Ion-pairing HILIC improves impurity profiling of therapeutic oligonucleotides. It resolves deaminated impurities from full-length products, beyond current LC-MS limits.

Cows fed multispecies swards produced milk with more polyunsaturated and bioactive fatty acids than ryegrass systems, suggesting benefits for milk quality and consumer health.

A novel AF4-MALS and Py-GC-MS workflow enables size-resolved polymer analysis of nanoplastics in wastewater. It improves detection, quantification, and offers insights into polymer composition.

Using UPLC-HRMS and SIMCA, 159 NPS standards were analyzed to build classification models. The approach showed strong validation and accurate identification of seized samples, aiding forensic drug analysis.

Using low-cost REIMS with a 450 nm laser, researchers detected pathogen-specific biomarkers in tomato plants, distinguishing infections from Meloidogyne incognita and Pseudomonas syringae.

A ZenoTOF 7600 modified for CID, EAD, and UVPD allowed LC–MS screening of pesticides in juices and wines. About 30 were detected at pg–ng/mL levels, confirmed by multiple dissociation methods.

Flow-injection ion mobility MS enables rapid multi-omics profiling of bacterial pathogens. It matches LC-IM-MS performance, cuts analysis time from 17 to 2 min.

A UHPLC-MS/MS assay using surrogate calibration and DMIS derivatization quantifies endogenous steroids and contraceptives in plasma with pg/mL sensitivity and regulatory-aligned validation.

A novel ion-repulsion strategy allows rapid ICPMS/MS detection of hydrophobic sulfonylureas with minimal organic solvent, achieving high sensitivity and bypassing the need for organic ICPMS mode.

A new dried plasma microsampling device enables home sampling with high precision and stability, correlating strongly (R > 0.99) with conventional plasma in targeted proteomic analysis.