Metabolomics researchers are often forced to choose between two powerful but different approaches. <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/metabolomics-lipidomics/metabolomics/untargeted-metabolomics.html">Untargeted metabolomics</a> is great for discovery: it surveys as many metabolites as possible to reveal biology you didn’t know to look for. <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/metabolomics-lipidomics/metabolomics/targeted-metabolomics.html">Targeted metabolomics</a> is built for precision: it measures a defined list of metabolites with high sensitivity and quantitative confidence. The challenge is that running both typically costs time, sample, and can introduce variability between workflows.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_One_Injection_Two_Answers_Introducing_Squad_Metabolomics_on_Orbitrap_Mass_Spectrometers_0f7ca7d1c8.jpg" alt="Thermo Fisher Scientific: One Injection, Two Answers: Introducing Squad Metabolomics on Orbitrap Mass Spectrometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_One_Injection_Two_Answers_Introducing_Squad_Metabolomics_on_Orbitrap_Mass_Spectrometers_0f7ca7d1c8.jpg 245w," sizes="100vw" width="1024" height="512">In order to deal with this the researchers at Thermo Fisher Scientific have developed <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/metabolomics-lipidomics/simultaneous-quantitation-discovery-squad.html">Simultaneous Quantitation and Discovery (SQUAD)</a> analysis as shown in this technical note <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004327_ov_squad_metabolomics_orbitrap_astral_tn004327_na_en_290c75edd9.pdf">Simultaneous Quantitation and Discovery Analysis: Combining Targeted and Untargeted Metabolomics on Orbitrap Mass Spectrometers</a>, a hybrid strategy that combines targeted quantitation and untargeted discovery in a single experiment. In practice, SQUAD lets you quantify a predefined metabolite panel using calibration curves built from authentic standards and isotopically labeled internal standards, while still capturing rich full-scan data that supports retrospective mining and identification of unknowns.A key theme of the technical note is that results are only as strong as the experiment design and quality controls. The workflow emphasizes calibration strategy, careful extraction choices (aligned to metabolite classes), and the smart use of blanks, pooled QCs, and system suitability tests to monitor drift, contamination, and reproducibility across a batch.SQUAD is also designed to scale across different Thermo Scientific Orbitrap mass spectrometers. The technical note outlines how the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1491">Thermo Scientific Orbitrap Exploris mass spectrometers</a> can use MS1-based SQUAD with polarity switching and optionally add tSIM/tMS2 for targeted sensitivity, while the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=Tribrid">Thermo Scientific Orbitrap Tribrid mass spectrometers</a> can pair high-resolution MS1 discovery with rapid ion-trap tMS2 quantitation, boosted by tools like <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1763">Thermo Scientific AcquireX Intelligent Data Acquisition</a> and Real-Time Library Search (RTLS).Finally, the data story comes together in software: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77">Thermo Scientific TraceFinder Software</a> for targeted quantitation and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759">Thermo Scientific Compound Discoverer Software </a>for untargeted discovery, annotation, and statistics, turning one injection into both confident numbers and new biological leads.<blockquote><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004327_ov_squad_metabolomics_orbitrap_astral_tn004327_na_en_290c75edd9.pdf">Download the SQUAD technical note</a></div></blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#SQUAD #Metabolomics #Lipidomics

One Injection, Two Answers: Introducing Squad Metabolomics on Orbitrap Mass Spectrometers

<h3><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/">ISC 2026</a></h3>The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/314">International Symposium on Chromatography (ISC)</a> represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/644">35th International Symposium on Chromatography</a></h4>📆6. - 10. September 2026📍Prague, Czech Republic<h3>Registration</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal">Register HERE for the ISC 2026</a>Late Registration until 25 August 2026!From 26 August 2026 only Onsite Registration.</blockquote><h4>Publishing Workshop</h4><ul><li>Wednesday, 9 September 2026&nbsp;</li><li>12:30–14:00&nbsp;</li></ul>This interactive workshop will provide practical guidance on scientific publishing in the field of separation science. Participants will have the opportunity to hear directly from journal editors about key aspects of the publication process and how to improve their chances of successful publication.Topics will include manuscript preparation, peer review, editorial decision-making, open access publishing, and the responsible use of artificial intelligence in scientific publishing. Editors will share insights into what they look for in submissions, common reasons for rejection, and strategies for preparing strong manuscripts. The workshop will also cover selected Wiley-specific topics, including the publisher’s submission platform and current guidelines on the use of AI in scientific publications.The session will include opportunities for questions and discussion, allowing participants to interact directly with editors and gain valuable advice for their future publishing activities.<h5>Attending Editors-in-Chief:</h5><ul><li>Michael Lämmerhofer — Journal of Separation Science and Separation Science Plus&nbsp;</li><li>Sebastiaan Eeltink — Analytical Science Advances&nbsp;</li><li>Mario Thevis — Drug Testing &amp; Analysis&nbsp;</li></ul>

Publishing Workshop at ISC 2026

We are excited to announce that the 18th MDCW will take place from January 25-27, 2027, in Liège, Belgium. This in-person event will feature:<ul><li>Keynote presentations from leading researchers</li><li>Flash talks and poster sessions highlighting the latest innovations</li><li>Focus group discussions addressing current challenges and future developments</li><li>💸FREE registration ensures that this event remains accessible to all researchers, students, and industry professionals interested in multidimensional chromatography. ​​We hope to see you there!</li></ul><h3>Registration</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://app.oxfordabstracts.com/auth?redirect=https%3A%2F%2Fapp.oxfordabstracts.com%2Fregister%2Fevent%2F77272%3Fpreview%3Dfalse">Register HERE</a>Registration deadline: December 1, 2026</blockquote><h3>Abstract Submission</h3>Abstracts for oral presentations must be submitted by September 15, 2026, to be considered.​Poster abstracts submitted by September 15, 2026, will be included in the preliminary program. Additional last-minute poster submissions will be accepted until November 30, 2026, for inclusion in the final program.<blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://app.oxfordabstracts.com/auth?redirect=/stages/81780/submitter">Submit your abstract HERE</a>&nbsp;Deadline for abstract submission: September 15, 2026</blockquote><h4>Presentation guidelines</h4><h5>Poster Presentations</h5><ul><li>Presenters must print and bring their own posters—onsite printing services and mailed submissions are not available.</li><li>Posters should be in landscape format: 36" tall × 48" wide.</li><li>Set up your poster during registration on the day of your assigned session and remove it at the end of the same day.</li><li>Poster presenters must be present at their posters during the designated poster session.</li><li>Posters will also be available for viewing during coffee and lunch breaks.</li><li>Presenters may optionally stand by their posters during these times for further discussions.</li></ul><h5>Oral Presentations</h5><ul><li>Keynote presentations: 30 minutes (25–28 min + Q&amp;A)</li><li>Full oral presentations: 20 minutes (18 min + 2 min Q&amp;A)</li><li>Flash presentations: 10 minutes (8 min + 2 min Q&amp;A)</li></ul>Presentation Format:<ul><li>Submit your slides as a PowerPoint (PPT) file (.ppt or .pptx).</li><li>Name your file with program code and surname, e.g. "O-28 Smith.pptx".</li><li>For optimal display, use 16:9 slide format (4:3 is also supported).</li></ul>Technical &amp; Session Logistics:<ul><li>A headset or portable microphone will be available.</li><li>A laser pointer with a slide change button will be provided.</li><li>Ensure your presentation allows time for questions within your allocated time.</li><li>Before your session, check in and introduce yourself to the conference or session chairs.</li></ul><h3>Program</h3><h4>Keynote Speakers</h4><h5>Finding Clarity in Challenging Samples: Multiple Heart-Cutting 2D-LC and the Technologies That Enable It &nbsp; &nbsp;</h5><ul><li>Stephan Buckenmaier (Principal Scientist R&amp;D, Agilent Technologies)</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Stephan_Buckenmaier_c84239ec30.jpg" alt="MDCW: Stephan Buckenmaier" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Stephan_Buckenmaier_c84239ec30.jpg 151w," sizes="100vw" width="284" height="294">Stephan Buckenmaier is a Principal Scientist in R&amp;D at Agilent Technologies, specializing in advanced separation science and the development of two-dimensional liquid chromatography (2D-LC) solutions. Since joining Agilent in 2006, he has held a variety of scientific and technical roles, with a particular focus on innovative chromatographic technologies. He earned his Ph.D. from the University of the West of England (Bristol, UK) and conducted postdoctoral research at the University of Tübingen. Stephan has authored numerous scientific publications, contributed a book chapter, and is listed as an inventor on numerous patents in the field of separation science. He regularly presents his work at international scientific conferences.<h4>Short Course</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/18th_MDCW_short_course_41ecd3c6cf.jpg" alt="18th MDCW: Short course" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_18th_MDCW_short_course_41ecd3c6cf.jpg 245w," sizes="100vw" width="1100" height="619">There will be 20 spaces available in a short course related to multidimensional chromatography. If you want to register for the short course, indicate so during your registration. We will send a separate link to pay for the short course to reserve your seat ($50 USD).&nbsp;<h4>A Beginner’s Guide to Multidimensional Chromatography short course</h4><ul><li>Instructors: Pierre-Hugues Stefanuto, Katelynn Perrault Uptmor, Dwight Stoll, Petr Vozka</li></ul><h5>Course Description&nbsp;</h5>So...you want to do multidimensional chromatography? If you are getting started in the field using either liquid or gas chromatography, you’re in the right place. This course will cover a brief history and introduction to both multidimensional gas chromatography and multidimensional liquid chromatography. Discussion will also include basic system components and data handling strategies to apply after acquiring your data. A hands-on portion of the course will also include familiarization with common system components and consumables for both GC and LC, as well as the opportunity to use a commercial GC×GC instrument.<h5>Target Participants&nbsp;</h5>This course is intended to be an initial touchpoint for those who are looking to explore multidimensional chromatography as a new option/capability, or who might be using it for the first time. The course is intended for new users to obtain a background on the techniques as a primer to the workshop. &nbsp;Advanced topics will not be discussed.<h5>Course Logistics&nbsp;</h5><ul><li>Morning Session (8:30 AM – 12:00 PM)</li><li>Afternoon Session (1:00 PM – 4:30 PM)</li></ul>Lunch and coffee will be provided.<h5>Cost&nbsp;</h5>A $50 fee is required to reserve a spot in the course. 20 seats are available. An expression of interest form will be available to indicate interest in a seat within the course. On November 10th, participants will be informed about seat availability and the payment process will be communicated.<h4>Outline (Total Time ~ 4 hrs)&nbsp;</h4><h5>Part I (1 hr) – History, Terminology, Fundamental Concepts&nbsp;</h5><ul><li>Brief history of the development of multidimensional separations&nbsp;</li><li>Terminology&nbsp;</li><li>Fundamental Concepts&nbsp;<ul><li>In what ways are multidimensional separations useful for analytical chemistry / measurement science?&nbsp;</li><li>First and second separations should be orthogonal / complementary&nbsp;</li><li>Fast second dimension separations are important to avoid undersampling&nbsp;</li><li>Structured chromatograms can provide chemical insight and facilitate data interpretation&nbsp;</li><li>Highlights of an example data processing workflow – from raw data to actionable information &nbsp;</li></ul></li><li>Break (30 min)&nbsp;</li></ul><h5>Part II (1.5 hrs) Introduction to Multidimensional Gas Chromatography&nbsp;</h5><ul><li>Method basics&nbsp;<ul><li>Column selection&nbsp;</li><li>Method parameters&nbsp;</li><li>Carrier gas choices&nbsp;</li><li>Detector considerations&nbsp;</li></ul></li><li>Modulator selection with a focus on current market options&nbsp;<ul><li>Thermal modulators&nbsp;</li><li>Flow modulators&nbsp;</li><li>Other commercial options&nbsp;</li></ul></li><li>Method development made simple&nbsp;</li><li>Data preprocessing and initial handling&nbsp;</li><li>Lunch (1 hr)&nbsp;</li></ul><h5>Part III (1 hr) Introduction to Multidimensional Liquid Chromatography&nbsp;</h5><ul><li>Modes of multidimensional separation commonly used with LC&nbsp;<ul><li>Heartcut&nbsp;</li><li>Multiple heartcut / selective comprehensive&nbsp;</li><li>Fully comprehensive&nbsp;</li></ul></li><li>Interfaces used for multidimensional LC (i.e., the hardware that does the transfer from first to second dimension)&nbsp;</li><li>Common use cases of multidimensional LC illustrated using examples from industry and academic research&nbsp;<ul><li>Evaluating peak purity&nbsp;</li><li>Unknown identification via multidimensional and MS or NMR detection&nbsp;</li><li>Multi-stage separation with analyte transformation between stages&nbsp;</li><li>Multi-attribute methods&nbsp;</li><li>Making complete analysis of moderately complex samples attainable in a reasonable analysis time&nbsp;</li><li>Digging deeper – comprehensive separations for comprehensive analysis&nbsp; Introduction to method development strategies&nbsp;</li></ul></li></ul><h5>Part IV (2 hrs) Laboratory Instrument Familiarization</h5><h5>Part V (30 min) Wrap-up and Q&amp;A &nbsp;</h5><h4>Venue</h4><ul><li>University of Liege</li><li>Pl. du Vingt Août 7</li><li>4000 Liège</li><li>​Belgium</li><li>​Main Room: Salle Academique</li></ul>

18th MDCW - Registration and abstract submission opens

Article

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Events

Science and research

The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography Workshop

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Mettler-Toledo

Agilent Technologies

Phenomenex

SelectScience

Waters Corporation

<h3>Solving Problems That Matter - a Waters webinar series featuring USP speakers</h3><h4>Episode 8: Lipid nanoparticles</h4><div class="summary-section section">Developing safe, compliant and efficacious lipid nanoparticles (LNP) requires adequate testing of the individual lipid components and impurities. In this webinar Anni Chang from the USP Excipient team will share current and future excipient solution approaches and describe how the USP provides support for stakeholders in discovery and early-stage development. Then Duanduan Han will discuss the benefits of mass detection for critical impurities analysis, and Empower software workflows for compliant and straightforward method migration from development to QC labs. Duanduan will also highlight how multi-angle light scattering (MALS) detection can be used to characterize the LNP.<h5>Key learning objectives</h5><ul><li>Explore current and future USP solutions for lipid nanoparticles (LNP)</li><li>Learn how mass detection and Empower software-based workflows expedite and enhance routine testing of LNP components and impurities</li><li>Discover orthogonal insights enabled by multi-angle light scattering detection (MALS)</li></ul><h5>Who should attend</h5>Scientists involved with lipid nanoparticle analysis<blockquote>Presenter: Anni Chang, Ph.D. (Sr Scientist II, Excipients Unit, US Pharmacopeia)Dr. Anni Chang is currently a Senior Scientist II in the Excipients unit at the United States Pharmacopeia (USP). In her current role, she is responsible for developing, revising, and modernizing USP monographs. One of her focus areas is lipid excipients used in nanomaterial carriers.Dr. Chang has more than 15 years of experience in the biotech/pharmaceutical industry in analytical method development, validation, and transfer. She received her Ph.D. in Chemistry from University of Maryland, College Park, Maryland, USA. Dr. Chang is also active in the American Association of Pharmaceutical Scientists and serves as a Member Engagement Manager in the Lipid Based Drug Delivery community.Presenter: Duanduan Han, Ph.D. (Senior Scientist QA/QC Biologics Solutions group, Waters Corporation)Duanduan is a Senior Scientist in the QA/QC Biologics Solutions group at Waters Corporation headquarters in Milford, MA. She joined Waters in 2021, and she has focused on LC method development in composition analysis, impurity profiling, and raw material screening of lipid nanoparticle components and products. Additionally, she has explored other subjects of pharmaceutical analysis including surfactant, protein, and peptide. Prior to joining Waters, she received her PhD in chemical engineering from Texas A&amp;M University.Presenter: Panelist: Martin Kurnik, Ph.D. (Senior Scientist, Analytical Sciences, Waters | Wyatt Technology​)Martin Kurnik is a senior scientist in the Analytical Sciences team at Waters | Wyatt Technology. He helps customers identify and develop the best solutions for their analytical needs by leveraging his expertise in multi-angle light scattering and dynamic light scattering as well as a wide range of other leading techniques for biomolecular characterization. His postdoctoral research in protein folding and misfolding biophysics focused on understanding and preventing misfolding in bulk solution and on artificial surfaces used in medicine and biotechnology, and he has also developed protein- and aptamer-based electrochemical biosensors for continuous real-time measurements in vitro and in vivo. Martin received his M.Sc. in Chemistry and Ph.D. in Biochemistry from Stockholm University, Sweden.Moderated by: Isabelle Vu Trieu (Pharmaceutical Market Development Manager, Americas, Waters Corporation)Isabelle is a business development professional dedicated to delivering benefits to analytical scientists in the life sciences industry. With over 20 years of experience in providing chromatography and mass spectrometry solutions, Isabelle is particularly interested in helping pharmaceutical scientists achieve the data quality and integrity needed to drive decisions for drug quality, safety and efficacy. Isabelle joined Waters in 2009 and currently manages the development of the pharmaceutical market in the Americas. She holds Masters’ degrees in Chemistry from Columbia University and the University Claude Bernard in Lyon, France as well as a Chemical Engineering degree from Ecole Supérieure de Chimie Physique Electronique in Lyon, France.</blockquote></div>

Waters Corporation: Solving Problems That Matter - a Waters webinar series featuring USP speakers

Lipid nanoparticles

Solving Problems That Matter - a Waters webinar series featuring USP speakers. Episode 8: Complex excipients: Lipid nanoparticles.

Complex excipients: Lipid nanoparticles

Data management and manual transcription of critical process data remain one of the major challenges and potential sources of errors in the analytical laboratory.
As a lot of the laboratory processes evolve around sample preparation for HPLC or GC, with crucial weighing and preparative steps, this webinar aims to showcase some seamless data management and transfer solutions, from balance to LC. The LabX™ balance software and OpenLab CDS platform can enable various levels of integrated data management, while also improving productivity and offering a high degree of data integrity.
Join the METTLER TOLEDO and Agilent teams for a webinar to understand how you can support digitalized and scalable sample preparation processes for better chromatography results. 
Program Overview
<ul>
<li>Introduction to the digital lab
</li>
<li>Improving analytical sample preparation workflows
</li>
<li>Live demonstration of seamless data transfer options
</li>
<li>Q&amp;A with presenters
</li>
</ul>
<blockquote>
Presenter: Andrea Brütsch (Head Business Development Initiatives)
</blockquote>
<blockquote>
Presenter: Kevin Koelliker (Agilent Technologies, Application Engineer)
</blockquote>

Mettler Toledo: Automated Data Management for LC/GC Workflows

Automated Data Management for LC/GC Workflows

How can you support digitalized and scalable sample preparation processes for better chromatography results.

In the second part of the stationary phases webinars, we look at other separation modes: IEX, SEC, ligand exchange and HILIC and what we think they are best suited for.<blockquote>Presenter: Cecilia Mazza (Product Specialist, EMEA IDO - Chemistries &amp; Suppliers, Agilent)With more than 20 years of professional experience, Cecilia is presently the Product Specialist for columns and supplies at Agilent. Supporting distributors and laboratory users in the analysis and purification of small and large molecules, for a wide range of LC and GC applications as well as sample preparation.Cecilia holds a Ph.D. in Chemical Engineering from Rensselaer Polytechnic Institute in US.</blockquote>

Agilent Technologies: HPLC Beginner Webinar Series

Stationary Phases in HPLC - Part II

We look at other separation modes: IEX, SEC, ligand exchange and HILIC and what we think they are best suited for.

The allowable adjustments to compendial methods published in USP General Chapter 621 and Ph. Eur. 2.2.46 provide scope for analysts to migrate methods to smaller column dimensions, providing advantages in terms of time and cost savings.This webinar will provide insight into the considerations necessary when applying allowable adjustments to gradient monographs.<h4>Key Learning Points:</h4><ul><li>Learn about Allowable adjustments possible when working with gradient monograph methods</li><li>Understand system considerations in terms of dwell volume</li><li>Dig into calculations to perform in order to scale gradient conditions correctly</li></ul><h4>Who Should Attend:</h4><ul><li>Any analysts working with pharmacopeia methods or chromatographers who work with gradient methods&nbsp;</li></ul><blockquote>Presenter: James Turner (Global Market Manager, Phenomenex)With more than 25 years of experience at Phenomenex, James has been responsible for providing specialist technical support to customers across Europe with method development assistance, troubleshooting advice and chromatographic solutions to various customer problems. James has also been involved with the technical training of many Phenomenex technical consultants, across the multiple techniques we serve.</blockquote>

Phenomenex: Working with Allowed Adjustments Pharmacopeia HPLC Methods – Gradient Considerations

Working with Allowed Adjustments Pharmacopeia HPLC Methods – Gradient Considerations

Insight into the considerations necessary when applying allowable adjustments to gradient monographs.

Working with Allowed Adjustments Pharmacopeia HPLC

Heightened interest in mRNA therapeutics has accelerated the need for analytical methodologies that facilitate the production of supplies for clinical trials. This webinar will present a concise panel of chromatography-based stability-indicating assays for evaluating thermally stressed in vitro transcribed mRNA as part of a forced degradation study.Our expert speakers will demonstrate the application of these methods to evaluate the critical quality attributes (CQAs) of mRNAs as well as to detect intrinsic process- and product-related impurities.<h4>Key learning objectives</h4><ul><li>Characterization of thermally stressed mRNA using a panel of chromatographic assays</li><li>Implementation of SEC-MALS to confirm transcripts reflect full-length sequence design</li><li>Platform 5’ cap/3’ tail analyses, circumventing antisense probe design</li><li>Design of QC-friendly methods fit for research, release, and comparability testing</li></ul><h4>Who should attend?</h4><ul><li>QC lab technicians or lab assistants.</li><li>Lab managers of development, process development, or QC.</li><li>Directors/Senior directors of development, process development or QC</li><li>VP of Quality; VP of Development or VP of CMC.</li><li>Anyone interested in learning more about light scattering and its applications on mRNA characterization.</li><li>Industry and academic researchers working in gene therapy and biotherapeutics.</li><li>Any scientist in discovery, development, and quality control.</li></ul><blockquote>Presenter: Jaclyn Cika (Scientist – Protein Biochemistry group, Regeneron)Jaclyn Cika joined the Protein Biochemistry group at Regeneron Pharmaceuticals in 2019. She provides late-stage development and commercial support through the biophysical characterization of Regeneron antibody and AAV reference standards. She also oversees the qualification status of various SEC-MALS systems, and is responsible for SEC-MALS method qualification for commercial products. Additionally, she focuses on the biophysical characterization of nucleic acids, primarily using light scattering techniques, for early research and development support.Presenter:&nbsp;James Greco (Regional Account Manager, Wyatt Technology, Waters | Wyatt Technology)James Greco is a Regional Account Manager at Wyatt Technology, bringing over 16 years of experience in the biopharma industry. He has a B.Sc. in Biology from Salve Regina University. He began his career at BMS, where he spent eight years specializing in biophysical characterization. In 2017, he joined Wyatt Technology as a Field Application Scientist, where he supported and provided advanced training to customers across various fields. He later transitioned to his current role as Regional Account Manager.Presenter:&nbsp;Charlie Carter (Life Sciences Editor, SelectScience)</blockquote>

SelectScience: Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA

Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA

The application of these methods to evaluate the critical quality attributes (CQAs) of mRNAs as well as to detect impurities.

Comprehensive chromatographic assessment of forced

The presence of per- and polyfluoroalkyl substances (PFAS) in food supply chains is a growing concern due to their environmental persistence and potential health risks.As awareness increases, the demand for effective regulations and advanced analytical methods for detecting PFAS in food is critical. In this webinar hosted by Agilent in association with AOAC India Section, we will explore the current PFAS contamination landscape, regulatory frameworks, and the latest analytical solutions.The session will cover PFAS characteristics and the challenges they present to food safety. We will examine global and regional regulations, with a focus on evolving standards in India and the South Asia Pacific region. Also, the webinar will highlight advanced analytical approaches for different food matrices like seafood, eggs, meat, infant formula, packaging material, including sample preparation, instrumentation, and reporting essential for effective PFAS detection. Agilent's robust LC/MS and GC/MS PFAS testing solutions will be showcased along with the Captiva EMR sample preparation kit, demonstrating how they can help food manufacturers, exporters, and regulatory bodies ensure compliance with global standards.<h4>Learning outcomes:</h4><ul><li>Comprehensive understanding of PFAS characteristics and the regulatory landscape across global and regional markets, including India and the South Asia Pacific.</li><li>Advanced analytical techniques for PFAS detection in food, covering sample preparation, instrumentation, and reporting methodologies.</li><li>Practical insights into implementing PFAS testing solutions to ensure compliance with international food safety standards.</li></ul><h4>Who should attend:</h4><ul><li>Food scientists, analytical chemists, regulatory authorities, government lab personnel, industry professionals in food manufacturing, packaging, exporting, R&amp;D scientists, toxicologists, QA/QC analysts and managers, academicians, and researchers focused on PFAS analysis and food safety.</li></ul><blockquote>Presenter: Dr. Nick Birse (Lecturer, School of Biological Sciences, Queen's University, Belfast, Northern Ireland, UK)Nick Birse is a Lecturer in Mass Spectrometry at Queen’s University Belfast, where he focuses on the use of mass spectrometry to solve key food integrity challenges, such as the measurement of chemical contaminants and natural toxins, fingerprinting foods to determine geographic origin and help detect fraud, or simply to measure key quality, flavour and taste attributes, all of which makes foods tastier, healthier and safer for consumers. Nick previously served as a Research Fellow within Prof Chris Elliott’s research group, assisting in the execution of Chris’s 2021 Agilent Thought Leader Award. He holds a PhD in Analytical Chemistry from Queen’s University Belfast.Presenter:&nbsp;Dr. Niladri Sekhar Chatterjee (Senior Scientist and DST Inspire Fellow, ICAR-Central Institute of Fisheries Technology, India)Dr. Niladri has more than 10 years of experience in precision measurement of small molecules in food, biological, and environmental matrices. His doctoral research is on pesticide metabolism, and environmental fate in crop, soil, and water. His postdoctoral research is on seafood authentication using high resolution mass spectrometry-based metabolomics and molecular spectroscopy fingerprinting. He currently works as a Senior Scientist in the Biochemistry and Nutrition Division at ICAR Central Institute of Fisheries in Kochi. At CIFT, he has been instrumental in establishing a state-of-the-art analytical chemistry laboratory from scratch which is today one of the National Reference Laboratories. He has received external grants from the Science and Engineering Research Board (SERB) India, National Agricultural Science Fund, and FSSAI. In the NRL, he has developed and validated precision measurement methods for multiclass analysis of pesticides, antibiotic residues, and endocrine disruptors and is actively managing the ISO 17025 accreditation of the laboratory. His research work has resulted in several peer reviewed publications.Presenter:&nbsp;Dr. Lorna De-Leoz (Global Food Segment Director, Agilent Technologies, USA)Lorna De Leoz has nearly 20 years of experience in the food industry. As the Global Food Segment Director, she collaborates with scientists to help develop accurate and reliable testing for food safety, quality, and authenticity. Lorna worked at the National Institute of Standards and Technology in the Mass Spectrometry Data Center for seven years. She completed her Ph.D. in Chemistry at University of California, Davis on milk oligosaccharides and glycan biomarkers analyses.</blockquote>

Agilent Technologies: PFAS in Food Supply Chains: Regulations and Analytical Approaches: in association with AOAC India Section

PFAS in Food Supply Chains: Regulations and Analytical Approaches: in association with AOAC India Section

PFAS characteristics and the challenges they present to food safety.

PFAS in Food Supply Chains: Regulations and Analytical

Nitrosamine Drug Substance-Related Impurities (NDSRI's) are a class of impurities that can form in drug substances and products. These impurities are of significant concern due to their potential carcinogenicity. Regulatory bodies, including the FDA, have established guidelines and acceptable intake limits to ensure the safety and efficacy of medications.NDSRI webinar series is a comprehensive three-part webinar series designed to provide valuable insights into the evolving landscape of analytical methods and regulatory requirements. This series will cover critical topics that are essential for professionals in the field.Key learnings:<ul><li>Understanding Nitrosamine / NDSRI and their impact on drug safety.</li><li>Latest regulatory guidelines and requirements.</li><li>Navigating Nitrosamines with Agilent 21 CFR compliant mass Hunter Software.</li><li>A focus on components in chromatographic challenges, with examples of NDSRI methods.</li><li>Case studies and real-world applications.</li><li>Column and consumable selection and how it influences the analysis.</li><li>Best practice for method optimization, development, and automation.</li><li>and more</li></ul><blockquote>Presenter: Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.Presenter:&nbsp;Dr. Prasanth Joseph (Application Engineer - LC/MS, Agilent Technologies)Prasanth is an experienced analytical instrumentation professional with a specialization in small molecule applications. Joining Agilent in 2015 as an Application Engineer for LC-MS/MS, he has 19 years of expertise in the field. Prasanth holds a Ph.D. in Environmental Science from Bharathiar University, India, and a master's degree in Business Administration from the University of Buckingham, UK. His extensive knowledge includes developing analytical methods for quantifying genotoxic impurities, analyzing extractables and leachables in pharma and food packaging, conducting bioavailability and bioequivalence studies, and more. Prasanth's proficiency extends to the analysis of phytochemicals, food residue screening, and environmental sample contaminants.Presenter:&nbsp;Mr. Ankush Sharma (Regional Marketing Program Manager- APAC (Pharma &amp; Biopharma), Agilent Technologies)Ankush Sharma is a seasoned professional with over 12 years of extensive experience in sales and marketing across the pharmaceutical and biopharmaceutical sectors. His professional journey commenced with a strong educational foundation, earning a Master's degree in Biotechnology. Building upon this knowledge, he furthered his academic pursuits by obtaining a Master's in Business Administration with a specialization in Sales and Marketing, demonstrating his commitment to blending scientific understanding with strategic business acumen. For the past five years, he has been an integral part of Agilent, serving as the Regional Marketing Program Manager for the India and now Asia-Pacific (APAC) region for Pharma and Biopharma Markets.</blockquote>

Agilent: Nitrosamines & NDSRI's: Be sure with Agilent workflows

Nitrosamines & NDSRI's: Evolving Regulatory Landscape in Nitrosamines and NDSRI’s analysis.

NDSRI webinar series is designed to provide valuable insights into the evolving landscape of analytical methods and regulatory requirements.

Nitrosamines & NDSRI's: Be sure with Agilent workflows

<h4>The Waters 2024 Virtual Summer School - An Educational Journey to Master Food &amp; Environmental Analysis</h4>Unlock the full potential of LC-MS techniques with our immersive and educational sessions at the Waters Virtual F&amp;E Late Summer School 2024. From September 24th to 26th, engage with leading experts and discover cutting-edge methods for environmental and food analysis.<h5>Why attend?</h5><ul><li>Comprehensive Learning: Dive deep into advanced LC-MS techniques and gain practical knowledge to enhance your laboratory's analytical capabilities.</li><li>Expert Insights: Learn from industry leaders and gain firsthand experience through detailed modules on chromatography, mass spectrometry, and sample preparation.</li><li>Regulatory Compliance: Stay ahead with the latest insights on EU regulations for PFAS analysis in food and water, ensuring your lab meets stringent standards.</li></ul><h3>Episode #1: Chromatography - UPLC | F&amp;E Summer School - Day 1 - Module 1</h3>This section will provide an overview of the Waters reference material available to customer to help plan the best columns and chromatographic conditions for their LC-MS methods, using common environmental contaminants as an example. We highlight how to create LC-MS methods using the Acquisition Method Editor (AME) application within waters_connect™. Finally, this section will cover some of the most troubleshooting issues: contaminated blank peaks, poor peak shape, etc, and how to address them.<h5>What you'll learn:</h5><ul><li>Important factors for developing a UPLC method - considering analyte solubility, pKa and partitioning coefficient (Kow)</li><li>Selecting the most appropriate UPLC column for your analytes</li><li>Setting up LC-MS methods in the waters_connectTM console</li><li>Troubleshooting common contamination issues</li></ul><blockquote>Presenter: Nicole Baumgarten (Sr Sales Applications Chemist, Waters Corporation)Nicole is part of the Customer Success team at Waters with a focus on LC-MS/MS application and sales support. She works in this role for more than 9 years and gained experience in previous roles as analyst for biopharmaceuticals in process controls at Boehringer Ingelheim and research Assistent at Zentrum für Humangenetik und Laboratoriumsmedizin in Munich after finishing a Master of Chemical engineering at Hochschule Fresenius, Idstein.Presenter: Caroline Davis (Sr Sales Applications Chemist, Waters Corporation)</blockquote>

Waters Corporation: The Waters 2024 Virtual Summer School

Chromatography - UPLC

An overview of the Waters reference material available to customer to help plan the best columns and chromatographic conditions for their LC-MS methods.

Chromatography - UPLC 

<h4>The Waters 2024 Virtual Summer School - An Educational Journey to Master Food &amp; Environmental Analysis</h4>Unlock the full potential of LC-MS techniques with our immersive and educational sessions at the Waters Virtual F&amp;E Late Summer School 2024. From September 24th to 26th, engage with leading experts and discover cutting-edge methods for environmental and food analysis.<h5>Why attend?</h5><ul><li>Comprehensive Learning: Dive deep into advanced LC-MS techniques and gain practical knowledge to enhance your laboratory's analytical capabilities.</li><li>Expert Insights: Learn from industry leaders and gain firsthand experience through detailed modules on chromatography, mass spectrometry, and sample preparation.</li><li>Regulatory Compliance: Stay ahead with the latest insights on EU regulations for PFAS analysis in food and water, ensuring your lab meets stringent standards.</li></ul><h3>Episode #2: Tandem Quadrupole MS and MS-Method Development | F&amp;E Summer School - Day 1 - Module 2</h3>In this episode it’s all about the tandem quadrupole mass specs and the setup of MS-methods. We will demonstrate, using actual hardware, how simple it is to prevent contamination or clean a system, regardless of whether it’s at the low or high end of the sensitivity spectrum. You will learn valuable tips and tricks about UniSpray, a unique ion source and alternative to ESI.With our new waters_connect for Quantitation software, we will guide you through the different stages of MS-method development. You will learn how straightforward automated compound optimization can be, and how intuitively the new Method Acquisition Editor can be utilized by operators providing a clear structured all in one view of compounds and parameters. Search options make it easy to navigate through large multi-residue methods. And in the end, you are just one click away from the processing method that will be the topic of Episode 4.<h5>What you'll learn:</h5><ul><li>Easy operation and maintenance of Waters TQ-MS systems</li><li>Usage and benefits of UniSpray ion source</li><li>Step by step MS-method development with waters_connect for Quantitation</li></ul><blockquote>Presenter:&nbsp;Benjamin Wuyts, PhD (Senior Solution Support Specialist Europe, Waters Corporation)Benjamin initially joined Waters as an application chemist working in the Belgian demo lab, performing liquid chromatography-mass spectrometry demonstrations, support and training. In 2016 Benjamin became a European application chemist focusing on projects to support emerging applications. Benjamin has been focused over several years in establishing the Waters solution to the analysis of polar anionic pesticides, utilising novel column phases and LC-MS/MS technologies.</blockquote>

Tandem Quadrupole MS and MS-Method Development

In this episode it’s all about the tandem quadrupole mass specs and the setup of MS-methods.

<h4>Overview</h4>We invite you to our 2nd Annual Virtual Biosymposium. This year, we will explore novel analytical characterization and quantitation of emerging modalities, such as DNA and mRNA, along with key method development considerations with global thought leaders.We look forward to seeing you! Key Event Objectives:<ul><li>Learn about novel approaches to characterizing established and modern biotherapeutic modalities</li><li>Understand key considerations when developing characterizing and quantitating methods for biomolecules</li><li>Take a deep dive into the values of fit-for-purpose methods to make critical drug decisions</li></ul>AGENDA7:30am AM (PT) - Welcoming Introductions<ul><li>Tran N. Pham, Global Biopharma Market Development Manager at Phenomenex</li></ul>7:35 AM (PT) - "Solutions &amp; Characterization Strategies for IVT mRNA Therapy Development"<ul><li>Charles Bai, Lead Application Scientist, VectorBuilder, Chicago, USA</li></ul>8:05 AM (PT) - &nbsp;"Utilizing Size Exclusion Chromatography for the Quality Control Analysis of Gene Therapeutics”<ul><li>Rebecca Hirschberger, QC Manager Bioanalytical Implementation, and Dr. Christopher Gawlig, QC Manager Research and development, Biospring, Germany</li></ul>8:35 AM (PT) "Impurity Profiling Optimization of GalNAc-conjugated Oligonucleotides by LC-MS-UV"<ul><li>Roxana Eggleston-Rangel, Senior Applications Scientist, Phenomenex, California, USA</li></ul>9:05 AM (PT) – Round Table Q&amp;A<ul><li>Tran N. Pham, Global Biopharma Market Development Manager at Phenomenex</li></ul>9:25 AM (PT) – Closing Remarks<blockquote>Presenter: Charles Bai (Lead Application Scientist)Charles has received his PhD in Microbiology at Purdue University. As a Lead Application Scientist at VectorBuilder, his main responsibilities are to provide technical consultation for clients regarding gene delivery using viral and non-viral vectors. Regarding the application of in vitro transcribed (IVT) RNA, Charles has been helping researchers with the design, production and encapsulation of IVT mRNA, circRNA or saRNA for therapy and vaccine development.Presenter: Rebecca Hirschberger (Quality Control Bioanalytical Method Development)Rebecca has been in the chromatography industry for over 2 years and has practical experience in the quality control of gene therapeutics. She has earnt a Masters in pharmaceutical science from Ludwig-Maximilians University, Munich, focused on instrumental analytics. Since Dezember 2022 she is a licensed Pharmacist in Germany. Rebecca Hirschberger joined BioSpring in August of 2021 and she serves as QC Manager Bioanalytical Implementation. Her area of responsibility includes: Various analyses of oligonucleotides, including (tandem) mass spectrometry via qToF, biochemical techniques, i.e. ELISA, enzymatic transformation of oligonucleotides for analytical and quality control purposes and the Separation of oligonucleotides by chromatographic methods.Presenter: Roxana Eggleston-Rangel (Senior Applications Scientist, Phenomenex)Roxana joined Phenomenex in 2018 as an Applications Scientist and is currently working with the applications team to produce analytical solutions for scientist in the biopharma industry. Roxana’s current work focuses on characterization of mRNA, sgRNA and siRNA. Prior to Phenomenex, Roxana worked for Caltech and the University of Southern California developing LM-CS workflows for the proteomics community. Roxana Eggleston-Rangel received her bachelor’s and master’s degree in Chemistry and Biochemistry from California State University, Los Angeles.</blockquote>

Phenomenex: 2nd Annual Virtual Biosymposium

2nd Annual Virtual Biosymposium

Explore novel analytical characterization and quantitation of emerging modalities, such as DNA and mRNA

Tandem Quadrupole MS and MS-Method Development

Stationary Phases in HPLC - Part II

Chromatography - UPLC

PFAS in Food Supply Chains: Regulations and Analytical Approaches: in association with AOAC India Section

Automated Data Management for LC/GC Workflows

Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA

Nitrosamines & NDSRI's: Evolving Regulatory Landscape in Nitrosamines and NDSRI’s analysis.

Lipid nanoparticles

2nd Annual Virtual Biosymposium

Working with Allowed Adjustments Pharmacopeia HPLC Methods – Gradient Considerations

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