🎤Rajas Poorna and Charles Anderson<h4>What if you could dry biofluid samples in the field—without a vacuum system, freeze dryer, or full lab setup?</h4>In this episode of Concentrating on Chromatography, I sit down with Rajas Poorna and Charles Anderson to explore their work on a frugal, field-deployable alternative to traditional lyophilization through the Evapinator project.Originally inspired by the principles of frugal science, their approach rethinks how we stabilize and prepare biofluid samples like blood and plasma—especially in environments where traditional lab infrastructure simply isn’t available.<h4>What This Episode Covers:</h4><h5>A Frugal Take on Lyophilization</h5>Can you replicate the outcome of a lyophilizer without the complexity? Why traditional freeze drying is often too expensive and impractical for field use How simplifying evaporation could unlock entirely new workflows<h5>Drying Biofluids in the Field</h5>The real-world challenge of handling blood and other biofluids outside the lab Why sample stability during transport is such a critical bottleneck How a portable system could enable on-site sample prep in remote or resource-limited settings<h5>Rethinking Evaporation (No Vacuum Required)</h5>The core idea behind the Evapinator—and how it challenges conventional assumptions The role of airflow, heat, and design in drying sensitive samples Where this approach fits relative to traditional evaporation and lyophilization techniques<h5>Early Results &amp; Practical Insights</h5>What’s working so far—and where limitations still exist The types of applications where this approach shows the most promise What still needs to be validated in upcoming peer-reviewed work<h4>Why This Matters</h4>From clinical research in remote regions to decentralized diagnostics, the ability to dry and preserve biofluid samples in the field could fundamentally change how and where analysis happens.This conversation challenges a core assumption in analytical science:Do you really need a full lyophilizer—or even a vacuum—to stabilize biofluid samples?<h3>Video Transcription</h3>The interview opens with a welcome to an episode of Concentrating on Chromatography. The host introduces guests Rajas Poorna and Charles Anderson and asks about their scientific backgrounds and how they became involved in solving evaporation challenges.<h4>Scientific background and project origin</h4>Rajas explains that he is trained as a physicist and is now pursuing a PhD in bioengineering. His lab focuses on building low-cost scientific equipment to make science more accessible, especially for schools and low-resource settings. This work is part of a broader “frugal science” approach, where students and researchers develop affordable versions of instruments that are normally expensive.The original challenge came from synthetic biology education. High school teams working on synthetic biology projects needed access to equipment such as lyophilizers, but conventional systems can cost tens of thousands of dollars. The team therefore began exploring whether a more affordable lyophilizer-like system could be built for education and field use.Charles describes joining the project early in his undergraduate studies. He was drawn to it because it had a clear practical purpose and seemed like something that could become useful outside the laboratory rather than remaining only a research prototype.<h4>Why evaporation became the key challenge</h4>The discussion turns to the practical limitations of traditional evaporation and drying systems. Rajas explains that during a collaboration in Thailand, researchers working on Raman spectroscopy for tuberculosis diagnostics needed to dry blood-derived samples before transporting them to a central laboratory. They used a centrifugal vacuum evaporator, but the system was slow, expensive, and difficult to service when it broke down.This experience led to a central question: could sample drying be achieved without a vacuum? Rajas notes that everyday drying processes, such as drying clothes, do not require vacuum. This insight opened the path toward a simpler, smaller, lower-cost and potentially battery-powered drying system.<h4>How Rajas and Charles began collaborating</h4>Charles explains that he met the lab’s principal investigator while discussing a different project. He was then invited to work on what would later become the Evaponator. At the beginning, the project was still small and exploratory.Rajas adds that Charles joined at a stage when the team was trying to understand the physics and engineering behind vacuum-free drying. Within a few months, they developed a prototype costing under 100 USD that could dry samples much faster than the conventional vacuum evaporator used by collaborators.<h4>Main limitations of conventional drying systems</h4>The interview identifies several major limitations of existing evaporation technologies:<ul><li>High cost</li><li>Limited reliability in remote or low-resource settings</li><li>Long drying times</li><li>Poor field portability</li><li>Challenges with sterility and cross-contamination</li></ul>Charles emphasizes that freeze drying can take 12–24 hours, which is impractical for field use. Rajas adds that centrifugal vacuum evaporators are not necessarily sterile and may pose a risk of cross-sample contamination. Together, these challenges shaped the requirements for the Evaponator.<h4>What the Evaponator is</h4>Charles introduces the Evaponator as a low-cost, portable drying system designed to dry small numbers of samples quickly without a vacuum chamber. The name was inspired by an episode of Phineas and Ferb.The system is based on the same principles as drying clothes: low humidity, gentle heating and airflow. Instead of using vacuum, the Evaponator generates dry air, directs it over the sample, removes moisture through a cold trap and repeats the process in a closed or semi-closed loop.The current design is aimed at drying approximately four 1 ml samples, which fits the intended use case of field diagnostics or low-throughput sample collection in remote settings.<h4>How the system works</h4>Rajas explains the operating principle in more detail. Moist air is passed through a cooled metal block using a thermoelectric cooler. As the air cools, moisture condenses inside the cold trap, producing dry air. This dry air is then directed over warmed samples, helping water evaporate while keeping the sample temperature moderate.The system can operate in a loop to improve efficiency. HEPA filtration and aerosol filtration help prevent contamination. The team also developed an ozone-based sterilization approach, allowing the device to sterilize itself using ozone generated from air rather than relying on consumables such as ethanol or peroxide.To prevent sample-to-sample contamination, the design uses separate airflow paths for individual samples, which merge only later in the system.<h4>Design assumptions and engineering constraints</h4>A key design assumption is that not every drying process needs sublimation or deep vacuum. For the biofluid applications targeted by the Evaponator, the team works around 40 °C, a temperature chosen because it is close to fever temperature and should be mild enough for many biological samples.The engineering constraints included:<ul><li>Use of widely available components</li><li>No specialized machining</li><li>Bill of materials under 100 USD</li><li>Low power consumption</li><li>Portability</li><li>Simple assembly</li><li>Robust airflow without splashing or sample loss</li></ul>Charles notes that the team intentionally selected accessible parts, including components similar to those used in computer cooling systems, vacuum-cleaner-style HEPA filters and disposable pipette tips for directing airflow.<h4>Sample types and solvents</h4>The prototype is currently focused mainly on aqueous biological samples. Rajas explains that using organic solvents such as ethanol would introduce ignition risks with the current architecture, so the early work is focused on water-based samples and biofluids.Charles adds that the system is intended primarily for blood-derived fluids, urine, saliva and similar samples where the target analytes can remain stable after drying and rehydration.<h4>Potential analytical applications</h4>The Evaponator is being developed for field sample preparation rather than as a replacement for every laboratory evaporator. The main idea is to dry samples near the point of collection, transport them more easily and then rehydrate them before analysis.Potential use cases include:<ul><li>Field diagnostics</li><li>Biofluid sample stabilization</li><li>Remote sample collection</li><li>Clinical or public-health testing in low-resource settings</li><li>Applications where dried plasma, serum, urine or saliva can later be analyzed</li><li>Situations where conventional dried blood spot methods lack enough sample volume</li></ul>Rajas notes that red blood cells may not be suitable for drying directly because they can rupture, so serum or plasma is expected to be more appropriate. He also points out that oxygen exposure during forced-air drying still needs further testing for oxygen-sensitive analytes.<h4>Current development status</h4>Charles explains that the project is approaching important validation milestones, especially around batch-to-batch and sample-to-sample sterility. The ozone cleaning system appears promising because it may reduce the need for cleaning consumables, aside from inexpensive items such as pipette tips and occasional filter replacement.He also mentions tests with trehalose-based solutions and collaboration with a Georgia Tech startup working on room-temperature-stable mRNA vaccines. In that context, the Evaponator was able to dry samples in about 30 minutes, compared with 12–24 hours using previous drying approaches.<h4>Commercialization and future direction</h4>Rajas explains that the team is exploring commercialization and has participated in a startup accelerator. They are investigating where the technology could have the strongest product-market fit, with particular interest from cost-sensitive and geographically dispersed healthcare settings, including India.The goal is to move beyond a lab prototype toward a manufacturable, user-friendly device with a straightforward interface and reliable sealing, sterilization and operation.<h4>Closing remarks</h4>The interview concludes with the host thanking Rajas Poorna and Charles Anderson for sharing the technical and practical challenges behind the Evaponator. Both guests emphasize that the conversation was a valuable opportunity to explain the project in depth and reflect on its progress.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Frugal Science Meets Sample Prep: A Field-Ready Lyophilizer for Biofluids

In the week of July 13, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. GERSTEL: Automated SPE Sample Preparation for PFAS and Ultra-Short-Chain PFAS in Aqueous Matrices</h5><ul><li>Tu, 14.7.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6329">Registration</a></li></ul>Learn how laboratories automate SPE sample preparation for PFAS and ultra-short-chain PFAS in aqueous matrices to obtain cleaner extracts ready for LC-MS/MS analysis.<h5>2. Phenomenex: Under Pressure: Mastering Backpressure in HPLC</h5><ul><li>We, 15.7.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6330">Registration</a></li></ul>Master HPLC backpressure troubleshooting. Learn how column dimensions, tubing, mobile phases, and sample matrices influence system pressure and how to resolve common issues.<h5>3. SCIEX: PFAS in Pharmaceuticals</h5><ul><li>We, 15.7.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6332">Registration</a></li></ul>Master PFAS analysis in pharmaceutical workflows. Learn analytical strategies and contamination control for sensitive detection in APIs and packaging materials.<h5>4. Thermo Fisher Scientific: Characterizing Complex Biotherapeutics Based on New Modalities: Uncover New LC-MS Workflow Strategies</h5><ul><li>We, 15.7.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6331">Registration</a></li></ul>Resolve complex oligonucleotide impurities. Learn how inert UHPLC flow paths and Orbitrap MS minimize metal adducts and improve chromatographic separation for ASO therapeutics.<h5>5. Waters Corporation: Does Chromatography Still Matter? The Critical Role of UPLC in Clinical LC-MS/MS Performance</h5><ul><li>We, 15.7.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6371">Registration</a></li></ul>Discover why LC remains essential in clinical LC-MS/MS workflows and how UPLC improves sensitivity, reproducibility, robustness, and analytical confidence in routine clinical testing.<h5>6. Unchained Labs: Get Hooked on Automated Buffer Exchange with Lil’ Tuna</h5><ul><li>We, 15.7.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6383">Registration</a></li></ul>See how easily Lil’ Tuna automates buffer exchange and concentration experiments, simplifying sample preparation while improving laboratory efficiency.<h5>7. Agilent Technologies: Food Fortification, Measured: The Analytical Testing Behind the Standards</h5><ul><li>Th, 16.7.2026 07:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6336">Registration</a></li></ul>Master food fortification testing. Learn how HPLC, LC-MS, and ICP-MS verify micronutrient levels and support compliance with regulatory standards.<h5>8. Restek Corporation: PFAS - Analysis of Per- and Polyfluorinated Alkyl Substances</h5><ul><li>Th, 16.7.2026 14:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6384">Registration</a></li></ul>Join this webinar to discover practical tips and proven methods for obtaining robust and reproducible PFAS data using Restek analytical solutions.<h5>9. Thermo Fisher Scientific: Sterility Testing Remains a Critical Component of Batch Release and Overall Sterility Assurance</h5><ul><li>Th, 16.7.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6364">Registration</a></li></ul>Explore compendial and rapid sterility testing approaches, method selection, media choice, and risk-based strategies to strengthen sterility assurance and support compliant pharmaceutical quality control.<h5>10. SciY/Mestrelab Research: No More Boxes on Slides. Examples of Workflow Orchestration and Their Impact from R&amp;D to Production on Demand</h5><ul><li>Th, 16.7.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6335">Registration</a></li></ul>Bridge the gap between laboratory automation and AI. Discover practical workflows for reaction screening, structure verification, and closed-loop experiments.<h5>11. SelectScience: Building Confidence at Scale in 4D-Metabolomics with Data Quality, Depth and Connectivity in Focus</h5><ul><li>Fr, 17.7.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6338">Registration</a></li></ul>Scale up your 4D-metabolomics workflows. Learn how timsMetabo and MetaboScape software ensure data quality, confident annotation, and AI-ready digital archives.

Webinars LabRulezLCMS Week 29/2026

Tracking Protein Misfolding and Oligomerization: A Temperature-Controlled Ion Mobility-Mass Spectrometry Approach

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

New Food magazine

Pittcon

Phenomenex

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Evosep Biosystems

Waters Corporation

Dioxins and POPs analysis is evolving as historic instrumentation reaches its limits and obsolescence. Learn how you can equip your lab for the future with APGC-MS/MS technology that simplifies operation while exceeding regulatory performance requirements.
Join our webinar to find out how APGC could improve your methods with: 
<ul>
<li>Sensitivity</li>
<li>Selectivity</li>
<li>Robustness</li>
</ul>
You will also hear from the industry experts about their experiences about APGC and how it helps to advance them further and stay in line (or exceed) regulatory limits, while also dealing with throughput demands.
<blockquote>
Presenter: Rhys Jones (Principal Consulting Scientist, Waters Corporation)
</blockquote>
<blockquote>
Rhys has worked for Waters in research and development for 20 years with a strong focus on gas chromatography mass spectrometry. ​The early part of his career was spent developing and supporting the AutoSpec magnetic sector instrument. ​One of his current responsibilities is the research, development and support of the atmospheric pressure gas chromatography (APGC) chemical ionization source, which has allowed the full range of Waters’ mass spectrometry techniques to be applied to GC analyses.
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<blockquote>
Presenter: Janitha de Alwis (JD) (Senior Applications Chemist, Waters Corporation)
</blockquote>
<blockquote>
Janitha de Alwis (known as JD) is an applications chemist in the European demo lab, based in Wilmslow, UK. His main role focuses on application development work for the food and environmental sector. JD takes great pride in speaking to, and advising, many food and environmental customers. His position requires him to be reactive and proactive to the changes in the food industry, such as changing regulations, topical issues and food safety risks.
</blockquote>

Waters Corporation: Change the Game Part I - POPs Analysis with Atmospheric Pressure GC (APGC)

Change the Game Part I - POPs Analysis with Atmospheric Pressure GC (APGC)

Join our webinar to find out how APGC could improve your methods with: Sensitivity, Selectivity, Robustness.

Part I - POPs Analysis with Atmospheric Pressure GC (APGC)

This time we will give an overview and demonstration of the SELECT SERIES MRT for small molecule metabolite workflows such as metabolomics and drug metabolite identification.
During this demo, Adam will show how the MRT’s mass resolution of 200,000 and sub ppm mass accuracy for MS and MS/MS data can be maintained at the fast acquisition rates needed for integration with UPLC and how this aids metabolite identification. In addition, you will discover new acquisition modes which further enhance performance.
The session will conclude with a live Q&amp;A where Adam and other members of the team will be on hand to answer all of your questions. 
Why Should You Attend?
<ul>
<li>Discover how the characteristics of the MRT combine with UPLC to aid metabolic profiling workflows.</li>
<li>Learn how the different acquisition modes work to enhance performance.</li>
<li>Understand how MRT data is processed for various small molecule workflows.</li>
</ul>
<blockquote>
Presenter: Adam King (Senior Scientist, MS Discovery Program, Waters Corporation)
</blockquote>
<blockquote>
Adam joined Waters in 2015 working for the phenotyping group based at Imperial College London, supporting the National Phenome centre with technical support and training. In 2018, Adam relocated to Wilmslow as part of the biomedical research team within SciOps focusing on metabolomic analysis using Waters high resolution MS solutions and Ion mobility.
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Prior to joining Waters, Adam obtained his BSc in Biochemistry from Kingston University, London, and worked in the pharmaceutical industry leading a team of scientist analyzing NCEs by LC-MS in the company&#39;s bioanalytical team.
</blockquote>
<blockquote>
Currently Adam is a Senior Scientist in the MS Discovery program group continuing to focus on high resolution MS and IM for metabolomics. Additionally, Adam is in the final stages of completing a part-time PhD in Metabolomics at Murdoch University in Perth, Australia.
</blockquote>

Unquestioned Confidence in Metabolic Profiling

How the MRT’s mass resolution of 200,000 and sub ppm mass accuracy for MS and MS/MS data can be maintained at the fast acquisition rates.

Have you fully exploited the potential of your analytical techniques in edible oil analysis? Our experts will reveal what you can achieve with CNSX-analysis, ICP-OES, AAS and UV/Vis in regulated standard analysis and beyond.
Price fluctuations, supply bottlenecks and export stops have highlighted in recent years how volatile and complex the supply chains of edible oils are. Exporters, importers and processors of edible oils face the challenges of rapid supplier qualification while achieving regulatory compliant, seamless, and efficient quality monitoring of their crude oil, intermediates and final products.
As agricultural products, edible oils are subject to natural quality fluctuations, while cultivation methods and long transport routes pose risks of contamination and oxidation. In addition, they go through a temperature- and additive-intensive process with the refinery, during which undesirable by-products can arise under certain circumstances.
Our webinar is aimed at industry, regulatory and contract laboratories involved in the analysis of edible oils. With combustion elemental analysis, ICP-OES, AAS and UV/Vis molecular spectroscopy, our experts will introduce four techniques which enable precise, efficient, and standard-compliant quality and process analysis of edible oils. They will also show you tips and tricks on how to exploit the additional potential for optimising your analytical workflows regarding the targeted and economic use of elaborate specific techniques.
Learn how to use these techniques for a variety of oils at different steps in the value and processing chain, and how to achieve optimal results and increase sample throughput.
Key learning points:
<ul>
<li>Explore how to carry out the comprehensive analysis of toxic elements, process inhibitors, catalyst poisons as well as the macro-mineral content with ICP-OES.
</li>
<li>Learn what combustion analysis can achieve in quality control and process monitoring, especially regarding the formation of unwanted compounds during refining.
</li>
<li>Discover how to streamline analytical workflows with quick screens for organic and inorganic Sulfur and Nitrogen as sum parameters with combustion analysis.
</li>
<li>Find out how to assess oxidation in oils via DOBI index, and how to monitor the efficiency of bleaching in refinery using UV/Vis spectrometry.
</li>
<li>Discover what AAS can do as an alternative spectrometric element technique in the analysis of edible oils.
</li>
<li>Meet our experts and discuss with us in the Q&amp;A.
</li>
</ul>
<blockquote>
Presenter: Dr. Angela Gröbel (Senior Product Manager / Expert Supervisor Chemical Analysis)
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Angela is a Senior Product Manager and Expert Supervisor for the combustion elemental analysis and related sample preparation portfolio. She holds a PhD in analytical chemistry. Angela developed Analytik Jena’s first trace elemental analysis product line for organic matter, later she became an expert in determination of Sulfur, Nitrogen, and Chlorine across a broad range of industry segments, including oil and gas, food and agriculture and environmental protection. Since 2013 Angela has been Product Manager, responsible for the entire combustion elemental analysis and related sample preparation portfolio.
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Presenter: Dr. Holger Sievers (Application Specialist Chemical Analysis)
</blockquote>
<blockquote>
Holger Sievers is an Application Specialist at Analytik Jena. He holds a PhD from the Technical University of Munich in the field of ultra-trace analysis of noble metals which he obtained after his Master’s focusing on inorganic and analytical chemistry. Holger joined Analytik Jena in 2018 after seven years of teaching at the University and is currently engaged in chemical analysis. His primary focus lies in atomic absorption spectrometry and element analysis in general.
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<blockquote>
Presenter: Sandra Wunsch (Application Specialist Chemical Analysis)
</blockquote>
<blockquote>
Sandra Wunsch has been an Application Specialist for molecular spectrometry at Analytik Jena since 2016. She has intense in-depth knowledge in scientific and industrial application of molecular spectrometry, and extensive experience in the market and application fields, especially in the areas of environment and food &amp; agriculture. As a graduated Nutritionist, she is an expert in the use of chemical analysis and especially the determination of molecular compounds in the food industry and related fields.
</blockquote>

New Food: Edible oil processing: How to monitor elements and compounds

Edible oil processing: How to monitor elements and compounds

How to use these techniques for a variety of oils at different steps in the value and processing chain, and how to achieve optimal results.

Immunopeptidomics is an emerging field that combines proteomics and immunology to study the complex repertoire of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface.
These MHC-bound peptides, known as immunopeptidomes, play crucial roles in immune recognition and activation, influencing various physiological and pathological processes such as immune surveillance, infectious diseases, autoimmunity, and cancer.
Join our webinar to explore recent advancements, challenges, and applications in immunopeptidomics. Discover how Evosep One accelerates discoveries, and support the understanding of immune responses and diseases.
<blockquote>
Presenter: Anthony Purcell (Professor, Purcell Lab, Monsah University)
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Presenter: Nicolai Bache (Head of Applications at Evosep)
</blockquote>

Advancing Immunopeptidomics

Recent advancements, challenges, and applications in immunopeptidomics.

<h5>Solving Problems that Matter: Risk Mitigation in the Pharma QC Laboratory</h5>
Expert Insights 3-Part Webinar Series: Risk Assessment, Control Strategies, and Intuitive Innovation to Improve Data Quality, Data Integrity and Lab Productivity. 
Pharma QC labs are facing increasing pressure on the cost of quality while maintaining compliance and assuring patient safety. From the harmonization of USP &lt;621&gt; to Empower™ workflows supporting data integrity to improving method transfer outcomes, you will learn from subject matter experts how to reduce errors and mitigate risk for reproducible data and enhanced productivity. 
Who should attend
<ul>
<li>Pharma QC Lab directors, managers and senior scientists with a drive to reduce errors, improve lab productivity and enhance data quality &amp; integrity.</li>
</ul>
<h3>PART 3 l Creating Efficiency in Your Routine Workflow with Simple Automation Steps in Empower</h3>
<ul>
<li>Wednesday, August 30th, 11:30-12:30 ET</li>
</ul>
According to the PIC/S guidance, complex or open-ended processes that lead to subjective interpretation can result in an increase in data failures. One way to reduce this risk is with a simplified, well-defined process. Empower software enables you with tools to create structure in your chromatographic processes and workflow.
In this presentation we will define a chromatographic workflow with Empower software to support data integrity goals - starting with method development, method validation, and routine usage to data acquisition, data processing, reporting results, and using control charts to track and trend data. This presentation will also introduce new features coming to Empower 3.8.0 such as safeguards to prevent common errors, enhanced column tracking &amp; history and more detailed audit trails.
<blockquote>
Presenter: Neil Lander (Principal Product Manager - Informatics Group, Waters Corporation)
</blockquote>
<blockquote>
Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager in Waters in the Informatics group. Neil provides internal support for Empower CDS software and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters Corporation, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.
</blockquote>

Waters Corporation: Creating Efficiency in Your Routine Workflow with Simple Automation Steps in Empower

Creating Efficiency in Your Routine Workflow with Simple Automation Steps in Empower

Chromatographic workflow with Empower software to support data integrity goals.

Creating Efficiency in Your Routine Workflow

Immunopeptidomics is a field that combines proteomics and immunology to study the complex repertoire of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface.
These MHC-bound peptides, known as immunopeptidomes, play crucial roles in immune recognition and activation, influencing various physiological and pathological processes such as immune surveillance, infectious diseases, autoimmunity, and cancer.
Join our webinar to explore recent advancements, challenges, and applications in immunopeptidomics. Discover how EvosepOne accelerates discoveries, and support the understanding of immune responses and diseases.
<h4>IMMUNOPEPTIDOMICS ON THE EVOSEP ONE – NEW LEVELS OF SAMPLE THROUGHPUT AND PRODUCTIVITY</h4>
Immunopeptidomics is the study of peptide antigens that are bound to and presented on the cell surface by molecules encoded by the Major Histocompatibility, a highly polymorphic region of the genome that encode molecules involved in immune responses. These peptides are derived from both intracellular and extracellular degradation of the parental proteins, generating a highly complex repertoire of peptide ligands, including peptides derived from pathogens, tissue specific and cancer specific antigens when relevant. In humans, human leukocyte antigen (HLA) class I and class II molecules are of particular interest for immunopeptidomic analysis. These molecules are encoded by several loci and constitute thousands different alleles that vary between individuals. Thus, immunopeptidomes are highly individualized and almost impossible to accurately predict. This predicates the empirical measurement of the complexity and diversity of immunopeptidomes using mass spectrometry. Due to the relatively small amounts of material available for analysis the use of nanoflow LC-MS for immunopeptidome analysis is critical. Here I explore the implementation of the high throughput EvoSEP one platform couples to a Bruker timsTOF Pro 2 for robust analysis of immunopeptidomes across a variety of tissues and cell lines. Using the Whisper 20SPD method data quality and depth is maintained whilst sample carryover is negligible allowing more productive use of instrument time; I highlight significant improvements in throughput with over 1500 immunopeptidomes characterised in just 3 months.
<blockquote>
Presenter: Anthony Purcell (Professor, Purcel Lab, Monsah University)
</blockquote>
<blockquote>
Presenter: Nicolai Bache (Head of Applications at Evosep)
</blockquote>
<h4>MAPPS: High throughput immunopeptidomics for the assessment of the immunogenic potential of protein biotherapeutics</h4>
Biologics, mostly monoclonal antibodies and recombinant proteins, are a class of drugs used to treat some particularly difficult conditions. These proteins, when recognized as non-self by the immune system, can elicit unwanted immunogenicity. One of the first steps in this cascade is the presentation of fragments of this protein by MHC complexes on antigen presenting cells, which might ultimately lead to generation of anti-drug antibodies (ADAs). These ADAs can lower the therapeutic efficiency and can lead to severe immunogenic effects. To bring safe biotherapeutics to the market it is critical to thoroughly assess the immunogenic profile of a biotherapeutic. MAPPS (MHC associated peptides proteomics) assays are the method of choice to define all potential immunogenic regions of a protein. ImmuneSpec, an advanced immunopeptidomics platform, offers MAPPS as a service. Here we show how the combination of high-throughput MHC peptide purification, fast LC using EvoSep, and high sensitive MS addresses these needs.
<blockquote>
Presenter: Kurt Boonen (Assistant Professor, Deparment of biomedical sciences, University of Antwerp)
</blockquote>
<blockquote>
Presenter: Nicolai Bache (Head of Applications at Evosep)
</blockquote>

Evosep: ADVANCING IMMUNOPEPTIDOMICS: LEVERAGING EVOSEP ONE FOR HIGH-THROUGHPUT ANALYSIS AND DISCOVERY

ADVANCING IMMUNOPEPTIDOMICS: LEVERAGING EVOSEP ONE FOR HIGH-THROUGHPUT ANALYSIS AND DISCOVERY

Immunopeptidomics: HIGH-THROUGHPUT ANALYSIS AND DISCOVERY

<h3>A New Era of Intuitive Simplicity</h3>
In March 2023 at Pittcon, Waters launched the Alliance iS HPLC System, designed specifically to help QC labs address their biggest challenges around error reduction, workflow efficiency, and compliance.
In this webinar, Debbie Francis, Principal Consulting Product Marketing Manager, QA/QC at Waters, will present some highlights from the product launch at this year’s Pittcon, and demonstrate a new, free tool that will help you to calculate approximately how much time and money the Alliance iS HPLC System could save your lab.
Agenda:
<ul>
<li>Overview of the new product from Fraser McLeod, Vice President of QA/QC at Waters, recorded live at Pittcon 2023
</li>
<li>Fireside chat with Fraser and Dr. Tina S. Morris, Executive Director of the American Association of Pharmaceutical Scientists (AAPS), recorded live at Pittcon 2023
</li>
<li>Demo of the ROI Calculator, a new tool that helps you see just how much time and money the Alliance iS HPLC System can save your lab.
</li>
</ul>
<blockquote>
Presenter: Debbie Francis (Principal Consulting Product Marketing Manager, Waters Corporation)
</blockquote>
<blockquote>
Debbie has worked for Waters since 2018 and has held multiple product marketing positions for Mass Spectrometry systems and is currently Principal Consulting Product Marketing Manager in QA/QC, focusing on next generation systems, where she has been leading the commercialization of the new era of simplicity in HPLC. Debbie began her career as a scientist in clinical laboratories, before moving into marketing, and prior to joining Waters held various regional and global marketing roles within the life science industry.
</blockquote>

Waters Corporation: Introducing the Alliance iS HPLC System

Introducing the Alliance iS HPLC System

How much time and money the Alliance iS HPLC System could save your lab.

Key Learning Points:
<ul>
<li>Learn different sample preparation techniques, including solid support liquid extraction, Quechers and SPE
</li>
<li>How to develop a SPE method based on sample matrix and compound properties
</li>
<li>The challenge and workflow in the food Industry
</li>
</ul>
Who Should Attend:
<ul>
<li>Any beginner or intermediate scientists looking to learn more about sample preparation</li>
</ul>
<blockquote>
Presenter: Grace Guo (Senior Technical Specialist, Phenomenex)
</blockquote>
<blockquote>
Grace graduated from the Johns Hopkins University with a Master’s degree in Material Science and Engineering in 2014. In her graduate study, she developed a low-voltage organic phototransistor with an organic small molecule. After her graduation she moved from the east coast to west coast because she loves the all year long sunshine in South California.
</blockquote>
<blockquote>
She spent 3 years in a start-up company as Device Scientist doing single walled carbon nanotube separation and making thin film transistor with them. Most of her experience with Flash system are gained from there. In 2017, she joined Phenomenex as a Technical Specialist supporting globally, especially the Asia-Pacific area. Bilingual in Chinese and English makes it easy for her to communicate with customers in both US and China.
</blockquote>
<blockquote>
At Phenomenex she has more opportunity to have hands-on experience in HPLC, GC and SPE. Discussing the crazy troubleshooting cases with other technical members improves her chromatographic skills every day!
</blockquote>

Phenomenex: Sample Prep for Crude Extraction Removal & SPE Method and Development

Sample Prep for Crude Extraction Removal & SPE Method and Development

Learn different sample preparation techniques, including solid support liquid extraction, Quechers and SPE.

Sample Prep for Crude Extraction Removal & SPE Method

Were you unable to attend your local pharma day? If so not to worry!
We are delighted to host our popular pharma seminar day online. Following a series of events across Europe we are now bringing the talks to you virtually this September.
<h3>Overview</h3>
The analytical challenges within pharma are constantly changing and evolving. In many laboratories the requirements to deliver fast, accurate and robust results is always present and often the workload is growing too. The webinar will focus on analytical challenges and workflows in pharma analysis to help pharma labs succeed in these challenges.
On the day, you will be able to:
<ul>
<li>Hear about Waters’ latest innovation bringing ultimate simplicity to routine HPLC separations
</li>
<li>Learn about the benefits and tools for risk assessment and mitigation in your QC lab
</li>
<li>Understand the latest in AQbD requirements and how to apply them in your lab
</li>
<li>See the latest trace impurity quantification workflows, including nitrosamines analysis
</li>
</ul>
<h3>Agenda</h3>
<h5>Risk Assessment and Mitigation for Analytical Procedures</h5>
<ul>
<li>Andrea Gheduzzi (Principal Pharma Market Development Manager-EMEA, Waters)</li>
</ul>
<h5>Introducing a New Era on Intuitive Simplicity for Routine HPLC Alliance iS and System monitoring</h5>
<ul>
<li>Arjan Timmerman (Principal Pharma Market Development Manager – EMEA, Waters)</li>
</ul>
<h5>Nitrosamines and Beyond. Technologies for Optimizing Performance and Minimizing Risk in Trace Impurity Quantification</h5>
<ul>
<li>Antonia Wierzbicki (Principal Pharma Market Development Manager- EMEA, Waters)</li>
</ul>
<h5>Live Q&amp;A session</h5>
<blockquote>
Presenter: Andrea Gheduzzi (Southern Europe Pharma Market Dev. Manager, Waters Corporation
</blockquote>
<blockquote>
Andrea has spent more than 30 years in the chromatography field. Across his career he had various roles, service engineer, chromatography lab position, and technical application support manager. He has mainly been dealing with pharma accounts, also supporting LC method development activities using DoE/QbD approaches. In his role as Pharma Business Development Manager at Waters he has further expanded his expertise in AQbD and related applications.
</blockquote>
<blockquote>
Presenter: Arjan Timmerman (Pharma Market Development Manager EMEA, Waters Corporation)
</blockquote>
<blockquote>
Arjan is an experienced business development manager with a demonstrated history of working in regulated pharmaceutical industry. He holds a BSc in analytical chemistry and is skilled in life sciences, method development &amp; validation, laboratory informatics, compliance and data integrity.
</blockquote>
Within Waters Europe, he is a business development manager in core markets focusing on compliance and regulatory challenges (e.g. data integrity for laboratories), impurity analyses and recently on extractables &amp; leachables.
<blockquote>
Presenter: Antonia Wierzbicki (Pharma Market Devlopment Manager EMEA, Waters Corporation)
</blockquote>
<blockquote>
Antonia Wierzbicki is a marketing manager at Waters working in EMEA. Antonia has BSc in Pharmaceutical Science and a MSc in Cancer Pharmacology. Following several years working as an analytical chemist in drug development roles within both academic labs and contract research organizations, Antonia has more recently spent time working with analytical chemists to provide solutions using cutting edge technologies to meet their needs and requirements, with a specific interest in ultra-sensitive quantitation of small molecules. Antonia is based in Cambridge UK and keen to connect with like-minded scientists in the field.
</blockquote>

Waters Corporation: Waters Virtual Pharma Day - Analytical Challenges and Workflows in Pharma Analysis

Waters Virtual Pharma Day - Analytical Challenges and Workflows in Pharma Analysis

We are delighted to host our popular pharma seminar day online. Following a series of events across Europe we are now bringing the talks to you virtually.

Analytical Challenges and Workflows in Pharma Analysis

Recent changes to EU recommendations and regulation of per- and polyfluoroalkyl substances (PFAS) compounds in food have resulted in a renewed focus on this area within food manufacturers and testing agencies.
A reliable and sensitive analytical method, appropriate and validated for routine use, is imperative for ensuring consumer safety, not only by meeting current enforced legislation, but also by addressing recommendations for very low limits of quantitation (LOQs) in different foodstuffs.
Nestlé recently developed and validated an LC-MS/MS method for analyzing 57 PFAS compounds at the ng/kg level using the SCIEX 7500 system in various matrices. In this extraordinary webinar, Nestlé scientists will present the findings and results of their analysis.
Please register to learn about:
<ul>
<li>The analytical challenges of achieving LOQs at the ng/kg level in food matrices</li>
<li>The development of a robust LC-MS/MS method</li>
<li>The challenges of the method for routine use</li>
</ul>
Speaker:
<blockquote>
Presenter: Xanthippe Theurillat (Nestlé Research Center, Switzerland)
</blockquote>
<blockquote>
Xanthippe Theurillat is an Analytical Chemist. In 2012, she joined the Official Food Control Laboratory in Lausanne, Switzerland, as a Scientific Expert in the contaminants section. In 2015, she joined Nestlé Research in Lausanne, Switzerland, as an Analytical Scientist in the Analytical Science Department. Here, she specializes in the field of food contaminants, with a specific focus on pesticides, polyphenols, process contaminants (including understanding them at the mechanistic level) and PFAS.
</blockquote>

SCIEX: Development and validation of a sensitive, routine LC-MS/MS method for PFAS in food samples using the SCIEX 7500 system

Development and validation of a sensitive, routine LC-MS/MS method for PFAS in food samples using the SCIEX 7500 system

Nestlé recently developed and validated an LC-MS/MS method for analyzing 57 PFAS compounds at the ng/kg level using the SCIEX 7500 system in various matrices.