<h5><strong>Tasty beer starts with knowing what’s in your hops. Explore how online SPE makes bitter acid analysis in hops faster and more reliable.</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_326238593f.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_326238593f.jpeg 245w," sizes="100vw" width="1024" height="512"></p><h3><strong>How can you detect bitter acid profiles quickly, reliably, and more sustainably?</strong></h3><p>For craft brewers and beer lovers alike, a refreshing experience is all about flavor.</p><p>So how can you achieve the desired bitterness in your beer? The answer is not just about the recipe. Finding the right flavor profile starts with the bitter acids present in the starting hops material.</p><div><div><p>Hops (the heart of your favorite beer) are the source of the brew’s distinctive flavor tied to bitterness and aroma.</p><p>At the molecular level, bitterness is driven by <a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0308814622016338">α- and β-bitter acids</a>, like humulones and lupulones, whose concentrations determine the final sensory profile of the beer (<strong>Figure 1</strong>).</p><p>Accurately characterizing these compounds in each batch allows brewers to unlock the full potential of every variety of hops.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 1. General chemical structure of hop bitter acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg 222w," sizes="100vw" width="700" height="493"></p><p>While conventional analytical methods rely on long, manual sample preparation steps and hazardous solvents, laboratories now strive for greener and more efficient workflows.</p><p>And moving from manual to online sample preparation is one of the easiest ways your lab can reduce waste and — most importantly — improve reliability with automation.</p><h3><strong>Key takeaways</strong></h3><ul><li>Online SPE reduces hands-on work, shortens turnaround time, and supports more sustainable methods by cutting solvent use and eliminating single-use cartridges.</li><li>Automated UHPLC workflows are easier for new users to execute, offering more reproducible quantifications of α- and β-bitter acids in hops.</li><li>Accurate bitter acid profiles help brewers distinguish hop varieties and control flavor with confidence.</li></ul><h3><strong>Comparing offline vs. online solid phase extraction for bitter acid HPLC analysis</strong></h3><p>If you’ve spent long hours in the lab preparing samples for hops analysis, you’re not alone.</p><p>Manual sample preparation often takes the most time in hops analysis, an area where online <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/chromatography-learning-center/chromatography-consumables/sample-prep.html">solid phase extraction</a> (SPE) can make a real difference. Here’s why.</p><p>Manual SPE has a lot of manual steps. Extraction. Cartridge loading. Washing. Elution. And sometimes solvent exchange or reduction. All before your actual analysis begins. This labor-intensive workflow can take up to an hour and depends strongly on operator skillsets, making reproducibility a challenge for new hires.</p><h3><strong>Online SPE analysis provides key benefits like:</strong></h3><ul><li>Hands-off workflow free of cartridges, manifolds, or vacuum steps.</li><li>Column washing and re-equilibration occur in parallel with separation.</li><li>SPE step is complete in just two minutes.</li><li>Minimizes operator-dependent variability.</li><li>Uses less than 8 mL of solvent.</li></ul><p>Let’s explore what this technique looks like in practice.</p><h3><strong>Online SPE for analyzing α- and β-bitter acids in hops standard solutions.</strong></h3><p>Changing your sample preparation from manual to automated isn’t complicated. With the right tools you can fully integrate online SPE with your UHPLC system (<strong>Figure 2</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 2. Schematic workflow for the determination of bitter acids in hops. The process involves clean up and instrumental analysis using the Thermo Scientific Vanquish Online SPE UHPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg 245w," sizes="100vw" width="700" height="323"></p><h3><strong>The process for analyzing a hops standard solution is straightforward:</strong></h3><ol><li>First, extract hop samples with ethanol (a greener alternative to toluene or diethyl ether in conventional methods).</li><li>Inject the extract directly into your instrument for analysis. Bitter acids retain<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1970"><strong> on the SPE column</strong></a> while matrix interferences that can comprise quantitation are removed.</li><li>Next, backflush the SPE column to transfer the analytes to the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/423"><strong> analytical column </strong></a>for separation. While this separation is taking place, the SPE column is washed and re-equilibrated in parallel, keeping the total run time to 15 minutes, with the separation of all six major bitter acids in a single analysis (<strong>Figure 3</strong>).</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 3. UV chromatogram of hop bitter acids in standard solution (1-cohumulone, 2-humulone, 3-adhumulone, 4-colupulone, 5-lupulone, 6-adlupulone)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg 245w," sizes="100vw" width="700" height="347"></p><h3><strong>Online SPE for analyzing α- and β-bitter acids in real hops samples</strong></h3><p>Analytical labs need methods that are accurate and reliable for brewers to develop distinct and reproducible flavor profiles across batches.</p><p>To assess the applicability of online SPE UHPLC methods for hops analysis, we analyzed bitter acid profiles from four species — Sultana, Barbe Rouge, Azacca, and Sabro.</p><p>The concentration of α-acids dominated all samples, while each hops species exhibited distinct profiles in terms of α-acid and β-acid content, making them suitable for different brewing strategies (<strong>Figure 4</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 4. Bitter acid profiles in four different hop species, error bars display SD (n=6). To check method consistency, we measured each hops extract six times. Variation between measurements was low, with relative standard deviation below 3.5 % across all hops species." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg 245w," sizes="100vw" width="700" height="410"></p><ul><li>For testing labs, this process translates into a workflow that is easy to run, fast, and delivers reliable results without added complexity.</li><li>For craft brewers, reliability means clear, trustworthy insights into hops bitter acid profiles, for better hop selection and more precise control of bitterness and flavor in your beer.</li></ul><h3><strong>From carefully procured samples to tasty sips</strong></h3><p>Efficient UHPLC workflows support faster results, less solvent use, and reliable bitterness data for brewers. And online SPE turns those advantages into practical, day-to-day benefits for brewers and labs alike.</p><ul><li>Less hands-on skills required for lab analysts</li><li>Faster results from labs to brewers</li><li>A more sustainable way to work</li><li>Clear insights into hops flavor</li></ul><p>To learn more about the method and see the full application data, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cn_004238_hplc_vanquish_online_spe_bitter_acids_hops_cn004238_na_en_587a5d300b.pdf"><strong>check out our application note today</strong></a>.</p><h3><strong>FAQs</strong></h3><div><div><h5><strong>What are the key compounds in hops analyzed by HPLC?</strong></h5><p>Bitter acids, namely α-acids and β-acids, especially the six major bitter acids (humulones and lupulones) that define hop bitterness and are required for quality control and brewing decisions.</p></div><div><h5><strong>What column types are recommended for hop acid separations?</strong></h5><p>Classical C18 Silica columns are ideal for bitter acids separation. UHPLC compatible columns with particle size ≤ 2 µm boost analysis with higher flow rate, thus shorter analysis time and solvent consumption.</p></div><div><h5><strong>What’s the best workflow for hops analysis?</strong></h5><p>A typical workflow for hop analysis consists of three main steps: extraction of the target compounds, clean-up of co-extracted matrix components, and instrumental analysis by HPLC or UHPLC. To keep this workflow efficient and reproducible, you should minimize manual handling and add in automation when possible. Integrating online SPE into your LC instrument allows sample clean-up to run automatically, reducing hands-on time, solvent use, and variability while delivering faster, more reliable results.</p></div></div><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#UHPLC #Automation</p></blockquote></div></div>

How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors

<p><strong>In the week of June 29, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Insights from an IC specialist: To be suppressed or not suppressed?</strong></h5><ul><li>Tu, 30.6.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6310">Registration</a></li></ul><p>Join Thermo Fisher’s Ask the Experts session to learn how suppressor technology impacts ion chromatography performance, sensitivity, reliability, maintenance, and troubleshooting.</p><h5><strong>2. SCIEX: Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery</strong></h5><ul><li>Tu, 30.6.2026 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6311">Registration</a></li></ul><p>Discover how ZenoTOF high-resolution mass spectrometry is accelerating single-cell proteomics and plasma biomarker discovery through enhanced sensitivity, throughput, and automation.</p><h5><strong>3. Agilent Technologies: Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres</strong></h5><ul><li>Tu, 30.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6052">Registration</a></li></ul><p>This webinar will discuss diffuse transmission and reflection UV/VIS measurements, including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer.</p><h5><strong>4. Waters Corporation: Informatics series #33 Tips, Tricks and Best Practices</strong></h5><ul><li>Th, 2.7.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6315">Registration</a></li></ul><p>This interactive session revisits essential features, shortcuts, and practical techniques in Empower software that can streamline everyday laboratory work and reduce unnecessary effort.</p><h5><strong>5. Waters Corporation: Unlocking Therapeutic Peptide Characterisation (GLP-1RAs) with Cyclic IMS</strong></h5><ul><li>Th, 2.7.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6313">Registration</a></li></ul><p>Discover how cyclic ion mobility spectrometry (cyclic IMS) improves characterization of GLP-1 analogues and therapeutic peptides, supporting development, quality control, and regulatory submissions.</p><h5><strong>6. Agilent Technologies: Spectral Flow Cytometry Masterclass - Session 1</strong></h5><ul><li>Fr, 3.7.2026 07:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6316">Registration</a></li></ul><p>Learn how full-spectrum flow cytometry enables high-dimensional cell analysis. Explore spectral flow technology, experimental design, and applications in immunology, oncology, and vaccine research.</p>

Webinars LabRulezLCMS Week 27/2026

<p><strong>The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;</strong></p><p>There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607"></p><p>A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;</p><h4><strong>Evaluation of measurement procedure performance&nbsp;</strong></h4><p>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;</p><ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"></p><h4><strong>Characterisation of candidate reference materials&nbsp;</strong></h4><p>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;</p><ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4><strong>Other ILCs&nbsp;</strong></h4><p>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).</p>

Interlaboratory comparisons other than proficiency testing

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Mestrelab Mnova Gears – Chrom QC software

This automation tool will run end-to-end QC workflows for you and deliver decision-enabling reports with all the results you’ll need.

<h3><strong>Automated workflow for high throughput quality control using LC/GC-MS</strong></h3>
<p>Compound quality control can be challenging and time consuming when manual input for processing or result interpretation is needed. If you are an organic chemist, medicinal chemist, formulation scientist, or a quality specialist and want to analyze your compound libraries to assert compound identity and assess purity, Chrom QC is your best ally. This automation tool will run end-to-end QC workflows for you and deliver decision-enabling reports with all the results you’ll need.</p>
<p><strong>Chrom QC</strong> runs on the Gears automation engine, which means that <strong>any LC/GC-MS format can be handled</strong> independently from the instrument software packages. <strong>Data is automatically retrieved</strong> from your directories (in batches or real time), matched to the corresponding molecular structures, formulae, masses, etc., and <strong>analyzed</strong> to <strong>confirm compound identity</strong> and <strong>determine purities</strong>. Custom csv, html, mnova, and PDF <strong>reports</strong> can also be <strong>automatically generated</strong>, and results can be sent directly to your database! Even better, all of this can be achieved with only minimal setup effort!</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_QC_software_All_your_purity_analyses_in_a_single_software_package_ff88cd29f6.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software: All your purity analyses in a single software package!"/></p>
<blockquote>
<h3><a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskq"><strong>Visit MestreLab Research Mnova Gears – Chrom QC product page to learn more!</strong></a></h3>
</blockquote>
<h3><strong>Chrom QC Benefits</strong></h3>
<ul>
<li><strong>Quality control all your compounds using one software package</strong> that supports all the major proprietary LC-MS data formats – make your quality control independent of the devices used!</li>
<li>Streamline your lot and batch release programs by <strong>automating data processing</strong>, <strong>analysis</strong>, and <strong>report generation</strong></li>
<li>High-quality data in a timely manner to <strong>enhance your lab productivity</strong></li>
<li>Effective <strong>result visualization</strong> with possible <strong>manual review</strong></li>
<li><strong>Save your compound results in your Mnova databases on-the-fly</strong></li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_2_8cff8a724b.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software."/></p>
<h3><strong>Chrom QC Features</strong></h3>
<ul>
<li><strong>Support to the majority of</strong> <a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gs6"><strong>LC/GC-MS data formats</strong></a></li>
<li><strong>Automatic detection and matching of input data</strong> files with provided information</li>
<li><strong>Flexible peak identification</strong> methods using molecular structures, formulae and masses, or peak size</li>
<li>Possible <strong>extraction of multiple traces</strong> for purity and concentration calculations</li>
<li><strong>Automated reporting with customization</strong> options and use of design templates (html, mnova, PDF, csv)</li>
<li><strong>Color-coded plate view</strong> to enable review-by-exception of the results</li>
<li><strong>Manual peak selection</strong> tool for result correction</li>
<li><strong>Automatic result archiving and databasing</strong></li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_QC_software_d27c9333ee.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software."/></p>
<h3><strong>Purification Workflow</strong></h3>
<h4><strong>More Automation</strong></h4>
<p>Looking for an enterprise-level solution for improving your purification and data management procedures? Check the <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskj"><strong>Best Method</strong></a> and <a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskm"><strong>Fraction Analysis</strong></a> bricks that also run in full automation, and learn more about our automated databasing solution with Mgears. You have the complete flexibility to combine and adapt these solutions to your standard procedures to reap even more benefits for your organization.</p>
<p><a href="http://www2.mestrelab.com/l/271522/2024-04-10/3p2gsh"><strong>Contact us</strong></a> for more information.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_4_f25f63daa7.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom QC software."/></p>
<h3><strong>Markets</strong></h3>
<p>Academic, Government &amp; Industrial</p>
<h4><strong>Who should be using Chrom QC?</strong></h4>
<p>Organic chemists, analysts, QC experts, and researchers using quantitative chromatographic methods for quality control, concentration/purity determination, or monitoring/optimization of reactions in one of the following markets and applications:</p>
<ul>
<li>Pharmaceutical/Drug development industry</li>
<li>Food &amp; Beverage industries</li>
<li>Personal care and Cosmetics</li>
<li>Fine chemical synthesis industries</li>
<li>Polymer industries</li>
<li>Academic research laboratories</li>
<li>Contract Research Organizations (CROs)</li>
<li>Quality control of synthesized or acquired compounds prior to registration</li>
<li>Quality control of compound collections prior to use in biological assays</li>
<li>Quality control of finished compounds prior release to the market (drugs, food additives, preservatives, etc.)</li>
<li>Quality control for formulation optimization and definition of storage recommendations</li>
</ul>


Mestrelab Mnova Gears – Affinity Screen software

Automated software tool for processing data from affinity selection mass spectrometry assays.

<h3><strong>Automated solution for affinity selection mass spectrometry data processing, interpretation, and hit identification</strong></h3>
<p><strong>Automated software tool for processing data from affinity selection mass spectrometry assays</strong>, where large libraries of compounds are tested against a target protein or other macromolecules (DNAs/RNAs) using a multiplexed approach.</p>
<p>The Affinity Screen software <strong>sorts input data</strong> files, <strong>processes the data</strong>, and <strong>compares the results</strong> from “free” and “bound” states to determine whether a molecule binds to a target or not. It <strong>generates human-readable reports</strong> where hits can be quickly identified and reviewed by experts to confirm positive result.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Affinity_Screen_software_Analyze_up_to_1_M_compounds_in_a_single_click_ee4ab26bc5.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Affinity Screen software - Analyze up to 1M compounds in a single click!"/></p>
<blockquote>
<h3><a href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwskt"><strong>Visit MestreLab Research Mnova Gears – Affinity Screen product page to learn more!</strong></a></h3>
</blockquote>
<h3><strong>Affinity Screen Benefits</strong></h3>
<ul>
<li><strong>Analyze affinity selection MS data from any LCMS instrument</strong>, regardless of the format</li>
<li><strong>Customize and streamline the analysis</strong> process from data pick up to results reporting and archiving</li>
<li><strong>Empower less experienced users</strong> to independently perform affinity selection MS assays and obtain results</li>
<li><strong>Minimize errors and enhance efficiency</strong> by reducing manual input</li>
<li><strong>Accelerate lead discovery</strong> by screening up to 1M compounds with a single click</li>
<li>Maintain <strong>control over data quality</strong> by setting controls and flags for result assessment</li>
<li><strong>Save time on routine and irrelevant data analysis</strong>, enabling a focus on innovation and decision-making</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Best_Method_software_2_8cff8a724b.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Affinity Screen software."/></p>
<h3><strong>Affinity Screen Features</strong></h3>
<ul>
<li><strong>Customizable configuration</strong> for picking up and sorting hundreds of datasets containing data for target-free, +target, and -target samples for each compound mixture with a single click</li>
<li>Flexibility to <strong>define criteria for peak detection and hit scoring</strong></li>
<li>Ability to <strong>review and interact with results</strong>, revise, and recalculate as needed</li>
<li><strong>Traffic light system</strong> indicating the presence or absence of hits in a well</li>
<li><strong>Detailed results for each hit</strong> displayed on a separate page with stacked EICs (Extracted Ion Chromatograms)</li>
<li>Generation of multiple and <strong>customizable outputs</strong>, <strong>automatically archived</strong> (reports can be generated in the user’s desired format, filtering data by target, compound, hit score, etc.)</li>
<li><strong>Results warnings and commenting</strong></li>
<li><strong>Flexible setup</strong> and <strong>robust integration</strong> capability with other laboratory systems</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Affinity_Screen_software_1_9a42987909.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Affinity Screen software."/></p>
<h3><strong>Markets</strong></h3>
<p>Academic, Government &amp; Industrial</p>
<h4><strong>Who should be using Affinity Screen?</strong></h4>
<ul>
<li>Drug discovery laboratories</li>
<li>Natural product research</li>
<li>Food and beverage industries</li>
<li>Personal care and cosmetics</li>
<li>Fine chemical synthesis industries</li>
<li>Polymer industries</li>
<li>Research laboratories</li>
<li>Contract Research Organizations (CROs) and other research service providers</li>
<li>Compound library screening for hit identification and lead discovery</li>
<li>Screening natural compounds, polymer-based biomaterials, food additives, etc., to identify their binding to a target protein</li>
</ul>


SciY Mnova Gears – Chrom Reaction Optimization software

With this new  Automated Software Solution for Chemical Reaction Optimization from Mnova Gears, determining the ideal reaction conditions becomes an easy, hassle-free, and quick task.

<h3><strong>Automated Software Solution for Chemical Reaction Optimization</strong></h3><p>With this new <strong>Automated Software Solution for Chemical Reaction Optimization</strong> from Mnova Gears, <strong>determining the ideal reaction conditions</strong> becomes an easy, hassle-free, and quick task. Chrom Reaction Optimization allows you to <strong>track</strong> a defined set of chemicals across <strong>multiple parallel reactions</strong> to compare their levels and <strong>conclude on the best experimental conditions</strong> to employ.</p><p>Set up your workflow from data pick-up to results drop-off, and scale it up as needed. <strong>Results</strong> are matched to the designed experimental points and are delivered <strong>in many formats</strong> including <strong>graphical visuals</strong> to enable quick and informed decision making.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Automate_data_processes_to_quickly_find_the_safest_most_efficient_c5ed26927d.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Automate data processes to quickly find the safest, most efficient, cost-effective synthetic schemes for your reactions."></p><blockquote><h3><a target="_blank" rel="noopener noreferrer" href="http://www2.mestrelab.com/l/271522/2024-03-25/3nwsl1"><strong>Visit Mnova Gears – Chrom Reaction Optimization product page to learn more!</strong></a></h3></blockquote><h3><strong>Chrom Reaction Optimization Highlights</strong></h3><ul><li>Seamless <strong>handling of large chromatography datasets</strong> removing bottleneck related to high throughput experimentation approaches</li><li><strong>Robust and repetitive data management workflows</strong> that will replace the tedious manual processing required for each sample</li><li>Huge <strong>time saving</strong> by enabling review-by-exception strategy</li><li><strong>Control over results quality</strong> and easy detection and correction of errors that may occur during processing and analysis</li><li>Quick and <strong>confident decision making</strong> based on global and <strong>graphical reports</strong> with the analysis results</li><li><strong>Structured analytical data reporting and archiving</strong> to comply with standards</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_features_a3c019c8e9.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software features."></p><h3><strong>Chrom Reaction Optimization Features</strong></h3><h4><strong>Fully customizable and reusable analysis methods</strong></h4><h5><strong>Reaction optimization input, data processing, analysis, reporting and results archiving is fully customizable to fit your needs.</strong></h5><p>Reaction optimization <strong>runs with the Mnova Gears</strong> platform and therefore benefits from the <strong>huge flexibility</strong> in input configuration which allows you to <strong>adapt analysis</strong> to your own data organization and formats. Input can come from disk directories or from the instrument in real time acquisition, and can be organized in many different ways. Mgears can be set to recognize and pick up the data for the analysis.</p><h5><strong>On the other hand, analysis options can be customized:</strong></h5><ul><li>Components to track/ignore</li><li>Compound matching options using structure or retention times</li><li>Analysis thresholds and controls, etc</li></ul><p>All analysis options can be saved, shared, and re-used in the future which allows huge time savings and robustness in the process.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Fully_customizable_and_reusable_analysis_methods_ad6b3b966c.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Fully customizable and reusable analysis methods."></p><h4><strong>Flag system for warnings about non-conformances</strong></h4><p>Analysis criteria can be defined by experts and colored <strong>flags configured to get warnings</strong> when sample analysis does not fulfill the specified requirements. For instance, a sample can be flagged when no peaks are detected, when component peaks overlap, and/or when RT variation exceeds an acceptable threshold.</p><p>Detecting these non-conformances is crucial to keep control over results quality. You can <strong>review the flagged sample in the Result Viewer</strong> to <strong>investigate</strong> the problem, easily <strong>correct</strong> peak assignments if needed, and <strong>re-analyze</strong> samples to <strong>update the results</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Flag_system_for_warnings_about_non_conformances_60517716c1.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Flag system for warnings about non-conformances."></p><h4><strong>Graphical summary of results and automatic global reports</strong></h4><p>Chrom Reaction Optimization <strong>simplifies decision making</strong> by generating <strong>global and graphical reports</strong> with the analysis results. Reports are generated in <strong>multiple formats</strong>, including a dynamic html format that allows data sorting (increasing or decreasing order) and export to new reports.</p><p><strong>Quantities</strong> of reaction starting materials, products, and other declared compounds are <strong>graphically represented</strong> in charts making it easier to <strong>decide on the best reaction conditions at a glance</strong>!</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mestrelab_Mnova_Gears_Chrom_Reaction_Optimization_software_Graphical_summary_of_results_and_automatic_global_reports_c5976ac1f6.jpg" alt="Mestrelab Research: Mestrelab Mnova Gears – Chrom Reaction Optimization software: Graphical summary of results and automatic global reports."></p><h3><strong>Markets</strong></h3><p>Academic, Government &amp; Industrial</p><h4><strong>Who should be using Chrom Reaction Optimization?</strong></h4><p>This Automated Software Solution for Chemical Reaction Optimization is suitable for all Organic, medicinal, and process chemists, in the following market fields:</p><ul><li>(bio)Pharmaceutical / Drug development and manufacturing</li><li>Food &amp; Bev industries / Synthesis of additives, flavors, etc.</li><li>Personal care and Cosmetics industry / Synthesis of preservatives, fragrances, emulsifiers, etc.</li><li>Agrochemical industry/ Synthesis of herbicides, insecticides, etc.</li><li>Polymers industry / Synthesis of new polymers</li><li>Other fine chemicals industries</li></ul>

Watrex Streamline GPC system

GPC system is an isocratic HPLC system consisting of one P1 pump, CT1i column thermostat with manual injector and RI1 refractive index detector.

<p><strong>GPC system is an isocratic HPLC system consisting of one P1 pump, CT1i column thermostat with manual injector and RI1 refractive index detector.</strong></p><h3><strong>FEATURES</strong></h3><ul><li>Optimized pump mechanics of P1 pump with parallel piston design offers excellent flow rate accuracy and low RI signal pulsation.</li><li>The thermal isolated optic with a counter-current heat exchanger and programmable temperature control, results in an extremly stable baseline and an optimal Signal/Noise ratio od RI1.</li><li>The system can be upgraded with autosampler and fraction collector, or VD 400 Viscometer Detector.</li><li>Data acquisition, processing and instrument control is done by Clarity Chromatography Station with GPC option or Agilent TriSEC software.</li></ul><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=streamline+p1+pump&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>P1 HPLC pump: Flow Rates</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/detectors/other-hplc-detectors/streamline-ri1-detector/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>RI1 refractive index detector</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/column-thermostats/streamline-ct1-columm-thermostat/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>CT1 Column thermostat</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity™ Chromatography Station</strong></a></li></ul><h5><strong>COMPONENT SPECIFICATION - P1 HPLC pump: Flow Rates</strong></h5><ul><li><strong>Flow Rates:</strong> 0.001 to 10.000 mL/min</li><li><strong>Pressure:</strong> 0 to 6,000 psi (42 MPa)</li><li><strong>Flow precision:</strong> &gt; 0.2% RSD</li><li><strong>Flow accuracy:</strong> ± 1 % @ 1mL/min and 7 MPa,</li><li><strong>Pressure accuracy:</strong> ± 2% of full-scale, with 80:20 H2O/IPA @ 7 MPa</li><li><strong>Pulsation:</strong> ± 0.5 % @ 1mL/min and 7 MPa</li><li><strong>Remote inputs:</strong> USB</li></ul><h5><strong>COMPONENT SPECIFICATION - RI1 refractive index detector</strong></h5><ul><li><strong>Light Source:</strong> Long-life LED</li><li><strong>Refractive index Range:</strong> 1.00 - 1.75 RIU</li><li><strong>Baseline Noise:</strong> ± 2.5 nRIU</li><li><strong>Baseline Drift:</strong> 200 nRIU/h</li><li><strong>Linearity:</strong> &gt; 1000 μRIU</li><li><strong>Flow cell pressure resistance:</strong> 5 bar</li><li><strong>Flow cell volume:</strong> 15 μl</li><li><strong>Time constant:</strong> 0.00/0.01/0.02/0.05/0.1/0.2/0.5/1.0/2.0/5.0/10.0 s</li><li><strong>Analog Output:</strong> 1x 0-2.5V</li><li><strong>Outputs:</strong> Event 1, Start (OUT), Error (OUT), + 5 V, 24 V Valve</li></ul><h5><strong>COMPONENT SPECIFICATIONS - CT1 Column thermostat</strong></h5><ul><li><strong>Temperature range:</strong> 10 °C above ambient temperature to 100 °C</li><li><strong>Temperature accuracy:</strong> max. 0,5 % of actual temperature</li><li><strong>Temperature stability:</strong> RSD &lt; 0,4 %</li><li><strong>Settability:</strong> 0,1 °C</li><li><strong>Internal dimensions:</strong> 320 x 50 x 30 mm (L x W x H)</li><li><strong>Compartment material:</strong> PTFE coated metal</li><li><strong>Compartment connection:</strong> USB</li><li><strong>Control:</strong> build-in color touch panel, datasystem</li></ul><h5><strong>COMPONENT SPECIFICATIONS - </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity™ Chromatography Station:</strong></a></h5><p>Advanced chromatographic datastation for data acquisition and evaluation supported with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1004"><strong>GPC module for MWD, Mw, Mn, Mz calculation</strong></a>. Enables rutine separations with pre-set methods, containing all experimental and conditions and data evaluation settings. PC Win 10 Professional with LCD monitor included.</p><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SGPC01-001</strong> Streamline™ manual GPC system with Refractive index detector (Includes P1 pump, RI1 detector, CT1i column thermostat with manual injector, solvent rack, Clarity PC station)</li></ul><p><strong>Optional configurations:</strong></p><ul><li><strong>ST99-002</strong> Remove CT1i column thermostat with manual injector from system</li><li><strong>SAS90-001</strong> Add AS1 Autosampler to system</li><li><strong>SFC90-001</strong> Add FC1 Fraction collector to system</li></ul>

Watrex SCS 205 GPC Sample cleanup system

The Watrex Streamline SCS 205 Sample Clean-up System is designed for GPC sample pretreatment.

<p>Sample clean-up is an <strong>essential method</strong> for many routine chromatography applications. One of the most common cases is analysis of <strong>polyaromatic hydrocarbons</strong> (PAHs), <strong>polychlorinated biphenyls</strong> (PCBs) and <strong>pesticides</strong> in complex mixtures.</p><p>The initial step is an isolation of hydrophobic (lipophilic) components from the rest of the sample mixture by <strong>gel-permeation</strong><br><strong>chromatography</strong> (GPC).</p><p>In such configuration, triglycerides (700-900Da) can be isolated from low molecular (200-300Da) PAHs, PCBs or pesticides using<br>GPC steric exclusion. SCS 205 is a dedicated system for GPC sample pretreatment. SCS 205 includes an isocratic pump double piston pump, manual injector with preparative sample loop, PAH/PCB preparative column (200mg sample loading capacity), fraction collector and start-up kit. .The entire system is controlled from a TFT touch display through intuitive screens.</p><p>After injection and GPC separation, the purified sample (PAHs, PCBs etc.) is captured by an automated fraction collection usinga3-way motorized switching valve. The timing of the collection is predetermined from the elution profile of the pollutants.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_column_7dce4f25e0.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - column"></p><h3><strong>FEATURES</strong></h3><ul><li>High performance pollutant izolation from complex matrices</li><li>Eluent flexibility</li><li>Easy programmable</li><li>Easy installation &amp; Simple operation</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_schema_ad45276ad0.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - schema"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_graph_10ce455cc3.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - graph"></p><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Sampling System:</strong> manual valve</li><li><strong>Sample volume:</strong> 2 mL loop</li><li><strong>Fraction collection:</strong> 50mL flask</li><li><strong>Collection time programming:</strong> alternating valve switching to waste/collect/waste</li><li><strong>Display:</strong> 4-character</li></ul><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SCS205-001</strong> SCS 205 Sample Clean-up System (<strong>Price 8 627 € ex VAT</strong>)</li><li><strong>WI02077</strong> WATREX 250x16 mm PAH Prep column, 10 um</li><li><strong>DGD.3008</strong> WATREX 300x8 mm DeltaGel Mixed-D column, 5 um</li><li><strong>DGB.25020</strong> WATREX 250x20 mm DeltaGel Mixed-B column, 5 um</li></ul><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/dedicated-instruments/scs-205-sample-clean-up-system/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

Watrex xTrovert XT Automatic DNA/RNA extractor

Watrex xTrovert XT is an automatic DNA/RNA extractor. It streamlines the extraction process, making it more efficient and reproducible.

<p><strong>Automatic extractor utilises a simple principle of two pipetting heads serving a 96-well plate.</strong></p><p>Thanks to easy replacement head options of pipetting with <strong>300 μl tips</strong> or <strong>1000 μl</strong> tips are available. <strong>Automatic optical sensor calibration</strong> enables the use of pipetting tips and <strong>96-well plates</strong> from virtually any supplier. The device is equipped with two magnetic arms for protocols including paramagnetic SPR beads. It also allows for thermal incubation in the range of <strong>25 to 85 °C</strong>. In addition to internal <strong>LED lighting</strong>, the station is equipped with an integrated <strong>UV-C sterilisation unit</strong>. Intuitive control from <strong>TFT touch panel</strong> user interface facilitates easy set-up. xTrovert™ XT is a <strong>fully programmable open system</strong> where user can create their own workflow scripts downloadable as text files from USB flas disk.</p><h3><strong>APPLICATIONS</strong></h3><ul><li><strong>Sample prep for PCR testing</strong></li><li><strong>NGS library prep</strong></li><li><strong>Sanger DNA sequencing</strong></li></ul><h3><strong>CURRENT PROTOCOLS</strong></h3><ul><li><strong>DNA/RNA extraction</strong></li><li><strong>DNA purification</strong></li><li><strong>PCR clean-up/desalting</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_x_Trovert_XT_Automatic_DNA_RNA_extractor_Compatible_with_any_magnetic_bead_based_kit_23886eea52.jpg" alt="Watrex: Watrex xTrovert XT Automatic DNA/RNA extractor - Compatible with any magnetic bead based kit"></p><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Capacity:</strong> 16 or 32 samples/run</li><li><strong>Volume range:</strong> 10 – 600 μl</li><li><strong>Temperature:</strong> 25 – 85 °C</li><li><strong>Sterilization:</strong> UV-C</li><li><strong>Display:</strong> 3,5“ TFT touch display</li><li><strong>Connectivity:</strong> USB 1.0/2.0</li><li><strong>Power source:</strong> 24 V adaptor</li><li><strong>Dimensions in cm:</strong> 65(w) x 65(h) x 34(d)</li><li><strong>Weight:</strong> 25 kg</li></ul><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>XTR000-001</strong> xTrovert™ XT Universal robotic pipettor for DNA/RNA extraction &amp; handling</li><li><strong>XTR000-003</strong> Replaceable 8-channel 1000uL pipetting head for xTrovert™ XT</li><li><strong>XTR000-004</strong> Replaceable 8-channel 300uL pipetting head for xTrovert™ XT</li><li><strong>XTR000-100</strong> Deepwell plates (empty) for xTrovert™ XT</li><li><strong>XTR000-220</strong> DNA/RNA extraction kit, mgn. beads, 16-rxns per plate</li></ul><p>The entire system was designed and developed by Watrex Praha and is <strong>manufactured in the Czech Republic</strong> and promises a shift in the performance and efficiency of laboratory processes worldwide!</p><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/laboratory-automation/xtrovert-xt/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

Watrex SPR-200 Solvent saver

Watrex SPR-200 Solvent Recycler is designed to save up to 90% of mobile phase during isocratic HPLC.

<p>This Solvent Recycler <strong>saves up to 90% of mobile phase</strong> by redirection of the pure solvent to the solvent reservoir during the isocratic HPLC. The stand alone device is powered by 5 V DC from <strong>power adapte</strong>r or from computer <strong>USB port</strong>. Working parameters (<strong>Threshold and Delay</strong>) are easily set on the display using a membrane keyboard.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SPR_200_Solvent_saver_I_Nputs_694d991f2c.jpg" alt="Watrex: Watrex SPR-200 Solvent saver - INputs"></p><p>The SPR-220™ Solvent Recycler <strong>continuously monitors the output signal</strong> of the chromatography detector and displays its current value on the built-in display. A <strong>highresolution analog-to-digital converter</strong> provides data for further evaluation in the built-in processor. If the input signal level exceeds a preset value (Threshold), the SPR-200 will redirect the flow to the waste.</p><p>When the signal drops, the solvent recycler waits for the transport delay and then switches the mobile phase <strong>back to the reservoir</strong>. An autosampler injection marker connected to the SPR-200 ZERO input can be used to zero the input signal at the time of injection.</p><h3><strong>FEATURES</strong></h3><ul><li>Stand alone operation</li><li>Detachable valve</li><li>Possibility of manual Waste/Recycle switching</li></ul><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Detector compatibility:</strong> compatible with any HPLC detector</li><li><strong>Connection:</strong> 1/16″ O.D. tubing, 1/4″-28 flat bottom fittings</li><li><strong>Maximum pressure:</strong> 30 p.s.i./0,2 MPa</li><li><strong>Wetted material:</strong> PEEK, PTFE</li><li><strong>Input range:</strong> +/- 1 V or +/- 100 mV, user selectable</li><li><strong>Computer connection:</strong> μUSB</li><li><strong>TTL/contact closure input:</strong> configurable (ZERO, start, valve position)</li><li><strong>Power:</strong> 5V DC/&lt;100 mA (power supply or computer USB port)</li><li><strong>User interface:</strong> large character LCD alphanumeric display + membrane keypad</li></ul><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SPR200-001</strong> SPR-200 Solvent Recycler, PEEK version (<strong>Price 1 250 € ex VAT</strong>)</li><li><strong>SPR200-002</strong> SPR-200 Solvent Recycler, PTFE version (<strong>Price 1 250 € ex VAT</strong>)</li></ul><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=SPR-200+Solvent&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

Waters Xevo MRT QTof Mass Spectrometer

Achieve exceptional science with the Xevo™ MRT Mass Spectrometer—100K resolution at 100 Hz, sub-ppm accuracy, and confident identification for greater lab productivity.

<h3><strong>Delivering Performance and SPEED</strong></h3><ul><li><strong>Resolution AND Speed Without Compromise</strong></li></ul><p><strong>Whether you’re in academia or industry achieve exceptional science - 100% of the time with the Xevo™ MRT Mass Spectrometer. This state-of-the art QTof delivers 100K resolution at 100 Hz with sub ppm mass accuracy for confident identification and greater productivity in your lab.</strong></p><h4><strong>Delivering performance at speed</strong></h4><p>The high resolution and mass accuracy of the Xevo MRT Mass Spectrometer are independent of acquisition rate. Working at maximum resolution ensures you can resolve analytes in complex matrices, providing comprehensive, high accurate mass data for scientific interpretation.</p><h4><strong>Increase compound identification confidence</strong></h4><p>Probe deeper at biologically relevant concentrations with high levels of mass accuracy. Search tolerances can be minimized resulting in efficient data review, improving turnaround times for increased lab productivity.</p><h4><strong>Connected solutions</strong></h4><p>A complete workflow for metabolomics, lipidomics, and metabolite identification through market leading chemistry and cutting-edge, informatics ensures your lab is operating with maximum efficiency – reducing the time to result.</p><h4><strong>Exceptional science - every day</strong></h4><p>System performance is critical. From instrument stability and robustness for extended studies to precision measurements in every injection, innovative multi reflecting time-of-flight technology delivers high quality experimental outcomes for every lab, every day.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Hmotnostni_spektrometr_1_63e746d310.jpg" alt="Waters Xevo MRT Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Hmotnostni_spektrometr_1_63e746d310.jpg 244w," sizes="100vw" width="1119" height="715"></p><h3><strong>Extraordinary Performance</strong></h3><h4><strong>Without compromises</strong></h4><h5><strong>Exceptional science for every lab, scientist, problem, question, and sample… Solved</strong></h5><p>The exceptional combination of high mass resolving power of 100,000 FWHM and mass accuracy of &lt;500 part per billion (ppb) of the Xevo MRT Mass Spectrometer are achieved independent of acquisition rates, up to 100Hz. Maximum performance, matched to throughput levels that matter for complex and challenging analyses, increases statistical power and confidence in results.</p><h5><strong>Feeling trapped?</strong></h5><p>Unlike other high-resolution MS technologies, multi-reflecting time-of-flight delivers mass resolution consistent over a broad m/z range independent of scan speed, even at the fastest acquisition rates for MS and MS/MS data, ensuring confident identification of analytes across a range of samples and matrices – an ideal solution for metabolite profiling and discovery.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Mass_Spectrometer_Extraordinary_Performance_d8879eda23.jpg" alt="Waters Xevo MRT Mass Spectrometer: Extraordinary Performance." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Mass_Spectrometer_Extraordinary_Performance_d8879eda23.jpg 245w," sizes="100vw" width="1309" height="774"></p><h3><strong>Connected Solutions</strong></h3><h4><strong>From advanced chemistry to flexible informatics</strong></h4><p>Make meaningful scientific discoveries more efficient with dedicated workflows combining column chemistries, separations, and informatics with the exceptional data quality of the Xevo MRT Mass Spectrometer. The waters_connect™ platform allows you to process and report your data in the way that you want. Whether using a Waters supported solution or exporting data via mzML to custom scripted workflows, we have you covered.</p><h4><strong>The Xevo MRT mass spectrometer readily integrates with your existing pipeline and workflow strategy</strong></h4><p>Waters has partnered with Mass Analytica™ (mass-analytica.com) and their market leading metabolomic, lipidomic, and metabolite identification software packages, MARS, Lipostar2, and MassMetaSite, respectively. Through either the waters_connect Application Programming Interface (API) or via mzML*, there is the option for you to transfer your data into the relevant software package for statistical interpretation and identification of analytes.</p><p>The DATA Convert Application within the waters_connect Platform enables you to convert to and export mzML file formats, ensuring a seamless integration of technology and informatics for every lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Hmotnostni_spektrometr_6_d0fc257136.jpg" alt="Waters Xevo MRT Mass Spectrometer: Connected Solutions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Hmotnostni_spektrometr_6_d0fc257136.jpg 236w," sizes="100vw" width="1212" height="802"></p><p>The waters_connect platform provides flexible data processing options, either using third-party applications via the waters_connect API or conversion of data sets to mzML file format via DATA Convert.&nbsp;</p><h3><strong>Unlocking a New Level of Confidence&nbsp;</strong></h3><h4><strong>By bringing an analytical powerhouse to every lab</strong>&nbsp;</h4><p>To meet the most challenging analytical problems that you experience head on, Waters has taken cutting edge technology that was pioneered in the SELECT SERIES™ MRT, scaling the raw power and resolution at speed into a compact flexible, benchtop platform.</p><h4><strong>The MRT Xevolution</strong></h4><p>The Xevo MRT Mass Spectrometer has been engineered to deliver high-end technology into a benchtop platform to solve your most challenging problems. The novel acquisition system, with dual gain analogue-to-digital converter, delivers long term system stability over a high dynamic range, ensuring exceptional quality data with consistent robustness and reproducibility.</p><p>The 4 m flight path with a total of 8 reflections within the MRT mass analyzer, achieves 100,000 FWHM resolution at scan rates of up to 100 Hz - for ultimate MS/MS performance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Hmotnostni_spektrometr_Schema_2448b0bc8d.jpg" alt="Waters Xevo MRT Mass Spectrometer: The Xevo MRT Mass Spectrometer schematic. ​" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Hmotnostni_spektrometr_Schema_2448b0bc8d.jpg 236w," sizes="100vw" width="1199" height="794"></p>

Thermo Scientific Stellar Mass Spectrometer

Move biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with breakthroughs in extended scale, massive throughput, higher sensitivity, greater specificity, and unrivaled productivity.

<div><div id="container-a1c36dfacf"><div><div><div id="text-913638046"><p><strong>A new paradigm for targeted quantitation.&nbsp;Move biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with breakthroughs in extended scale, massive throughput, higher sensitivity, greater specificity, and unrivaled productivity.</strong></p><p>The Thermo Scientific Stellar Mass Spectrometer introduces revolutionary technology combining robust quantitation with the specificity of rapid full scan MS<sup>n</sup>&nbsp;acquisition creating unrivaled improvements in laboratory productivity.</p><div><div id="text-801893275"><h3><strong>Expanded experimental capabilities to meet the most challenging biomarker verification</strong></h3></div></div><div><div id="container-1e8e478f3a"><div><div><div id="text-1204752335"><p>The Thermo Scientific Stellar Mass Spectrometer offers an array of data acquisition capabilities to deliver robust and reproducible quantitation for a wide range of analytes across an extended dynamic range.</p></div></div></div></div></div><h4><strong>System highlights</strong></h4><div><div id="container-a89a56f063"><div><div><div id="text-451891225"><h5><strong>Improve ionization efficiency for more compounds at higher LC flow rates&nbsp;</strong></h5></div></div><div><div id="text-1671602085"><p>For a wider range of compounds separated using liquid chromatography operated at analytical flow rates, the Stellar Mass Spectrometer comes equipped with the Thermo Scientific OptaMax Plus Ion Source, which can deliver higher vaporizer temperatures to improve desolvation and ionization potentials.</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/725;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_Opta_Max_c303cf500a.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys OptaMax" width="1290" height="725"></figure><div><div id="container-d79c3b2946"><div><div><div id="text-251514658"><h5><strong>Spend less time on instrument set-up and focus on the science</strong></h5></div></div><div><div id="text-989104128"><p>Trigger on-demand or scheduled system calibrations remotely and without disruption to your LC-MS system with the integrated Auto-Ready ion source.</p></div></div></div></div></div><div><div id="container-81dd07c9bb"><div><div><div id="text-1289282711"><h5><strong>Improve ion utilization by extending the capabilities of the new collision cell</strong></h5></div></div><div><div id="text-1641484825"><p>The ion concentrating routing multipole (ICRM) is a curved collision cell performing both beam-type fragmentation (HCD) and precursor/product ion accumulation capabilities as controlled by dynamic automatic gain control (AGC) with synchronized ion packet release to the high-pressure linear ion trap for downstream manipulation or detection.</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/725;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_ICRM_3b2326f3af.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys ICRM" width="1290" height="725"></figure><div><div id="container-dbf5a6cdd9"><div><div><div id="text-813962034"><h5><strong>Efficiently manage ion populations for fast and sensitive analysis</strong></h5></div></div><div><div id="text-2033771024"><p>The&nbsp;hyper-fast dual-pressure linear ion trap mass analyzer expands analytical capabilities while maximizing fast, high-quality data acquisition.</p><p>The differential neutral pressures maintained in the high- and low-pressure linear ion traps prepares ions for higher-order manipulation or fast and sensitive ion ejection at scan rates up to 220 kDa/S, but typically operates at 125 kDa/S for robust data acquisition.</p></div></div></div></div></div><div><div id="container-9a523f34e0"><div><div><div id="text-1491120095"><h5><strong>Extended analytical capabilities to increase laboratory productivity</strong></h5></div></div><div><div id="text-328051555"><p>The high-pressure linear ion trap maximizes ion packet manipulation enabling multi-notch RF excitation for dissociation or ejection for SIM, higher order MS<sup>n</sup>, SPS MS<sup>3</sup>, or data-independent acquisition (DIA) to address the most challenging quantitative experiments.&nbsp;</p><div><div id="container-82e5907416"><div><div><div id="text-693866740"><h5><strong>Leverage single ion detection sensitivity to address the most challenging quantitation demands</strong></h5></div></div><div><div id="text-737565098"><p>Efficient and sensitive ion detection drives improved quantitative performance at scale. The dual conversion dynode configuration coupled to the photomultiplier tube detects ca. 84% of trapped ions for single ion sensitivity.</p></div></div></div></div></div></div></div></div></div></div><figure class="image"><img style="aspect-ratio:2048/1152;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_hmotnostni_spektrometr_SF_Sys_Extended_Scale_750dc20128.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys Extended Scale" width="2048" height="1152"></figure><div><div id="text-1993749933"><h5><strong>Automated intelligence manages tMSn acquisition</strong></h5></div></div><div><div id="text-1206797739"><p>Streamline tMSn method creation and data acquisition management. PRM Conductor software effectively and efficiently creates robust targeted quantitative methods and manages reproducible data acquisition and processing.</p></div></div><div><div id="container-b03b606507"><div><div><div id="text-2005266584"><h5><strong>Maximize data completeness with the Adaptive RT routine</strong></h5></div></div><div><div id="text-671832198"><p>Eliminate the cost and time of optimizing RT kits to the study samples to boost timed/scheduled data acquisition performance using the Adaptive RT routine.</p><p>The method leverages a novel real-time mapping routine to dynamically adjust timed/scheduled data acquisition windows at narrower time intervals to eliminate missing values that compromise data quality.&nbsp;</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/654;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_PRM_Conductor_5b596e7e4c.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys PRM Conductor" width="1290" height="654"></figure><div><div id="container-a192ba4b83"><div><div><div id="container-38d4c699d2"><div><div><div id="text-1578189934"><h5><strong>Industry-leading polarity switching speeds increase laboratory productivity</strong></h5></div></div><div><div id="text-1173595596"><p>Reduce the time, cost, and challenges associated with creating and implementing highly multiplexed quantitative metabolite analysis. Fast polarity switching speeds enable comprehensive compound interrogation in +ESI and -ESI at all MS<sup>n</sup> levels on an LC timescale.</p><div><div id="container-b5fb525888"><div><div><div id="text-18006314"><h5><strong>Environmentally friendly dry pumps decrease energy usage and maintenance</strong></h5></div></div><div><div id="text-1704557304"><p>Changing from two oil-based fore pumps to a single dry pump reduces heat output by 22% and decreases maintenance.</p><p>The use of a single dry pump also eliminates oil vapors and the need for oil checks and changes.</p><h3><strong>Solutions for additional research support</strong></h3><div><h4><strong>Translational proteomics</strong></h4><p>The Stellar Mass Spectrometer offers new possibilities for translational proteomics with improved specificity for greater quantitative performance at scale.</p><h4><strong>Quantitative proteomics</strong></h4><p>Accurate and precise quantitation for label-free and TMT multiplexing sample analysis strategies with the Stellar Mass Spectrometer.</p><div><h4><strong>Metabolomics and Lipidomics</strong></h4><p>Extended analytical capabilities quantify more metabolites and lipids with greater specificity using faster liquid chromatography gradients to increase laboratory productivity.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Modern HPLC separations in theory and practice

This book is a unique combination of theory and practice, but also overviews of stationary phases, sample prep materials, and vendor’s brief presentations.

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