<p><strong>In the week from March 8, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 LC and GC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: 2D or Not 2D - Agilent 2D-LC Forum</strong></h5>
<p>During this 2D-LC forum we will cover: Recent Advances in 2D-LC for Biopharmaceutical Analysis; 2D-LC: A Tutorial focusing on Best Practices - Part 1 and Part 2; Ask the Experts.</p>
<h5><strong>2. Agilent Technologies: Experts Webinar Series: Adeno Associated Viruses Characterization</strong></h5>
<p>In this webinar series, hear from mass spec experts as they pour you a cup of innovative new findings they have discovered in their field. </p>
<h5><strong>3. Agilent Technologies: Native MS and IM-MS Analyses of Large Proteins and Protein Complexes</strong></h5>
<p>We will describe simple modifications to the Agilent electrospray source to accommodate static nanoelectrospray ionization (nESI). This allow for MS and IM-MS analyses of large protein complexes (&gt;100 kDa).</p>
<h5><strong>4. Agilent Technologies/Metrohm: Haloacetic Acids Analysis by IC-TQ</strong></h5>
<p>In this webinar we will review instrumentation and method setup using a Metrohm ion chromatogram (IC) for separation and the 6470 TQ for detection. Data compliant with EPA 557 will be presented.</p>
<h5><strong>5. Agilent Technologies: Analysis of Mycotoxins in Food Matrices</strong></h5>
<p>The combination of the cleanup of matrix interferences, chromatography, and the Ultivo triple quadrupole LC/MS allows for sensitive and precise detection of mycotoxins.</p>
<h5><strong>6. Agilent Technologies: Expanded Automated Protein &amp; Peptide Sample Preparation Capabilities: New Larger Capacity Cartridges</strong></h5>
<p>This talk will provide an overview of the platform and its flex. to address a wide range of workflows, with a particular focus on the new cap. enabled by the availability of large-capacity AssayMAP cartridges.</p>


LC and LCMS webinars - Week 10

<p><strong>MS/MS (Tandem) spectra can be used to identify unknowns employing library searches. This is accomplished in much the same approach as that employed for EI GC-MS with the NIST search software. The much improved NIST Search Version 2.4 is included with the 2020 library release.</strong> </p>
<p>I will attempt to introduce the user to the use of the <strong>NIST Version 2.4 search software</strong> employing NIST, Wiley, “crowd-sourced (MoNA)”, and user libraries for the <strong>identification of unknowns</strong>.</p>
<p>NIST has an ambitious program to extend their already comprehensive, high-quality MS/MS databases. </p>
<p>See the following link: <a href="https://littlemsandsailing.files.wordpress.com/2020/12/xiaoyu_yang_asms2020_presentation.pdf">NIST Pipeline for Extending MS/MS Libraries</a></p>
<p>This involves a very comprehensive process for <strong>selecting</strong> pertinent compounds for purchase and subsequent <strong>analyses</strong>. The problem with variability of the spectra is reduced by analyzing the samples on a <strong>variety of instruments</strong> at a <strong>variety of energy levels</strong> (20 steps). In addition, many different <strong>precursor ions</strong> and <strong>fragment ions</strong> are characterized (MSⁿ). This has already led to a very large high quality library of <strong>accurate mass MS/MS spectra in the 2020 release version</strong> (31K compounds/1.3 M spectra) and the effort is ongoing.</p>
<h3><strong>The Part IV will cover:</strong></h3>
<p>Detailed Handouts including tables of content are available in the <a href="https://lcms.labrulez.com/library?search=lc%2Fms%20unknown%20identifications%20using%20msms%20libraries&amp;manufacturerItems=55">LabRulezLCMS library</a>.</p>
<ul>
<li>Introduction of Presenter, James Little</li>
<li>Table of Contents </li>
<li>Series Topics</li>
<li>Help Files for NIST Search</li>
<li>NIST Software in General is “Windows Compliant” </li>
<li>Abbreviations Used in Text and Useful Keyboard Sequences </li>
<li>Methods for ImportingSpectra Directlyin MSP Format to NIST</li>
<li>Mass Spec Manufactures Current Use of NIST Search</li>
<li>Example of Capability Utilized by Agilent</li>
<li>Example of Imported Agilent Spectrum</li>
<li>Example of Mult-Spectra Import of Agilent Spectra </li>
<li>Importance of Proper Settings in NIST Spectrum Import Options</li>
<li>Importing Spectra Manually Indirectlyin MSP and Other Formats </li>
<li>Exporting Spectra Manually in MSP and Other Formats </li>
<li>Example of Typical NIST Entry in *.MSP Format</li>
<li>Live YouTube Demonstration </li>
<li>References with Internet Links </li>
<li>Acknowledgements</li>
</ul>
<h3><strong>Future parts will focus on:</strong></h3>
<ul>
<li>Part V:    <strong>NIST Structure Searches</strong></li>
<li>Part VI:   <strong>MS Interpreter Correlation of Substructure to MSMS Ions</strong></li>
<li>Part VII:  <strong>Using and Creating Other MSMS Libraries</strong></li>
<li>Part VIII: <strong>Identification of Unknowns with “Spectraless” Libraries</strong></li>
</ul>


LC/MS Unknown Identifications Using MSMS Libraries Part IV: Importing MSMS Spectra

<p><strong>In the week from March 15, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 LC and GC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: Native Mode Analysis of Biologics- Charge Variant Profiling Protein Therapeutics Using Ion Exchange Chromatography (IEX) Solutions</strong></h5>
<p>In this webinar, speakers will discuss the importance of charge variant analysis and Ion-Exchange (IEX) methods for intact analysis of biotherapeutics with the utilization of some specific case studies.</p>
<h5><strong>2. Agilent Technologies: 1st Agilent Lab Informatics Virtual Summit</strong></h5>
<p>In this 1-day Virtual Summit don’t miss the opportunity to hear and speak with Agilent Lab Informatics experts.</p>
<h5><strong>3. PerkinElmer: Analysis of Polar contaminants and Glyphosate with Qsight LC-MS/MS</strong></h5>
<p>In this webinar we present a series of solutions with optimized sample preparation and LC coupled with laminar flow MS/MS for the detection and quantitation of several polar water contaminants.</p>
<h5><strong>4. Technology Networks/SCIEX: Bioanalysis of Therapeutic Oligonucleotides by HRMS</strong></h5>
<p>A pharmacokinetics assessment strategy for siRNA modalities will be presented, featuring ion-pairing reverse phase chromatography and quantitation by QTOF HRMS.</p>
<h5><strong>5. Agilent Technologies: High Throughput Native MS With Robust Ion Source Operation For The Analysis Of Proteins And Protein Complexes</strong></h5>
<p>Here we explore the feasibility of high flow approaches for native mode analysis of non-covalent complexes.</p>
<h5><strong>6. Agilent Technologies: Fully automated 2D-LC/MS for biotherapeutics charge variant characterization using Ion Exchange (IEX) and Reversed-Phase (RP) Chromatography</strong></h5>
<p>In this webinar we will discuss the importance of charge variants analysis of therapeutic mAbs and a fully automated multiple heart-cutting 2D-LC/MS workflow solution for charge variant characterization.</p>
<h5><strong>7. Restek Corporation: Restek’s Workflows and Products for the Cannabis Market</strong></h5>
<p>Don’t reinvent the wheel! Join us to learn more about our testing solutions, literature and resources, and some of our first-hand experiences in this market. </p>
<h5><strong>8. C&amp;EN/PerkinElmer: Advancing Research, Technology and Detection of PFAS in Our Environment</strong></h5>
<p>This webinar will provide updates on the latest research and technologies related to these contaminants of emerging concern and their detection, impact, and management.</p>
<h5><strong>9. Agilent Technologies: Cracking Cellular Metabolism</strong></h5>
<p>In this webinar, we will demonstrate a complete untargeted metabolomics workflow from sample prep to data analysis, within the context of cancer cell biology. </p>
<h5><strong>10. Agilent Technologies: Charge variants analysis of biotherapeutics by fully automated Capillary Isoelectric Focusing (cIEF) and High Res Mass Spectrometry</strong></h5>
<p>In this Webinar, speakers will discuss the fully automated on-line charge variants analysis of biotherapeutics (mAbs and other molecules) using online cIEF/MS workflows.</p>
<h5><strong>11. Agilent Technologies: Experts Webinar Series: Oligonucleotide Analysis</strong></h5>
<p>In this webinar series, hear from mass spec experts as they pour you a cup of innovative new findings they have discovered in their field.</p>


LC and LCMS webinars - Week 11

<p><strong>Covid-19 has had a major impact on how a lab operates. Personnel well-being as well as safe access to a reliable gas supply are now even greater priorities for analytical facilities and institutions. Labs supplying their instruments using bulk gas methods, such as cylinders or dewars, need to take extra precautions to minimize covid-19 exposure risks from outside third party contact and manual handling of cylinders. Ensuring the lab facility has contingency storage of gas in the event of lockdown transport restrictions is an additional stressor for laboratory staff.</strong></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Peak_Scientific_Generatory_plynu_a_bezpecnost_laboratore_behem_Covid_19_2_7a5a032e9c/Peak-Scientific-Generatory-plynu-a-bezpecnost-laboratore-behem-Covid-19-2.jpg" alt="Peak Scientific: Reduce risks of Covid-19 contact transmission"/></p>
<h3><strong>Safety - Reduce risks of Covid-19 contact transmission</strong></h3>
<p>Having strict outside contact policies in place, labs must limit third party contact to protect their members of staff, which can make regular cylinder deliveries and installations daunting tasks due to the risks of Covid-19 contact transmission.</p>
<p>Among the other safety benefits an in-house gas generation has to offer, including advanced fail-safe technology and minimal gas storage, labs operating with a gas generator for applications such as LC-MS or GC, can eliminate the Covid-19 infection vector of recurring material delivery to site and manual handling of cylinders, with the additional contact touchpoints that incurs.</p>
<p>A Peak in-house gas generator only requires a one-time delivery, granting lab personnel the independence to operate the unit by themselves without the assistance or supply provision from third parties, thereby limiting contact to their employees. What is more, as an equipment fully integrated in a closed lab environment, an in-house gas generator is easier to sanitize, making sure all your lab equipment maintains the adequate hygiene standard required for all employees to be able to use safely.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Peak_Scientific_Generatory_plynu_a_bezpecnost_laboratore_behem_Covid_19_3_22ada1a7b8/Peak-Scientific-Generatory-plynu-a-bezpecnost-laboratore-behem-Covid-19-3.jpg" alt="Peak Scientific: Gas supply access on-demand, 24/7"/></p>
<h3><strong>Reliability – Gas supply access on-demand, 24/7</strong></h3>
<p>The Covid-19 pandemic has caused supply chain disruption across a number of industries, heightening the uncertainty over future gas delivery capability in the event of potential future lockdowns imposing logistics infrastructure restrictions.</p>
<p>Performing LC-MS or GC analysis with a Peak <a href="https://www.peakscientific.com/nitrogen-generators/"><strong>nitrogen</strong></a>, <a href="https://www.peakscientific.com/products/hydrogen/"><strong>hydrogen</strong></a> or <a href="https://www.peakscientific.com/products/air/"><strong>zero air</strong></a> gas generator provides a continuous supply of gas available on-demand, 24/7. Labs can have peace of mind knowing they have the independence which allows them to be in control of their own gas source without having to rely on the availability of third party suppliers.</p>
<p>Free of touchpoints and outside contact through deliveries and installation, running your LC-MS or GC instrument with a Peak gas generator is a step towards a safer and more independent lab. Producing your own laboratory-grade gas means you can focus on what’s important without any concerns over safety or supply shortages.</p>
<h3><strong>Peak Protected - World class generator care</strong></h3>
<p>At Peak Scientific, we understand that a reliable and consistent gas supply is essential to the critical nature of your work. That&#39;s why we have developed <a href="https://www.peakscientific.com/service/about-peak-protected/"><strong>Peak Protected</strong></a> first-class after-sales care allowing you to have peace of mind knowing our support keeps your generator in great condition, with optimized performance throughout the product life span. Should you require a service or in the unlikely event of a breakdown, one of our Field Service Engineers will be on your site within 24-72 hours (Note), thanks to our global rapid call-out response. With <strong>Peak Protected</strong>, your lab is our priority. For further enquiries on our after-sales care, contact us today on protected@peakscientific.com</p>
<p>Note: Response time is dependent on region and service plan. Monday to Friday working days only.</p>


On-site Gas Generators & Lab Safety During Covid-19

<p><strong>In the week from March 22, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>700 LC and GC webinars</strong>.</p>
<h5><strong>1. Dr. Maisch: MODCOL Preparative Scale SPRING COLUMN Hardware and MULTIPACKER</strong></h5>
<p>In this webinar you will learn more about our dependable MODCOL preparative SPRING COLUMN hardware and our latest upgrades on available dimensions and MULTIPACKER.</p>
<h5><strong>2. Waters Corporation: Waters LC Symposium - Plenary and Pharma</strong></h5>
<p>Waters Corporation is pleased to bring together chromatography thought leaders for a week of scientific talks, demonstrations, discussions, and networking regarding novel LC technologies and applications.</p>
<h5><strong>3. PerkinElmer: Mycotoxins Webinars Series: Portfolio</strong></h5>
<p>Learn about the mycotoxin analytical solutions which will help you in your daily tasks to ensure food safety, comply with regulations, reduce time to results and improve efficiency. </p>
<h5><strong>4. Waters Corporation: Waters LC Symposium - Pharma</strong></h5>
<h5><strong>5. Phenomenex: Getting Low With Sample Preparation: How to Achieve Less Background Interference and Lower Limits of Detection</strong></h5>
<p>This webinar will focus on how to develop an easy sample preparation method using solid supported liquid extraction (SLE) to achieve a fast clean-up solution from biological matrices.</p>
<h5><strong>6. Agilent Technologies: Exploring Agilent Software for Machine Learning and Classification with High Resolution Liquid Chromatography Mass Spectrometry Data and Experimental Design Ideas to Maximize Success</strong></h5>
<p>Here we will explore different application spaces for HR-LCMS in food, environment and the life sciences with MassHunter Classifier software that can directly read raw data and make predictions.</p>
<h5><strong>7. SelectScience/Thermo Scientific: Robust metabolic profiling for routine quantitation and confident unknown identification</strong></h5>
<p>In this webinar, we present a targeted profiling workflow for the nutrient evaluation of bovine serum samples as supplements in cell culture by Orbitrap Exploris 120 mass spectrometer.</p>
<h5><strong>8. Waters Corporation: Applications of Ion Mobility-Mass Spectrometry in Lipid Profiling and Imaging</strong></h5>
<p>In recent years, liquid chromatography coupled to ion mobility-mass spectrometry (LC-IM-MS) for lipidomics has shown advantages in lipid identification.</p>
<h5><strong>9.  Waters Corporation: Waters LC Symposium - Pharma and Food</strong></h5>
<h5><strong>10. Agilent Technologies: GPC Analysis with Fraction collection using OpenLAB CDS: A practical approach to simplify further characterization of complex mixtures</strong></h5>
<p>This webinar will present a complete solution for an Agilent 1260 Infinity II GPC system coupled to a Fraction Collector controlled by Open LAB CDS software with integrated GPC workflows.</p>
<h5><strong>11. Phenomenex/SCIEX: Danaher Life Sciences eSeminar - Latest Trends in Precision Medicine</strong></h5>
<p>This eSeminar, “Latest Trends in Precision Medicine,” will bring together Beckman, Leica, Phenomenex, Pall, Integrated DNA and SCIEX to share the latest innovations and tools.</p>
<h5><strong>12. Waters Corporation: Oxyanions in the water – a tale of 4 analytes in 5 minutes</strong></h5>
<p>The purpose of our work is to demonstrate a direct injection LC-MS/MS method for the determination of Oxyanions in drinking water.</p>
<h5><strong>13. VWR/Avantor: How to double your sample capacity in less time with an existing autosampler!</strong></h5>
<p>Join us to review sample handling efficiencies for LC and GC autosamplers that you can implement into your workflow.</p>
<h5><strong>14. SGS: Chemical Characterization of Medical Device Materials According to ISO 10993-18:2020</strong></h5>
<p>This presentation will focus on the analytical considerations of medical device extractable and leachable (E&amp;L) studies as per the new ISO 10993-18 chapter.</p>
<h5><strong>15. Evosep Biosystems: Rapid, robust and reproducible Host Cell Protein analysis with Evosep One</strong></h5>
<p>In this webinar we will explore the possibilities of using the Evosep One technology to perform rapid, robust and reproducible HCP analysis. </p>
<h5><strong>16. Technology Networks/Victus Capital Ventures: Uncovering the Lineage of Extraction and the Future of the Craft</strong></h5>
<p>During this webinar we will discuss the history of extraction, the most common methodologies of extraction and the technical developments of each and the future of cannabis extraction and innovations.</p>
<h5><strong>17. Waters Corporation: Waters LC Symposium - Materials and Pharma</strong></h5>
<h5><strong>18. Agilent Technologies: How Can Automation Help Advance my Infectious Disease Research?</strong></h5>
<p>Learn how automation can help advance your infectious disease research.</p>
<h5><strong>19. Waters Corporation: Waters LC Symposium - Biomedical Research</strong></h5>


LC and LCMS webinars - Week 12

<p><strong>MS/MS (Tandem) spectra can be used to identify unknowns employing library searches. This is accomplished in much the same approach as that employed for EI GC-MS with the NIST search software. The much improved NIST Search Version 2.4 is included with the 2020 library release.</strong> </p>
<p>I will attempt to introduce the user to the use of the <strong>NIST Version 2.4 search software</strong> employing NIST, Wiley, “crowd-sourced (MoNA)”, and user libraries for the <strong>identification of unknowns</strong>.</p>
<p>NIST has an ambitious program to extend their already comprehensive, high-quality MS/MS databases. </p>
<p>See the following link: <a href="https://littlemsandsailing.files.wordpress.com/2020/12/xiaoyu_yang_asms2020_presentation.pdf">NIST Pipeline for Extending MS/MS Libraries</a></p>
<p>This involves a very comprehensive process for <strong>selecting</strong> pertinent compounds for purchase and subsequent <strong>analyses</strong>. The problem with variability of the spectra is reduced by analyzing the samples on a <strong>variety of instruments</strong> at a <strong>variety of energy levels</strong> (20 steps). In addition, many different <strong>precursor ions</strong> and <strong>fragment ions</strong> are characterized (MSⁿ). This has already led to a very large high quality library of <strong>accurate mass MS/MS spectra in the 2020 release version</strong> (31K compounds/1.3 M spectra) and the effort is ongoing.</p>
<h3><strong>The Part V will cover:</strong></h3>
<p>Detailed Handouts including tables of content are available in the <a href="https://lcms.labrulez.com/library?search=lc%2Fms%20unknown%20identifications%20using%20msms%20libraries&amp;manufacturerItems=55">LabRulezLCMS library</a>.</p>
<ul>
<li>Introduction of Presenter, James Little </li>
<li>Table of Contents</li>
<li>Series Topics</li>
</ul>
<p>-Help Files for NIST Search </p>
<ul>
<li>NIST Software in General is “Windows Compliant”</li>
<li>Session Topics and Choice of Drawing Program</li>
<li>Critical Settings for Similar Structure Searches</li>
<li>Critical Settings for Exact Structure Searches </li>
<li>Critical Settings Turn Off Any Filtering Options Initially</li>
<li>Obtaining Structure from Drawing Program </li>
<li>Pasting Structure into NIST Search </li>
<li>Search for Similar Structures after Inserting Clipboard Structure </li>
<li>Search for Exact Structures </li>
<li>Tips for Displaying Similar and Exact Search Result with DeltaMass </li>
<li>Reverse Process: Sending Structures from NIST to Drawing Program </li>
<li>Using Compare Window to Display Multiple Spectra </li>
<li>Sending Structures Directly to Drawing Program</li>
<li>Live Demo YouTube Presentation</li>
<li>Presentation References (Internet Links)</li>
<li>Acknowledgements</li>
</ul>
<h3><strong>Future parts will focus on:</strong></h3>
<ul>
<li>Part VI:   <strong>MS Interpreter Correlation of Substructure to MSMS Ions</strong></li>
<li>Part VII:  <strong>Using and Creating Other MSMS Libraries</strong></li>
<li>Part VIII: <strong>Identification of Unknowns with “Spectraless” Libraries</strong></li>
</ul>
<h3><strong>The past sections have focused on:</strong></h3>
<ul>
<li><p><a href="https://lcms.labrulez.com/article/1068"><strong>Part I: Overview of Software and User-Customized Configurations</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1088"><strong>Part II: NIST Search Software and Libraries</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1110"><strong>Part III: More Detailed Discussion of MSMS Hybrid Search</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1130"><strong>Part IV: Importing MSMS Spectra</strong></a></p>
</li>
</ul>


LC/MS Unknown Identifications Using MSMS Libraries Part V: NIST Structure Searches

<p><strong>In the week from March 29, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>700 LC and GC webinars</strong>.</p>
<h5><strong>1. Waters Corporation: Increasing Efficiency in a Remote Environment</strong></h5>
<p>In this webinar we’ll discuss how laboratory automation can help address some of new challenges due to pandemic situation and enhance COVID-19 research.</p>
<h5><strong>2. C&amp;EN/Bruker Daltonics: MALDI Tandem Mass Spectrometry – the Most Versatile Analytical Tool for Analysis of Polymeric Materials</strong></h5>
<p>Advantages of MALDI/MS/MS will be demonstrated with the precise structural analysis of a wide variety of synthetic materials, including large and crosslinked polymers, additives and synthetic polymer surfaces.</p>
<h5><strong>3. VWR: Back To Basics: Fundamental Concepts of HPLC &amp; UHPLC</strong></h5>
<p>The basis of the separation process and retention mechanisms will be covered, as well as how the important parameters of resolution, peak shape and efficiency are measured.</p>
<h5><strong>4. Agilent Technologies: Characterization of MassTech AP MALDI Source with Agilent 6545 QTOF and 6560 IM-QTOF for MS Imaging</strong></h5>
<p>The AP MALDI source developed by MassTech Inc was hyphenated to Agilent 6545, a high-resolution mass spectrometer. AP MALDI MS imaging was demonstrated using tissue-simulating peptide spots.</p>
<h5><strong>5. Phenomenex: Understanding Ion-Exchange Selectivity In Biomolecules Analysis</strong></h5>
<p>In this webinar we will cover: Ion Exchange Chromatography, PTMs &amp; Charge Heterogeneity, bioZen WCX, Effects of pH &amp; Common Buffers, Salts VS pH Gradient, Method Optimization, etc...</p>
<h5><strong>6. SelectScience/Agilent Technologies: Comprehensive pesticide testing required to ensure safe cannabis and cannabinoid products</strong></h5>
<p>In this SelectScience webinar, learn analytical methodologies for comprehensive targeted and semi-targeted pesticide analysis to better ensure the safety of cannabis products, where legalized.</p>
<h5><strong>7. Waters Corporation: A Focus on PCR Diagnostic Probes: Oligonucleotide LC Analysis and Purification</strong></h5>
<p>We’ll discuss strategies for lab scale and semi-preparative purification of diagnostic probes through illustrated examples. In addition, we’ll review PREMIER solutions.</p>
<h5><strong>8. Technology Networks/SCIEX: Digital Freezing of Metabolomics Samples</strong></h5>
<p>This webinar showcases the use of SWATH® Acquisition on the benchtop X500R QTOF System for digital freezing of metabolomics samples.</p>
<h5><strong>9. Agilent Technologies: WHY Did That Happen?</strong></h5>
<p>In this webinar we will discuss some common problems, how to identify their source, and how to fix them.</p>
<h5><strong>10. Agilent Technologies: Analysis of Water-Soluble B Vitamins by the Ultivo LC-MS TQ</strong></h5>
<p>In this webinar we will present analysis of Water-Soluble B Vitamins by the Agilent Ultivo LC-MS TQ (triple quadrupole liquid chromatography/mass spectrometry system).</p>
<h5><strong>11. Agilent Technologies: Agilent RapidFire 400: A Complete Approach To High-Throughput Mass Spectrometry</strong></h5>
<p>Explore some of the applications being accelerated using RapidFire and learn how it can enhance your laboratory’s capabilities.</p>


LC and LCMS webinars - Week 13

<p><strong>In the week from April 5, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>700 LC and GC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: Advanced Algorithms for the Discovery of Related Components and Application to PFAS and Fentanyl Research</strong></h5>
<p>The MassHunter acquisition concept of a Preferred MSMS list will be presented together with concept of Mass Defect, MSMS pseudo Constant Neutral Loss, and MSMS Reporter Ions.</p>
<h5><strong>2. Technology Networks/SCIEX: Accelerating AAV-Based Gene Therapy Development with MS</strong></h5>
<p>Using MS data to improve characterization of AAV from different sources will help scientists to make informed decisions in the development of cost-effective, safe and potent gene therapeutics.</p>
<h5><strong>3. Technology Networks/Bruker: Flow Injection Analysis-Magnetic Resonance Mass Spectrometry for High-Throughput Metabolomics</strong></h5>
<p>This webinar will introduce the FIA-MRMS workflow and present two case studies where it is used.</p>
<h5><strong>4. The Analytical Scientist/PIC Solution: Advances in Eco-Sustainable CO2 Technologies</strong></h5>
<p>The Forum provides a unique opportunity to discuss advances in next-generation of eco-sustainable CO2 Separation (SFC) and Extraction (SFE) technologies.</p>
<h5><strong>5. Agilent Technologies: Mass Spectrometry for the Masses, Open Access LC and LC/MS Using Agilent WalkUp</strong></h5>
<p>We will provide an introduction to WalkUp briefly discussing the user experience from the administrator (setting up groups, users, methods, data analysis confirmation) and users’ (running samples) perspectives.</p>
<h5><strong>6. Waters Corporation: Nitrosamines Analysis (Step 2): Confirmatory testing</strong></h5>
<p>In this webinar, we will going through the latest regulatory requirements for testing nitrosamines in solvents, drug substance and drug products.</p>
<h5><strong>7. Shimadzu Scientific Instruments: Subsurface Microbiology: Metabolism by HPLC</strong></h5>
<p>In this work, we discovered a novel strict anaerobic thermophilic bacterium from a monitoring borehole at a depth of 691 meters below land surface.</p>
<h5><strong>8. Agilent Technologies: VWorks version 14.0: Enhanced Features of Compliance</strong></h5>
<p>Join us and learn about how the new VWorks comes in two different editions to suit your laboratory’s specific regulatory needs.</p>


LC and LCMS webinars - Week 14

<p><strong>In the week from April 12, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>700 LC and GC webinars</strong>.</p>
<h5><strong>1. PerkinElmer: Food Safety: Determination of Mycotoxins in food by LC-MS/MS</strong></h5>
<p>This webinar will present insights into risk assessment with a focus on the LC-MS/MS methods, along with solutions for performing selective, sensitive and compliant analysis. </p>
<h5><strong>2. Thermo Fisher Scientific: Charged Aerosol Detection Symposium - Session 1</strong></h5>
<p>Join our interactive and live charged aerosol detection symposium with tips, tricks, pointers and expert advice from our guest speakers! </p>
<h5><strong>3. Phenomenex: Strategies, Tips and Tricks for Simplified Chiral Method Development</strong></h5>
<p>In this presentation, we will explore the factors that contributes to successful chiral separation.</p>
<h5><strong>4. Agilent Technologies: A Comprehensive Approach to Targeted and Untargeted Screening Methodology for Emerging Synthetic Fentanyl Analogues using High Resolution Accurate Mass Spectrometry</strong></h5>
<p>Herein, a targeted and untargeted screening workflow by LC/MS/MS using Agilent’s 6546 QTOF will be presented for approximately 150 fentanyl analogues.</p>
<h5><strong>5. Thermo Fisher Scientific: Charged Aerosol Detection Symposium - Session 2</strong></h5>
<p>Learn how CAD can be applied in your work with tips, tricks, pointers, and expert advice from our guest speakers.</p>
<h5><strong>6. Waters Corporation: Benefits of IMS to MetID and Structural Elucidation</strong></h5>
<p>Our two guest speakers Dr. Ralf Laux and Dr. Ian Wilson bring decades of experience in Drug Metabolism and Pharmacokinetics.</p>
<h5><strong>7. LCTech: FREESTYLE XANA - The Specialist for your Water Samples</strong></h5>
<p>Learn more about FREESTYLE XANA robotic system for automatic SPE sample preparation for analysis of large volumes of water samples.</p>
<h5><strong>8. Waters Corporation: Solving Large Molecule Questions with Accessible LC/MS in Academia</strong></h5>
<p>Join Christian Winter, UNI of Frankfurt, and Dr John Walsby-Tickle, UNI of Oxford, online to learn how an easy-to-use routine LC/MS brings academics in life sciences closer to the point of decision.</p>
<h5><strong>9. Thermo Fisher Scientific: Charged Aerosol Detection Symposium - Session 3</strong></h5>
<p>Learn more from our speakers in these industries sharing tips and tricks, with pointers, and expert advice. </p>
<h5><strong>10. Bruker Daltonics: Bead Assisted Mass Spectrometry assay platform for targeted proteomics</strong></h5>
<p>The webinar will focus on the detailed description of the workflow and case studies of BAMS™ assays developed for targets relevant to neurology and virology.</p>
<h5><strong>11. SelectScience/Merck: BioSPME: A new tool for drug-protein binding determination</strong></h5>
<p>In this webinar, Dr. Olga Shimelis will present the use of new product – Supel™ BioSPME C18 96-Pin Devices – for in vitro measurement of protein binding properties of pharmaceutical compounds in plasma. </p>
<h5><strong>12. Thermo Fisher Scientific: The Delights of Diversity: A Multitude of Separation Techniques Combined with Mass Spectrometry for Characterization in Biopharmaceutical Development</strong></h5>
<p>Here the impact of hyphenating a broad range of separation techniques to high resolution accurate mass (HRAM) mass spectrometry (MS) will be discussed through case studies.</p>
<h5><strong>13. Agilent Technologies: WHO Do I Turn To? Chromatography Resources</strong></h5>
<p>Looking for answers to your chromatography questions? Who do you turn to? This webinar will look at available resources to help meet your chromatography needs.</p>
<h5><strong>14. SelectScience/Waters Corporation/Andrew Alliance: Virtual Event: Leveraging automation technologies to work smarter</strong></h5>
<p>This virtual event brings you three webinars from experts in the field of automation who will discuss how you can work smarter.</p>


LC and LCMS webinars - Week 15

<p><strong>In the week from April 19, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>800 LC and GC webinars</strong>.</p>
<h5><strong>1. Dr. Maisch High Performance LC GmbH: Chiral HPLC: From Basics to the Latest and Unique Novelties</strong></h5>
<p>We invite you to join our free webinar to understand the principles of chiral HPLC, different types of stationary phases and their characteristics and separation modes.</p>
<h5><strong>2. Separation Science/Thermo Fisher Scientific: The Challenges of Pesticide Analysis - LC or GC Triple Quadrupole?</strong></h5>
<p>This webinar takes a look at the pros and cons of LC-QqQ and GC-QqQ for the analysis of pesticides in food and agricultural matrices. Industry and technology experts will provide their insights.</p>
<h5><strong>3. C&amp;EN/Wyatt Technology: Quality attributes and extended characterization of lentiviral and gammaretroviral vectors using light scattering</strong></h5>
<p>We will demonstrate batch dynamic light scattering (DLS) for rapid, low-resolution measurements and MALS in combination with field-flow fractionation (FFF) for extended characterization of viral vectors.</p>
<h5><strong>4. Thermo Fisher Scientific: BioPharma Finder software for characterization of protein and oligonucleotide based biotherapeutics</strong></h5>
<p>BioPharma Finder software is a workflow driven solution for complete characterization of biotherapeutics.</p>
<h5><strong>5. Agilent Technologies: Method Development &amp; Optimization Workshop</strong></h5>
<p>In this online workshop, Agilent presents the common challenges faced these days and focuses on Method Development Solutions with maximum efficiency to optimize your workflows.</p>
<h5><strong>6. Phenomenex: LC Method Development and Problem Prevention for Pharmaceutical Methods</strong></h5>
<p>This webinar will cover topics like LC Column Selection and Method Development and Overview of USP Allowable Adjustments and Avoid LC Problems through Proper Column Care and Troubleshooting.</p>
<h5><strong>7. Waters Corporation: Meet the Experts - Part 1 - Alternative Procurement Strategies</strong></h5>
<p>Richard Styles details the alternative buying options available to you in today&#39;s market. </p>
<h5><strong>8. Wiley Analytical Science/Merck: Lipidomics from Structure to Function</strong></h5>
<p>Part I: Lipidomics from Structure to Function</p>
<h5><strong>9. Wiley Analytical Science/Merck: Quantitative Bottom-Up Shotgun Lipidomics Using High-Resolution Orbitrap FTMS</strong></h5>
<p>Part II: Quantitative Bottom-Up Shotgun Lipidomics Using High-Resolution Orbitrap FTMS</p>
<h5><strong>10. Thermo Fisher Scientific: GlycanExplorer – A software solution for high throughput bio-therapeutic glycan characterization</strong></h5>
<p>In this presentation, we will discuss how the software detects the peaks from your raw data, identify the probable glycans with the help of different search workflows, and present the results.</p>
<h5><strong>11. Petro Industry News/Waters Corporation: High Resolution MS and Statistical Analysis Approaches to Lubricant Formulation Research and Development</strong></h5>
<p>We will outline a simple and efficient workflow that uses HRMS and statistical analysis of the acquired data to understand the differences between several automotive lubricant oils at a molecular level.</p>
<h5><strong>12. Waters Corporation: MaxPeak HPS Innovation to reduce analyte/surface interactions</strong></h5>
<p>This 1st session will introduce you to MaxPeak High Performance Surface (HPS) technology, the integral part of our ACQUITY PREMIER Solution to reduce analyte/surface interactions.</p>
<h5><strong>13. Wiley Analytical Science/YMC Europe:Characterisation and Quantification of Biomolecules</strong></h5>
<p>The first part of the talk will provide a brief introduction to bioanalytics in general, as well as to the quantification and characterization of intact proteins.</p>
<h5><strong>14. Wiley Analytical Science/YMC Europe: Analysing Antibodies by Different LC Separation Modes</strong></h5>
<p>The second part is dedicated to peptide analysis and covers classical and multidimensional chromatography as well as automated sample preparation using enzyme reactors.</p>
<h5><strong>15. Thermo Fisher Scientific: Increasing proteoform level insight with quantitative Top-Down proteomics using Proteome Discoverer 2.5 software</strong></h5>
<p>This presentation will provide and overview of Top-Down proteomics from sample prep to generating results. Topics will be presented in practical terms with relevant background information. </p>
<h5><strong>16. Agilent Technologies: Cannabis Safety - Trace Analysis of Pesticides &amp; Mycotoxins via LC/QQQ in Cannabis Flower and Concentrates</strong></h5>
<p>This presentation will detail an LC/MS/MS analytical workflow developed by Agilent for the accurate measurement of combined pesticide and mycotoxin action lists according to the requirements of U.S.</p>


LC and LCMS webinars - Week 16

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Peak Scientific is a leading innovator in the design, manufacture and support of high performance gas generators for analytical laboratories, with direct operations in every continent around the world.

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My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

LC and LCMS webinars - Week 16

LC and LCMS webinars - Week 15

LC and LCMS webinars - Week 14

LC and LCMS webinars - Week 13

LC/MS Unknown Identifications Using MSMS Libraries Part V: NIST Structure Searches

LC and LCMS webinars - Week 12

On-site Gas Generators & Lab Safety During Covid-19

LC and LCMS webinars - Week 11

LC/MS Unknown Identifications Using MSMS Libraries Part IV: Importing MSMS Spectra

LC and LCMS webinars - Week 10

Upcoming events

Discovery continuum seminar

SCIEX Brazil food testing innovation day

Agilent Innovation Tour 2026

Webinars

Characterising Advanced Materials with the Agilent UV-Vis-NIR: From Thin Films and Solar Cells to Glass and Optical Coatings

LC Coffee Breaks: Mastering Overpressure - Prevention and Solutions that Work

Spatial Imaging Series: More Than Mass Spec