<p><strong>Derivatizing amino acids doesn’t have to take hours to do. A more hands-off solution can save your lab hours of prep work. And help you trust your data even more.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_f41f58db04.jpeg" alt="Thermo Fisher Scientific: How to Cut HPLC Sample Preparation Time for Derivatizing Amino Acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_f41f58db04.jpeg 245w," sizes="100vw" width="1024" height="512"></p><p><strong>Ever wonder what makes a simple molecule like valine so complicated to measure?</strong></p><p>Amino acids—the building blocks of proteins—are everywhere. In your food. Body. And even the fertilizers that help grow our food. But measuring these compounds precisely? That’s a classic analytical headache, even for an experienced chromatographer.</p><p>Ask any lab scientist who’s done amino acid analysis, and they’ll tell you the chromatographic separation isn’t the hard part. The challenge is sample preparation, or everything before the chromatography. Handling toxic reagents. The repeated pipetting. And then timing the derivatization reactions just right.</p><p>All these manual steps can contribute to lower method precision and data reproducibility.</p><p>So, what’s the solution? Using a more hands-off approach. You get the same trusted chemical reaction, but your method is now faster, cleaner, and more reliable.</p><p>Let’s walk through a real-life example of how your lab can derivatize amino acids directly inside the HPLC autosampler needle.</p><h3><strong>Key takeaways</strong></h3><div><ul><li>Manual derivatization of amino acids is laborious, error-prone, and handling toxic chemicals can pose health hazards to lab staff.</li><li>Automated in-needle OPA/FMOC derivatization of amino acids is a time- and labor-saving approach for HPLC-FLD analysis.</li><li>Reliable method performance, column stability over several hundred injections, and using inexpensive reagents facilitates high sample throughput at low costs per sample for routine laboratories.</li><li>Sample matrices of medium and high complexity (beverages, food, fertilizers) using in-needle derivatization is robust and reproducible.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_2_a906250f79.jpeg" alt="Thermo Fisher Scientific: How to Cut HPLC Sample Preparation Time for Derivatizing Amino Acids: Illustration showing manual derivatization versus in-needle derivatization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_2_a906250f79.jpeg 245w," sizes="100vw" width="700" height="410"></p><h3><strong>Why does the derivatisation of amino acids still matter when aerosol detectors are an option? The unmatched sensitivity of fluorescence detection compared to evaporative technology.</strong></h3><p>Most amino acids don’t have double bonds that naturally absorb UV light, meaning your HPLC detector can’t “see” the compounds directly.</p><p>To solve these visibility issues, chemists use derivatization. The conjugation reaction is brilliant chemistry, facilitating the formation of <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/chromatography-learning-center/liquid-chromatography-information/hplc-system-components/how-hplc-detectors-work.html"><strong>fluorescent derivatives</strong></a> suitable for sensitive and precise analysis.</p><p>This technique involves reacting amino acids in the solution for analysis with reagents that make the amino acids fluorescent. The most common pair are OPA (ortho-phthaldialdehyde) for primary amino acids and FMOC-Cl (9-fluorenylmethyloxycarbonyl chloride) for secondary ones.</p><p>Now here’s what can go wrong. You measure reagents, mix samples by hand, wait for the reaction, then inject onto your HPLC instrument. Small inconsistencies, such as a few seconds too long or a reagent variation, can mean BIG differences in peak response, method accuracy, and data reproducibility. Removing these inconsistencies is where automated in-needle derivatization comes in.</p><h3><strong>Let your HPLC autosampler needle handle the not-so-friendly laborious tasks</strong></h3><p>Switching from manual to automated in-needle derivatization can help make this labor-intensive process easier for everyone in your lab, while improving data consistency and overall lab safety. &nbsp;</p><p>Here’s how:</p><div><div><ul><li>Instead of manually preparing reaction mixtures, you can use a compatible instrument, like<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;manufacturerItems=3&amp;search=vanquish"><strong> Thermo Scientific Vanquish LC Systems</strong></a>, to perform in-needle derivatization.</li><li>And, with the helpful guidance of supporting software, you can automatically mix samples and reagents in the needle, time the reaction more precisely, and inject the derivatized sample onto the column.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_3_5c636b1584.jpeg" alt="Thermo Fisher Scientific: How to Cut HPLC Sample Preparation Time for Derivatizing Amino Acids: In-needle derivatization of primary and secondary AAs with OPA/MPA and FMOC-Cl reagents for subsequent LC analysis of the fluorescent derivatives. *Borate buffer pH 10, **acetic acid for quenching." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_3_5c636b1584.jpeg 245w," sizes="100vw" width="768" height="384"></p><h3><strong>A real-life example showcasing better efficiency, robustness, and throughput capabilities.</strong></h3><p>What makes this automated workflow stand out isn’t a new reaction—but rather a faster way of working with your HPLC instrument.</p><p>The reactions between OPA/MPA and FMOC-Cl still happen as before, but now the reaction is controlled digitally through <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cn_003698_hplc_vanquish_workflow_amino_acid_analysis_derivatization_cn003698_na_en_e76e3abe44.pdf"><strong>Thermo Scientific Chromeleon Chromatography Data System</strong></a> (CDS).</p><p>As demonstrated in our whitepaper, each reagent draw, mix, and injection step is defined in a Custom Injection Program (CIP), eliminating timing errors and variability. <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS</strong></a> visualizes every step in its Instrument Method Editor, tracks parameters in real time, and logs events in the Audit Trail for compliance.</p><p>And since the workflow design has flexibility in mind, you can use Chromeleon CDS or a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ab_004093_hplc_vanquish_core_amino_acids_needle_derivatization_ab004093_na_en_edb37df857.pdf"><strong>third-party software</strong></a>, with identical parameters, which gives your labs the freedom to work within your preferred environment without retraining staff or rewriting SOPs.</p><h3><strong>Trusting your data and a faster derivatization technique. That’s the science behind putting your sample preparation inside the needle.</strong></h3><p>The most beneficial part of this workflow is the hours of time your lab and broader QC team will save.</p><ul><li>Consistent fluorescence response and accurate quantitation for all amino acids</li><li>Excellent injection-to-injection reproducibility, even across reagent batches</li><li>Improved safety through reduced manual solvent handling</li><li>Less hands-on time, freeing analysts for higher-value work</li><li>Seamless CDS integration for full audit traceability</li></ul><p>So next time you’re pipetting derivatization reagents by hand, secretly wishing there was a better way, why not consider an automated method approach?</p><p>You get the same chemistry, performed automatically inside the autosampler, hands-free, ready to inject in minutes with reproducible data that you can trust.</p><p>Learn more about this new automated amino acid analytical workflow in our <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cn_003698_hplc_vanquish_workflow_amino_acid_analysis_derivatization_cn003698_na_en_e76e3abe44.pdf"><strong>customer application note today</strong></a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_4_341aed0b3a.jpeg" alt="Thermo Fisher Scientific: How to Cut HPLC Sample Preparation Time for Derivatizing Amino Acids: Chromatographic results of calibration standard (50 µM) measured with the Vanquish Core HPLC system, comparing method performance on 1st and 14th day of measurements." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_to_Cut_HPLC_Sample_Preparation_Time_for_Derivatizing_Amino_Acids_4_341aed0b3a.jpeg 245w," sizes="100vw" width="768" height="384"></p><h3><strong>Helpful tips to improve method robustness with Vanquish LC Systems+ Chromeleon CDS</strong></h3><ol><li>Use a 100 µL sample loop for thorough and reproducible mixing of the sample and reagents during the derivatization step.</li><li>Install a passive pre-heater to facilitate proper dilution of the reagents before the column.</li><li>Use guard cartridges for your columns and replace the cartridges when column performance diminishes. Apply smart tools like intelligent run control in Chromeleon CDS for automated checks.</li><li>Replace derivatization reagents in your autosampler daily.</li><li>Periodically flush your column with 100% acetonitrile for 30 minutes to remove persistent reaction products and matrices.</li></ol><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#AutomatedSamplePreparation #HPLC</p></blockquote></div></div></div>

How to Cut HPLC Sample Preparation Time for Derivatizing Amino Acids

<h3><strong>How long does it actually take to install all the capillaries and fittings on a conventional HPLC system?</strong></h3><h4><strong>The Small Components That Matter Most</strong></h4><p>When people think about HPLC systems, they often focus on pumps, detectors, columns, or software. Capillaries and fittings are usually seen as minor components because they are relatively inexpensive and physically small. However, every chromatographer eventually discovers that these tiny parts can have a major influence on system performance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Connecting_a_U_HPLC_system_can_be_difficult_at_some_poorly_accessible_locations_3b837b441b.webp" alt="KNAUER: Connecting a (U)HPLC system can be difficult at some poorly accessible locations" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Connecting_a_U_HPLC_system_can_be_difficult_at_some_poorly_accessible_locations_3b837b441b.webp 208w," sizes="100vw" width="720" height="540"></p><p>Even decades ago, chromatographers recognized the importance of proper connections. In the 1980s, long before UHPLC became common, John Dolan wrote about minimizing dead volume through correct fitting installation. Today, with UHPLC systems operating at extremely high pressures and using columns with very small particle sizes, dead volume is even less tolerable than before. The topic remains just as relevant today as it was back then.</p><p>Interestingly, despite what many users assume, the chromatographic column itself is often not the primary source of HPLC or UHPLC problems. In my experience, poor connections are far more commonly responsible for issues such as peak broadening, leaks, or loss of efficiency.</p><h4><strong>The Early Days of HPLC Capillaries</strong></h4><p>Anyone who has been working with HPLC for many years will probably remember the era of rigid <strong>1/16" stainless steel tubing</strong>. Whenever PEEK tubing was unsuitable, stainless steel capillaries were the standard choice.</p><p>Setting up a system back then was far from convenient. You first had to locate an appropriate length of tubing somewhere in a drawer full of capillaries. Usually, this meant finding a several-meter-long piece and cutting it yourself using a dedicated capillary cutter. After cutting, you needed to ensure the tubing end was smooth and undamaged, hoping that the previous person using the cutter had not accidentally crushed the inner diameter.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Standard_1_16_Capillary_and_needed_tools_and_the_drawer_we_all_know_pretty_well_943d7ed0b2.jpg" alt="KNAUER: Standard 1/16” Capillary and needed tools and the drawer we all know pretty well" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Standard_1_16_Capillary_and_needed_tools_and_the_drawer_we_all_know_pretty_well_943d7ed0b2.jpg 245w," sizes="100vw" width="1277" height="456"></p><p>Once cut, the tubing often required additional preparation. You might need to deburr the capillary using a grater, shape it carefully with bending tools, and then finally install it using separate fittings and ferrules. And of course, everyone remembers the frustration of dropping a ferrule onto the laboratory floor, where it effectively disappeared forever.</p><p>At the same time, laboratories often accumulated drawers filled with pre-assembled capillaries that had fixed fittings attached. Reusing these assemblies was risky. If the fitting geometry did not perfectly match the receiving port, users could unintentionally introduce dead volume into the system. The result was often degraded chromatographic performance, broad peaks, and frustrating troubleshooting sessions involving the entire laboratory team. In worse cases, excessive force could damage threads or receiving ports while attempting to stop leaks.</p><p>During that period, assembling and connecting a complete HPLC system could easily consume half a day of work.</p><h4><strong>The Improvement: Flexible and Pre-Cut Capillaries</strong></h4><p>Later, laboratories gradually adopted pre-cut tubing and flexible capillaries, which represented a significant improvement over manually preparing stainless steel tubing.</p><p>With these newer capillaries, users simply selected the correct length and installed the tubing directly. Flexible capillaries adapted naturally to the required shape, eliminating much of the manual bending and shaping work. Installation became faster, easier, and far less stressful.</p><p>Still, these systems had limitations. Although the capillary itself improved, the fitting technology remained largely unchanged. Many of these capillaries were still effectively single-use components. If a connection was installed incorrectly because the tubing was not fully inserted into the receiving port before tightening, the result was often another unusable capillary destined for the growing “capillary drawer.” Sustainability was certainly not a strong point of these systems.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_A_typical_capillary_drawer_It_was_tricky_to_open_and_close_it_sometimes_530dd2087c.webp" alt="KNAUER: A typical capillary drawer. It was tricky to open and close it sometimes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_A_typical_capillary_drawer_It_was_tricky_to_open_and_close_it_sometimes_530dd2087c.webp 208w," sizes="100vw" width="1024" height="768"></p><p>Even with these advancements, system setup still required considerable time and effort.</p><h4><strong>The Real Breakthrough: Modern Tool-Free Connection Systems</strong></h4><p>A major breakthrough finally arrived when manufacturers introduced a completely redesigned fitting and capillary concept aimed specifically at simplifying UHPLC connections.</p><p>These newer systems came with fittings pre-installed directly on the capillary. Unlike traditional ferrule-based systems, the fittings automatically adjusted to different port depths and sealed directly at the bottom of the port. This dramatically reduced the amount of torque required and eliminated the need for complicated installation techniques.</p><p>Perhaps the biggest advantage was convenience. These capillaries could be connected and disconnected more than 100 times without tools, while remaining entirely finger-tight. And best of all, ferrules no longer disappeared onto the laboratory floor.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_The_little_things_that_do_the_click_3a0469d516.jpg" alt="KNAUER: The little things that do the “click”" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_The_little_things_that_do_the_click_3a0469d516.jpg 245w," sizes="100vw" width="1866" height="1022"></p><p>The system I currently use includes an especially useful feature: a patented torque-limiting mechanism that prevents both under-tightening and over-tightening. Once the correct torque is reached, the fitting produces a tactile “<strong>click</strong>,” providing immediate feedback that the connection is secure and properly installed every time.</p><h4><strong>From Half a Day to Fifteen Minutes</strong></h4><p>Thanks to these modern connection systems and pre-configured startup kits, installing an HPLC or UHPLC system today is dramatically faster than it used to be.</p><p>What once consumed hours of work can now be completed in less than 15 minutes. The improvements in usability, reproducibility, and sustainability over recent years have been remarkable.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_e62b80154b.webp" alt="KNAUER: Trouble-free connection systom for HPLC and UHPLC" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_e62b80154b.webp 221w," sizes="100vw" width="690" height="487"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_2_71c24acdf5.webp" alt="KNAUER: Trouble-free connection systom for HPLC and UHPLC" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Trouble_free_connection_systom_for_HPLC_and_UHPLC_2_71c24acdf5.webp 224w," sizes="100vw" width="1920" height="1339"></p><p>And while today’s solutions already represent a huge leap forward, the evolution of HPLC connection technology is certainly not over yet. Looking ahead, it will be exciting to see how future innovations continue to simplify chromatography workflows even further.</p><blockquote><p>If you want to learn more about KNAUER´s capillaries, fittings and (U)HPLC system start-up kits and are interested in details and numbers, I highly recommend our brand <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/r75ev6rjivdbid246k60zrs3gjpvwdi5b8em_fad0f92fd9.pdf"><strong>new tech note "Benefits of KNAUER´s trouble-free analytical capillaries in terms of HPLC and UHPLC system performance</strong></a><strong>"</strong> and a visit to our <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2402"><strong>products online</strong></a>.</p></blockquote>

Let´s Connect a whole (U)HPLC system without tools and trouble

News from LabRulezLCMS Library - Week 21, 2026

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A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

KNAUER AZURA 1240 bar UHPLC System

High-end solution for most challenging tasks. Ideally suited for quality control tasks with high sample throughput.

<p><strong>High-end solution for most challenging tasks.&nbsp;Ideally suited for quality control tasks with high sample throughput. This solution is recommended whenever lowest detection limits, highest analysis speed and resolution or most accurate flow delivery is needed.</strong></p><div><div><ul><li>Developed with innovative technology and decades of continuous improvements <strong>the AZURA®&nbsp;UHPLC 1240 bar systems enter&nbsp;a new level of performance and durability</strong></li><li><strong>Covers ultra high pressure applications</strong> due&nbsp;to&nbsp;working conditions in the range of&nbsp;<strong>0.1–5.0&nbsp;ml/min at up to 1240&nbsp;bar&nbsp;</strong></li><li>This system is made for&nbsp;high resolution <strong>UHPLC columns packed with smallest particles &lt; 2 µm</strong> or <strong>core shell materials</strong>, while any other HPLC or UHPLC column can also be used&nbsp;</li><li><strong>Perfect partner for MS/MS coupling</strong> due to very precise and accurate delivery also in the low flow rate range</li><li>Typical applications include food, pharmaceutical and environmental analyses with high throughput</li></ul></div></div><div><div><p>Choose this system whenever highest performance and speed is needed!</p><p><strong>If your applications do not require such a high back pressure and resolution, then you should take a look at the KNAUER AZURA HPLC systems. These can be operated at up to 862 bar.</strong></p></div></div><h3><strong>Specifications</strong></h3><ul><li><strong>Back pressure range:</strong> 1240 bar max.</li><li><strong>Flow rate range:</strong> 0.001–5 ml/min</li><li><strong>Available pump systems:</strong> Binary HPG</li><li><strong>Special pump features:</strong> Active pulsation compensation, RFID for automatic pump head detection, Integrated pressure sensor, Leak management, Piston seal wash, Purge valve (automatic)</li><li><strong>Injection options:</strong> Autosampler, Liquid handler</li><li><strong>Injection volume range:</strong> 0.1 µl–5000 µl depending on sample loop</li><li><strong>Sample capacity:</strong> 108 standard HPLC vials (1.5 ml) or up to 768 positions when equipped with microtiter plates, with liquid handler up to 390 HPLC vials</li><li><strong>Column thermostatting range: </strong>5–85 °C</li><li><strong>Eluent preheating:</strong> Optional cartridge for eluent pre-heating</li><li><strong>Column switching options:</strong> Optional switching between up to 8 columns</li><li><strong>Choice of detectors:</strong> DAD 190–700 nm, DAD 190–1000 nm, RID, UVD, MWD, FLD, ELSD, MS</li><li><strong>Choice of software packages:</strong> ClarityChrom® CDS, OpenLAB® CDS EZChrom Edition, Mobile Control, Chromeleon™ 7.2</li></ul><h3><strong>System components</strong></h3><div><div><p>An AZURA UHPLC system adapts to your application requirements. The highly modular system design allows you to choose the best suited components for your specific task.</p></div></div><h4><strong>Eluent delivery</strong></h4><h5><strong>Binary high-pressure gradient (HPG) pump system</strong></h5><p>The new <strong>AZURA®&nbsp;P 8.1L UHPLC pump</strong> is specially designed for ultra-fast and high-resolution applications.&nbsp;It features a 2-channel internal degassing unit, a 2x2 channel solvent selection valve, and a low dwell-volume eluent mixer.</p><p>The adaptive pulsation compensation of the pump is independent of flow rate, backpressure, and eluent type through real-time eluent compressibility monitoring and variable piston stroke. Together with the ultra-precise piston movement thanks to KNAUER’s proprietary advanced piston drive technology, this results in outstanding flow reproducibility at any working conditions.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_Binary_high_pressure_gradient_HPG_pump_system_b94a8018c7.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - Binary high-pressure gradient (HPG) pump system" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_Binary_high_pressure_gradient_HPG_pump_system_b94a8018c7.jpg 245w," sizes="100vw" width="1280" height="550"></p><h4><strong>Sample Injection</strong></h4><h5><strong>Autosampler 1240 bar</strong></h5><p>The&nbsp;<strong>autosampler AZURA AS 6.1L 1240&nbsp;bar</strong> can inject from up to 768 positions when equipped with microtiter plates or from up to 108 standard 2 ml sample vials. It&nbsp;is equipped with an ILD<sup>TM</sup> valve, consisting of a rotor-stator combination with a central port for depressurizing the sample loop before receiving the sample. This way, the sample is not diluted with solvent. A Cooling/heating option (4–40 °C) is optionally available.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_autosampler_AZURA_AS_6_1_L_1240_bar_ff1ac03e70.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - autosampler AZURA AS 6.1L 1240&nbsp;bar" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_autosampler_AZURA_AS_6_1_L_1240_bar_ff1ac03e70.jpg 245w," sizes="100vw" width="1280" height="780"></p><h5><strong>Liquid handler&nbsp;</strong></h5><p>The <strong>Liquid handler LH 8.1 </strong>offers automatic sample preparation to speed up your workflow. No sample loss and high precision injection of small and large sample volumes are provided. High-throughput with up to 4 robotic coolers with&nbsp;max. of 24 racks for up to 390 HPLC vials or well plates. Washing station with two different wash solvents minimizes carry-over. Flexibility of modules and functions according to your needs.</p><h4><strong>Column selection and thermostat</strong></h4><h5><strong>Column thermostat</strong></h5><p>The <strong>forced air column thermostat</strong><i> </i><strong>AZURA CT 2.1</strong> is capable of heating or cooling from 5 to 85 °C. The powerful fan and robust peltier element keep the column at a very stable temperature, thus allowing reproducible analysis results.&nbsp;Optional eluent preheating cartridges can be installed.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_Educational_HPLC_System_Column_selection_and_thermostat_567c35ab61.jpg" alt="Knauer: KNAUER AZURA Educational HPLC System - Column selection and thermostat" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_Educational_HPLC_System_Column_selection_and_thermostat_567c35ab61.jpg 245w," sizes="100vw" width="1700" height="881"></p><h5><strong>Column switching valves</strong></h5><p><strong>KNAUER valves V&nbsp;4.1</strong>&nbsp;and the <strong>KNAUER valve drive VU 4.1&nbsp;</strong>are designed for a wide range of chromatographic applications. Flexibility is provided by choice of different materials and sizes as well as drivers for various software packages.</p><h4><strong>Detection</strong></h4><h5><strong>Diode array detectors (DAD or PDA)</strong></h5><p>The AZURA Diode array detectors (DAD)&nbsp;are high-end diode array detectors with a wavelength range from 190–1000 nm for the <strong>AZURA DAD 6.1L</strong> and 190–700 nm for the <strong>AZURA DAD 2.1L</strong>. The intelligent temperature management of both devices enables fast operational readiness after startup. It also minimizes baseline drift. Due to the frontally accessible deuterium and halogen lamp, the device is easy to service.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_DAD_6_1_L_Diode_array_detectors_DAD_or_PDA_919e55c936.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - AZURA DAD 6.1L Diode array detectors (DAD or PDA)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_DAD_6_1_L_Diode_array_detectors_DAD_or_PDA_919e55c936.jpg 245w," sizes="100vw" width="1280" height="387"></p><h5><strong>Mass Detector for MS/MS</strong></h5><p>The <strong>SCIEX Triple Quad™ 4500 MS/MS</strong> system offers superior quantitative performance with high sensitivity combined with excellent robustness and long-term stability. Designed for food, environmental, forensic and clinical research, this MS/MS system enables test development for even the most demanding applications.</p><ul><li>Workhorse triple quad mass spectrometer for dependable everyday use&nbsp;</li><li>High sensitivity for food and environmental contaminant screening and target quantitation</li><li>High scan speed for reliable quantitation of sharp UHPLC peaks</li><li>Simple and fast data processing powered by SCIEX OS software</li></ul><h5><strong>Variable or multiple wavelength detectors (MWD or VWD)</strong></h5><p>The <strong>AZURA MWD 2.1L</strong> is an 8 channel, sensitive multiwavelength detector combining high performance with easy handling at an affordable price. The newly developed optical unit and intelligent temperature management ensure for maximum sensitivity combined with minimal baseline drift.&nbsp;</p><h5><strong>UV/VIS detectors with single variable wavelength</strong></h5><p>The UV/VIS Detector <strong>AZURA UVD 2.1L</strong> is a competitively priced HPLC spectrophotometer for routine HPLC applications including fast LC methods.&nbsp;It comes with an installed deuterium lamp which covers a wavelength range from 190 to 750 nm.&nbsp;Due to a smart design the flow cell is easily accessible and can be changed very quickly.&nbsp;</p><h5><strong>Refractive index detection (RI)</strong></h5><p>The <strong>AZURA RID 2.1L</strong> is a sensitive and competitively priced differential refractometer. It is suitable for detecting compounds with little or no UV activity such as alcohols, sugars, lipids or polymers.&nbsp;The intelligently designed optical unit with advanced temperature control ensures high sensitivity, fast baseline stabilization, and excellent reproducibility. The wide linear dynamic range, its low internal volume of 43 µl from the inlet to the flow cell and 10 ml/min maximum flow rate make the AZURA RID 2.1L the perfect choice for most laboratory tasks.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_RID_2_1_L_Refractive_index_detection_RI_8cd15bf26d.jpg" alt="Knauer: KNAUER AZURA 1240 bar UHPLC System - AZURA RID 2.1L Refractive index detection (RI)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_1240_bar_UHPLC_System_AZURA_RID_2_1_L_Refractive_index_detection_RI_8cd15bf26d.jpg 245w," sizes="100vw" width="1280" height="387"></p><h5><strong>Fluorescence detection (FLD)</strong></h5><p>The fluorescence detectors <strong>RF-20A </strong>and <strong>RF-20Axs</strong> provide&nbsp;world-class sensitivity, excellent maintainability and diverse validation / support functions. They&nbsp;support&nbsp;a wide range of applications in the wavelength range of 200 to 750 nm for the RF-20Axs and 200 to 650 nm for the RF-20A from conventional analysis to high-performance analysis.</p><h5><strong>Evaporative light scattering detection (ELSD)&nbsp;</strong></h5><p>As an universal detector, an <strong>ELSD </strong>offers numerous possibilities for detecting substances that have few or no chromophores. Since the eluents are evaporated, the use of non-UV-compatible solvents poses no problems and the ELSD is gradient compatible. KNAUER offers different models for different application tasks.</p><h4><strong>Software solutions</strong></h4><h5><strong>Mobile Control</strong></h5><p>The Mobile Control is an intuitive and cost-effective software solution for controlling and monitoring your AZURA devices and systems. The clear system overview provides instant information on key parameters and system status. Adjust and operate single devices or even whole systems with a few fingertips.&nbsp;The well-structured block programming assists you to clearly and quickly automate device control. A smart user management makes the Mobile Control safe. Device parameters can only be changed by authorized operators.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_KNAUER_AZURA_Educational_HPLC_System_Mobile_Control_software_2052b3ed77.jpg" alt="Knauer: KNAUER AZURA Educational HPLC System - Mobile Control software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_KNAUER_AZURA_Educational_HPLC_System_Mobile_Control_software_2052b3ed77.jpg 241w," sizes="100vw" width="1280" height="830"></p><h5><strong>ClarityChrom® CDS</strong></h5><p>ClarityChrom is an easy-to-use chromatography data system for workstations. The optional control extensions for GC, PDA and GPC allow to use the software for a wide range of applications.</p><h5><strong>OpenLAB® CDS EZChrom Edition</strong></h5><p>Basic Workstation license, includes System Suitability, Fraction Collector Control and Software Maintenance Agreement</p><h5><strong>Chromeleon™ 7.2</strong></h5><p>Thermo Scientific™ Dionex™ Chromeleon™ is one of the most wide-spread chromatography data systems. Its intuitive handling benefits laboratory workflow and the highly developed algorithms simplify data processing. It offers a broad range of third-party drivers and can be easily used with existing HPLC systems. KNAUER offers drivers for a lot of its devices.&nbsp;</p>

Thermo Scientific Vanquish Tandem LC Systems

The Thermo Scientific Vanquish Tandem LC Systems increase throughput and maximize detector output by using a second pump and intelligent column switching to eliminate the time required for column equilibration in a gradient elution. 

<h3><strong>Optimize your productivity</strong></h3><p><strong>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;</strong></p><p>At the same time, <strong>advancements and innovations</strong> are needed to improve <strong>operational efficiency</strong> and <strong>performance</strong>. How do you accomplish this? It’s easy with the <strong>Thermo Scientific™ Vanquish™ High-throughput LC systems</strong> built for <strong>enhanced productivity</strong>. <strong>Vanquish High-throughput LC systems</strong> combine <strong>individual Vanquish components</strong> and <strong>software wizards</strong> to deliver <strong>increased throughput</strong> or <strong>detector utilization</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"></p><h3><strong>Two flow paths for maximized productivity</strong></h3><p>Your laboratory may be facing <strong>increased pressure to improve working efficiency</strong> and deal with <strong>limiting resources</strong>, such as <strong>budget</strong>, <strong>space</strong>, or <strong>manpower</strong>. <strong>Vanquish High-throughput LC systems</strong> are designed to <strong>overcome these limitations</strong> by providing <strong>multiple flow paths</strong> for <strong>parallelization of specific stages of the LC run</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"></p><h4><strong>Unique dual technology</strong></h4><p>The <strong>Vanquish platform</strong> contains <strong>two unique dual modules</strong>. <strong>Vanquish dual pumps</strong> merge <strong>two individual, low pressure mixing pumps</strong> in one housing enabling <strong>separate eluents and gradients</strong> for each pump.</p><p><strong>Vanquish dual split samplers</strong> possess <strong>two independently controlled injection units</strong> including <strong>separate injection valves and injection needles</strong>. Used in <strong>Dual LC and LC-MS workflows only</strong>, this enables <strong>high throughput</strong> and <strong>extensive sample characterization workflows</strong>.</p><h3><strong>Two configurations to best serve your needs</strong></h3><p><strong>Vanquish High-throughput workflows</strong> are configured with <strong>Thermo Scientific™ Vanquish™ Core system</strong>, <strong>Thermo Scientific™ Vanquish™ Flex system</strong> or <strong>Thermo Scientific™ Vanquish™ Horizon system</strong> modules. Both workflows make use of <strong>two pumps</strong> to <strong>increase instrument productivity</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"></p><h4><strong>Vanquish Duo UHPLC Systems</strong></h4><ul><li><strong>Supported systems:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li><strong>Sampler:</strong> Dual split sampler</li><li><strong>Detector:</strong> Two out of the complete detector portfolio</li><li><strong>Software control:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4><strong>Vanquish Tandem LC Systems</strong></h4><ul><li><strong>Supported systems:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li><strong>Sampler:</strong> Split sampler</li><li><strong>Detector:</strong> One out of the complete detector portfolio and/or one mass spectrometer</li><li><strong>Software control:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3><strong>Vanquish Tandem LC systems</strong></h3><div><div><div><div><p><strong>Gradient separations</strong> are commonly used in <strong>LC or LC-MS</strong>. <strong>Column reconditioning</strong>, such as <strong>washing and re-equilibration</strong>, takes time and <strong>reduces your overall sample throughput</strong>. The <strong>Vanquish Tandem LC systems</strong> eliminate these limitations and <strong>improve productivity</strong> by:</p><ul><li><strong>Increasing sample throughput</strong> without modifying a <strong>validated method</strong></li><li><strong>Improving return on investment</strong> by <strong>maximizing mass spectrometer utilization</strong></li><li><strong>Reducing column carry over</strong> through <strong>extended column washing</strong> without <strong>sacrificing throughput</strong></li><li><strong>Simplifying method setup</strong> with <strong>automatic method conversion</strong> from your original <strong>gradient method</strong></li></ul></div></div></div></div><div>&nbsp;</div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_4_a031ad3221.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_4_a031ad3221.jpg 245w," sizes="100vw" width="1749" height="530"></p><h4><strong>Throughput increase using Tandem LC</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_3_6bc55942ed.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Throughput increase by Tandem LC is between 10–80% for most common conditions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_3_6bc55942ed.jpg 245w," sizes="100vw" width="894" height="434"></p><p>The <strong>Vanquish Tandem LC system</strong> splits the analysis between <strong>two pumps</strong> and <strong>two columns</strong>. One pump delivers the <strong>analytical gradient</strong> while the second pump runs the <strong>reconditioning gradient</strong>. This configuration allows you to use <strong>two identical columns</strong> to <strong>run your sequence faster</strong> without <strong>compromising data quality</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_5_d818007fe4.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Reproducible results for the Thermo Scientific™ Vanquish™ Horizon Tandem UHPLC system—Thermo Scientific™ Q Exactive™ HF hybrid quadrupole-Orbitrap™ mass spectrometer showing an overlay of five total ion current chromatograms. The sample shown is digested Infliximab using the Thermo Scientific™ SMART ™ Digest Kit." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_5_d818007fe4.jpg 245w," sizes="100vw" width="1123" height="499"></p><h4><strong>Simply upgrade your method</strong></h4><p>Implementing <strong>Tandem LC-MS</strong> into your workflow is easy with <strong>compliance-ready Chromeleon software</strong> for LC or LC-MS users and <strong>Thermo Scientific Standard Instrument Integration (SII)</strong> for <strong>Thermo Scientific Xcalibur software</strong> for LC-MS users.</p><p>A <strong>simple dedicated instrument method wizard</strong> enables you to <strong>create new methods without the need for additional training</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_0c7f310b1e.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_0c7f310b1e.jpg 193w," sizes="100vw" width="353" height="285"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_2_47128950b2.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Chromeleon CDS and SII for Xcalibur guides users through the implementation of a Tandem LC or LC-MS method with automatic system volume considerations and gradient formation of the reconditioning pump." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_2_47128950b2.jpg 160w," sizes="100vw" width="361" height="353"></p><h3><strong>Thermo Scientific LC portfolio overview</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660"></p>

Waters ACQUITY Arc LC System

The ACQUITY™ Arc™ System is an all-in-one platform for HPLC and UHPLC, designed for robust method development and seamless transfer between modern LC systems, addressing a wide range of analytical challenges.

<p class="cke-user_style-important"><strong>Built upon a foundation of reliability</strong></p><p data-pm-slice="1 1 []"><strong>The method development process is changing. New regulations, software and analytical technologies are rapidly changing how methods are designed, transferred, and monitored over their lifecycle. An all-in-one platform for HPLC and UHPLC separations, the ACQUITY™ Arc™ System is designed to meet the spectrum of challenges you face from robust method development to seamless transfer between any modern LC systems.</strong></p><p data-pm-slice="1 1 []">With the <strong>ACQUITY Arc System</strong>, you can experience true plug-and-play method compatibility for HPLC and UHPLC separations. Significant productivity gains can be realized by deploying a single LC platform that allows for the efficient transfer, adjustment, and improvement of methods from any LC platform without compromise in method integrity.</p><figure class="image"><img style="aspect-ratio:768/886;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_63246061ea.jpg" alt="Waters ACQUITY Arc System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_63246061ea.jpg 136w," sizes="100vw" width="768" height="886"></figure><p data-pm-slice="1 1 []">Laboratory-driven organizations have relied on Waters for over 60 years to deliver reliable, robust, and reproducible solutions to ensure confidence in their analytical results. With over 100,000 LC systems installed, we understand the significant impact the right technology has on your business, and the implications it has on characterizing the quality and safety of your products.</p><p data-pm-slice="1 1 []">Methods with greater agility, robustness, and capacity for change can help you reduce regulatory burden, risk of failure and costs. Visit <a disabled="true">www.methods.waters.com</a> to learn more about how method life cycle management (MLCM) connects your method today to your method tomorrow.</p><h3><strong>Designed for discovery to routine QC applications</strong></h3><p>The <strong>ACQUITY Arc System</strong> is the only available LC system with regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument. With unrivaled column capacity and Arc Multi-flow path™ technology, the<strong> ACQUITY Arc System</strong> allows you to generate new methods and modernize legacy HPLC methods faster than ever before.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_2_c06ba42baa.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Comprehensive detector portfolio</strong></h4><p>High-performance analytical detectors designed to maximize HPLC and UHPLC performance, delivering exceptional sensitivity and linearity for your assays.</p><p>Photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, and mass detection, including the ACQUITY QDa™ Detector.</p><h4><strong>Gradient SmartStart</strong></h4><p>Automatically manage gradient start time and pre-injection steps to maximize sample throughput. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.</p><h4><strong>Quaternary solvent management</strong></h4><p>Precise and accurate blending of up to four solvents with automated solvent compressibility compensation. Increase solvent flexibility with an optional, integrated solvent select valve, providing access to six additional solvents.</p><h4><strong>Negligible carryover</strong></h4><p>Advanced flow-through needle design minimizes carryover by continuously cleansing the needle during run. User-configurable wash settings provide flexibility to address even the most complex sample matrices.</p><h4><strong>Thermal management options</strong></h4><p>Column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm, with a temperature range of 4 °C to 90 °C. Integrated column selection valve options provide unattended, fast column changeover.</p><h4><strong>Auto•Blend™ Plus Technology</strong></h4><p>Program gradients directly in terms of pH and ionic strength to minimize manual mobile phase preparation, reduce potential for human error, and accelerate method robustness testing for chromatographic methods.</p><h4><strong>Arc Multi-flow path technology</strong></h4><p>Delivers plug-and-play method compatibility with HPLC or UHPLC methods with the flip of a switch.</p><p>Easily replicate or improve established methods by simply selecting between Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention.</p><h4><strong>Column Technology</strong></h4><p>Industry-leading selectivity choices to meet the needs of virtually every LC application.</p><h4><strong>Laboratory Informatics</strong></h4><p>Software control within your existing Empower™ or MassLynx™ infrastructure.</p><h3><strong>Replicate your established methods</strong></h3><p data-pm-slice="1 1 []">The <strong>ACQUITY Arc System</strong>, enabled by unique Arc Multi-flow path technology, easily accepts and replicates methods from any HPLC platform, without compromise.&nbsp;</p><p data-pm-slice="1 1 []">Whether you are trying to replicate an out-of-date HPLC method, transfer methods across the organization, or to contract partners, the <strong>ACQUITY Arc System</strong> gives you ultimate flexibility to reproduce, modernize, and transfer existing methods with ease and greater cost efficiency, while preserving the integrity of your methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg" alt="Waters ACQUITY Arc System: Analysis run on a Vendor X LC system and replicated on the ACQUITY Arc System. Conditions: 15 to 35% B in 3 min, 35 to 95% B in 2 min; Mobile phase A: 0.1% HCOOH in H 2 O, mobile phase B: 0.1% HCOOH in ACN; Flow rate = 2.0 mL/min; Column: XSelect™ CSH C 18 , 4.6 x 150 mm, 5 μm; Temp. = 30 °C; UV@ 260 nm; 10.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_3_c8c7901de3.jpg 245w," sizes="100vw" width="1099" height="596"></p><p>Upgrade your laboratory with a versatile, modern LC system that delivers HPLC and UHPLC method compatibility at the flip of a switch.</p><h3><strong>Modernize your methods</strong></h3><p>The United States Pharmacopeia (USP) is championing pharmacopeial harmonization and modernization efforts, and international organizations are following suit. As a result, the USP is encouraging the modernization of older compendial methods to ensure they are fit for purpose.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg" alt="Waters ACQUITY Arc System: Quetiapine fumarate system suitability solution analyzed on the ACQUITY Arc System using HPLC, UHPLC, and UPLC™ column/method conditions for the quetiapine impurity method. Peak identification: (1) quetiapine related compound G, (2) quetiapine related compound B, (3) quetiapine desethoxy, and (4) quetiapine." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_4_a1aaab8d02.jpg 245w," sizes="100vw" width="1092" height="678"></p><p>Revisions to these guidelines give you more flexibility to modify your existing pharmacopeial methods with modern techniques and technologies, and in some cases avoid revalidation. The <strong>ACQUITY Arc System</strong>, featuring the Waters Columns Calculator, allows you to confidently scale your gradient methods from a 3.5 μm to a 2.5 μm particle, decreasing run times, lowering solvent consumption, and increasing sample throughput.</p><h3><span><strong>Save time. Reduce cost.</strong></span></h3><p data-pm-slice="1 1 []">With the right column, the <strong>ACQUITY Arc System</strong> is the ideal solution to accommodate methods from any LC platform.&nbsp;</p><p data-pm-slice="1 1 []">From concept to production, the transition your product takes through the product development cycle often requires rigorous LC assays to properly characterize and assess its readiness to advance to the next stage. These LC assays are often adapted to accommodate the technology available from one stage to the next, in some cases requiring an adjustment from a smaller particle size (sub-2-μm) to a larger particle size (2.5 μm–5 μm).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg" alt="Waters ACQUITY Arc System: The ACQUITY Arc System enables the support of HPLC and UHPLC methods on a single platform." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_5_d9dd95135c.jpg 173w," sizes="100vw" width="959" height="860"></p><p>The <strong>ACQUITY Arc System</strong> provides the flexibility to maximize productivity through efficient and rapid 2.5 μm–2.7 μm UHPLC separations, or to accommodate larger 3.0 μm–5 μm HPLC particles.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg" alt="Waters ACQUITY Arc System: Save time. Reduce cost." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_6_1ebc2c67e7.jpg 245w," sizes="100vw" width="1683" height="469"></p><h3><span><strong>Mitigate your risk</strong></span></h3><p data-pm-slice="1 1 []">With an expanded range of column manager options enabling up to 15-column switching from 4 °C to 90 °C, the <strong>ACQUITY Arc System</strong> will help you significantly reduce the time spent generating robust methods. Equipped with the plug-and-play ACQUITY QDa Mass Detector, the <strong>ACQUITY Arc System</strong> tracks peaks in your method and reveals hidden coelutions of similar analytes, ensuring you have complete confidence in the reliability and reproducibility of your method now and far into the future.</p><h4><strong>Thermal management options</strong></h4><p data-pm-slice="1 1 []">Active and passive pre-heating options available, with up to 15-column switching from 4 °C to 90 °C. Automated monitoring and tracking of column usage with eCord™ technology available with active pre-heating options.</p><h4><strong>Quaternary solvent management</strong></h4><p data-pm-slice="1 1 []">Accelerate your method development with precise and accurate blending of up to four solvents. Increase solvent flexibility with an optional solvent select valve, providing access to six additional solvents.</p><h4><strong>Auto•Blend Plus Technology</strong></h4><p data-pm-slice="1 1 []">Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</p><h4><strong>Comprehensive detector portfolio</strong></h4><p>Diverse portfolio of detectors for method development, method transfer, and routine use.</p><h4><strong>ACQUITY QDa Detector</strong></h4><p>Mass detection built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no adjustments, it easily integrates with your<strong> ACQUITY Arc System.</strong></p><h5><strong>Support</strong></h5><p data-start="0" data-end="175">Empower eLearning modules to help train your lab on Empower 3 and Method Validation. Applications support that’s customized based on your method development needs.</p><h5><strong>Consumables</strong></h5><p data-start="177" data-end="410" data-is-last-node="">Industry-leading selectivity choices to meet the needs of virtually every LC application. Quality Control (QC) Reference Material benchmarks your <strong>ACQUITY Arc System </strong>and enables perfect resolution. Certified clean vials.</p><h5><strong>Laboratory Informatics</strong></h5><p>Software control within your existing Empower or MassLynx infrastructure. Empower 3 Method Validation Manager allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</p><h3><span><strong>Develop methods that stand the test of time</strong></span></h3><p>Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.</p><p>The <strong>ACQUITY Arc System</strong> is fully compatible with the ACQUITY Arc, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram, leaving nothing to chance.</p><ul><li>Confirm the identity of peaks in a separation without injecting standards.</li><li>Identify new peaks in a separation with molecular weight information.&nbsp;</li><li>Detect unresolved peaks and determine if a peak is homogeneously pure.</li><li>Easily track peaks as method conditions are changed.</li></ul><p data-start="272" data-end="600">Using Empower 3 Software and its Custom Calculations and Custom Reporting functions enables you to quickly and automatically evaluate chromatographic data. Configurable reports allow you to choose optimal conditions based on metrics rather than judgment, ensuring a comprehensive assessment of data and best method conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Arc_System_7_e7ef959203.jpg" alt="Waters ACQUITY Arc System: Method transfer of USP Assay for Fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. Conditions: Mobile phase: 20:80 acetonitrile/ water; Flow rate = 0.5 mL/min; Column: XSelect HSS T3, 4.6 x 150 mm, 3.5 μm; UV@ 260 nm; 20.0 μL injection volume." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Arc_System_7_e7ef959203.jpg 224w," sizes="100vw" width="939" height="654"></p><h3><strong>Streamline your workflow</strong></h3><div><div data-message-author-role="assistant" data-message-id="7b732be9-0a45-45fb-b585-70a90c1a74d6" dir="auto" data-message-model-slug="gpt-4o"><div><div><p data-start="602" data-end="827">How would you benefit from increased assay consistency between analysts and from lab to lab? What would you gain by accelerating your robustness testing prior to transferring methods to QA/QC?</p><p data-start="829" data-end="1392" data-is-last-node="">Auto•Blend Plus Technology is a novel software tool that extends traditional quaternary solvent blending to permit gradient programming directly in units of pH and ionic strength, providing the ability to vary composition in even the smallest increments of pH (even those differing by 0.1 pH units or less).&nbsp;</p><p data-start="829" data-end="1392" data-is-last-node="">With Auto•Blend Plus, the cumbersome and error-prone approach of manually preparing several pre-mixed mobile phases can now be eliminated with on-demand mobile phase creation, providing significant time savings and improved productivity to the laboratory.</p></div></div></div></div>

Thermo Scientific Transcend Multichannel UHPLC Systems

Thermo Scientific Transcend Multichannel UHPLC Systems are advanced LC-MS systems with a multichannel UHPLC architecture that increase analytical productivity and maximize mass spectrometer utilization without compromising data quality.

<p><strong>Thermo Scientific™ Transcend™ Multichannel UHPLC Systems are advanced LC-MS platforms designed for laboratories that demand higher throughput, improved efficiency, and stronger return on investment. Their multichannel UHPLC architecture connects up to four fully independent LC channels to a single mass spectrometer, dramatically increasing system utilization without compromising data quality.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_8_5f824e5e08.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: The Transcend LX systems feature either 2 or 4 (shown) completely independent LC channels." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_8_5f824e5e08.jpg 245w," sizes="100vw" width="955" height="404"></p><h3><strong>Key benefits</strong></h3><ul><li>Significantly increased LC-MS throughput</li><li>Maximized mass spectrometer utilization</li><li>Maintained sensitivity, selectivity, and robustness</li><li>Reduced operating costs and analysis time</li><li>Scalable configurations tailored to laboratory needs</li></ul><h3><strong>Multichannel UHPLC architecture</strong></h3><p>Conventional single-channel LC-MS systems process samples sequentially, leaving the mass spectrometer idle during injection, column washing, and equilibration.<br>Transcend systems overcome this limitation by <strong>intelligently interleaving injections from multiple LC channels</strong>, delivering data to the mass spectrometer only during relevant retention time windows and enabling substantial productivity gains.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_5_ab4093366d.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Injections are interleaved to maximize throughput and mass spectrometer use." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_5_ab4093366d.jpg 169w," sizes="100vw" width="831" height="764"></p><h3><strong>Vanquish UHPLC platform</strong></h3><p><strong>Thermo Scientific™ Transcend™ Multichannel UHPLC Systems</strong> are built on proven <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=40&amp;manufacturerItems=3&amp;search=vanquish"><strong>Thermo Scientific Vanquish UHPLC</strong></a> technology. The Transcend multichannel architecture integrates up to four independent Vanquish-based UHPLC channels into a single LC-MS platform.</p><p><strong>The Vanquish UHPLC platform provides:</strong></p><ul><li>high mechanical and operational robustness</li><li>reproducible long-term performance</li><li>precise gradient formation and stable flow control suitable for multichannel operation</li><li>flexible pump configurations (binary or quaternary) tailored to application requirements</li></ul><p>By combining the Transcend multichannel concept with Vanquish UHPLC technology, laboratories can achieve high throughput without compromising chromatographic performance, sensitivity, or system reliability.</p><h3><strong>System configurations</strong></h3><ul><li><strong>Transcend LX and VLX</strong><br>Designed for high-throughput LC-MS workflows without on-line sample cleanup<ul><li>2- and 4-channel configurations</li><li>Fully independent LC channels</li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_1567f69a93.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend LX UHPLC Systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_1567f69a93.jpg 245w," sizes="100vw" width="968" height="500"></p><ul><li><strong>Transcend TLX</strong><br>Designed for workflows requiring automated on-line sample cleanup<ul><li>1-, 2-, and 4-channel configurations</li><li>Integrated TurboFlow™ technology</li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_2_8ac2e32016.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend TLX UHPLC Systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_2_8ac2e32016.jpg 245w," sizes="100vw" width="1674" height="523"></p><p>Each LC channel operates independently, allowing identical methods to run in parallel or multiple methods to be combined within a single system.</p><h3><strong>On-line sample cleanup with TurboFlow™ technology (TLX)</strong></h3><p><strong>TurboFlow™ technology</strong> enables rapid on-line removal of matrix interferences directly within the LC-MS system, resulting in:</p><ul><li><strong>Reduced or eliminated </strong>manual sample preparation</li><li><strong>Direct injection</strong> of complex biological and environmental samples</li><li><strong>Improved sensitivity and reproducibility</strong></li><li><strong>Increased method robustness and simplified workflows</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_3_efccaa3928.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: On-line sample cleanup with TurboFlow™ technology (TLX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_3_efccaa3928.jpg 245w," sizes="100vw" width="1105" height="556"></p><h3><strong>System control and software</strong></h3><p>All system functions are managed by <strong>Thermo Scientific™ Aria™ MX software</strong>, providing:</p><ul><li>Control of pumps, valves, gradients, and injection scheduling</li><li>Intuitive multichannel method setup</li><li>Parallel execution of up to four methods</li><li>A user-friendly graphical interface for complex LC-MS workflows</li></ul><p>Aria MX software is fully compatible with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Thermo Scientific™ Xcalibur™</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>Thermo Scientific™ TraceFinder™</strong></a> software.</p><h3><strong>Mass spectrometer compatibility</strong></h3><p>Transcend systems are designed as a flexible LC-MS platform compatible with a broad range of <strong>Thermo Fisher Scientific</strong> mass spectrometers, including:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=tsq"><strong>TSQ triple quadrupole systems</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3&amp;search=orbitrap"><strong>High-resolution Orbitrap instruments</strong></a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_4_fc2c09672b.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend TLX-2 system with a TSQ Altis Plus triple quadrupole mass spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_4_fc2c09672b.jpg 245w," sizes="100vw" width="1178" height="646"></p><h3><strong>Typical application areas</strong></h3><ul><li>Clinical research and bioanalysis</li><li>Pharmaceutical development and quality control</li><li>Toxicology</li><li>Environmental analysis</li><li>High-throughput screening workflows</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_6_db70763211.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Retention time (A) and peak area (B) reproducibility of a high-throughput targeted proteomics assay for quantifying SARS-CoV-2 peptides in clinical research samples across five days. The Transcend TLX-4 UHPLC system was used for on-line sample clean-up and analysis of 500 respiratory tract swab samples per day. (Cardozo, K.H.M., Lebkuchen, A., Okai, G.G. et al. Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts. Nat Commun 11, 6201 (2020))" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_6_db70763211.jpg 245w," sizes="100vw" width="1489" height="862"></p>

KNAUER AZURA HTQC UHPLC System

KNAUER AZURA HTQC UHPLC (1240 bar) enables high-throughput QC with parallel analysis and column re-equilibration for faster workflows.

<p><strong>The KNAUER AZURA HTQC UHPLC (1240 bar) is a high-performance UHPLC system designed for high-throughput quality control (QC) where speed, robustness, and reproducibility are essential.</strong></p><p>The system features a unique concept of <strong>parallel analysis and offline column re-equilibration</strong>, significantly increasing productivity. With <strong>two gradient pumps</strong>, one column performs the analytical run while the second is <strong>re-equilibrated in backflush mode</strong>.</p><p>This architecture enables:</p><ul><li><strong>≥30% reduction in cycle time</strong></li><li><strong>increased sample throughput</strong></li><li><strong>column protection from matrix contamination</strong></li><li><strong>consistent retention times</strong></li></ul><p>It is ideal for <strong>pharmaceutical QC laboratories</strong> requiring <strong>automation and validated workflows</strong>.</p><h4><span><strong>Key Features</strong></span></h4><ul><li>UHPLC system <strong>up to 1240 bar (124 MPa)</strong></li><li><strong>Dual gradient pumps</strong> (HPG + LPG)</li><li><strong>Parallel analysis</strong> and column re-equilibration</li><li>Backflush mode for column protection</li><li><strong>≥30% faster analysis</strong> cycles</li><li>High flow reproducibility</li><li>Autosampler with cooling</li><li>Column thermostat (Peltier)</li><li><strong>Fully automated modular system</strong></li><li><strong>MS detector compatibility</strong></li></ul><h4><span><strong>System Configuration</strong></span></h4><p>Included components:</p><ul><li>Eluent tray E 2.1L</li><li>Pump P 8.1L (HPG)</li><li>Pump P 6.1L (LPG)</li><li>Liquid handler LH 8.1 + Robotic Cooler</li><li>Column thermostat CT 2.1</li><li>Column switching &amp; backflush valve</li><li>Accessories and tools</li></ul><h3><span><strong>Technical Specifications</strong></span></h3><h4><span><strong>Pumps</strong></span></h4><h5><strong>P 8.1L (HPG – analytical pump):</strong></h5><ul><li><strong>Max pressure:</strong> <strong>1240 bar</strong></li><li><strong>Flow rate:</strong> up to <strong>5 mL/min</strong></li><li>Adaptive pulsation compensation</li><li>Degasser + binary solvent selection</li><li>Low baseline noise</li></ul><h5><strong>P 6.1L (LPG – re-equilibration):</strong></h5><ul><li>Quaternary gradient</li><li>Integrated degasser</li><li>Low dwell volume</li><li>Inline filter</li></ul><h4><span><strong>Autosampler</strong></span></h4><h5><strong>LH 8.1:</strong></h5><ul><li>XYZ autosampler</li><li>Capacity: up to 390 samples</li><li>Temperature: 4–40 °C</li><li>Low carryover</li></ul><h4><span><strong>Column Thermostat</strong></span></h4><h5><strong>CT 2.1:</strong></h5><ul><li>Peltier controlled</li><li>Above and below ambient operation</li><li>High precision</li></ul><h4><span><strong>Valve System</strong></span></h4><ul><li>Column switching + backflush</li><li>Up to 1200 bar</li><li>Parallel column operation</li></ul><h4><span><strong>Detection</strong></span></h4><ul><li>Compatible with all HPLC detectors</li><li>Ideal for LC-MS coupling</li></ul><h4><span><strong>HTQC Concept</strong></span></h4><ul><li>Independent flow paths (analysis vs re-equilibration)</li><li>Backflush re-equilibration</li><li>Parallel operation</li><li>Increased throughput without compromise</li></ul><h4><span><strong>Typical Applications</strong></span></h4><ul><li>Pharmaceutical QC</li><li>Routine validated workflows</li><li>High sample throughput environments</li><li>Reversed-phase HPLC</li></ul>

Waters Arc Premier LC System

The Arc Premier System features new, innovative MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interactions, without complicated mobile phases or laborious methods.

<div><div><h4><strong>See clearly and consistently, with confidence.</strong></h4></div></div><div><div><p><strong>Today’s scientists and lab managers need to confidently produce the most accurate, reliable, and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily.&nbsp;</strong></p><p>The <strong>Arc Premier System</strong> features the new, innovative solution of <strong>MaxPeak High Performance Surfaces (HPS) Technology</strong>, which effectively reduces non-specific adsorption due to metal interaction — without complicated mobile phases or laborious methods. The <strong>Arc Premier System</strong> sharpens chromatographic peaks for <strong>metal-sensitive compounds</strong> by eliminating secondary interactions from metals, resulting in:</p><ul><li>Improved compliance from higher quality data</li><li>Faster, more reproducible, and accurate data integration</li><li>Shorter time from sample to result, without conditioning</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_6d7c95a93a.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_6d7c95a93a.jpg 245w," sizes="100vw" width="1024" height="611"></p><p>With the Arc Premier System, we continue to deliver on the product quality you expect, combined with recent innovations in <strong>MaxPeak HPS Technolog</strong>y, to always deliver the<strong> best possible results</strong>.&nbsp;</p><p>Whether you are working to ensure the safety of a new and innovative product, maintain the consistency and supply of a current one, or test your food safety and quality, the Arc Premier System gives you<strong> greater data quality, flexibility, reproducibility, and faster data integration </strong>with right first-time results right out of the box, <strong>without the need for complicated mobile phases and laborious methods to prepare your system.</strong></p><div><div><div><div><div><div><ul><li><strong>MaxPeak HPS Technology</strong>, minimizing risk of metal-analyte interactions</li><li>Pressure envelope extends to <strong>9500 psi </strong>through a flow rate range of <strong>1–5 mL/min</strong>, providing an optimized pairing with column dimension and particle size</li><li><strong>Flexible quaternary and binary pumping options</strong></li><li>High performance analytical optical detectors, include photodiode array (PDA), UV/Vis, and fluorescence (FLR)</li><li>Mass detection options with the <strong>ACQUITY™ QDa™ Mass Detector</strong>,<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1543"> <strong>SQD2 Detector</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/209"><strong>Xevo™ TQ-S micro</strong></a>, and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/212"><strong>Xevo TQ-S cronos</strong></a></li><li>Flexible column manager options available for up to six columns ranging in length from <strong>50 mm to 300 mm</strong>, with a temperature range of <strong>4 °C to 90 °C</strong></li><li><strong>Auto•Blend Plus™ Technology</strong> for mobile phase reproducibility and <strong>Gradient SmartStart</strong> for method transfer</li><li>Wide range of trusted particle technologies in <strong>MaxPeak Premier Columns</strong></li><li>Compliance-ready<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627"><strong>Empower™ Chromatography Data System</strong> </a>(CDS) delivering high quality data integrity</li><li>Automated quantification tools to minimize compliance costs and time</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_2_d1a922ae6d.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_2_d1a922ae6d.jpg 245w," sizes="100vw" width="1024" height="585"></p></div></div><div><div><h3><strong>Flexible and Robust HPLC Designed for Your Development and Routine Testing Needs</strong></h3><ul><li><strong>Low dispersion HPLC: </strong>High performing HPLC with bandspread of &lt;30 μL for high chromatographic resolution.&nbsp;</li><li><p><strong>Versatile column management: </strong>Support for analytical LC column dimensions up to 300* mm with capacity to automatically select between as many as six analytical columns. Equipped with independently controlled temperature zone, active pre-heating, and<strong> eCord™ Intelligent Chip Technology </strong>for Waters columns.</p><p>* MaxPeak Premier Columns are recommended for use with the Arc Premier System and are currently only available in lengths up to 150 mm.</p></li><li><strong>Flow-through needle Injector: </strong>Volume range of 0.1 to 1000 μL and ultra-low carryover performance compatible with sensitive LC-MS applications.</li><li><strong>High Performance Surfaces Technology: </strong>With MaxPeak HPS Technology, analytes are impeded from Lewis acid-base interactions and adsorptive losses. This technology has proven to be effective in improving the analysis of electron-rich compounds, such as those containing phosphate and carboxylate groups.</li><li><strong>Consumables: </strong>Compatible with MaxPeak Premier Column chemistry to meet the needs of your reversed-phase and HILIC applications. Quality Control (QC) Reference Material benchmarks your Arc Premier System and enables perfect resolution. <strong>Certified clean </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/197"><strong>QuanRecovery™ vials</strong></a> to give full sample integrity.</li><li><strong>High performance analytical detectors : </strong>A wide range of high-performance detection capabilities, optimized with HPS, to support diverse applications. Includes photodiode array, UV/Vis, and fluorescence, with the additional option of single and triple quad mass detection.</li><li><strong>Solvent blending: </strong>Quaternary or binary solvent mixing. Delivers precise and accurate separations at pressures up to 9500 psi. Optional solvent select valve adds access to additional solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision, and reliability.</li><li><strong>Auto•Blend Plus Technology: </strong>Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</li><li><strong>Gradient SmartStart: </strong>Adjust the injection relative to the gradient start to emulate other HPLC systems’ dwell volumes, without the need to alter the gradient table. Successfully transfer most methods in just two injections.</li><li><strong>Laboratory Informatics: </strong>Software control within your existing <strong>Empower </strong>or <strong>MassLynx™ </strong>infrastructure. Empower Method Validation Manager (MVM) allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_3_5db411b90a.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_3_5db411b90a.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div></div></div><div><div><div><div><div><div><h3><strong>The Universal Platform for Liquid Chromatography</strong></h3><p>Non-specific adsorption of metal-sensitive compounds is an unpredictable challenge, resulting in chromatography with large relative standard deviations (RSDs) and broad, overlapping peaks, which can be challenging to integrate quickly and be accurate consistently.</p><p>Designed with MaxPeak HPS Technology and paired with <strong>MaxPeak Premier 2.5 μm Columns</strong>, the Arc Premier System improves data quality for challenging compounds, including metal-sensitive compounds tested with LC methods – so you can see clearly and consistently, with confidence.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_8_a4038daa52.jpg" alt="Waters Arc Premier LC System: Figure 1. Analysis of adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate. Significant improvements to sensitivity and recovery are observed with the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_8_a4038daa52.jpg 245w," sizes="100vw" width="1123" height="520"></p></div></div></div></div></div></div></div></div><div><div><h3><strong>Clear</strong></h3><p>Future-proof your lab for the next generation of challenging compounds with MaxPeak HPS Technology, which sharpenspeaks for metal-sensitive compounds, resulting in higher data quality and improved sensitivity with chromatographic reproducibility and precision.</p><p>Data quality and performance are <strong>critical </strong>for your lab, but those can’t come at the sacrifice of ruggedness and ease of use.&nbsp;</p><p>With MaxPeak HPS Technology and flexible LC performance, your lab gets the typical benefits of an LC system optimized for <strong>2.x μm column chemistry </strong>with the MaxPeak HPS Technology’s ability to shorten run times and achieve sharp peaks - no lengthy and complex conditioning and conditioning methodologies for metal-sensitive compounds required.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_9_34ec4befec.jpg" alt="Waters Arc Premier LC System: Figure 2. Analysis of adenosine triphosphate. Lower limits of detection and increased calibration curve linearity are demonstrated with the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_9_34ec4befec.jpg 245w," sizes="100vw" width="940" height="523"></p></div></div><div><div><h3><strong>Consistent</strong></h3><p>Seeing your results more clearly than ever is critical, but those results must be consistent and error-free and your methods easily reproducible, so you can spend less time on analysis and ensure compliance.&nbsp;</p><p>By <strong>significantly sharpening peak shapes</strong> for metal-sensitive analytes, scientists report an improvement in %RSD when integrating data from metal-sensitive compounds on the Arc Premier System. Along with the improvement in data consistency users also report a decrease of time needed to integrate peaks by <strong>approximately 30%</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_f80500f8a4.jpg" alt="Waters Arc Premier LC System: Figure 3. Analysis of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate. Peak heights increased and peak shapes are more symmetrical for metal- sensitive compounds on the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_f80500f8a4.jpg 235w," sizes="100vw" width="1381" height="918"></p><p>The Arc Premier System <strong>eliminates </strong>the need for<strong> variability-prone conditioning and complex mobile phases</strong> – so you can minimize user errors, improve compliance, and reduce expensive audits from red flag-inducing conditioning injections.</p><p>Your organization needs to reliably migrate higher-quality methods between your systems for maximum reproducibility. With MaxPeak HPS Technology and flexible pump configurations, your lab can easily, reliably <strong>migrate methods between MaxPeak HPS-based systems </strong>quickly, saving you time and money from unnecessary rework. You can also<strong> migrate methods from non-MaxPeak HPS-enabled systems </strong>safely, as method performance of non-metal-sensitive compounds have been shown to not be adversely affected.</p><p>Combining higher data quality with ease of use for your analysts and seamless method transfer, enables results that can be generated consistently between runs and with various analysts.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_6_5332aab31f.jpg" alt="Waters Arc Premier LC System: Figure 4. Analysis of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate. A zoom in on the baseline shows improved peak shapes and resolution for metal-sensitive compounds on the Arc Premier Solution compared to a conventional LC system, improving baseline resolution." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_6_5332aab31f.jpg 229w," sizes="100vw" width="1380" height="942"></p><h3><strong>Confident</strong></h3><p><strong>Reducing analytical uncertainty and achieving peace</strong> of mind are important for your organization. With MaxPeak HPS Technology, metal-sensitive analytes become visible that were previously undetectable. This allows you to quickly and confidently know that you’ve seen everything in your sample, giving you the confidence to stand behind your data-driven decisions.</p><p>The <strong>combination of MaxPeak HPS Technology, flexible pump and column management options, and precise optical and MS detection</strong> give you the method development and verification capabilities to know that no matter the sample - you can deliver a robust method you can stand behind.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_2_85f2f7cc29.jpg" alt="Waters Arc Premier LC System: Figure 5. Analysis of data of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate from an Arc Premier System and a conventional LC system by six users. Peak area reproducibility improved 9 – 124x when integrating the same data from metal-sensitive compounds across six users." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_2_85f2f7cc29.jpg 239w," sizes="100vw" width="1243" height="810"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_5_514749f32d.jpg" alt="Waters Arc Premier LC System: Figure 6. Analysis of acetaminophen, caffeine, leucine enkephalin, sulfadimethoxine, amitriptyline, reserpine, and terfenadine shows that non-metal-sensitive compounds demonstrate comparable performance between the Arc Premier Solution and conventional LC systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_5_514749f32d.jpg 245w," sizes="100vw" width="1242" height="735"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_7_edc8ecaa93.jpg" alt="Waters Arc Premier LC System: Figure 7. Comparison of adenosine triphosphate and adenosine diphosphate peaks using a conventional LC system and the Arc Premier Solution over 120 injections. The peak areas of metal-sensitive compounds remain constant from the first to the 120th injection using the Arc Premier Solution. Peak areas of metal-sensitive compounds on a conventional LC system continuously increase over time and do not stabilize even after 120 injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_7_edc8ecaa93.jpg 218w," sizes="100vw" width="1038" height="744"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_3_f1cca337bc.jpg" alt="Waters Arc Premier LC System: Figure 8. Comparison of adenosine triphosphate and adenosine diphosphate peaks using a conventional LC system and the Arc Premier Solution over 120 injections. The peak areas of metal-sensitive compounds remain constant from the first to the 120th injection using the Arc Premier Solution showing less than a 1% change in peak area for all compounds. Peak areas of metal-sensitive compounds on a conventional LC system show an increase of 2–35% when compared to the first injection and show no signs of stabilization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_3_f1cca337bc.jpg 216w," sizes="100vw" width="1039" height="750"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_4_1dae3909ae.jpg" alt="Waters Arc Premier LC System: Figure 9. Adenosine triphosphate, adenosine diphosphate, adenosine monophosphate, and adenosine stability using the Arc Premier Solution over 1000 injections. The peak areas of metal-sensitive compounds remain consistent over 1000 injection using the Arc Premier Solution demonstrating the robustness of the system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_4_1dae3909ae.jpg 243w," sizes="100vw" width="1040" height="669"></p></div></div></div></div>

Thermo Scientific™ Vanquish™ Neo UHPLC System

Take advantage of outstanding performance and productivity for all LC-MS workflows with nano-, capillary, and microflow using the Thermo Scientific™ Vanquish™ Neo UHPLC system.

Thermo Scientific Vanquish Duo UHPLC Systems

A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance.

<h3><strong>Optimize your productivity</strong></h3><p><strong>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;</strong></p><p>At the same time, <strong>advancements and innovations</strong> are needed to improve <strong>operational efficiency</strong> and <strong>performance</strong>. How do you accomplish this? It’s easy with the <strong>Thermo Scientific™ Vanquish™ High-throughput LC systems</strong> built for <strong>enhanced productivity</strong>. <strong>Vanquish High-throughput LC systems</strong> combine <strong>individual Vanquish components</strong> and <strong>software wizards</strong> to deliver <strong>increased throughput</strong> or <strong>detector utilization</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"></p><h3><strong>Two flow paths for maximized productivity</strong></h3><p>Your laboratory may be facing <strong>increased pressure to improve working efficiency</strong> and deal with <strong>limiting resources</strong>, such as <strong>budget</strong>, <strong>space</strong>, or <strong>manpower</strong>. <strong>Vanquish High-throughput LC systems</strong> are designed to <strong>overcome these limitations</strong> by providing <strong>multiple flow paths</strong> for <strong>parallelization of specific stages of the LC run</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"></p><h4><strong>Unique dual technology</strong></h4><p>The <strong>Vanquish platform</strong> contains <strong>two unique dual modules</strong>. <strong>Vanquish dual pumps</strong> merge <strong>two individual, low pressure mixing pumps</strong> in one housing enabling <strong>separate eluents and gradients</strong> for each pump.</p><p><strong>Vanquish dual split samplers</strong> possess <strong>two independently controlled injection units</strong> including <strong>separate injection valves and injection needles</strong>. Used in <strong>Dual LC and LC-MS workflows only</strong>, this enables <strong>high throughput</strong> and <strong>extensive sample characterization workflows</strong>.</p><h3><strong>Two configurations to best serve your needs</strong></h3><p><strong>Vanquish High-throughput workflows</strong> are configured with <strong>Thermo Scientific™ Vanquish™ Core system</strong>, <strong>Thermo Scientific™ Vanquish™ Flex system</strong> or <strong>Thermo Scientific™ Vanquish™ Horizon system</strong> modules. Both workflows make use of <strong>two pumps</strong> to <strong>increase instrument productivity</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"></p><h4><strong>Vanquish Duo UHPLC Systems</strong></h4><ul><li><strong>Supported systems:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li><strong>Sampler:</strong> Dual split sampler</li><li><strong>Detector:</strong> Two out of the complete detector portfolio</li><li><strong>Software control:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4><strong>Vanquish Tandem LC Systems</strong></h4><ul><li><strong>Supported systems:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li><strong>Sampler:</strong> Split sampler</li><li><strong>Detector:</strong> One out of the complete detector portfolio and/or one mass spectrometer</li><li><strong>Software control:</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3><strong>Vanquish Duo UHPLC systems</strong></h3><p>A <strong>Vanquish Duo UHPLC system</strong> enables you to <strong>run two methods simultaneously on one instrument</strong>, <strong>doubling your throughput</strong> or <strong>deepening your sample knowledge</strong> while <strong>maximizing your productivity and performance</strong>. The <strong>unique Vanquish Duo UHPLC system</strong> will:</p><ul><li><strong>Improve return on investment</strong> by <strong>reducing cost per sample</strong></li><li><strong>Increase sample throughput</strong> without changing <strong>validated methods</strong></li><li><strong>Increase capacity</strong> without sacrificing <strong>bench space</strong></li><li><strong>Accelerate your method development process</strong></li><li><strong>Analyze the same set of samples with multiple methods</strong>, <strong>reducing sample preparation time</strong> and <strong>maximizing sample knowledge</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg 245w," sizes="100vw" width="1678" height="512"></p><h4><strong>What can you do with a Vanquish Duo UHPLC system?</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: What can you do with a Vanquish Duo UHPLC system?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg 245w," sizes="100vw" width="1604" height="658"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two independent assays run simultaneously from a single sample on one LC instrument to deepen your sample knowledge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg 245w," sizes="100vw" width="1372" height="385"></p><h4><strong>Complete control with just a few clicks</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS</strong></a><strong> </strong>delivers <strong>industry-leading ease-of-use</strong> for the <strong>Vanquish Duo system</strong>. <strong>Independently control</strong> the <strong>two channels</strong> of the Vanquish Duo system from a <strong>single interface</strong> with <strong>full traceability of all actions</strong> that is <strong>21 CFR Part 11 compliant</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Easy-to-use and intuitive system control of the Dual LC workflow within Chromeleon CDS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg 245w," sizes="100vw" width="1190" height="632"></p><h3><strong>See the Vanquish Duo UHPLC system</strong></h3><p>The <strong>Vanquish Duo UHPLC system</strong> has been built to <strong>utilize a wide range of analytical detectors</strong>, including <strong>mass spectrometry (MS)</strong>, <strong>diode array detection (DAD)</strong>, <strong>charged aerosol detection (CAD)</strong>, <strong>variable wavelength detection (VWD)</strong>, and <strong>fluorescence detection (FLD)</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: See the Vanquish Duo UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg 174w," sizes="100vw" width="939" height="841"></p><h5><strong>1. Vanquish Solvent Monitor</strong></h5><p>Use the <strong>Vanquish Solvent Monitor</strong> to <strong>increase your regulatory compliance, productivity, and safety</strong> of your laboratory. That device guarantees that your <strong>HPLC systems will never run dry</strong> and the <strong>waste will not spill over</strong> during your analysis, <strong>reducing loss of valuable measurement time and sample material</strong>.</p><h5><strong>2. Vanquish User Interface</strong></h5><p>With the <strong>Vanquish User Interface</strong>, you are the <strong>master of your LC instrument</strong>. The display always shows you the <strong>key parameters</strong> of your instrument such as <strong>flow and pressure</strong> and guides you in a <strong>visual step-by-step video tutorial</strong> through <strong>key maintenance tasks</strong>.</p><h5><strong>3. Versatile detection capabilities</strong></h5><p>Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitate <strong>multiple detector methodologies</strong>. <strong>Vanquish Duo UHPLC systems</strong> can be used with <strong>any two detectors</strong> out of the <strong>broad detector portfolio</strong> including <strong>MS, DAD, VWD, FLD and CAD</strong>.</p><h5><strong>4. Compatible with your software infrastructure</strong></h5><p>A <strong>Vanquish Duo UHPLC system</strong> can be operated in <strong>various software environments</strong> including the latest <strong>Chromeleon software feature release</strong>, <strong>Chromeleon CDS long-term</strong>, and <strong>extended support version</strong> and <strong>Waters Empower</strong>.</p><h5><strong>5. Versatile column management</strong></h5><p>Greater <strong>column capacity</strong> (two 30 cm columns or a greater number of shorter columns per compartment), plus <strong>class-leading temperature range and temperature stability</strong>.</p><h5><strong>6. Delivering powerful separations</strong></h5><p>Run samples with <strong>two similar or different columns</strong> to <strong>increase throughput</strong> or <strong>maximize output</strong>. Setup with <strong>optional second compartment</strong> for <strong>independent column temperatures</strong>.</p><h5><strong>7. Easier operation</strong></h5><p><strong>Patented tool-free Thermo Scientific™ Viper™ Fingertight Fittings</strong> with <strong>near-zero dead volume operation</strong> and <strong>ergonomic design</strong>.</p><h5><strong>8. Unique Thermo Scientific™ SmartInject technology</strong></h5><p><strong>Superior retention time precision</strong> and <strong>enhanced column protection</strong> with <strong>intelligent SmartInject technology</strong> on both flow paths.</p><h5><strong>9. Two proprietary injection valves</strong></h5><p><strong>Two separate injection valves</strong> with <strong>no shared fluidics</strong> allowing <strong>full application flexibility</strong>, including <strong>individual eluents, wash liquids and loop sizes</strong>.</p><h5><strong>10. Easier sample handling</strong></h5><p><strong>Automated barcode reader</strong> to eliminate <strong>tedious rack configuration</strong>.</p><h5><strong>11. Higher sample capacity</strong></h5><p><strong>High sample capacity is standard</strong> (four plates versus two plates on industry average). <strong>Increase capacity</strong> further with the optional <strong>Thermo Scientific™ Vanquish™ Charger module</strong>.</p><h5><strong>12. Accurate flow for more data confidence</strong></h5><p>The flow is delivered by a <strong>dual pump</strong> offering <strong>two truly individual devices</strong> in a single housing with <strong>ternary gradient proportioning</strong>.</p><h5><strong>13. Simple maintenance</strong></h5><p><strong>Module maintenance is reduced to a minimum</strong> and can be worked on <strong>without instrument de-stacking</strong>, plus <strong>smart light bars</strong> on the front of the system provide <strong>instant system status update</strong>.</p><h5><strong>14. Keep the lab tidy</strong></h5><p>The <strong>built-in drawer stores accessories</strong>, related documents, or any other useful material for the system.</p><h3><strong>Thermo Scientific LC portfolio overview</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660"></p>

Thermo Scientific Vanquish FLEX UHPLC System

Whether you are analyzing innovative biotherapeutics or novel chemical medicines, method development with Thermo Scientific™ Vanquish™ Flex™ UHPLC system has never been easier.

Thermo Scientific Vanquish Horizon UHPLC System

Designed with innovative technology and fine detail, the Vanquish Horizon UHPLC delivers outstanding precision, sensitivity, and simplicity for unmatched performance and robustness.

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