAbs), proteins, and peptides. These paramagnetic beads feature a streptavidin-coated surface, enabling high-affinity binding in immuno-based workflows. Compared to traditional sample preparation techniques, magnetic bead-based immunocapture offers greater speed and consistency by delivering high binding capacity with uniform particle size, ensuring accurate and reproducible results in significantly less time.</p><h5><strong>Centrifugation</strong></h5><p>Centrifugation of crude protein mixtures is an essential step in the investigation of protein purification and aggregation. Outlined below are the various types of centrifugations employed in protein purification.</p><p><strong>Preparative Ultracentrifugation</strong><br>Ultracentrifugation is an effective method of purifying proteins from aggregates based on their size, shape and density. Centrifugation, widely recognized as a robust and versatile method, is commonly used to separate complex mixtures of cellular components. Ultracentrifuges separate small particles by spinning at high speeds, utilizing centrifugal force based on size and density.</p><p><strong>Differential Centrifugation</strong><br>Differential centrifugation operates by separating components based on differences in size and density, using varying speeds of centrifugation to achieve this. Its resolving power ranges from low to medium. A key advantage of this technique is its convenience for processing multiple samples simultaneously, making it effective for purifying crude samples. Additionally, it preserves cell viability and maintains the natural distribution of hematopoietic cell populations.</p><p><strong>Rate-zonal Gradient Centrifugation</strong><br>This technique separates components based on their sedimentation rate within a medium that contains a density gradient. It offers medium resolving power and is particularly effective for separating multiple components in complex mixtures with high precision. It is also considered a cost-effective and widely used technique in molecular biology and biochemistry.</p><p><strong>Isopycnic Centrifugation (Equilibrium Centrifugation)</strong><br>Isopycnic centrifugation is an advanced protein purification method that relies on the principle of separating particles according to their intrinsic buoyant density, irrespective of their size or morphology. During the process, proteins migrate through a density gradient until they equilibrate at a position where their density matches that of the surrounding medium, resulting in precise separation without further sedimentation.</p></div></div></div><div><div><div><div><h4><strong>Chromatographic Approaches</strong></h4><p>Chromatography is a common method of protein purification and is based on the separation of molecules in a mixture as they move through a stationary phase and a mobile phase. Outlined below are the various types of chromatography employed in protein purification.</p><h5><strong>Ion Exchange Chromatography</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/techniques/hplc-ion-exchange">Ion exchange chromatography</a> relies on the interaction between a charged stationary phase and oppositely charged analytes, with cation exchange chromatography attracting positively charged molecules to a negatively charged stationary phase. Successful application of this technique requires careful selection of the appropriate ion exchange column, buffer pH, and salt concentration. This approach is often used in the biopharmaceutical industries as mAb polishing steps, viral clearance and charge variant analyses as part of the product quality control.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/">Phenomenex</a> offers a range of protein purification columns. Their ion exchange chromatography solutions include:&nbsp;</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1526"><strong>Luna SCX </strong></a>for strong selectivity of positively charged compounds, such as peptides</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1540"><strong>Biozen WCX</strong></a> for efficient separation of proteins such as monoclonal antibodies charged variants</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/part/00g-3151-e0">PhenoSphere SAX</a>, a strong anion-exchanger with fully porous 80Å particles, particularly useful for small molecules such as nucleotides</li></ul><h5><strong>Size Exclusion Chromatography</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/techniques/hplc-sec">Size exclusion chromatography (SEC)</a> separates molecules based on their size, with larger analytes eluting first due to their exclusion from the pores in the column packing material, while smaller molecules are able to enter the pores, facing a longer travelling path, and hence, eluting later. This method can be categorized into aqueous SEC (gel filtration chromatography, GFC) for analyzing biomolecules such as proteins and antibodies. This type of chromatography is widely used as an analytical tool for quality control in the biopharmaceutical industry and can also be an approach of choice for polishing steps.</p><p>Phenomenex offers a range of <strong>Biozen columns for SEC</strong> separations. In the case of mAbs, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1534"><strong>Biozen dSEC-2</strong></a> and<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1537"><strong> Biozen dSEC-7 </strong></a>columns are the top choices for monoclonal antibody (mAb) analysis, delivering high-resolution separation of monomers, aggregates, and fragments formed during mAb manufacturing, processing, or storage. The dSEC-7 column, featuring a larger pore size and optimized particle design, extends the dynamic range to accommodate larger biomolecules and complex biotherapeutics.</p><p>For more general applications, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1533"><strong>Biozen SEC-2</strong></a><strong> </strong>and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1532"><strong>Biozen SEC-3</strong></a> phases cover different MW ranges for high-efficiency separation of biomolecules (e.g., proteins and antibodies). Additionally, the BioSep and Yarra lines become top choices when looking for preparative scale columns.</p><h5><strong>Reversed-Phase Chromatography</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/techniques/hplc-reversed-phase">Reversed-phase chromatography</a>, the most common mode in high-performance liquid chromatography/ ultra-high-performance liquid chromatography (HPLC/UHPLC), separates compounds based on hydrophobic and van der Waals interactions using alkyl (C18, C8, C4) stationary phases or other hydrophobic polymers. For large biomolecules such as proteins and peptides, <a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/resources/blog/wider-pore-biozen-column">wide-pore</a> (typically 300 Å) C4, C8 and C18 columns are ideal, as the larger pore size allows better accessibility of the protein molecules to the stationary phase surface, improving mass transfer and peak shape during separation.</p><p>The Biozen line from Phenomenex offers a wide range of HPLC/UHPLC columns for the analysis of biomolecules.These include phases optimized for high-resolution analysis of intact proteins (Native-RP, Widepore C4, Intact XB-C8) and peptides (Peptide PS-C18, Peptide XB-C18 and Peptide Polar-C18). Kinetex could also be an option when looking for more selectivities for the analysis of peptides and small proteins. Additionally, when aiming to preparative scale processes, several of these media are also available in Phenomenex Axia formats to easily up-scale your separations.</p><h5><strong>Hydroxyapatite Chromatography</strong></h5><p>Hydroxyapatite chromatography (HAC) is a sophisticated mixed-mode chromatographic technique that exploits the unique properties of hydroxyapatite (Ca10(PO4)6(OH)2), utilizing both cation-exchange interactions via its phosphate groups and metal affinity through its calcium sites to achieve highly selective protein separations.</p><p>Renowned for its efficacy in resolving complex biomolecular separations, HAC excels in tasks like aggregate removal from monoclonal antibodies, surpassing the capabilities of traditional single-mode chromatographic methods such as ion-exchange or hydrophobic interaction chromatography.</p><h5><strong>Hydrophobic Interaction Chromatography</strong></h5><p>Hydrophobic interaction chromatography (HIC) is a method of protein purification that separates molecules based on their hydrophobicity, using high-salt buffers to promote protein-ligand interactions while maintaining the protein's biological activity. The process involves gradually reducing the salt concentration to elute proteins in order to increase hydrophobicity, making it effective for purifying target molecules and removing impurities or aggregates, making it a valuable approach for intermediate and polishing steps during purification processes.</p><h5><strong>Affinity Chromatography</strong></h5><p>Affinity chromatography is a powerful and highly selective technique used to purify biomolecules based on specific, reversible interactions between a target molecule and an immobilized ligand. In many cases, recombinant proteins are engineered with affinity tags—such as His-tags or GST-tags—that facilitate binding to complementary ligands on the chromatography matrix.</p><p>This method offers the advantage of achieving several thousand-fold purifications in a single step while preserving the biological activity of the protein. It is widely employed for purifying enzymes, antibodies, and antigens, using a variety of ligands including specific antibodies, enzymes, and multifunctional compounds like concanavalin A and triazine dyes.</p></div></div></div></div>

Exploring Protein Purification Methods: Essential Techniques for Accurate Results

<h3><span><strong>A Practical Guide to Getting the Most from Syringe Filters: Tips, Tricks, and Common Pitfalls</strong></span></h3><p><span><strong>Syringe filters play a crucial role in chromatography and many other laboratory applications by removing particulate matter before analysis. Proper sample filtration helps protect analytical instruments, extends column lifetime, and improves data quality. However, selecting an unsuitable filter—or using one incorrectly—can introduce contamination, reduce filtration efficiency, or even compromise analytical results. The following recommendations will help you avoid common mistakes and ensure reliable filtration every time.</strong></span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp" alt="KNAUER: Avoiding Common Syringe Filter Mistakes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_3_150e8c1c2b.webp 133w," sizes="100vw" width="1276" height="1496"></p><h4><span><strong>1. Improper Filter Handling</strong></span></h4><p><span>Using excessive force during filtration or attempting to reuse disposable syringe filters can damage the membrane and increase the risk of sample contamination.</span></p><ul><li><span><strong>Solution:</strong> Apply slow, even pressure throughout the filtration process and always dispose of single-use filters after one use. If the flow rate decreases noticeably, replace the filter instead of applying additional force.</span></li></ul><h4><span><strong>2. Selecting an Inappropriate Pore Size</strong></span></h4><p><span>Using the wrong pore size may either fail to remove unwanted particles or cause the membrane to clog prematurely, reducing filtration efficiency.</span></p><ul><li><span><strong>Solution:</strong> A 0.45 µm membrane is generally suitable for routine particulate removal, while a 0.22 µm membrane is recommended for finer filtration and bacterial removal. Samples with higher viscosity may require a pre-filter to prevent rapid clogging. It is also important to consider the intended analytical technique. For example, 0.22 µm filters are typically preferred for UHPLC and LC-MS applications, whereas 0.45 µm filters are often sufficient for conventional HPLC analyses.</span></li></ul><h4><span><strong>3. Choosing the Wrong Membrane Material</strong></span></h4><p><span>Different membrane materials exhibit different chemical resistance. Using an incompatible membrane may lead to degradation of the filter, sample contamination, or complete filtration failure.</span></p><ul><li><span><strong>Solution:</strong> Always verify solvent compatibility before filtration. PTFE membranes are an excellent choice for organic solvents, while PES and nylon membranes are better suited to aqueous samples. If compatibility is uncertain, perform a small-scale trial before filtering valuable samples.</span></li><li><span><strong>Pro Tip:</strong> For additional guidance, see our blog article <strong>"How to Choose the Right Membrane for your Syringe Filter"</strong>, which provides a detailed comparison of membrane materials and their recommended applications.</span></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg" alt="KNAUER Sepapure® Syringe Filters are available with multiple membrane materials, each identified by a dedicated color code for quick and reliable selection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_2_e47021fb11.jpg 245w," sizes="100vw" width="1580" height="902"></p><h4><span><strong>4. Ignoring Filter Capacity</strong></span></h4><p><span>Using a filter with insufficient capacity can result in rapid membrane blockage, increasing filtration time and reducing laboratory productivity.</span></p><ul><li><span><strong>Solution:</strong> When filtering larger sample volumes, choose high-capacity syringe filters or introduce a pre-filtration step. Never force liquid through a clogged membrane, as doing so may damage the filter and negatively affect sample quality.</span></li></ul><h4><span><strong>5. Overlooking Sample Adsorption</strong></span></h4><p><span>Certain membrane materials may adsorb analytes of interest, leading to lower recoveries and potentially affecting quantitative results.</span></p><ul><li><span><strong>Solution:</strong> For protein samples or other adsorption-sensitive analytes, select membranes with low binding characteristics, such as nylon or glass fiber, whenever appropriate. Performing a small recovery test before routine analysis can help identify potential analyte losses.</span></li></ul><h4><span><strong>6. Failing to Optimize Filtration Performance</strong></span></h4><p><span>Slow filtration is more than just an inconvenience—it often indicates that the filtration conditions are not optimal.</span></p><ul><li><span><strong>Solution:</strong> If filtration becomes unusually slow, investigate possible causes such as membrane clogging, excessive sample viscosity, or an unnecessarily small pore size. Depending on the sample, dilution or sequential filtration using progressively finer filters may significantly improve performance.</span></li></ul><h4><span><strong>Final Thoughts</strong></span></h4><p><span>Selecting the appropriate syringe filter is a straightforward process, but overlooking small details can have a significant impact on analytical performance. Choosing the correct membrane material, pore size, and filtration strategy helps improve laboratory efficiency, protects chromatography systems and columns, and contributes to accurate, reproducible analytical results.</span></p><p><span>With the right syringe filter and proper filtration technique, you can minimize sample preparation problems and maximize confidence in every analysis.</span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg" alt="KNAUER: Sepapure® Syringe Filter Selection" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Avoiding_Common_Syringe_Filter_Mistakes_4_983a15e289.jpg 245w," sizes="100vw" width="1160" height="627"></p><p><span><strong>Happy filtering!</strong></span></p>

Avoiding Common Syringe Filter Mistakes

News from LabRulezLCMS Library - Week 27, 2026

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

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Thermo Scientific™ GENESYS™ 30 Vis Spectrophotometer

Perform both basic and complex analyses with the Thermo Scientific™ GENESYS™ 30 Visible Spectrophotometer, an intuitive, reliable solution for education or in the lab.

<h3><strong>Designed for Users, Designed for Results</strong></h3><p><strong>The Thermo Scientific ™ GENESYS ™ 30 is the most thoughtfully designed spectrophotometer available today. Its high resolution color display, large sample compartment, and data export options meet modern expectations for students, educators and lab technicians. The GENESYS 30 blends the simplicity to satisfy novice students with the capabilities that labs need for accurate quantitative analysis.</strong></p><h4><strong>System Benefits:</strong></h4><ul><li>Large sample compartment with front access simplifies sample handling</li><li>High resolution color display</li><li>Outstanding durability in challenging environments thanks to:</li><li>Waterproof screen</li><li>Sealed, rubberized keypad</li><li>Removable, washable sample compartment</li><li>Sloping surfaces that shed spills</li><li>Chemical resistant PC-ABS covers</li><li>3A linear measurement range for concentrated solutions</li><li>Multi-point quant offers higher measurement confidence</li><li>Traditional monochromator paired with advanced electronics delivers outstanding stability</li><li>Scan mode for spectral analysis and interpretation</li><li>Data any way you want it - excellent snap-on thermal printer or USB data export</li><li>Expanded capabilities with optional VISIONlite software</li><li>2-year warranty</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_GENESYS_30_Vis_Spectrophotometer_4_4442fcccc5.jpg" alt="Thermo Scientific™ GENESYS™ 30 Vis Spectrophotometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_GENESYS_30_Vis_Spectrophotometer_4_4442fcccc5.jpg 195w," sizes="100vw" width="2103" height="1685"></p><h3><strong>Modern Power meets Traditional Simplicity</strong></h3><h4><strong>Live Display and Concentration Mode</strong></h4><p>Replicate the familiar display of absorbance or transmittance, and single standard concentration measurements of prior generation instruments in the GENESYS 30 Live Display mode. All your parameters are set and kept in view on a single screen as the calculated concentration updates every two seconds.</p><h4><strong>Fixed Mode</strong></h4><p>Apply a factor to an absorbance measurement at one wavelength, or measure at two wavelengths with two factors and perform addition, subtraction or division of the values. Display results for up ten samples then print, save or clear your data before going on to the next sample series.</p><h4><strong>Quantitative Analysis with up to Six Standards</strong></h4><p>Go beyond the basic spectrophotometer by recording and storing up to six standards to calibrate your method. Choose a linear fit with an intercept or forced through zero. Name and save your method on the instrument or back it up to a USB memory device. All data are recorded with an index number (S1 – S10) and a time stamp. The result table accommodates up to ten samples for you to print or save before going on to the next sample series or analysis.</p><h4><strong>Go negative!</strong></h4><p>Some methods call for blanking the instrument on a dark standard and reading absorbance in the negative range. Most single beam instruments cannot measure below -0.3A. GENESYS 30 uses advanced signal processing to deliver stable, reliable results down to -3A.</p><h4><strong>Simple to Sophisticated:</strong></h4><p>The GENESYS 30 has the flexibility to perform routine analysis one minute and complex analytical methods the next. The custom Analyzer mode enables you to build your formula with up to six wavelengths, six factors, standard arithmetic operators and absorbance values raised to the 2nd or 3rd power. Use the included Windows® application to design your method. Transfer the method to your GENESYS 30 and run it with the touch of a button. Analyzer mode shows your method name and a continuous display of your results. Technicians can write the result down or print it with a time stamp using the printer accessory.</p><h4><strong>Smarter by Design:&nbsp;</strong></h4><p>GENESYS 30 offers the convenient SmartStart™ feature that has delighted GENESYS 10S users since its introduction. The SmartStart menu gives you direct access to your<strong> 12 favorite methods</strong>. Allowing you to work smarter, not harder.</p><h4><strong>Snap on Printer:&nbsp;</strong></h4><p>Fast and clear printing when you need it. Add printing capability to your instrument. The snap-on thermal printer installs<br>in moments.&nbsp;</p><h4><strong>Quick and Simple Lamp Replacement:&nbsp;</strong></h4><p>No need to remove the cover, just loosen two screws, slide out the old lamp fitting and slide a new one back in. Everything is pre-aligned, just let the new lamp warm up and go back to work.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_GENESYS_30_Vis_Spectrophotometer_3_82082740d3.jpg" alt="Thermo Scientific™ GENESYS™ 30 Vis Spectrophotometer: Quick and simple lamp replacement." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_GENESYS_30_Vis_Spectrophotometer_3_82082740d3.jpg 197w," sizes="100vw" width="1737" height="1376"></p><h3><strong>At Home in the Instructional Laboratory</strong></h3><p><strong>GENESYS spectrophotometers are core teaching instruments in chemistry and biology laboratories around the world. The Thermo Scientific™ GENESYS™ 30 allows students and teachers to focus on examining scientific data and learning scientific concepts instead of learning instrumentation.</strong></p><h4><strong>Easy to Teach, Easy to Learn&nbsp;</strong></h4><p>Clearly labeled, uniquely colored keys simplify instrument operation. New users require little or no training.</p><h4><strong>Get Working – Faster!</strong></h4><p>Large, color digital screen and numeric keypad help you set up methods faster. Simplified software interface gives users maximum control and efficiency.</p><h4><strong>Designed for Today, Built for Tomorrow – Inside and Out!</strong></h4><p>On the inside, GENESYS 30 uses advanced optics, electronics and signal processing to deliver superior measurement performance for its class. On the outside, GENESYS 30 presents a tough exterior built to last for years in the most demanding environments.</p><ul><li>Resistant to spills</li><li>Removable and washable sample compartment</li><li>The sample compartment lid<ul><li>stays where you put it - open or closed</li><li>has a magnetic latch to hold it closed during measurements</li><li>is customer-replaceable should it get broken through abuse</li></ul></li></ul><h4><strong>Simple and Familiar</strong></h4><p>Open the Live Display application with a single button-press to monitor the absorbance or transmittance live – just like a GENESYS 20 or SPECTRONIC 20. The spectrum indicator shows the color of light being absorbed.</p><h4><strong>Special support for OD 600 and test-tube measurements</strong></h4><p>For measurements in test-tubes, the test-tube holder accessory accommodates 100mm x 13mm test-tubes with the lid closed. Or add the tall test-tube adaptor to use larger diameter, taller tubes (up to 150mm, 6 inches) with the lid open. Special OD600 mode for cell growth measurements. Select it from the Home menu and go! No method setup required.</p><h4><strong>Scanning: Simple and Fast</strong></h4><p>Find peaks in the spectrum of your sample by scanning across the spectrum in any range from 325nm to 1100nm with 1nm precision and noise-free peaks up to 3A. Use the cursor and zoom controls to identify λ<sub>max</sub>.</p><h4><strong>Data you can use</strong></h4><ul><li>Print your scan and stick it into a lab notebook using the printer accessory and optional self-stick printer paper.</li><li>Save the data points of your scan to a USB memory device and load the data into a spreadsheet or graphing program for optimal reporting.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Genesys_30_USB_stick_A_c45fd86787.jpg" alt="Thermo Scientific™ GENESYS™ 30 Vis Spectrophotometer: USB stick." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_Genesys_30_USB_stick_A_c45fd86787.jpg 181w," sizes="100vw" width="543" height="469"></p><h3><strong>VISIONlite Software</strong></h3><p><strong>For users who need the power of computerized data analysis, optional Thermo Scientific™ VISIONlite™ software pairs a simple user</strong><br><strong>interface with a wider range of options for experiment design and data analysis.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg" alt="Thermo Scientific - Genesys spectrophotometers: VISIONlite Software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg 239w," sizes="100vw" width="1422" height="928"></p><h4><strong>Scan Application:</strong></h4><ul><li>Automated peak pick and label</li><li>Overlay spectra and print the results</li></ul><h4><strong>Kinetics Application:</strong></h4><ul><li>Data intervals as low as 1 second</li><li>Enzyme rate calculation with factor</li></ul><h4><strong>Quantitative Analysis:</strong></h4><ul><li>Up to 100 standards</li><li>Linear, quadratic or cubic data fits</li></ul><h4><strong>Performance Verification:</strong></h4><ul><li>Full suite of tests to verify performance of your instrument</li><li>Pre-loaded pass/fail limits specific to your instrument</li></ul><h3><strong>GENESYS 30 Accessories</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_GENESYS_30_Vis_Spectrophotometer_59d912ddd3.jpg" alt="Thermo Scientific™ GENESYS™ 30 Vis Spectrophotometer: GENESYS 30 Accessories." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_GENESYS_30_Vis_Spectrophotometer_59d912ddd3.jpg 243w," sizes="100vw" width="1444" height="929"></p><h3><strong>GENESYS 30 Vis Spectrophotometer Specifications</strong></h3><ul><li><strong>Baseline Flatness:</strong> &lt;0.003 A, 325 to 1000 nm smoothed</li><li><strong>Compartments:</strong>&nbsp;<ul><li>Accessible from top, front or side</li><li>Able to accommodate cells up to 100mm pathlength</li><li>Available accessory for test-tubes up to 25mm diameter and 150mm height</li><li>Removable, washable sample compartment liner with magnetic placement and hold-down</li></ul></li><li><strong>Connections:</strong> USB-A, USB-B</li><li><strong>Description:</strong> GENESYS 30 VIS Spectrophotometer with EU Power Cable</li><li><strong>Dimensions (L x W x H):</strong> 35.5 x 38.5 x 19.5 cm</li><li><strong>Drift:</strong> &lt;0.002 A/hr. (At 500 nm after 2 hr. warmup.) Typical &lt;0.004 A/hr. after 1 hr. warmup</li><li><strong>Electrical Requirements:</strong> External AC to DC converter. Voltage and Frequency (Hz) selected automatically, 100/250 V, 50/60 Hz</li><li><strong>Keypad:</strong> Tactile rubber 23 keys with numeric keypad</li><li><strong>Lamp Life:</strong> 1000 hrs.</li><li><strong>Noise:</strong> (RMS at 500nm. 60 consecutive measurements)<ul><li>≤0.001A at 0A</li><li>≤0.001A at 1A</li><li>≤0.002A at 2A</li></ul></li><li><strong>Optical Design:</strong> Single Beam</li><li><strong>Photometric Accuracy:</strong> ±0.002 A (0 to 0.3 A), 0.5% of ABS reading (0.301 A to 2.5 A)</li><li><strong>Photometric Display:</strong> -3A to +3A, 0 to 200 000 %T, 0 to 9 999 999 C</li><li><strong>Photometric Range:</strong> -3A to +3A</li><li><strong>Photometric Repeatability:</strong> ± 0.002 A (Measured at 1.0 A at 546 nm)</li><li><strong>Printer Included:</strong> Thermal printer accessory with 80 mm width paper</li><li><strong>Scan Speed:</strong> Automatic – up to 1200 nm/min.</li><li><strong>Stray Light:</strong> &lt;0.1%T at 340 nm and 400 nm</li><li>Measured using glass cutoff filters or NaNO₂ at 340 nm</li><li><strong>Warranty:</strong> 2 years standard with 1 year extension upon registration of the instrument with Thermo Fisher Scientific within 6 months of purchase</li><li><strong>Wavelength Accuracy:</strong> ±2 nm</li><li><strong>Wavelength Data Interval:</strong> 1 nm</li><li><strong>Wavelength Repeatability:</strong> &lt; ±1 nm</li><li><strong>Weight (Metric):</strong> 7.5 kg</li><li><strong>Detector Type:</strong> Silicon Photodiode</li><li><strong>Display:</strong> 5 in. 32-bit Color Display, 800 x 480 pixels</li><li><strong>Languages:</strong> English, French, German, Spanish, Italian, Portuguese, Russian, Chinese, Japanese, Korean, Thai, Arabic</li><li><strong>Wavelength Range:</strong> 325 to 1100 nm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ GENESYS™ 40 Vis Spectrophotometer

Perform routine measurements for quality control or teaching in the chemistry classroom with rugged Thermo Scientific™ GENESYS 40 Vis Spectrophotometer.

<h4><strong>GENESYS - developed for users, designed for results</strong></h4><p>Built on the foundation of 60 years of spectroscopy experience, the next generation Thermo Scientific™ GENESYS™ family of Vis/UV-Vis spectrophotometers provides exceptional performance with a contemporary design.</p><ul><li>Start taking measurements immediately with the simple-to-use, high-resolution, color-display start menu</li><li>Exchange samples with ease with large, accessible sample compartment</li><li>Save your data fast any way you want it with multiple data-export options</li></ul><p>There is a GENESYS spectrophotometer you can count on to provide accurate, reproducible results for your application requirements.</p><h3><strong>GENESYS 40 Vis Spectrophotometer</strong></h3><p><strong>For teaching labs, research labs and industrial QC requiring robust construction, ease-of-use and software capability.</strong></p><h5><strong>Advanced usability, modern functionality</strong></h5><ul><li>7-inch, high-resolution touchscreen interface</li><li>Local control increases speed and reliability for routine analysis</li><li>Large sample compartment with front access simplifies sample handling</li><li>Wi-Fi ready - save data and methods, print results from on-board control</li></ul><h5><strong>Designed for</strong></h5><ul><li>Chemistry labs</li><li>Routine measurements</li><li>Moderate throughput requirements</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Genesys_40_Kyveta_A_7955a6a01a.jpg" alt="Thermo Scientific™ GENESYS™ 40 Vis Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_Genesys_40_Kyveta_A_7955a6a01a.jpg 234w," sizes="100vw" width="1536" height="1024"></p><h3><strong>Walk-up convenience</strong></h3><p><strong>Simple-to-use, touchscreen user interface features the methods and applications most important to you.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg" alt="Thermo Scientific GENESYS Spectrophotometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg 239w," sizes="100vw" width="1422" height="928"></p><h5><strong>Flexible computer control</strong></h5><p>Optional VISIONlite software offers complete control from a Microsoft ® Windows ® computer providing applications for:</p><ul><li>Scanning</li><li>Quantitative analysis</li><li>Kinetics</li><li>Fixed wavelength measurements</li></ul><h3><strong>GENESYS 40 Vis Spectrophotometer Specifications</strong></h3><ul><li><strong>Baseline Flatness:</strong> ±0.005 A</li><li><strong>Compartments:</strong>&nbsp;<ul><li>Accessible from top, front or side</li><li>Able to accommodate cells up to 100mm cells</li><li>Available accessory for test tubes up to 25 mm diameter and 150 mm height</li><li>Removable, washable sample compartment liner with magnetic placement and hold-down</li></ul></li><li><strong>Connections:</strong>&nbsp;<ul><li>Single USB-A</li><li>Duplex USB-A</li><li>Export data to network or PC via USB, Ethernet, or Wi-Fi USB adaptor, available&nbsp;</li><li>Print via USB, Ethernet or Wi-Fi USB adaptor available</li></ul></li><li><strong>Dimensions (L x W x H):</strong> 35.5 x 38.5 x 19.5 cm</li><li><strong>Drift:</strong> (At 500 nm after 1 hour warmup) &lt;0.0010 A/hr.</li><li><strong>Electrical Requirements:</strong> External AC to DC converter. Voltage and Frequency (Hz) selected automatically, 100/240 V, 50/60 Hz</li><li><strong>Includes:</strong> GENESYS 40 Spectrophotometer</li><li><strong>Keypad:</strong> Touchscreen</li><li><strong>Lamp Life:</strong> &gt;1000 hrs.</li><li><strong>Noise:</strong> (RMS at 500 nm 60 consecutive measurements)<ul><li>≤0.00020A at 0A at 260 and 500 nm</li><li>≤0.00030A at 1A at 260 and 500 nm</li><li>≤0.00040A at 2A at 260 and 500 nm</li></ul></li><li><strong>Optical Design:</strong> Dual Beam</li><li><strong>Photometric Accuracy:</strong> ±0.002 A at 0.5 A, ±0.004 A at 1.0 A, ±0.008 A at 2.0 A</li><li><strong>Photometric Display:</strong> -3A to +5A</li><li><strong>Photometric Range:</strong> –3A to +3.5A</li><li><strong>Photometric Repeatability:</strong> ±0.001A at 1A measured at 1.0A at 546 nm</li><li><strong>Printer Included:</strong> Snap-on printer available</li><li><strong>Scan Speed:</strong> Automatic – up to 1800 nm/min.</li><li><strong>Stray Light:</strong> &lt;0.05%T at 340 nm and 400 nm</li><li><strong>Warranty:</strong> 2 yrs std + 1 yr ext upon reg</li><li><strong>Wavelength Accuracy:</strong> ±0.5 nm</li><li><strong>Wavelength Data Interval:</strong> 0.2 nm, 0.5 nm, 1 nm, 2 nm, 5 nm</li><li><strong>Wavelength Repeatability:</strong> &lt; ±0.2 nm</li><li><strong>Weight (Metric):</strong> 7.5 kg</li><li><strong>Detector Type:</strong> Dual Silicon Photodiodes</li><li><strong>Display:</strong> 7 in. High Definition Color Touchscreen, Fixed, 800 x 1280 pixels</li><li><strong>Light Source:</strong> Tungsten Halogen</li><li><strong>Spectral Bandwidth:</strong> 5 nm</li><li><strong>Wavelength Range:</strong> 325 to 1100 nm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ GENESYS™ 140 Vis Spectrophotometer

Perform quantitative measurements in routine industrial QA/QC or university chemistry labs with the automated and network-capable Thermo Scientific™ GENESYS 140 Vis Spectrophotometer.

<h4><strong>GENESYS - developed for users, designed for results</strong></h4><p>Built on the foundation of 60 years of spectroscopy experience, the next generation Thermo Scientific™ GENESYS™ family of Vis/UV-Vis spectrophotometers provides exceptional performance with a contemporary design.</p><ul><li>Start taking measurements immediately with the simple-to-use, high-resolution, color-display start menu</li><li>Exchange samples with ease with large, accessible sample compartment</li><li>Save your data fast any way you want it with multiple data-export options</li></ul><p>There is a GENESYS spectrophotometer you can count on to provide accurate, reproducible results for your application requirements.</p><h3><strong>GENESYS 140 Vis Spectrophotometer</strong></h3><p><strong>For advanced teaching labs, R&amp;D, research and life science applications requiring higher throughput or temperature control.</strong></p><h5><strong>Elite performance, enhanced capabilities</strong></h5><ul><li>7-inch, high-resolution touchscreen interface</li><li>Local control increases speed and reliability for routine analysis</li><li>Large sample compartment with front access simplifies sample handling</li><li>Wi-Fi ready - save data and methods, print results from on-board control</li></ul><h5><strong>Designed for</strong></h5><ul><li>Chemistry labs</li><li>Routine measurements</li><li>Moderate throughput requirements</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_vis_spektrofotometr_genesys_140_titul_B_bd2a19cbcb.jpg" alt="Thermo Scientific GENESYS Spectrophotometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_vis_spektrofotometr_genesys_140_titul_B_bd2a19cbcb.jpg 225w," sizes="100vw" width="516" height="358"></p><h3><strong>Walk-up convenience</strong></h3><p><strong>Simple-to-use, touchscreen user interface features the methods and applications most important to you.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg" alt="Thermo Scientific: Genesys spectrophotometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg 239w," sizes="100vw" width="1422" height="928"></p><h5><strong>Flexible computer control</strong></h5><p>Optional VISIONlite software offers complete control from a Microsoft ® Windows ® computer providing applications for:</p><ul><li>Scanning</li><li>Quantitative analysis</li><li>Kinetics</li><li>Fixed wavelength measurements</li></ul><h3><strong>GENESYS 140 Vis Spectrophotometer Specifications</strong></h3><ul><li><strong>Baseline Flatness:</strong> ±0.005 A</li><li><strong>Compartments:</strong> Accommodates (optional):<ul><li>8-position cell changer</li><li>4-position cell changer (long path cells)</li><li>Peltier thermostatted cell holder (20–60 °C)</li><li>Sipper accessory</li><li>Fiber optic probe coupler</li></ul></li><li><strong>Connections:</strong>&nbsp;<ul><li>Single USB-A</li><li>Duplex USB-A</li><li>Export data to network or PC via USB, Ethernet, or Wi-Fi USB adaptor, available&nbsp;</li><li>Print via USB, Ethernet or Wi-Fi USB adaptor available</li></ul></li><li><strong>Dimensions (L x W x H):</strong> 35.5 x 38.5 x 19.5 cm</li><li><strong>Drift:</strong> (At 500 nm after 1 hour warmup) &lt;0.0010 A/hr.</li><li><strong>Electrical Requirements:</strong> External AC to DC converter. Voltage and Frequency (Hz) selected automatically, 100/240 V, 50/60 Hz</li><li><strong>Includes:</strong> Genesys 140 Spectrophotometer</li><li><strong>Keypad:</strong> Touchscreen</li><li><strong>Lamp Life:</strong> &gt;1000 hrs.</li><li><strong>Noise:</strong> (RMS at 500 nm 60 consecutive measurements)<ul><li>≤0.00020A at 0A at 260 and 500 nm</li><li>≤0.00030A at 1A at 260 and 500 nm</li><li>≤0.00040A at 2A at 260 and 500 nm</li></ul></li><li><strong>Optical Design:</strong> Dual Beam</li><li><strong>Photometric Accuracy:</strong> ±0.002A at 0.5A, ±0.004A at 1.0 A±0.008 A at 2.0A</li><li><strong>Photometric Display:</strong> -3A to +5A</li><li><strong>Photometric Range:</strong> –3A to +3.5A</li><li><strong>Photometric Repeatability:</strong> ±0.001 A at 1 A measured at 1.0 A at 546 nm</li><li><strong>Printer Included:</strong> Snap-on printer available</li><li><strong>Scan Speed:</strong> Automatic – up to 1800 nm/min.</li><li><strong>Stray Light:</strong> &lt;0.05%T at 340 nm and 400 nm</li><li><strong>Warranty:</strong> 2 yrs std + 1 yr ext upon reg</li><li><strong>Wavelength Accuracy:</strong> ±0.5 nm</li><li><strong>Wavelength Data Interval:</strong> 0.2 nm, 0.5 nm, 1 nm, 2 nm, 5 nm</li><li><strong>Wavelength Repeatability:</strong> &lt; ±0.2 nm</li><li><strong>Weight (Metric):</strong> 7.5 kg</li><li><strong>Detector Type:</strong> Dual Silicon Photodiodes</li><li><strong>Display:</strong> 7 in. High Definition Color Touchscreen, Tiltable, 800 x 1280 pixels</li><li><strong>Light Source:</strong> Tungsten Halogen</li><li><strong>Spectral Bandwidth:</strong> 5 nm</li><li><strong>Wavelength Range:</strong> 325 to 1100 nm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ GENESYS™ 50 UV-Vis Spectrophotometer

Perform routine measurements for quality control or teaching in the chemistry classroom with rugged Thermo Scientific™ GENESYS 50 UV-Vis Spectrophotometer.

<h4><strong>GENESYS - developed for users, designed for results</strong></h4><p>Built on the foundation of 60 years of spectroscopy experience, the next generation Thermo Scientific™ GENESYS™ family of Vis/UV-Vis spectrophotometers provides exceptional performance with a contemporary design.</p><ul><li>Start taking measurements immediately with the simple-to-use, high-resolution, color-display start menu</li><li>Exchange samples with ease with large, accessible sample compartment</li><li>Save your data fast any way you want it with multiple data-export options</li></ul><p>There is a GENESYS spectrophotometer you can count on to provide accurate, reproducible results for your application requirements.</p><h3><strong>GENESYS 50 UV-Vis Spectrophotometer</strong></h3><p><strong>For teaching labs, research labs and industrial QC requiring robust construction, ease-of-use and software capability.</strong></p><h5><strong>Advanced usability, modern functionality</strong></h5><ul><li>7-inch, high-resolution touchscreen interface</li><li>Local control increases speed and reliability for routine analysis</li><li>Large sample compartment with front access simplifies sample handling</li><li>Wi-Fi ready - save data and methods, print results from on-board control</li></ul><h5><strong>Designed for</strong></h5><ul><li>Chemistry labs</li><li>Routine measurements</li><li>Moderate throughput requirements</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Genesys_50_Kyveta_bae9677ae0.jpg" alt="Thermo Scientific™ GENESYS™ 50 UV-Vis Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_Genesys_50_Kyveta_bae9677ae0.jpg 188w," sizes="100vw" width="534" height="443"></p><h3><strong>Walk-up convenience</strong></h3><p><strong>Simple-to-use, touchscreen user interface features the methods and applications most important to you.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg" alt="Thermo Scientific GENESYS Spectrophotometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg 239w," sizes="100vw" width="1422" height="928"></p><h5><strong>Flexible computer control</strong></h5><p>Optional VISIONlite software offers complete control from a Microsoft ® Windows ® computer providing applications for:</p><ul><li>Scanning</li><li>Quantitative analysis</li><li>Kinetics</li><li>Fixed wavelength measurements</li></ul><h3><strong>GENESYS 50 UV-Vis Spectrophotometer Specifications</strong></h3><ul><li><strong>Baseline Flatness:</strong> ±0.002 A</li><li><strong>Compartments:</strong>&nbsp;<ul><li>Accessible from top, front or side</li><li>Able to accommodate cells up to 100 mm cells</li><li>Available accessory for test-tubes up to 25 mm diameter and 150 mm height</li><li>Removable, washable sample compartment liner with magnetic placement and hold-down</li></ul></li><li><strong>Connections:</strong>&nbsp;<ul><li>Single USB-A</li><li>Duplex USB-A</li><li>Export data to network or PC via USB, Ethernet, or Wi-Fi USB adaptor, available</li><li>Print via USB, Ethernet or Wi-Fi USB adaptor available</li></ul></li><li><strong>Dimensions (L x W x H):</strong> 35.5 x 38.5 x 19.5 cm</li><li><strong>Drift:</strong> (At 500 nm after 1 hour warmup) &lt;0.0005 A/hr.</li><li><strong>Electrical Requirements:</strong> External AC to DC converter. Voltage and Frequency (Hz) selected automatically, 100/240 V, 50/60 Hz</li><li><strong>Includes:</strong> GENESYS 50 Spectrophotometer</li><li><strong>Keypad:</strong> Touchscreen</li><li><strong>Lamp Life:</strong> &gt; 5 years typical, 3 years guaranteed</li><li><strong>Noise:</strong> (RMS at 500 nm 60 consecutive measurements)<ul><li>≤0.00020A at 0A at 260 and 500 nm</li><li>≤0.00030A at 1A at 260 and 500 nm</li><li>≤0.00040A at 2A at 260 and 500 nm</li></ul></li><li><strong>Optical Design:</strong> Dual Beam</li><li><strong>Photometric Accuracy:</strong> ±0.002A at 0.5A, ±0.004A at 1.0A, ±0.008 A at 2.0 A</li><li><strong>Photometric Display:</strong> -3A to +5A</li><li><strong>Photometric Range:</strong> –2A to +3.5A</li><li><strong>Photometric Repeatability:</strong> ±0.001 A at 1 A measured at 1.0 A at 546 nm</li><li><strong>Printer Included:</strong> Snap-on printer available</li><li><strong>Scan Speed:</strong> Slow, medium and fast – up to 1600 nm/min.</li><li><strong>Stray Light:</strong> &lt; 1.0%T 198 nm (KCl) , &lt;0.05%T at 220 nm (NaI), &lt;0.03%T at 340 nm (NaNO<sub>2</sub>)</li><li><strong>Warranty:</strong> 2 yrs std + 1 yr ext upon reg</li><li><strong>Wavelength Accuracy:</strong> ±0.5 nm</li><li><strong>Wavelength Data Interval:</strong> 0.2 nm, 0.5 nm, 1 nm, 2 nm, 5 nm</li><li><strong>Wavelength Repeatability:</strong> &lt; ±0.2 nm</li><li><strong>Weight (Metric):</strong> 7.5 kg</li><li><strong>Detector Type:</strong> Dual Silicon Photodiodes</li><li><strong>Display:</strong> 7 in. High Definition Color Touchscreen, Fixed, 800 x 1280 pixels</li><li><strong>Spectral Bandwidth:</strong> 2 nm</li><li><strong>Wavelength Range:</strong> 190 to 1100 nm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system

The Inuvion Core system gives you all the benefits of chemical suppression and higher-pressure operation, with manual eluent preparation.

<h3><strong>Welcome to the evolution of everyday IC reliability</strong></h3><p>The new<strong> Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system</strong> makes ion analysis simpler and more intuitive than ever before. And it delivers exactly what a busy analytical testing lab is looking for: <strong>consistently excellent results-every shift, every day, for every operator.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg 245w," sizes="100vw" width="825" height="498"></p><h3><strong>Start with Inuvion Core</strong></h3><p>The <strong>Inuvion Core system</strong> gives you<strong> </strong>all the benefits of chemical suppression and higher-pressure operation, with manual eluent preparation. You still enjoy the<strong> same robust Dionex Inuvion platform</strong>-easily configurable and economically upgradeable to full-featured capabilities as budget allows.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_Core_ion_chromatography_system_6c8824cb1d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_Core_ion_chromatography_system_6c8824cb1d.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>SIMPLE, INTUITIVE USER EXPERIENCE&nbsp;</strong></h3><ul><li><strong>Smart, function-driven design</strong> lets you quickly and safely access everything on the instrument—no hard-to-reach compartments, and no step stools or extra tools needed!</li><li><strong>Automated startup and shutdown routines</strong> ensure the system is quickly ready for the day’s work without user intervention.&nbsp;</li><li><strong>Built-in how-to videos</strong> reduce training time and simplify setup and operation.</li></ul><h3><strong>ULTRA-RELIABLE PERFORMANCE&nbsp;</strong></h3><ul><li><strong>Advanced high-performance pump technology and electronics</strong> let you take advantage of a wider range of columns and chemistries to improve the speed and quality of your results.</li><li><strong>Fast, flexible, convenient electrolytic suppression: </strong>Just connect the suppressor; no external pump or offline conditioning needed for regeneration.</li><li><strong>Reagent-free IC (RFIC™) capability</strong> makes eluent preparation as simple as “just add water,” while ensuring more consistent results and enabling optimized gradient separations.</li></ul><h3><strong>EASILY CONFIGURABLE AND UPGRADEABLE</strong></h3><ul><li><strong>Versatile, adaptable platform</strong> lets you configure the exact Dionex Inuvion IC system for today’s needs and budget, with confidence that your system will also meet your future needs.</li><li><strong>Multiple options and peripherals </strong>extend IC capabilities, letting you easily—and cost-effectively—adapt to changing sample types and workflow requirements.</li></ul><h3><strong>Simply the best system for everyday ion analysis</strong></h3><figure class="image"><img style="aspect-ratio:1107/755;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg 229w," sizes="100vw" width="1107" height="755"></figure><p><strong>1. Operator-friendly engineering </strong>saves time and reduces errors by allowing easy, unobstructed access to all components, connections and consumables</p><p><strong>2. Compact design </strong>helps you make the most of valuable bench space</p><p><strong>3. Digital gas pressure regulator </strong>increases precision of gas delivery for maximum day-to-day consistency (optional)</p><p><strong>4. Temperature-controlled conductivity cell </strong>improves reproducibility and ensures baseline stability</p><p><strong>5. Vacuum degassing capability</strong> enables more consistent peak identification from smoother baselines</p><p><strong>6. Seal wash pump</strong> reduces maintenance costs when using manually prepared eluents (optional)&nbsp;</p><p><strong>7. Reagent-free IC (RFIC)</strong> saves time and ensures greater day-to-day and operator-to-operator consistency, while also allowing the use of gradient separations</p><p><strong>8. Electrolytic suppression</strong> entirely eliminates the need for manual regenerant preparation (or, opt for a continuously regenerated, always- ready-to-go chemical suppressor)</p><p><strong>9. Thermo Scientific™ Dionex™ IC PEEK Viper™ fittings</strong> ensure confident, low dead volume connections every time—no tools required! (optional)</p><p><strong>10. Integrated column heater</strong> minimizes the impact of fluctuations in lab temperature that can adversely affect results (optional)</p><p><strong>11. 6- or 10-port auxiliary valve</strong> lets you automate in-line sample preparation</p><p><strong>12. State-of-the-art high-pressure pump (up to 5000 psi)</strong> lets you increase flow rates with smaller particle columns to reduce run times or add additional separation capacity with longer column length</p><p><strong>13. System self-diagnostics </strong>automatically detect any issues with hardware and consumables</p><p><strong>14. Self-service capabilities and user-swappable parts</strong> help you get back up and running in a hurry Automatic eluent monitor alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><p><strong>15. Automatic eluent monitor </strong>alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><h3><strong>Flexible, adaptable Dionex Inuvion platform</strong></h3><p>You can <strong>configure your Dionex Inuvion system</strong> to meet specific analytical and budget requirements, and easily reconfigure as needed. Multiple configurations and peripherals extend IC capabilities, letting you easily-and cost-effectively-adapt to changing sample types and workflow requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg 245w," sizes="100vw" width="1246" height="572"></p><h3><strong>Consistently excellent results every day</strong></h3><p>The <strong>Dionex Inuvion IC system supports a full range of columns </strong>to improve the speed and quality of results, for both<strong> anions and cations.</strong> Expanded capabilities, such as Reagent-Free IC (RFIC), enhance operator-to-operator consistency, while enabling the use of eluent gradients to optimize separations.</p><h4><strong>Rapid results</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 1. Elution of seven common inorganic anions using carbonate eluent. Short columns and fast flow rates let you reduce run times." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg 245w," sizes="100vw" width="1622" height="739"></p><h4><strong>Exceptional reproducibility</strong></h4><figure class="image"><img style="aspect-ratio:1693/754;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_3_Ukazka_reprodukovatelnosti_analyzy_zakladnich_aniontu_40_nastriku_Spickova_technologie_cerpadla_a_elektronika_pristroje_poskytuji_konzistentni_a_reprodukovatelne_vysledky_f66e7430cf.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 2. Overlay of 40 replicate injections. State-of-the-art pump technology and Electronics deliver consistent, reproducible results." width="1693" height="754"></figure><h4><strong>Increased sensitivity and consistency</strong></h4><figure class="image"><img style="aspect-ratio:1860/836;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_4_Ukazka_vysoce_citlive_analyzy_aniontu_ve_vodach_Eluent_generator_KOH_a_elektrolyticka_suprese_snizuji_pozadi_cimz_dochazi_ke_zvyseni_citlivosti_da55facfd0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 3. Determination of inorganic anions in drinking and surface waters. KOH eluent generation and electrolytic suppression yield lower backgrounds for greater sensitivity and increased day-to-day consistency." width="1860" height="836"></figure><h4><strong>Method optimization</strong></h4><figure class="image"><img style="aspect-ratio:1799/889;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_5_Ukazka_optimalizace_metody_zkraceni_doby_analyzy_pouzitim_gradientu_mobilni_faze_fc1fbe9cb0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 4. Comparison of isocratic and gradient runs using eluent generation. Reduce run length and sharpen later-eluting peaks with the same ease as an isocratic run with no need for two separate eluents or a proportioning pump." width="1799" height="889"></figure><h3><strong>Compliance-ready Chromeleon CDS</strong></h3><p>A trusted industry standard all over the world, ”Simply Intelligent”<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software </strong></a>brings out the full power of the Dionex Inuvion IC system. Easy to learn and easy to use, it automates and optimizes daily tasks and helps even inexperienced users achieve consistent, high quality results.</p><p><img style="aspect-ratio:3700/1660;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Thermo_Scientific_Dionex_Inuvion_2_303a6eb73b.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system." width="3700" height="1660"></p>

Thermo Scientific™ LipidSearch™ Software

Thermo Scientific™ LipidSearch™ software provides accurate identification of lipids and automatically integrates complex data into a concise report.

<h3><strong>The promise of lipidomics</strong></h3><p><strong>Lipidomics is a new field of study crucial for understanding cellular physiology and pathology. The application of lipidomic profiling to disease phenotype analysis is a rapidly growing aspect of translational medical research. Identification of unique lipid biomarkers has the potential to distinguish healthy individuals from individuals at risk for disease, detect diseases earlier, and facilitate development of personalized treatments.</strong></p><p>Liquid chromatography combined with mass spectrometry (LC/MS) is a widely adopted technique for lipidomics analyses. Relative and absolute quantitation, and identification, of lipids from biological samples requires sophisticated software with an extensive, comprehensive database.<strong> Thermo Scientific™ LipidSearch™ software provides accurate identification of lipids and automatically integrates complex data into a concise report. With its easy-to-use web-based interface, it dramatically reduces data analysis time.</strong></p><figure class="image"><img style="aspect-ratio:915/494;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Lipid_Search_Software_2_73b7d0a9e2.jpg" alt="Thermo Scientific™ LipidSearch™ Software: Easy-to-use web browser interface for automated and reliable identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Lipid_Search_Software_2_73b7d0a9e2.jpg 245w," sizes="100vw" width="915" height="494"></figure><h3><strong>Automated identification and relative quantitation with LipidSearch software</strong></h3><p>LipidSearch software, developed jointly by Professor Ryo Taguchi and MKI, (Tokyo, Japan), is a powerful new tool for<strong> automatic identification and relative quantification of cellular lipid molecular species from large amounts of mass spectrometric data obtained in nano-infusion or LC-MS experiments. </strong>Using the industry-leading, high-resolution, accurate-mass <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=orbitrap"><strong>Thermo Scientific Orbitrap™ technology</strong></a> with exclusive<strong> LipidSearch software</strong>, the most accurate and confident lipid profiles and identifications can be achieved more quickly than ever before.</p><ul><li><strong>Compatible with</strong> data acquired from Thermo Scientific™ triple quadrupole, ion trap, and Orbitrap mass spectrometers</li><li><strong>Largest lipid database</strong> containing <strong>&gt;1.5 million</strong> lipid ions and their predicted fragment ions</li><li><strong>Identification algorithms</strong> for product ion, precursor ion and neutral loss scans</li><li><strong>Alignment of lipid data</strong> obtained from multiple<strong> LC-MS and MS<sup>n</sup> experiments</strong></li><li><strong>Relative quantitation </strong>of identified lipid precursors in either LC-MS or infusion experiments</li></ul><p>The database contains <strong>defined structures and includes more than 1.5 million lipid ions and their predicted fragment ions. </strong>Fragmentation patterns are calculated and improved by using expert knowledge based on experimental results. Lipid adduct ions and MS<sup>n</sup> fingerprints are also included. Data are stored in XML files and are easily customized.</p><figure class="image"><img style="aspect-ratio:990/497;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Lipid_Search_Software_3_91f1458663.jpg" alt="Thermo Scientific™ LipidSearch™ Software: Lipid fragment ions related to lipid headgroup, fatty acids, and backbone." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Lipid_Search_Software_3_91f1458663.jpg 245w," sizes="100vw" width="990" height="497"></figure><h3><strong>LipidSearch software provides an easy-to-use, automated workflow</strong></h3><p><strong>From peak detection to relative quantitaiton and identification, LipidSearch software provides an easy-to-use, automated workflow.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Lipid_Search_Software_4_2043f3d667.jpg" alt="Thermo Scientific™ LipidSearch™ Software: LipidSearch software provides an easy-to-use, automated workflow." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Lipid_Search_Software_4_2043f3d667.jpg 245w," sizes="100vw" width="1122" height="530"></p><h4><strong>Step 1 Data Analysis Module — Peak Detection</strong></h4><ul><li><strong>Raw data file reading</strong></li><li><strong>Smart peak detection</strong></li></ul><p>The peak detection engine implemented in<strong> LipidSearch software </strong>can handle<strong> different MS experiments and platforms. </strong>The combination of unique peak detection algorithms, tailored for each experiment and instrument type, and mass spectral processing functions enables accurate peak detection.</p><p><strong>LipidSearch software provides two different identification algorithms as well as scoring algorithms:</strong></p><ul><li><strong>A group-specific algorithm</strong> identifies lipids based on the polar head groups or fatty acids using a combination of precursor ion scanning and neutral loss scans from lipids mixtures.</li><li><strong>The comprehensive ID algorithm</strong> is used for product ion scans and can discriminate each lipid by matching the predicted fragmentation pattern stored in the database.</li><li>LipidSearch software also provides a <strong>set of scoring algorithms</strong> to filter out lower probability results</li></ul><h4><strong>Step 2 Identification Module — Lipid Identification</strong></h4><ul><li><strong>Group-specific ID (targeted)</strong></li><li><strong>Comprehensive ID (untargeted)</strong></li><li><strong>Scoring algorithms</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Lipid_Search_Software_5_0abd534dd5.jpg" alt="Thermo Scientific™ LipidSearch™ Software: PG 17:0/17:0 Search Results." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Lipid_Search_Software_5_0abd534dd5.jpg 245w," sizes="100vw" width="1003" height="456"></p><h4><strong>Step 3 Quantitation Module — Alignment and Quantitation</strong></h4><ul><li><strong>XIC peak integration</strong></li><li><strong>Retention time alignment</strong></li><li><strong>Relative quantitation</strong></li><li><strong>Statistical analysis</strong></li></ul><p>Prior to quantitation, lipid results from each sample are aligned within a retention time window. Identified lipids are quantified by detecting their precursor ions from full-scan MS and integrating extracted ion chromatograms.</p><p>Accurate peak areas are computed by denoising and smoothing the peak profiles prior to separating any partially overlapped peaks. Comparative analysis is then carried out between the multiple sample and control groups using <strong>t-test statistics.</strong> The mean peak area result for each group is displayed in a “box and whisker” plot.</p><figure class="image"><img style="aspect-ratio:1129/909;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Lipid_Search_Software_6_196073034c.jpg" alt="Thermo Scientific™ LipidSearch™ Software: Alignment results for CoQ7, [M+NH4]+." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Lipid_Search_Software_6_196073034c.jpg 194w," sizes="100vw" width="1129" height="909"></figure><p>Using the industry-leading, high-resolution, accurate-mass <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=orbitrap"><strong>Thermo Scientific™ Orbitrap™ technology</strong></a><strong> </strong>with exclusive<strong> LipidSearch software</strong>, achieve the most accurate and confident lipid profiles and identifications more quickly than ever before. For targeted quantitation, LipidSearch software also supports the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=tsq"><strong>Thermo Scientific TSQ triple quadrupole MS systems</strong></a><strong>. </strong>For both lipidomics workflows, LipidSearch software <strong>automatically integrates complex data into a combined report to dramatically reduce data analysis.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Lipid_Search_Software_7_f6a5102f0a.jpg" alt="Thermo Scientific™ LipidSearch™ Software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Lipid_Search_Software_7_f6a5102f0a.jpg 245w," sizes="100vw" width="924" height="570"></p><h5><strong>Minimum/Recommended PC Requirements</strong></h5><ul><li><strong>OS: </strong>Microsoft® Windows® 7 Professional (x64) or Windows 8 (x64); English language<br><strong>CPU: </strong>Quad - or multi-core CPU, 2 GHz or higher<br><strong>Memory:</strong> 8 GB RAM or higher<br><strong>HDD: </strong>50 GB free space for LipidSearch software; 500 GB hard drive<br>SSD (optional): 50 GB free space for LipidSearch software; 256 GB solid-state drive</li></ul>

Thermo Scientific™ ProSightPD Software

Perform comprehensive analysis of top-down proteomics data with Thermo Scientific™ ProSightPD™ software.

<div container-id="cq-colctrl-lt8" comp-id="B1"><div><h3><strong>Confident proteoform identification and characterization</strong></h3></div></div><div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Uncover and confidently characterize proteoforms within complex matrices, including proteoforms containing truncations, alternative splices, and post-translationally modified proteins.</strong>&nbsp;</p><p>Extensive searches make use of <strong>various fragmentation methodologies (e.g., ETD, HCD, UVPD)</strong>, allowing you to make full use of the high-quality <strong>MS/MS data</strong> obtained when searching against the<strong> full biological complexity present in UniProt. </strong>With<strong> Thermo Scientific ProSightPD software, </strong>see what is really there and make the most of your data.</p><div><h3><strong>Key benefits</strong></h3><h5><strong>Sophisticated tools at your fingertips</strong></h5><p><strong>Utilize several search modes</strong> for identifying intact and truncated proteins. ProSightPD software offers the ability to search entire raw files or quickly select specific MS<sup>2</sup> scans for further searching. Information in UniProt enables the identification of modified or processed proteins.</p><h5><strong>Remove the guesswork from database management</strong></h5><p><strong>Import result files </strong>from<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1782"><strong> Proteome Discoverer</strong></a><strong> software</strong> or entire proteomes via UniProt formatted XML and FASTA files with Database Manager. Fully customize imported databases using thr<strong> ProSight Annotator GUI </strong>to characterize PTMs, disulfide bonds, mutations and truncations.</p><h5><strong>Intuitive user interface</strong></h5><p><strong>Analyze large datasets</strong> with many data files using <strong>ProSightPD nodes for </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1782"><strong>Proteome Discoverer</strong></a><strong> software. </strong>Create multi-step searches and utilize built in results interpretation tools.</p><h3><strong>Search Types</strong></h3><div><p><strong>Different database search modes</strong> allow you to optimize data interrogation based upon your experimental needs. Searches are driven through the use of a node-based system allowing flexibility of experimental design.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Pro_Sight_PD_Software_8a96430534.jpeg" alt="Thermo Scientific™ ProSightPD Software: ProSightPD Database Searching." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Pro_Sight_PD_Software_8a96430534.jpeg 245w," sizes="100vw" width="960" height="540"></p><div><p>Further information relating to the two search modes, Absolute Mass Search and Biomarker Search.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Pro_Sight_PD_Software_2_01f6c31076.jpeg" alt="Thermo Scientific™ ProSightPD Software: Complementary Search Types: Digging Deeper in Complex Samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Pro_Sight_PD_Software_2_01f6c31076.jpeg 245w," sizes="100vw" width="960" height="540"></p><h3><strong>Database Management</strong></h3><div><p><strong>Confident proteoform identification </strong>is realized through the use of XML-formatted databases, ensuring that nothing is missed.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Pro_Sight_PD_Software_3_db19f0cee9.jpeg" alt="Thermo Scientific™ ProSightPD Software: Database Manager: Add remove isoforms and PTMs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Pro_Sight_PD_Software_3_db19f0cee9.jpeg 245w," sizes="100vw" width="960" height="540"></p><div><p><strong>Improvements to data visualization</strong> ensure that you can better interact with and interpret your data, minimizing the time taken to deliver actionable results.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Pro_Sight_PD_Software_4_575aa9dff5.jpeg" alt="Thermo Scientific™ ProSightPD Software: LFQ Visualizations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Pro_Sight_PD_Software_4_575aa9dff5.jpeg 245w," sizes="100vw" width="960" height="540"></p><h3><strong>ProSightPD nodes</strong></h3><p><strong>Top-Down Workflows:</strong> ProSightPD&nbsp;includes templates to easily build the most commonly used-top down data analysis workflows.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Pro_Sight_PD_Software_5_4f28a7434d.jpg" alt="Thermo Scientific™ ProSightPD Software: ProSightPD 2.0: Tailored Workflows for All Types of Data." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Pro_Sight_PD_Software_5_4f28a7434d.jpg 245w," sizes="100vw" width="740" height="400"></p></div></div></div></div></div></div></div>

Thermo Scientific™ Mass Frontier™ Spectral Interpretation Software

Transform your mass spectral data into knowledge quickly and easily using Thermo Scientific™ Mass Frontier™ spectral interpretation software. 

<p><strong>Transform your mass spectral data into knowledge quickly and easily using Thermo Scientific™ Mass Frontier™ spectral interpretation software. Take the challenge out of small molecule structural elucidation for metabolism, metabolomics, forensics, natural products, impurities, and degradants studies.</strong></p><p><strong>High-quality, curated experimental spectral and fragmentation libraries</strong> simplify the deconvolution, evaluation, interpretation and management of infusion, and LC, nominal mass, or high resolution mass spectral data. Streamline building and curating your library and sharing it with your colleagues and collaborators. <strong>Mass Frontier software complements Thermo Scientific™ </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Compound Discoverer™</strong></a><strong> software</strong> for routine-based small molecule discovery and identification.</p><h3><strong>See what's really there</strong></h3><ul><li>Deconvolute your nominal mass or high resolution LC-MS<sup>n</sup> or infusion data.</li><li>Capture all of your data, no matter how complex, with simple interrogation of all components.</li></ul><h3><strong>Know more unknowns</strong></h3><ul><li><strong>Transform </strong>your small molecule unknown data into actionable knowledge.</li><li><strong>Search </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong>mzCloud™</strong></a><strong> mass spectral library</strong>, the world's most comprehensive and structurally diverse fully curated mass spectral database.</li><li><strong>Maximize the utility of your MS<sup>n</sup> data</strong> for the confident identification of unknown with spectral tree searching.</li><li><strong>Enhance your confidence</strong> in proposed unknown candidate structures by using <strong>Thermo Scientific™ </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1762"><strong>mzLogic™</strong></a><strong> algorithm</strong>, based on similarity searching to millions of fragment annotated spectra.</li></ul><figure class="image"><img style="aspect-ratio:740/405;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_3_167df5dc63.jpg" alt="Thermo Scientific™ Mass Frontier™ Spectral Interpretation Software: mzCloud mass spectral library." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_3_167df5dc63.jpg 245w," sizes="100vw" width="740" height="405"></figure><h3><strong>Go from spectra to structure</strong></h3><ul><li>The HighChem Fragmentation Library™ includes <strong>&gt;54,000 fragmentation schemes, ∼ 220,000 individual reactions, and 256,000 chemical structures</strong>, all from peer-reviewed literature.</li><li>Spectral trees are fully annotated with fragmentation structures.</li><li><strong>FISh (fragment ion search) detection</strong> enables detection of structurally related compounds, indicating the site of transformations for drug metabolites.</li></ul><figure class="image"><img style="aspect-ratio:740/350;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_2_37f024ef32.jpg" alt="Thermo Scientific™ Mass Frontier™ Spectral Interpretation Software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_2_37f024ef32.jpg 245w," sizes="100vw" width="740" height="350"></figure><h3><strong>Build your pathways</strong></h3><ul><li>Interactively search more than <strong>370 curated</strong> <strong>biochemical pathways</strong> with<strong> Thermo Scientific™ Metabolika™</strong> pathway mapping.</li><li>Create and understand fragmentation pathways and mechanisms using advanced fragmentation scheme knowledge base drawn from more than 99% of published fragmentation pathways.</li></ul><figure class="image"><img style="aspect-ratio:740/410;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_4_7d1b4f8671.jpg" alt="Thermo Scientific™ Mass Frontier™ Spectral Interpretation Software: An example of an included Metabolika biological pathway, which can be fully edited and added to." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_4_7d1b4f8671.jpg 245w," sizes="100vw" width="740" height="410"></figure><h3><strong>Store, share and utilize your knowledge</strong></h3><ul><li><strong>Translate your data into actionable knowledge:</strong> create, curate and store your own spectral libraries and pathways.</li><li><strong>Ensure the highest quality proprietary libraries</strong> with full curation and mass recalibration tools.</li></ul><figure class="image"><img style="aspect-ratio:740/345;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_5_e89924a0b7.jpg" alt="Thermo Scientific™ Mass Frontier™ Spectral Interpretation Software: The new curator module automates spectral tree curation, fragment annotation and mass recalibration for your proprietary compounds to build a high quality curated local MSn library." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Mass_Frontier_Spectral_Interpretation_Software_5_e89924a0b7.jpg 245w," sizes="100vw" width="740" height="345"></figure>

Thermo Scientific Xcalibur Software

Confidently control, acquire, and interrogate data from a range of Thermo Scientific LC-MS systems and related instruments using Thermo Scientific Xcalibur software.

<div container-id="cq-colctrl-lt8" comp-id="B1"><div><h3><strong>Acquire high-quality data, regardless of your mass spectrometry platform</strong></h3></div></div><div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Confidently control, acquire, and interrogate data from a range of Thermo Scientific LC-MS systems and related instruments using Thermo Scientific Xcalibur software.</strong></p><p>With simple method set-up, data acquisition, in-depth data interrogation and reporting tools as well as seamless integration to a range of additional Thermo Scientific application-specific software and cloud-based tools, Xcalibur software serves as the powerful, yet easy-to-use platform for your LC-MS analyses.</p><div><h3><strong>Key benefits of Xcalibur data acquisition software</strong></h3><h5><strong>Comprehensive toolset and landing page for all your installed applications</strong></h5><p>With a homepage that conveniently hosts all your installed applications and provides easy access to instrument control, method development, data acquisition, and reviewing, Xcalibur software makes it quick and easy to navigate through your workflows.</p><h5><strong>Ad-hoc data reviewing and quantitative capabilities</strong></h5><p>When you need to interrogate your data—from elemental compositions, plotting chromatograms, spectral views, performing library searches and much more—or perform basic quantitation, the <strong>FreeStyle and Quan Browser applications included with the Xcalibur software</strong> allow you to gain insights into your data.</p><h5><strong>Integration with cloud-based tools for productivity</strong></h5><p>The landing page for the Xcalibur software not only serves as the configurable portal to your applications, you can also receive application update information, ensuring that you have the latest version of software. Additionally, cloud-based applications allow you to remotely monitor your systems and drive productivity.</p><h3><strong>About Xcalibur data acquisition software</strong></h3><div><p>The <strong>customizable landing page (or Roadmap View) </strong>enables easy access to all your installed applications, from those included with Xcalibur software to your application-specific software packages.</p><p>Not only can you receive notification when there is a new version of any installed application, you can also access the <a target="_blank" rel="noopener noreferrer" href="https://thermo.flexnetoperations.com/control/thmo/login" aria-label="XApp Store - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://thermo.flexnetoperations.com/control/thmo/login$xappstore"><strong>XApp Store</strong></a> for more information on the latest applications and try many of them for free for 60 days.</p><p>A host of<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong> cloud-based applications </strong></a>are available from the Roadmap View, including <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/xcalibur-data-acquisition-interpretation-software.html?open=almanac#almanac"><strong>Almanac</strong></a>, which allows for web- or smartphone-based monitoring of your MS.</p><figure class="image"><img style="aspect-ratio:740/400;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_35361ffe4b.jpg" alt="Thermo Scientific™ Xcalibur™ Software: The customizable landing page (or Roadmap View)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_35361ffe4b.jpg 245w," sizes="100vw" width="740" height="400"></figure><div><p>Regardless of the experimental design, it should be easy to set-up your mass spectrometer to acquire high-quality data. <strong>The Method Editor allows you to quickly and simply create acquisition methods</strong> that control the necessary parameters and drive your acquisition requirements.</p><p>For the <strong>latest generation of mass spectrometers,</strong> there are numerous <strong>pre-configured method templates </strong>arranged by application area. These methods allow users of any experience level to acquire data relevant to their questions. Alternatively, the templates can be used as a starting point to facilitate rapid method development. Each method covers all instrument parameters as well as those for data acquisition, reducing complexity of set up.</p><figure class="image"><img style="aspect-ratio:740/410;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_2_baa5610a5d.jpg" alt="Thermo Scientific™ Xcalibur™ Software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_2_baa5610a5d.jpg 245w," sizes="100vw" width="740" height="410"></figure><div><p>Modern visualization tools allow you to rapidly answer questions as you qualitatively interrogate your data.</p><p>The <strong>FreeStyle application,</strong> <strong>provided with the Xcalibur software</strong>, allows you to interact with your data from simple chromatographic detection and integration to spectral library searching, spectral deconvolution or diagnostic plots.</p><figure class="image"><img style="aspect-ratio:740/400;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_3_221d41f756.jpg" alt="Thermo Scientific™ Xcalibur™ Software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_3_221d41f756.jpg 245w," sizes="100vw" width="740" height="400"></figure><div><p><strong>For rapid quantitation of a small number of targets, </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/xcalibur-data-acquisition-interpretation-software.html?open=quan#quan"><strong>Quan Browser</strong></a><strong>, included with the Xcalibur software, </strong>allows you to quickly identify component peaks, determine integration criteria, and visualize calibration curves, integrations, and results.</p><p><strong>Xcalibur software allows you to interactively edit </strong>processing parameters, report data and rapidly access your quantitative information while processing your quantitation sequences.</p><figure class="image"><img style="aspect-ratio:740/410;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_4_40201472f4.jpg" alt="Thermo Scientific™ Xcalibur™ Software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_4_40201472f4.jpg 245w," sizes="100vw" width="740" height="410"></figure><h3><strong>FreeStyle data review application for Xcalibur software</strong></h3><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><p><strong>For the qualitative analysis of any mass spectral data (.raw or .sld) in a highly visual environment, FreeStyle allows you to display chromatograms and spectra, detect and integrate chromatographic peaks, search mass spectral libraries, simulate mass spectra, subtract background spectra, apply scan filters, annotate plots with text and graphics, create and save layouts, and view the status of various instrument parameters during data acquisition.</strong></p></div></div></div></div><figure class="image"><img style="aspect-ratio:800/195;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_5_6a0f093b2f.jpg" alt="Thermo Scientific™ Xcalibur™ Software: FreeStyle data review application for Xcalibur software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_5_6a0f093b2f.jpg 245w," sizes="100vw" width="800" height="195"></figure><div><p>With a familiar interface, the tools needed to access the information stored in your data are readily accessible. <strong>HRAM</strong> data intelligence means that <strong>data is displayed according to the mass accuracy of the MS system used to acquire it.</strong></p><p><strong>When it comes to visualizing your data, </strong>make use of unlimited plots, quick creation of plots from spectra, spectral annotation with structures, text and graphics, trending/diagnostic plots for status parameters, and scan header entries; float/dock/hide multiple windows and split across monitors to really get the most out of your data.</p><figure class="image"><img style="aspect-ratio:740/400;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_6_e6a704b2dc.jpg" alt="Thermo Scientific™ Xcalibur™ Software: FreeStyle data review application for Xcalibur software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_6_e6a704b2dc.jpg 245w," sizes="100vw" width="740" height="400"></figure><p><strong>Create and customize highly visual map views of complex datasets</strong>, with simple modification of any plots and data views. Then use those views to generate your own visual reports, enhancing your insights.</p><figure class="image"><img style="aspect-ratio:740/420;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_7_1ac807c5fa.jpg" alt="Thermo Scientific™ Xcalibur™ Software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_7_1ac807c5fa.jpg 245w," sizes="100vw" width="740" height="420"></figure><p><strong>High-resolution protein mass spectral data </strong>can be deconvoluted using <strong>the Xtract deconvolution algorithm</strong>, contained in the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837"><strong>Thermo Scientific BioPharma Finder</strong></a><strong> software</strong> to obtain the intact mass and a single, deconvoluted mass spectrum for the protein components within the charge state envelope.</p><figure class="image"><img style="aspect-ratio:740/420;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_8_c6820a5e8c.jpg" alt="Thermo Scientific™ Xcalibur™ Software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_8_c6820a5e8c.jpg 245w," sizes="100vw" width="740" height="420"></figure><div><p>Discovering what is in your data doesn’t need to be challenging. The ability to search the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong>mzCloud</strong></a><strong> mass spectral library,</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1760"><strong>mzVault</strong></a>,<strong> or NIST </strong>with a single-click means that compound identification from MS and MS<sup>2</sup> data is quick and easy. You can also export spectral data to the NIST application.</p><p>Elemental compositions can be calculated using MS and MS<sup>2</sup> data, with isotopic simulations for added confidence.</p></div><div><h3><strong>Quan Browser application for Xcalibur software</strong></h3><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><p><strong>When you require a quick answer, the Quan Browser, included in the Xcalibur software, allows you to determine the concentration of analytes within your sample set when there is a small number of targets.</strong></p><figure class="image"><img style="aspect-ratio:800/195;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_9_781c806926.jpg" alt="Thermo Scientific™ Xcalibur™ Software: Quan Browser application for Xcalibur software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_9_781c806926.jpg 245w," sizes="100vw" width="800" height="195"></figure><p>You can <strong>review or rework </strong>your component peak identifications and integration criteria, calibration curves for your quantitation standards, your standards, QC samples, blanks and unknowns with interactive editing of processing parameters.</p><figure class="image"><img style="aspect-ratio:740/385;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Xcalibur_Software_10_55b04eedae.jpg" alt="Thermo Scientific™ Xcalibur™ Software: Quan Browser application for Xcalibur software." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Xcalibur_Software_10_55b04eedae.jpg 245w," sizes="100vw" width="740" height="385"></figure><p><strong>The Quan Browser, included in the Xcalibur software,</strong> incorporates a results view where you can observe the data used to create calibration curves and peak integrations. Quantitation sequences, including bracketed sequences, can be processed, and any processing parameters interactively edited with the results are dynamically updated.</p><p>For <strong>larger quantitative studies</strong> we recommend either<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>Thermo Scientific TraceFinder software</strong></a><strong> </strong>for high-throughput analyses, or <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon Chromatography Data System (CDS) software</strong></a> for regulated studies, such as regulated bioanalysis, which require tools for compliance.</p></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific Compound Discoverer software

Compound Discoverer software addresses small molecule identification needs and workflows including untargeted metabolomics, drug metabolism, impurity, E&L, environmental, food & beverage, and forensic research.

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