A validated QbD-based RP-HPLC method enables robust, stability-indicating impurity analysis of Elexacaftor, supporting process development and quality control in drug manufacturing.

LC-HRMS screening combined with temporal clustering identified daily domestic discharge patterns in wastewater, enabling improved interpretation of population chemical exposure.

A novel persistence-directed testing approach combined with nontarget GC-MS and LC-HRMS revealed a significant fraction of persistent chemicals in offshore oil platform produced waters.

LC-HRMS detected more prescribed and non-prescribed drugs than immunoassays and would have influenced clinical decisions for 25% of patients, mainly those with opioid-use history.

Gunacins, new compounds from Exobasidium, display strong anti-Leishmania and anti-Trypanosoma effects and also show antibacterial and antifungal activity.

Researchers at IOCB Prague developed a highly precise and ultra-stable fluorescent labeling method that stays attached even inside cells, enabling long-term, reliable tracking of biomolecules.

A fast HPLC-UV method was optimized to quantify trigonelline, 5-CQA, and caffeine in multiple Arabica cultivars. The method proved robust and highlighted major cultivar and roasting-related changes.

RECETOX researchers showed that some flame retardants in car interiors rise up to 700× in summer compared to winter, revealing strong temperature-driven exposure risks for drivers and passengers.

Copper/PVA films showed strong visible-light antiviral activity against MHV-3. Films with copper microparticles reduced viral load by 43% under illumination, compared with minimal reduction in the dark.

HPLC-HRMS with chemometrics showed clear metabolomic changes in herbicide-treated rice, including reduced sugars, lower flavonoids, and disrupted phenylpropanoid pathways.