<div><div><div>Scientists at IOCB Prague have developed a breakthrough technology that streamlines aptamer development. The new method integrates several biochemical and bioinformatics steps and paves the way for new diagnostic and therapeutic applications. Ongoing applications include wearable sensors that monitor selected biomarkers in real time and provide early warnings of impending health complications. The findings were published in Nature Communications.</div></div><div>Aptamers are short DNA or RNA strands that can recognize and bind to a specific target molecule with high precision. Similar to antibodies, they can be used to detect these molecules or modulate their activity. Unlike antibodies, they are much more stable, can be produced synthetically, and can be chemically modified to achieve the desired properties. As a result, they can offer capabilities that cannot be achieved with antibodies.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg" alt="IOCHB Prague: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Chemically modified DNA aptamer bound to the target protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg 228w," sizes="100vw" width="1343" height="916">As demand grows for accurate and rapid diagnostic tools, aptamers are often better suited to these applications than antibodies. However, developing aptamers is both experimentally demanding and time-consuming. A team of scientists from IOCB Prague, led by Dr. Marek Ondruš and <a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en">Prof. Michal Hocek</a>, has now developed a technology that significantly shortens the development process.“Developing an aptamer is often like looking for a needle in a haystack. Among trillions of different DNA sequences, we search for the one that binds strongly and specifically to a target molecule. Our new approach first screen for ‘aptamer families’ – hundreds of related sequences – and then identify the best-performing member of the family. This approach can reduce development time from several months to only a few days,” says Marek Ondruš.<blockquote>Video:<a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=_3zXUeVMugU"> New technology streamlines the development of aptamers, synthetic alternatives to antibodies&nbsp;</a></blockquote>The team has also expanded the potential applications of aptamers by chemically modifying their building blocks. For example, introducing functional groups similar to those found naturally in amino acids allows the resulting molecules to combine the advantages of both DNA and antibodies: Their sequence is encoded by the order of nucleotides in DNA, while the attached chemical modifications greatly expand their ability to recognize biologically relevant targets and mimic interactions between proteins that are underlying many biological processes.The researchers demonstrated the potential of this new method using the human insulin receptor, a key protein that regulates blood sugar levels. They developed an aptamer that specifically binds to the receptor and elucidated the molecular basis of this interaction using cryo-electron microscopy. “We have shown that chemically introduced functional groups play a crucial role not only in target recognition and formation of the aptamer–protein complex, but also in stabilizing the DNA aptamer’s structure. Our findings provide new insights into how chemically modified nucleic acids can mimic key properties of proteins,” says Marek Ondruš.In the future, the technology could complement – or, in some applications, even replace – antibody-based diagnostic tools. Researchers are collaborating with <a target="_blank" rel="noopener noreferrer" href="http://iocbtech.cz/">IOCB Tech</a> on its further development, as the company helps to bring discoveries from IOCB Prague into practical applications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg" alt="IOCHB Prague/Tomáš Belloň: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Dr. Marek Ondruš, first author of the study, and Prof. Michal Hocek, head of the Bioorganic and Medicinal Chemistry of Nucleic Acids research group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg 234w," sizes="100vw" width="2000" height="1335"><blockquote><h4>Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-73676-y#citeas">Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries</a></h4>ablo Alberto Franco-Urquijo, Marek Ondruš, Jaroslav Kurfürst, Jana Škerlová, Irena Selicharová, Lucie Mužíková Čechová, Hana Šváchová, Alena Semerádtová, Anatolij Filimoněnko, Adéla Fejfarová, Jiří Homola, Tomáš Kouba &amp; Michal HocekNat. Commun., 2026<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41467-026-73676-y">https://doi.org/10.1038/s41467-026-73676-y</a>&nbsp;<h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable of identifying high-affinity modified aptamers. Double partition followed by amplification of eluted sequences, NGS analysis and clustering provides fast identification of aptamer candidates. Screening of modified DNA libraries containing modified adenine and uracil nucleotides bearing hydrophobic aromatic phenyl and indole moieties results in development of an aptamer binding human insulin receptor with sub-nanomolar affinity and exquisite specificity. Cryo-EM structure reveals the importance of each aromatic modification, either in stabilizing the secondary structure or facilitating interactions with the protein surface. This approach addresses the main drawbacks of aptamer selection and has potential for high-throughput screening and accelerating the development of next-generation aptamers for diagnostics or therapeutics.</div>

New technology streamlines the development of aptamers, synthetic alternatives to antibodies

Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity</a> 10.2 highlights</h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4>Instrument control modules</h4>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"><h4>MS data import/export improvements</h4>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"><h4>Obsolete hardware support terminated</h4>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"><blockquote>Explore the complete list of all changes, fixes, and additions in version 10.2.👉<a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">See the complete changelog&nbsp;</a></blockquote>

Clarity Chromatography Software 10.2 released!

🎤Dr. Leigh Terry (University of Alabama)In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.While most regulatory methods focus on a small number of compounds like PFOA and PFOS, there may be thousands of PFAS compounds in the environment—and much of that burden goes undetected.<h4>In this episode, we cover:</h4><ul><li>Why PFAS are called “forever chemicals” (and why that label is evolving)</li><li>The limitations of targeted LC-MS/MS methods</li><li>What the fluorine mass balance problem reveals about PFAS destruction</li><li>How combustion ion chromatography (CIC) helps measure total organofluorine</li><li>Why “99.99% removal” doesn’t always mean what you think</li><li>Where PFAS actually end up in wastewater treatment systems</li><li>The most effective technologies for PFAS removal today</li><li>Why drinking water may only account for ~20% of total PFAS exposure</li></ul><h4>Key Insight:</h4>Even when analyzing dozens of PFAS compounds, researchers may only be capturing a small fraction of total organic fluorine—raising major questions about how we monitor and regulate these contaminants.<h3>Video Transcription</h3>In this episode of Concentrating on Chromatography, Dr. Leigh Terry discusses PFAS contamination in drinking water, the analytical challenges associated with measuring these compounds, current treatment technologies, and future directions for monitoring and regulation. The conversation highlights how analytical chemistry, environmental engineering, and public health intersect in addressing one of today's most discussed classes of emerging contaminants.<h4>Understanding PFAS and Their Significance</h4><h5>The University of Alabama Water Quality Research Center</h5>Dr. Leigh Terry is part of the University of Alabama's Center for Water Quality Research. The center operates an analytical laboratory focused on drinking water quality and the detection of contaminants at extremely low concentrations.The laboratory specializes in:<ul><li>Drinking water analysis</li><li>Organic contaminants</li><li>Emerging contaminants</li><li>PFAS monitoring</li><li>Water quality research</li></ul>Their work supports both research initiatives and practical solutions for water utilities and environmental agencies.<h4>Why Focus on PFAS?</h4>Although PFAS compounds have existed since the 1940s, public awareness has increased dramatically only in recent years.According to Dr. Terry, several factors contributed to the rapid growth of PFAS research:<ul><li>Increased media attention</li><li>New regulatory initiatives</li><li>Growing evidence of human exposure</li><li>Expanding research opportunities</li><li>Greater understanding of potential health risks</li></ul>PFAS are not new contaminants. Rather, society is only beginning to understand their prevalence in the environment and their potential impacts on human health.<h4>The Development of Standardized PFAS Methods</h4>One major advancement in PFAS analysis has been the development of standardized EPA methods.These methods allow:<ul><li>Consistent testing procedures</li><li>Comparable results between laboratories</li><li>Regulatory monitoring</li><li>Reliable data interpretation</li></ul>Dr. Terry notes that many of these standardized approaches began appearing around 2018–2019, providing a common framework for analytical laboratories and researchers.<h4>How Large Is the PFAS Universe?</h4>Many people are familiar with PFOA and PFOS, two of the most heavily studied PFAS compounds. However, these represent only a small fraction of the broader PFAS family.PFOA and PFOS are often referred to as:<ul><li>Legacy PFAS compounds</li><li>Original PFAS contaminants</li><li>Early commercial PFAS chemicals</li></ul>The challenge is that even minor modifications to molecular structure create entirely new PFAS compounds.Researchers estimate:<ul><li>Thousands of PFAS compounds exist</li><li>Some estimates exceed 10,000 compounds</li><li>Exact numbers depend on how PFAS are defined</li></ul>Scientific debate continues regarding classification and definition, making precise counting difficult.<h4>Why PFAS Are Called "Forever Chemicals"</h4>Dr. Terry notes that the phrase "forever chemicals" has become widely used, although she suggests the terminology could benefit from rebranding.PFAS persistence results from two key chemical properties.<h5>1. Amphiphilic Structure</h5>PFAS molecules contain:<ul><li>A water-loving (hydrophilic) head group</li><li>A water-repelling (hydrophobic) fluorinated tail</li></ul>This unusual combination allows PFAS to partition between:<ul><li>Water</li><li>Solids</li><li>Air-water interfaces</li><li>Foam</li></ul>Unlike many organic compounds, PFAS can interact effectively with multiple environmental phases.<h5>2. Extremely Strong Carbon–Fluorine Bonds</h5>The carbon–fluorine bond is among the strongest bonds in organic chemistry.As Dr. Terry explains:<ul><li>Large amounts of energy are required to break these bonds</li><li>Natural degradation processes are often ineffective</li><li>Destruction can require highly aggressive treatment conditions</li></ul>These properties make PFAS extremely persistent in both environmental systems and biological organisms.<h4>Toxicity, Regulations, and Environmental Behavior</h4><h5>Understanding PFAS Toxicity</h5>One of the biggest challenges in PFAS regulation is the incomplete understanding of toxicity.Dr. Terry explains that EPA regulations generally consider three factors:<ul><li>Presence in drinking water sources</li><li>Toxicity to humans</li><li>Availability of practical treatment options</li></ul>While some PFAS compounds are known to be harmful, many others remain insufficiently studied. Furthermore, PFAS often occur as mixtures rather than individual compounds.This creates important scientific questions:<ul><li>What is the toxicity of individual PFAS?</li><li>What is the toxicity of PFAS mixtures?</li><li>How should cumulative exposure be evaluated?</li></ul>These uncertainties continue to drive active research.<h4>What Happens to PFAS in Wastewater Treatment Plants?</h4>PFAS do not behave like many conventional contaminants.Rather than remaining fully dissolved in water, they often accumulate at interfaces such as:<ul><li>Water-solid interfaces</li><li>Water-air interfaces</li><li>Foam layers</li><li>Biological solids</li></ul>As a result:<ul><li>Some PFAS accumulate in biosolids</li><li>Some partition into foam</li><li>Some remain in treated effluent</li></ul>Their distribution depends on wastewater composition and treatment processes.<h4>Regulatory Monitoring and Targeted LC-MS Analysis</h4>Current EPA regulations focus on targeted analysis of specific PFAS compounds.Examples include:<ul><li>PFOA</li><li>PFOS</li></ul>Drinking water regulations currently establish maximum contaminant levels (MCLs) for these compounds at extremely low concentrations.Advantages of targeted LC-MS analysis include:<ul><li>Clearly defined analytes</li><li>Established regulatory limits</li><li>High analytical sensitivity</li><li>Reliable quantitation</li></ul>However, limitations remain:<ul><li>Only a small subset of PFAS is measured</li><li>Many PFAS compounds remain undetected</li><li>Total PFAS burden may be underestimated</li></ul>As Dr. Terry notes, targeted analysis provides only part of the overall picture.<h4>The Fluorine Mass Balance Problem</h4>One of the most important concepts discussed in the interview is fluorine mass balance.When PFAS degrade, fluorinated fragments may remain in the environment.This creates a critical question:Are treatment technologies truly destroying PFAS, or merely transforming them into shorter-chain PFAS compounds?To answer this, researchers perform fluorine mass balance calculations using:<ul><li>Targeted PFAS analysis</li><li>Fluoride measurements</li><li>Total organic fluorine measurements</li></ul>A successful destruction process should ultimately convert PFAS into fluoride ions rather than simply producing smaller PFAS molecules.<h4>Advanced Analysis, Treatment Technologies, and Future Directions</h4><h5>Combining Targeted and Bulk Fluorine Measurements</h5>Dr. Terry's group complements targeted LC-MS analysis with measurements of total organic fluorine.Approaches include:<ul><li>Absorbable Organic Fluorine (AOF)</li><li>Extractable Organic Fluorine (EOF)</li><li>Combustion Ion Chromatography (CIC)</li></ul>In these methods:<ul><li>Organic fluorine is captured</li><li>Samples are combusted</li><li>Released fluoride is quantified</li></ul>This provides insight into total fluorinated content, although contributions may originate from sources beyond PFAS, including pharmaceuticals and consumer products.<h4>Surprising Findings from Combined Analysis</h4>One important finding from wastewater studies was that targeted PFAS measurements accounted for only a small fraction of total organic fluorine.Dr. Terry reports that:<ul><li>Approximately 4% of measured AOF could be explained by targeted PFAS compounds</li><li>The majority of organic fluorine remained unidentified</li></ul>This suggests that environmental fluorine chemistry is considerably more complex than currently represented by routine monitoring programs.<h4>Preventing PFAS Contamination in the Laboratory</h4>PFAS analysis requires exceptionally strict quality control.Dr. Terry's laboratory routinely:<ul><li>Tests every new batch of SPE cartridges</li><li>Tests carbon tubes before use</li><li>Uses DI water blanks</li><li>Verifies consumables labeled as PFAS-free</li><li>Collects field blanks</li><li>Monitors analytical blanks throughout workflows</li></ul>These practices help prevent contamination from laboratory materials and consumables, a common challenge in ultra-trace PFAS analysis.<h4>Current PFAS Treatment Technologies</h4>Three technologies currently dominate PFAS removal in drinking water treatment:<ul><li>Granular Activated Carbon (GAC)</li><li>Ion Exchange Resins</li><li>Reverse Osmosis (RO)</li></ul>Selection depends on:<ul><li>PFAS concentration</li><li>Water quality</li><li>Local operating conditions</li><li>Utility infrastructure</li></ul>Although many emerging technologies are being investigated, these remain the most widely implemented solutions.<h4>Membrane Filtration and Pretreatment</h4>Dr. Terry collaborates with colleagues studying membrane-based PFAS treatment.Her own work focuses on pretreatment through biological filtration.The strategy involves:<ul><li>Removing natural organic matter</li><li>Reducing membrane fouling</li><li>Improving membrane performance</li><li>Extending operational efficiency</li></ul>This integrated approach demonstrates how multiple treatment technologies can work together to improve PFAS removal.<h4>Regional Monitoring Projects</h4>The University of Alabama team participates in EPA-supported monitoring efforts along the Gulf Coast.Their observations indicate:<ul><li>PFAS rarely occur alone</li><li>Multiple PFAS compounds frequently co-occur</li><li>Contamination often originates from identifiable point sources</li></ul>Examples include:<ul><li>Industrial facilities</li><li>Manufacturing operations</li><li>Military installations</li><li>Carpet manufacturing facilities</li></ul>Source identification remains a critical component of environmental monitoring programs.<h4>Future Directions for PFAS Monitoring</h4>Looking ahead, Dr. Terry sees several opportunities for improvement.Desired advances include:<ul><li>In situ monitoring technologies</li><li>Portable detection systems</li><li>Reduced analytical complexity</li><li>Lower instrument costs</li><li>Less expensive consumables</li><li>Faster analysis workflows</li></ul>Current PFAS testing requires substantial expertise, specialized instrumentation, and rigorous quality control, making widespread implementation challenging.<h4>Dr. Terry's Perspective on Long-Term Solutions</h4>When asked what major PFAS challenge she would most like to solve, Dr. Terry offered a broader perspective.Rather than focusing solely on remediation, she emphasized prevention.Her view is that society should:<ul><li>Better evaluate chemical toxicity before commercialization</li><li>Assess risks before large-scale deployment</li><li>Reduce introduction of harmful compounds into the environment</li><li>Support utilities tasked with contaminant removal</li></ul>She notes that water utilities often bear the responsibility of removing contaminants they did not create, highlighting the need for broader societal and regulatory support.<h4>Final Thoughts</h4>Dr. Terry encourages consumers to:<ul><li>Learn where their drinking water originates</li><li>Read annual water quality reports</li><li>Stay informed about local water quality</li><li>Consider appropriate home filtration where needed</li></ul>At the same time, she emphasizes confidence in municipal water systems and the importance of continued investment in water quality research, monitoring, and treatment technologies.<h4>Conclusion</h4>PFAS remain one of the most complex challenges in environmental chemistry and water treatment. Through advanced analytical methods such as LC-MS/MS, combustion ion chromatography, fluorine mass balance approaches, and large-scale monitoring programs, researchers like Dr. Leigh Terry are helping improve our understanding of these persistent contaminants.The interview highlights that solving the PFAS challenge will require a combination of better analytical tools, improved treatment technologies, stronger regulatory frameworks, and a greater emphasis on prevention before contaminants enter the environment.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

PFAS in Water: Why We’re Missing 96% of the Problem

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Scientists

Water

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Science and research

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Waters XBridge BEH C8 HPLC Columns

Waters XBridge BEH C8 sorbent is less retentive compared to the XBridge BEH C18 with improving peak shape and chromatographic performance

The XBridge BEH C8 sorbent is less retentive compared to the XBridge BEH C18 sorbent. Anyone developing methods may prefer the speed offered by a less retentive column, while improving peak shape and chromatographic performance. The trifunctionally bonded sorbent offers you the widest usable pH range (1-12), superior low pH stability, and ultra-low column bleed. Packed in ultra-low dispersion hardware, 2.5 µm eXtended Performance [XP] columns enable exceptional separation performance, robustness and throughput for HPLC assays while enabling a seamless transition path toward UPLC&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_C18_HPLC_Column_e96c520ca3.jpg" alt="Waters: XBridge BEH C8 HPLC Column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_C18_HPLC_Column_e96c520ca3.jpg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: C8</li><li>Separation Mode: Reversed Phase</li><li>Particle Substrate: Hybrid</li><li>pH Range Min: 1 pH</li><li>pH Range Max: 12 pH</li><li>Maximum Pressure: 10000 psi (690 Bar)</li><li>Endcapped: Yes</li><li>Silanol Activity: Low</li><li>Particle Shape: Spherical</li><li>System: UHPLC, UPLC</li><li>Particle Technology: BEH</li><li>USP Classification: L7</li><li>Carbon Load: 13 %</li></ul><h4>The Waters XBridge BEH C8 HPLC Column is also available in these types:</h4><h5>Waters XBridge BEH C8 Column with eConnect Column Tag</h5><ul><li>This column comes equipped with an electronic eConnect column tag containing unique column-specific information. These NFC-enabled device-tagged columns were developed to automatically identify, track and digitally trace column use history. eConnect columns can be used on any HPLC, but its advantages are unlocked when used with the Waters Alliance iS System running Empower software.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg" alt="Waters: XBridge BEH C8 Column with eConnect Column Tag" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg 234w," sizes="100vw" width="660" height="440"><h3>XBridge Columns</h3><h4>Particle stability and performance for methods development</h4>Withstanding extreme operating conditions like high pH and high temperatures is essential for methods development. XBridge HPLC and UHPLC Columns utilize Ethylene Bridged Hybrid (BEH) Particle Technology and are built to withstand high pH, high temperatures, and other extreme operating conditions like volatile eluents, for a wide range of small molecule and biomolecule LC-MS analysis.XBridge HPLC and UHPLC Columns are available in a broad range of sorbent particles and sizes: XBridge eXtended Perfomance (XP) 2.5 µm Columns for rapid analytical UHPLC separations; 3.5 and 5 µm HPLC columns for reliable analytical method development; and 5 and 10 µm optimum bed density (OBD) preparative columns for purification chromatography.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_Columns_b0b55de501/Waters-XBridge-Columns.jpg" alt="Waters: XBridge Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_Columns_b0b55de501/thumbnail_Waters-XBridge-Columns.jpg 203w," sizes="100vw" width="900" height="691">

Waters XBridge BEH Protein C4 HPLC Columns

Waters XBridge Protein BEH C4 column is QC tested and optimized to separate proteins based on size, hydrophobicity and isoelectric point. 

The XBridge Protein BEH C4 column is QC tested and optimized to separate proteins based on size, hydrophobicity and isoelectric point. If you compare to traditional C18 phases, the C4 ligand is less retentive and will minimize protein carryover, increase protein recovery, and improve peak capacity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_Protein_C4_HPLC_Columns_0aa4f56918.jpeg" alt="Waters: XBridge BEH Protein C4 HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_Protein_C4_HPLC_Columns_0aa4f56918.jpeg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: C4</li><li>Separation Mode: Reversed Phase</li><li>Particle Substrate: Hybrid</li><li>pH Range Min: 2 pH</li><li>pH Range Max: 10 pH</li><li>Maximum Pressure: 6000 psi (415 Bar)</li><li>Endcapped: No</li><li>Silanol Activity: Low</li><li>Molecular Weight Range Max: 150000</li><li>Particle Shape: Spherical</li><li>System: HPLC</li><li>Particle Technology: BEH</li><li>USP Classification: L26</li><li>Carbon Load: 8 %</li></ul><h3>XBridge Columns</h3><h4>Particle stability and performance for methods development</h4>Withstanding extreme operating conditions like high pH and high temperatures is essential for methods development. XBridge HPLC and UHPLC Columns utilize Ethylene Bridged Hybrid (BEH) Particle Technology and are built to withstand high pH, high temperatures, and other extreme operating conditions like volatile eluents, for a wide range of small molecule and biomolecule LC-MS analysis.XBridge HPLC and UHPLC Columns are available in a broad range of sorbent particles and sizes: XBridge eXtended Perfomance (XP) 2.5 µm Columns for rapid analytical UHPLC separations; 3.5 and 5 µm HPLC columns for reliable analytical method development; and 5 and 10 µm optimum bed density (OBD) preparative columns for purification chromatography.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_Columns_b0b55de501/Waters-XBridge-Columns.jpg" alt="Waters: XBridge Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_Columns_b0b55de501/thumbnail_Waters-XBridge-Columns.jpg 203w," sizes="100vw" width="900" height="691">

Waters XBridge BEH HILIC HPLC Columns

Waters XBridge BEH HILIC columns contain unbonded BEH substrate and are designed to retain and separate very polar compounds.

The XBridge BEH HILIC columns contain unbonded BEH substrate and are designed to retain and separate very polar compounds. These unique columns are optimized and tested to produce efficient, reproducible separations under HPLC HILIC conditions. More rugged than silica based HILIC phases, the BEH particle’s chemical stability results in long column lifetimes. Packed in ultra-low dispersion hardware, 2.5 µm eXtended Performance [XP] columns enable exceptional separation performance, robustness and throughput for HPLC assays while enabling a seamless transition path toward UPLC adoption.The maximum operating pressure for the XBridge BEH HILIC XP Column is up to 18000 psi (1240 Bar). It is important to note that pressures greater than the range of 18000 psi should be avoided as they can result in reduced column lifetime and decreased column performance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_HILIC_HPLC_Columns_f39fb8f689.jpg" alt="Waters: XBridge BEH HILIC HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_HILIC_HPLC_Columns_f39fb8f689.jpg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: HILIC</li><li>Separation Mode: Hydrophilic Interaction (HILIC)</li><li>Particle Substrate: Hybrid</li><li>pH Range Min: 1 pH</li><li>pH Range Max: 9 pH</li><li>Maximum Pressure: 18000 psi (1240 Bar)</li><li>Endcapped: No</li><li>Silanol Activity: Low</li><li>Particle Shape: Spherical</li><li>System: UHPLC, UPLC</li><li>Particle Technology: BEH</li><li>USP Classification: L3</li></ul><h4>The Waters XBridge BEH HILIC HPLC Column is also available in these types:</h4><h5>Waters XBridge BEH HILIC Column with eConnect Column Tag</h5><ul><li>This column comes equipped with an electronic eConnect column tag containing unique column-specific information. These NFC-enabled device-tagged columns were developed to automatically identify, track and digitally trace column use history. eConnect columns can be used on any HPLC, but its advantages are unlocked when used with the Waters Alliance iS System running Empower software.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg" alt="Waters: XBridge BEH HILIC Column with eConnect Column Tag" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg 234w," sizes="100vw" width="660" height="440"><h3>XBridge Columns</h3><h4>Particle stability and performance for methods development</h4>Withstanding extreme operating conditions like high pH and high temperatures is essential for methods development. XBridge HPLC and UHPLC Columns utilize Ethylene Bridged Hybrid (BEH) Particle Technology and are built to withstand high pH, high temperatures, and other extreme operating conditions like volatile eluents, for a wide range of small molecule and biomolecule LC-MS analysis.XBridge HPLC and UHPLC Columns are available in a broad range of sorbent particles and sizes: XBridge eXtended Perfomance (XP) 2.5 µm Columns for rapid analytical UHPLC separations; 3.5 and 5 µm HPLC columns for reliable analytical method development; and 5 and 10 µm optimum bed density (OBD) preparative columns for purification chromatography.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_Columns_b0b55de501/Waters-XBridge-Columns.jpg" alt="Waters: XBridge Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_Columns_b0b55de501/thumbnail_Waters-XBridge-Columns.jpg 203w," sizes="100vw" width="900" height="691">

Waters XBridge BEH Phenyl HPLC Columns

Waters XBridge BEH Phenyl columns provide complementary selectivity to C18 stationary phases, especially for polyaromatic compounds.

XBridge BEH Phenyl columns provide complementary selectivity to C18 stationary phases, especially for polyaromatic compounds. This most chemically stable commercially available Phenyl sorbent on the market and provides you with ultra-low column bleed, long column lifetimes and excellent peak shape.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_Protein_C4_HPLC_Columns_0aa4f56918.jpeg" alt="Waters: XBridge BEH Phenyl HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_Protein_C4_HPLC_Columns_0aa4f56918.jpeg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: Phenyl</li><li>Separation Mode: Reversed Phase</li><li>Particle Substrate: Hybrid</li><li>pH Range Min: 1 pH</li><li>pH Range Max: 12 pH</li><li>Maximum Pressure: 6000 psi (415 Bar)</li><li>Endcapped: Yes</li><li>Bonding Technology: Phenyl-Hexyl</li><li>Silanol Activity: Low</li><li>Particle Shape: Spherical</li><li>System: HPLC</li><li>Particle Technology: BEH</li><li>USP Classification: L11</li><li>Carbon Load: 15 %</li></ul><h4>The Waters XBridge BEH Phenyl HPLC Column is also available in these types:</h4><h5>Waters XBridge BEH Phenyl Column with eConnect Column Tag</h5><ul><li>This column comes equipped with an electronic eConnect column tag containing unique column-specific information. These NFC-enabled device-tagged columns were developed to automatically identify, track and digitally trace column use history. eConnect columns can be used on any HPLC, but its advantages are unlocked when used with the Waters Alliance iS System running Empower software.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg" alt="Waters: XBridge BEH Phenyl Column with eConnect Column Tag" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg 234w," sizes="100vw" width="660" height="440"><h5>Waters XBridge BEH Phenyl XP Column</h5><ul><li>Packed in ultra-low dispersion hardware, 2.5 µm eXtended Performance [XP] columns enable exceptional separation performance, robustness and throughput for HPLC assays while enabling a seamless transition path toward UPLC adoption.&nbsp;</li><li>Maximum Pressure: 10000 psi (690 Bar)</li><li>System: UHPLC, UPLC</li></ul><h3>XBridge Columns</h3><h4>Particle stability and performance for methods development</h4>Withstanding extreme operating conditions like high pH and high temperatures is essential for methods development. XBridge HPLC and UHPLC Columns utilize Ethylene Bridged Hybrid (BEH) Particle Technology and are built to withstand high pH, high temperatures, and other extreme operating conditions like volatile eluents, for a wide range of small molecule and biomolecule LC-MS analysis.XBridge HPLC and UHPLC Columns are available in a broad range of sorbent particles and sizes: XBridge eXtended Perfomance (XP) 2.5 µm Columns for rapid analytical UHPLC separations; 3.5 and 5 µm HPLC columns for reliable analytical method development; and 5 and 10 µm optimum bed density (OBD) preparative columns for purification chromatography.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_Columns_b0b55de501/Waters-XBridge-Columns.jpg" alt="Waters: XBridge Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_Columns_b0b55de501/thumbnail_Waters-XBridge-Columns.jpg 203w," sizes="100vw" width="900" height="691">

Thermo Scientific™ BioPharma Finder™ Software for the Characterization of Biotherapeutics

Simplify comprehensive biotherapeutic attribute characterization with advanced capabilities to increase throughput and confidence in a connected environment.

<div><div container-id="cq-colctrl-lt7" comp-id="A1"><div>Discover how the features of Thermo Scientific BioPharma Finder Software are engineered to support the world of complex biopharmaceutical characterization. Featuring novel data processing algorithms and easy-to-interpret data visualization tools, the software supports users looking to confidently characterize biopharmaceuticals.Power BioPharma Finder&nbsp;Software with the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"> Thermo Scientific Ardia Platform</a> to automate file centralization during acquisition, expand file access, enable report creation and result sharing, and remove data management barriers from your daily routine.<div><h3>Key benefits</h3></div><div><ul><li>Confident characterization: Explore a solution for confident animo acid sequence characterization with the Peptide Mapping Analysis module featuring a novel MS2 prediction algorithm.</li><li>Customized Nucleotide sequence support: Leverage the ability to create customized nucleotide sequences to support confirmation with the Oligonucleotide Analysis module featuring an improved MS2 fragmentation model (available in BioPharma Finder Software version 5.3).</li><li>Efficient data handling: Move through vast amounts of data with remarkable efficiency using the Intact Mass Analysis module. With innovative deconvolution algorithms and features, you can generate multi-consensus reports effortlessly, providing a comprehensive view of your results.</li><li>Unparalleled Modification Exploration and Flexibility: The Top-Down Analysis module empowers you to search through an extensive range of modifications, even at the per-peak level. With multiple fragmentation modes and a cross-array processing algorithm, you have the flexibility to explore your samples in greater detail.</li><li>Seamless integration: See how easy it is to move from sophisticated characterization using BioPharma Finder Software to confident quantitation in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS software</a> with benefits added by the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821">Ardia Platform</a> including connecting instrument data, supporting global access and centralizing BioPharma Finder reports.</li></ul><h3>Learn more about BioPharma Finder Software</h3><div>The right combination of data and software makes all the difference in accurately characterizing molecules, especially for large molecule.<h4>Peptide mapping analysis</h4>Characterization of a macromolecule comprised of an amino acid sequence can involve a lot of moving targets. Techniques for confident confirmation typically include comparisons of data collected against theoretical knowledge of the sequence. The best processing tools will also give users the ability to model probable sequences against the data collected with easy-to-use tools to increase the confidence of the identification and supply the summary reports with easy-to-interpret results.<div><h5>Featured in the Peptide Mapping Analysis</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_b88e243207.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Processing with the novel MS2 algorithm in the Peptide Mapping Analysis module, generates a predictive model that includes Kinetical predictions that are compared with the measured spectra to increase confidence in the identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_b88e243207.jpg 245w," sizes="100vw" width="1160" height="540"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_2_6dda72b394.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: These processing tools, when combined, produce intuitive result review tools including comprehensive coverage maps, deep dive spectral comparison views and graphical sample comparison options." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_2_6dda72b394.jpg 245w," sizes="100vw" width="1160" height="600"><div><h5>Detect and quantify host cell proteins</h5></div><div>The sensitivity of the detection algorithm and prediction analytics allow for high confidence even for low abundance targets to support residuals applications like Host Cell Protein (HCP) analysis.</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_3_e493898dc1.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Detect and quantify host cell proteins." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_3_e493898dc1.jpg 245w," sizes="100vw" width="1160" height="600"></div><h4>Oligonucleotide analysis</h4><div>Sequence confirmation for oligonucleotides can be daunting. Take the question out of sequence confirmation with our enhanced MS2 predictive algorithms that can iteratively create the best array of possibilities without iterating into infinity. Summarize your characterization with visual tools, generate easy-to-interpret results and enhance collaboration by saving and sharing reports in a connected environment.&nbsp;&nbsp;<h5>Featured in the Oligonucleotide Analysis module</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_4_f709ce5528.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: The oligonucleotide sequence editor provides an easy-to-use interface for quickly and easily building and visualizing customized oligonucleotide sequences. Build out multiple expected sequences from custom building block subunits, a wide selection of modifications from the predefined list or with user-defined custom modifications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_4_f709ce5528.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_5_f204e2cd40.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Eliminate alternative possibilities based on the entered sequence with the random sequence generator and leverage the in silico digest tools to support confident sequence verification - all using an updated MS2 prediction algorithm (available in BioPharma Finder Software version 5.3)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_5_f204e2cd40.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_6_f7f2d9e029.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Perform mRNA mapping with selected in silico mRNA digestion or define the cleavage locations manually. Dig into the identity of fragments and expected or unexpected modifications and assess the overall coverage with intuitive visual coverage maps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_6_f7f2d9e029.jpg 245w," sizes="100vw" width="1160" height="600"></div><h4>Intact mass analysis</h4><div><div container-id="cq-colctrl-lt2" comp-id="B1"><div>Intact analysis on its face is a simple mathematical calculation used to deconvolute a series of m/z values into components but throw in the complexity of large molecule targets with modifications in a mixture of other like-molecules and mass accuracy becomes harder to achieve. No matter your data resolution, leverage innovative software tools engineered to filter and process through complex spectra with the Intact Analysis module. Discover how to quickly acquire and process batches of samples supported by a central data location on the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821">Ardia Platform</a> and speed through large batch-to-batch comparison studies to create summaries with connected multi-consensus reports.<div><h5>Featured in the Intact Analysis module</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_7_72cfbd44c3.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Accurately determine molecular weights utilizing the Sliding Window algorithm coupled with our optimized Xtract (for high resolution) and Respect (for lower resolution) deconvolution algorithms. Achieve comprehensive detection, even for co-eluting, low-intensity components in complex mixtures and account for any shifts in retention time." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_7_72cfbd44c3.jpg 245w," sizes="100vw" width="1160" height="323"></div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_8_d0c92fbca9.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Use the expanded sequence matching capabilities for oligonucleotides which includes the ability to perform Terminal Truncation Searching from either the 3' or 5' terminus, facilitating the identification of impurities with greater ease. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_8_d0c92fbca9.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_9_d345484402.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: The intact mass analysis of heavily modified oligonucleotides presents analytical and data processing challenges due to the frequent usage of sulfur modifications. Pairing Thermo Scientific Orbitrap mass spectrometers with BioPharma Finder Software allows for confident intact mass identification of phosphorothioate conversion of oligonucleotides with less than 5 ppm error." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_9_d345484402.jpg 245w," sizes="100vw" width="1160" height="600"></div></div></div><h4>Top-down analysis</h4><div><div container-id="cq-colctrl-lt2" comp-id="B1"><div>Higher order structure characterization requires a combination of some of the most variable sample treatment techniques, variable data acquisition techniques, and combined or complex data processing techniques. Looking to gently pry apart large complexes without reducing them to their smallest parts and understand them is an art and a science that can be supported by the Top-Down Analysis module. Explore the tools offered to help refine the field of predicted possibilities without restricting them, the support for multi fragmentation mode data, and the easy-to-use multi-consensus summaries to understand your molecule.<div><h5>Featured in the Top-Down Analysis module</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_10_7e7ef85413.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: With the ProSightBP processing tool users can set variable or static sites for modification, select peak specific deconvolution parameters and even select peak specific sequence searching then let ProSightBP create the predictions. Combine the data from multi fragmentation modes including CID, HCD, ETD, EThcD, and UVPD resulting in confident identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_10_7e7ef85413.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_11_e3c9f5084b.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Combining the predictive power of ProSight BP against the deconvoluted accurate mass with the sequence coverage from ETD and UVPD fragmentation reveals a comprehensive set of results to support confident molecule characterization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_11_e3c9f5084b.jpg 245w," sizes="100vw" width="1160" height="600"></div></div></div></div><h4>Connecting to the Ardia Platform</h4><div>Living in a world connected by networks that enable people to share everything doesn’t have to stop in the lab. With the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"> Ardia Platform</a> see how easy it can be to automatically centralize files, connect into those files from anywhere and process them with BioPharma Finder Software or any connected application.&nbsp;&nbsp;<div><h5>Featured enhancements through connection</h5><div><div container-id="cq-colctrl-lt2" comp-id="B1"><div>Faster data review<ul><li>Review a result generated by another colleague without having to import the results, open it from the shared secured Ardia Platform data repository, make comments or changes, and the software will automatically generate a new version to record the changes.</li></ul>Better data management with centralized secured data<ul><li>All results are securely saved in one place, no more finding the “right” computer or hard drive that contains the experiment and data.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_12_b6a814cd90.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Keep data secure and controlled. Gain insights into file history, method history, and manage user access with control." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_12_b6a814cd90.jpg 245w," sizes="100vw" width="1160" height="600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Bio_Pharma_Finder_Software_13_1e3b879f18.jpg" alt="Thermo Scientific™ BioPharma Finder™ Software: Save and review individual reports without having to open BioPharma Finder Software for oligonucleotide, peptide mapping and intact mass applications. Utilize default reporting templates to speed development of customized reports and effectively modify templates to achieve desired result summary with the help of the customizable report designer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Bio_Pharma_Finder_Software_13_1e3b879f18.jpg 245w," sizes="100vw" width="1160" height="600">Enable collaboration on a global scale in a secure fashion to collaborate, compare, track, and finalize peptide results and workbooks using dynamic versioning history. Accelerate method optimization and review through a shared secure environment.</div></div></div></div></div></div></div></div></div></div>

Thermo Scientific SII for Empower Software

Incorporate and operate Thermo Scientific UHPLC, HPLC, GC, and IC instruments within other vendors' software platforms with the Thermo Scientific™ SII for Empower 3 Software plug-in.

<div id="product-description">Incorporate and operate Thermo Scientific UHPLC, HPLC, GC, and IC instruments within other vendors' software platforms with the Thermo Scientific™ Standard Instrument Integration (SII) for Empower 3 Software plug-in. The SII for Empower 3 plug-in is based on the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a> and offers unique and smart features that deliver maximum ease-of-use, reliability, and performance. It also enables Thermo Scientific™ chromatography systems to be operated and controlled by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS software</a>.</div><div>While Chromeleon CDS is the recommended software for control of Thermo Scientific UHPLC, HPLC, GC, and IC instruments due to its maximum ease of use, reliability, and performance, other vendors' CDS software can also incorporate and operate these instruments with the SII for Empower™ 3 Software plug-in.The SII for Empower™ Software installs and uses portions of <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a>, such as the Services Manager, Instrument Configuration Manager, Instrument View, and Instrument Method Editor, to deliver flawless integration of Thermo Scientific LC, IC, and GC instrumentation into Empower™ 3 CDS without loss of functionality. Instrument control, data acquisition, and data processing are performed completely under Empower™ 3 Software.Configure your instruments Up to four instruments can be configured per Empower™ node using the standard Chromeleon Instrument Configuration Manager.Control your instruments SII for Empower™ Software provides a complete set of commands because they are present under native Chromeleon CDS control. For the user, this means that all the Chromeleon CDS tools and advanced features, such as preparing the next sample during an ongoing analysis, can be implemented to increase productivity and receive more data with fewer injections.SII for Empower™ controls the following systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;manufacturerItems=3&amp;search=Vanquish">Thermo Scientific™ Vanquish™ HPLC and UHPLC systems</a></li><li>Thermo Scientific™ UltiMate™ 3000 HPLC systems</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/410">Thermo Scientific™ Dionex™ ICS-6000 HPIC™ system</a></li><li>Thermo Scientific™ Dionex™ ICS-5000 HPIC™ system</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/408">Thermo Scientific™ Dionex™ Integrion™ HPIC™ system</a></li><li>Thermo Scientific™ Dionex™ Aquion™ system</li><li>Thermo Scientific™ TRACE™ 1300 GC systems</li></ul>Monitoring instrument status within Empower™ can be performed using the Empower™ Control Panel. Here, an enhanced SII Instrument View is easily accessed to provide further options to control and monitor the instrument and its modules.Instrument Methods Setting up an instrument method is simple, intuitive, and fast due to the SII for Empower™ Instrument Method Wizard and Editor, both of which are integrated into the Instrument Method Editor of Empower™. The wizard guides the user through all modules, enabling the entry of all necessary information, while the editor allows the review and modification of all aspects of a method.Process your data Complete data processing takes place inside Empower™ Software, which allows you to use all functionalities as you would normally, for example, overlay of chromatograms or other channels like pressure traces. The Empower™ user experience does not change for any data processing aspect.</div>

Thermo Scientific LC-MS Data Acquisition Software

Acquire the highest quality data possible to unlock the information, knowledge, and value in your samples with Thermo Scientific LC-MS Data Acquisition Software.

Thermo Scientific™ Chromeleon™ XPS Open Access Software

Thermo Scientific™ Chromeleon™ XPS provides streamlined and easy-to-use interface for Thermo Scientific™ Chromeleon™ CDS, while maintaining full capabilities of the CDS software.

In modern laboratories, chromatography techniques and the use of mass spectrometry (MS) detection are in high demand. Until recently, MS detectors were regarded as sophisticated detection tools that could be operated only by a highly trained specialist. Nowadays mass spectrometers are increasingly used as straightforward detectors for chromatography.Alongside this move into routine use of MS is the continued deskilling of staff in the laboratory world, causing highly experienced chromatographers to be in short supply. The result is a substantial number of regular scientists and process operators that need to generate chromatographic results using advanced instrumentation themselves.The solution is an Open Access tool enabling users to simply walk up and use a very straightforward interface to exploit the full power of the chromatography data system (CDS), without actually using the CDS software itself. Thermo Scientific™ Chromeleon™ XPS provides this streamlined and easy-to-use interface for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ CDS</a>, while maintaining full capabilities of the CDS software, like instrument control, data processing, reporting and compliance tools.<h3>Workflow</h3>Users can walk up to any chromatography instrument connected to the CDS, with or without MS detection, and start to run their analysis with only a few mouse-clicks.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5e8f8c3dec.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: First, select the analysis to perform (A) and which instrument should be used (B). The instrument overview shows the current instrument status’ and displays the estimated wait time until each instrument is available and the number of sample positions still available. The instrument list is filtered depending on the analysis selected and the users privileges to only show appropriate instruments." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5e8f8c3dec.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_2_a8b64a52ae.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: Next, enter the sample names (C) and any other parameters (D) required for the analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_2_a8b64a52ae.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_3_4b4367ffae.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: Place the sample vials in the indicated positions and select Submit." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_3_4b4367ffae.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_4_0386d31c9a.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: The sequence is submitted and will run. The operator is shown the expected start and finish time of the analyses." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_4_0386d31c9a.jpg 245w," sizes="100vw" width="625" height="263"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5_1b51ab8dd2.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: At the end of the run, the results are automatically printed and/or exported and a link to the exported report can be distributed via email." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5_1b51ab8dd2.jpg 245w," sizes="100vw" width="814" height="309"><h3>Configuration and management</h3>Running samples is as easy as described above once Chromeleon XPS software is set up, configured and managed by an experienced chromatographer.<ul><li>All the methods required for the analysis must be created; the instrument method with all instrument control and data acquisition parameters, the processing method with all data processing parameters and the report template with all required results, to be reported.&nbsp;</li><li>A Chromeleon eWorkflow is created using these methods. An eWorkflow is an electronic procedure that automates all steps of the laboratory process related to a chromatographic analysis</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_6_a3b2219e42.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: The lab manager can customize Chromeleon XPS to show or hide individual toolbar buttons (A), which eWorkflows are visible to users (B) and which instruments they can access (C)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_6_a3b2219e42.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_7_d647111f5d.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: In addition, it is possible to define various system options, such as which email notifications to send." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_7_d647111f5d.jpg 193w," sizes="100vw" width="659" height="533">Chromeleon XPS Open Access software lets any user run samples on their own by delivering a clean, streamlined walk-up interface that utilizes the full power of Chromeleon CDS. Users can access all instruments controlled by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a>, including MS, and automatically receive results or notifications about run completion or failure. The management console contains advanced customization options to fulfill any organization’s requirements, included fully regulated environments.Chromeleon XPS software provides error-free execution of any chromatography analysis with minimal training requirements for users.

Waters Atlantis Silica HILIC HPLC Columns

Waters Atlantis HILIC Silica columns are used in combination with high organic mobile phases (>80% ACN) to provide retention of analytes that are too polar 

Atlantis HILIC Silica columns are used in combination with high organic mobile phases (&gt;80% acetonitrile) to provide retention of analytes that are simply too polar to be retained by reverse-phase chromatography. HILIC separation mechanisms provide orthogonal analyte selectivity compared to traditional chromatographic reversed-phase approaches.Due to their hydrophilic nature combined with their net positive charge at acidic pH, retention and separation of very basic polar analytes are extremely difficult using reversed-phase chromatography. The HILIC technology is able to resolve these challenging separation problems. This is what makes the Atlantis Silica HILIC Column the ideal lab equipment for use in metabolism, drug discovery, and combinatorial chemistries.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Atlantis_d_C18_HPLC_Columns_d7a741df9f.jpg" alt="Waters: Atlantis Silica HILIC HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Atlantis_d_C18_HPLC_Columns_d7a741df9f.jpg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: HILIC</li><li>Separation Mode: Hydrophilic Interaction (HILIC)</li><li>Particle Substrate: Silica</li><li>pH Range Min: 1 pH</li><li>pH Range Max: 5 pH</li><li>Maximum Pressure: 6000 psi (415 Bar)</li><li>Endcapped: No</li><li>Silanol Activity: High</li><li>Particle Shape: Spherical</li><li>Pore Size: 100 Å</li><li>System: HPLC</li><li>USP Classification: L3</li></ul><h4>The Waters Atlantis Silica HILIC HPLC Column is also available as:</h4><h5>Waters Atlantis Silica HILIC HPLC Column&nbsp;with eConnect Column Tag</h5><ul><li>This column comes equipped with an electronic eConnect column tag containing unique column-specific information. These NFC-enabled device-tagged columns were developed to automatically identify, track and digitally trace column use history. eConnect columns can be used on any HPLC, but its advantages are unlocked when used with the Waters Alliance iS System running Empower software.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg" alt="Waters: Atlantis Silica HILIC HPLC Column with eConnect Column Tag" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg 234w," sizes="100vw" width="660" height="440"><h3>Atlantis Columns</h3><h4>Reversed-phase and HILIC HPLC Columns for superior polar compound retention</h4>Polar analytes are difficult to retain using traditional reversed-phase (RP) chromatography as they often elute in the void volume of the column. You can solve this challenge today with Atlantis Columns, which retain and separate polar analytes under reversed phase and HILIC conditions and provide quick, accurate, and reproducible quantification with increased retention and sensitivity.Available in T3, dC18, and the unbonded HILIC chemistries, the Waters Atlantis Column family provides exceptional performance, versatility, retention, and chromatographic stability for polar compounds and balanced retention for broad analyte mixtures.&nbsp;<h4>Overview</h4><ul><li>Retains and separates small, water-soluble polar organic compounds</li><li>Compatible with 100% aqueous mobile phases</li><li>Improves detection limits, method reproducibility, and robustness by eliminating ion-pairing reagents</li><li>Long column lifetimes using low-pH mobile phases</li><li>Fully scalable in 3, 5, and 10 μm particle sizes</li><li>Recommended Use: For the reproducible retention and separation of a broad range of polar and non-polar compounds.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Atlantis_HPLC_Columns_6651612161.jpg" alt="Waters: Atlantis HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Atlantis_HPLC_Columns_6651612161.jpg 234w," sizes="100vw" width="1024" height="682">

Waters SunFire C18 HPLC Columns

Waters SunFire C18 columns are used for general purpose method development at low pH.

SunFire C18 columns are used for general purpose method development at low pH. The C18 ligand is highly retentive, especially for basic compounds and it is ideally suited for purification and impurity profile assays.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Atlantis_d_C18_HPLC_Columns_d7a741df9f.jpg" alt="Waters: SunFire C18 HPLC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Atlantis_d_C18_HPLC_Columns_d7a741df9f.jpg 234w," sizes="100vw" width="660" height="440"><h4>Specifications</h4><ul><li>Chemistry: C18</li><li>Separation Mode: Reversed Phase</li><li>Particle Substrate: Silica</li><li>pH Range Min: 2 pH</li><li>pH Range Max: 8 pH</li><li>Maximum Pressure: 6000 psi (415 Bar)</li><li>Endcapped: Yes</li><li>Silanol Activity: Low</li><li>Particle Shape: Spherical</li><li>Pore Size: 100 Å</li><li>System: HPLC</li><li>USP Classification: L1</li><li>Carbon Load: 16 %</li></ul><h4>The Waters SunFire C18 HPLC Column is also available in these types:</h4><h5>Waters SunFire C18 HPLC Column&nbsp;with eConnect Column Tag</h5><ul><li>This column comes equipped with an electronic eConnect column tag containing unique column-specific information. These NFC-enabled device-tagged columns were developed to automatically identify, track and digitally trace column use history. eConnect columns can be used on any HPLC, but its advantages are unlocked when used with the Waters Alliance iS System running Empower software.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg" alt="Waters: SunFire C18 HPLC Column with eConnect Column Tag" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_BEH_C18_Column_with_e_Connect_Column_Tag_c056302ec7.jpeg 234w," sizes="100vw" width="660" height="440"><h5>Waters SunFire C18 Intelligent Speed (IS) Column</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Atlantis_Intelligent_Speed_IS_Column_488e1ab406.jpg" alt="Waters: SunFire C18 Intelligent Speed (IS) Column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Atlantis_Intelligent_Speed_IS_Column_488e1ab406.jpg 234w," sizes="100vw" width="660" height="440"><h3>SunFire Columns</h3><h4>Superior mass loading at low pH</h4>High efficiency at a low pH can be challenging. Waters SunFire HPLC Columns, available in analytical and preparative dimensions, help you do just that with state-of-the-art bonded silica designed for high mass loading, excellent low pH stability, superior peak shapes, and high efficiency.SunFire Analytical Columns are available in 2.5 µm to 10 µm particle sizes across two reversed-phase column chemistries, C18 and C8, sure to meet your silica-based HPLC column requirements. For preparative applications, in addition to the C18 and C8 chemistries, SunFire silica is offered in 5 and 10 µm particle sizes for preparative normal-phase purification.<h4>Overview</h4><ul><li>Exceptional loading capacity for both analytical and preparative columns</li><li>Excellent low pH stability for longer lifetimes</li><li>Superior peak shapes for faster and easier integration</li><li>Low mass spectral (MS) bleed, for enhanced analyte MS signal</li><li>Seamless scalability from analytical to optimum bed density (OBD) preparative columns</li><li>Recommended Use: For increased mass loading with excellent column stability.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Sun_Fire_Columns_3f48bd770c/Waters-SunFire-Columns.jpg" alt="Waters: SunFire Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Sun_Fire_Columns_3f48bd770c/thumbnail_Waters-SunFire-Columns.jpg 242w," sizes="100vw" width="900" height="580">

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