Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer

The most powerful tribrid MS platform for deep, multidimensional analysis in proteomics, metabolomics, and structural biology

The Orbitrap Fusion Lumos Tribrid MS is a cutting-edge mass spectrometer that combines a quadrupole, a linear ion trap, and an Orbitrap™ high-resolution accurate-mass analyzer in a single platform. With unmatched sensitivity, selectivity, and versatility, it enables scientists to tackle complex biological questions with confidence—whether in discovery proteomics, targeted quantitation, top-down protein analysis, glycoproteomics, lipidomics, or small molecule research.

Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer

🔬 Unmatched Analytical Performance

• >500,000 resolution with Orbitrap Ultra-High Field analyzer
• Sub-ppm mass accuracy with real-time calibration
• Attomole-level quantification using PRM and DIA
• High sensitivity MS/MS with HCD, CID, ETD, EThcD, and new ETD HD fragmentation

🔄 Flexibility Across Workflows

• Tribrid architecture: combine quadrupole precursor selection, ion trap MSn, and Orbitrap detection
• DIA, PRM, and SPS-MS3 quantification workflows with isobaric tags (e.g., TMT, TMTpro)
• Top-down intact protein analysis with high sequence coverage
• Fast polarity switching and intelligent acquisition for lipidomics

🧪 Ideal for Multi-Omics and PTMs

• Deep profiling of glycopeptides, phosphoproteins, and other post-translational modifications
• Resolution of isobaric isoforms, methylation patterns, and histone modifications
• Confident structure elucidation of small molecules with fine isotope resolution

💡 Smart Technology for Productivity

• Advanced Quadrupole Technology (AQT) for high transmission and selectivity
• Automatic gain control (AGC) for optimal ion population
• Easy ETD™ source and vent-free maintenance with source plug
• Method templates and visual method editor for intuitive setup

🧬 Applications

• Quantitative and discovery proteomics (e.g., large-scale TMT SPS-MS3)
• Structural characterization of antibodies and proteoforms
• Targeted metabolite quantitation and small molecule identification
• Comprehensive glycoproteomics and lipidomics workflows

🧷 Software Compatibility

• Xcalibur™ and Tune for control and calibration
• Proteome Discoverer™, ProSight™, TraceFinder™, Mass Frontier™, Compound Discoverer™ for data analysis across omics

Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer