News from LabRulezLCMS Library - Week 14, 2026

<h3>We're excited to announce that <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity Chromatography Software</a> version 10.1.2 is now available!</h3>This minor update expands Clarity’s portfolio with new control modules.<h4>Newly added Instrument control modules</h4><ul><li>Ecom auxiliary modules</li><li>HTA ICF control modules</li><li>Spark pump</li></ul><h4>Updated Instrument control modules</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/168">Ecom</a> HPLC</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/328">Knauer</a> HPLC</li><li>Spark ICF control modules</li><li>YoungIn Chromass HPLC</li></ul><blockquote>For a complete list of module changes, see the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">Changelog</a>. For more info about exciting new features directly in Clarity, explore what was introduced in the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5622">Clarity 10.1 release highlights</a>.Clarity can control 1000+ instruments; the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/controls">list can be previewed here</a>.</blockquote><h4>Supported Instruments in Clarity (DataApex) — Quick Guide</h4>Clarity Chromatography Software supports a wide range of chromatographs and peripherals via digital control (DD) and analog acquisition (A/D) using the Colibrick module.<h5>Gas Chromatographs (GC)</h5>Digital integration over LAN/RS232 (many via ICF):<ul><li>Agilent: 5890, 6890, 7890, 8860, 8890, Intuvo 9000</li><li>Shimadzu: GC-2010/2014, Nexis GC-2030</li><li>Thermo Fisher: TRACE 1300/1310</li><li>PerkinElmer: Clarus 400–690</li><li>Also supported: Dani, Ellutia, Young In Chromass, Apix, Fuli, GOW-MAC (selected models)</li></ul><blockquote>Note: Most Agilent 6890–8890 and Intuvo use LAN – ICF.</blockquote><h5>HPLC Systems</h5>Full system/module control:<ul><li>Agilent 1100–1290 Infinity II (ICF)</li><li>Shimadzu LC-10/20 and Nexera LC-40</li><li>PerkinElmer Flexar / NexSAR</li><li>Knauer Azura / BlueShadow / Smartline</li><li>Hitachi Chromaster / Primaide</li><li>Young In Chromass ChroZen series</li><li>Sykam S500–S600, Watrex Streamline, Hanon LC7000–7300</li></ul><h5>HPLC Modules (Pumps, Detectors, Ovens, Fraction Collectors)</h5><ul><li>Pumps: Agilent 1100–1290 families, Knauer, Shimadzu, PerkinElmer, Sykam, SSI, Ecom</li><li>Detectors: VWD/DAD(PDA)/RID/FLD/ELSD across Agilent, Shimadzu, Knauer, PerkinElmer, Young In Chromass, Ecom, etc.</li><li>Column Ovens: Agilent G1316x / G7116x, Shimadzu CTO-20/30/40, Knauer CT2.1, PerkinElmer Flexar</li><li>Fraction Collectors: Knauer FC 6.1, Teledyne FOXY series, Ecom ECF 2096, Waters Fraction Collector II</li></ul><h5>Autosamplers</h5><ul><li>Agilent GC ALS (7673/7683/7693/8697), HPLC ALS modules (G1313A–G7167C)</li><li>Shimadzu AOC-20 / AOC-5000+, SIL-10 / SIL-20 / SIL-40 series</li><li>CTC Analytics PAL, HTA autosamplers, Spark Alias/UHPLC, Knauer AS 6.1L</li><li>PerkinElmer Flexar / NexSAR AS</li></ul><h5>Other Devices</h5><ul><li>GC×GC modulators (e.g., Charles University GC×GC Modulator)</li><li>Valves &amp; switch modules (Agilent, Knauer, Shimadzu, VICI-Valco)</li><li>Degassers, flow monitors, managers, interfaces</li><li>LC-MS / GC-MS: Advion Expression CMS, Microsaic 4500 MiD, Markes BenchTOF (and others)</li><li>Balances (EA extension): Mettler Toledo, Sartorius</li></ul><h5>Analog Acquisition (Colibrick)</h5>A/D support for legacy or analog-output devices:<ul><li>GC: Agilent 5880/4890A, Varian 3xxx/3800/3900, PerkinElmer Clarus series, Thermo TRACE, Shimadzu GC-14/9A, Scion 43x/45x/83xx/85xx, etc.</li><li>HPLC Detectors: Waters 2487/2489, ESA Corona, Hitachi L-series, JASCO FP/UV, Ecom LCD series, many others</li><li>Elemental &amp; Amino Acid Analyzers: Carlo Erba/Costech ECS, Biochrom 20/30+</li></ul>If you are interested in a DEMO VERSION, contact us!

DataApex Clarity Chromatography software 10.1.2 just released!

🎤Dan Reddy (PhD candidate in the Department of Chemistry at Queen's University and a recipient of the NSERC Vanier Canada Graduate Scholarship. He was recently named one of the top 35 early-career scientists globally in the 2025 CAS Future Leaders program.)In this episode, we interview Daniel Reddy, 2025 CAS Future Leader and PhD candidate at Queen's University, about his groundbreaking research on automated mass spectrometry and dried matrix spots (DMS).Dan's work combines computer vision, 3D printer automation, and laser micromachining to revolutionize sample preparation—reducing CO₂ emissions by 28-fold and organic solvent use by 21-fold compared to traditional methods.<h4>What You'll Learn:</h4><ul><li>How to give a mass spectrometer "sight" and "taste" using computer vision and the LMJ-SSP (Liquid Microjunction Surface Sampling Probe)</li><li>The breakthrough technology behind Surface Energy Traps (SETs) for confining liquid droplets on paper substrates</li><li>Why dried matrix spots eliminate the need for cold-chain shipping and enable analysis of blood, urine, and saliva samples via standard mail</li><li>How DIY chemists are hacking 3D printers to build cost-effective autosamplers (replacing $10K+ systems)</li><li>The role of green chemistry and systems thinking in modernizing analytical methods</li><li>Why interdisciplinary collaboration (chemistry + computer science) is critical to innovation</li></ul><h4>Key Topics:</h4><ul><li>Dried Matrix Spots (DMS) for automated sample prep</li><li>Laser-micromachined Surface Energy Traps</li><li>Direct surface sampling mass spectrometry</li><li>Sustainability in analytical chemistry</li><li>3D printer customization for laboratory automation</li><li>The importance of science communication and community outreach</li></ul><h3>Video Transcription</h3><h4>Introduction</h4>Recent advances in analytical chemistry increasingly focus on simplifying workflows, improving sustainability, and enabling automation. In this context, the work of Dan Reddy centers on the concept of “bringing mass spectrometry to life” through the integration of automated sampling, computer vision, and dried matrix spot (DMS) methodologies.The primary objective is to enable efficient and reproducible analysis of biological and liquid samples—such as blood, urine, saliva, or other solutions—by depositing them onto substrates, drying them, and extracting meaningful analytical information directly via mass spectrometry.<h4>Conceptual Framework: Enabling “Sight” and “Taste” in Mass Spectrometry</h4>A central innovation in this work is the conceptual transformation of mass spectrometry from a passive analytical tool into an active, semi-autonomous system.<ul><li>“Sight” is introduced through camera-based computer vision, allowing the system to identify predefined patterns on a substrate.</li><li>“Taste” is implemented via a liquid microjunction surface sampling probe (LMJSSP), which enables direct extraction of analytes from surfaces.</li></ul>The LMJSSP consists of two concentric capillaries forming a continuously flowing microdroplet. When brought into contact with the sample surface, this droplet facilitates localized extraction, effectively enabling direct surface analysis without traditional chromatographic separation.Combined with an automated positioning system (adapted from 3D printer mechanics), the platform can autonomously locate sampling sites and perform reproducible measurements.<h4>Dried Matrix Spots as an Analytical Platform</h4><h5>Principle and Advantages</h5>Dried matrix spots involve depositing a small volume of liquid sample onto a substrate (commonly paper), followed by drying. This approach offers several advantages:<ul><li>Reduced need for cold-chain transport</li><li>Simplified sample handling and storage</li><li>Compatibility with remote or decentralized sampling</li><li>Lower solvent consumption</li></ul>These features contribute significantly to greener analytical workflows and improved logistical efficiency.<h5>Sustainability Impact</h5>The implementation of DMS-based workflows has demonstrated:<ul><li>Up to 28-fold reduction in CO₂ emissions</li><li>Up to 21-fold reduction in organic solvent use</li></ul>These improvements arise from eliminating cold-chain logistics and minimizing solvent-intensive preparation steps.<h4>Surface Energy Traps (SCTs): Controlled Micro-Sampling Environments</h4><h5>Definition and Fabrication</h5>Surface Energy Traps (SCTs) are microstructured regions on a substrate designed to confine liquid droplets within defined boundaries.The fabrication process involves:<ol><li>Coating paper with a hydrophobic layer</li><li>Using laser ablation to selectively remove the coating in defined patterns</li><li>Creating hydrophilic circular regions (typically ~0.5 mm diameter)</li></ol>These patterned regions act as micro-wells that confine droplets spatially and prevent lateral diffusion.<h5>Analytical Benefits</h5>SCTs address key limitations of traditional dried matrix spots:<ul><li>Improved spatial confinement of analytes</li><li>Reduced diffusion variability</li><li>Enhanced reproducibility</li><li>Preconcentration effects due to controlled drying</li></ul>Additionally, the SCT diameter is smaller than the sampling probe, enabling near-complete analyte collection during surface extraction.<h4>Drying Dynamics and Analyte Distribution</h4>Traditional dried matrix spots often suffer from the “coffee-ring effect”, where analytes redistribute unevenly during drying. This leads to variability depending on sampling location.The SCT approach mitigates these effects by:<ul><li>Limiting diffusion area</li><li>Maintaining analytes near the surface</li><li>Producing more uniform analyte distribution</li></ul>Preliminary investigations (e.g., via SEM imaging) indicate improved homogeneity, although further studies are needed to fully characterize drying kinetics and their influence on signal intensity.<h4>Integration with Automated Sampling Systems</h4><h5>3D Printer-Based Positioning</h5>A key engineering innovation is the repurposing of 3D printer hardware for automated sample positioning:<ul><li>Provides cost-effective XYZ motion control</li><li>Enables programmable sampling routines</li><li>Supports integration with analytical instrumentation</li></ul>Custom software—developed in collaboration with computer engineers—allows users to define coordinates, dwell times, and sampling parameters.<h5>Computer Vision Integration</h5>The addition of computer vision enables:<ul><li>Pattern recognition (e.g., alignment markers near SCTs)</li><li>Autonomous targeting of sampling locations</li><li>Reduced operator intervention</li></ul>This transforms the system into a semi-autonomous analytical platform.<h4>Comparison with Conventional Workflows</h4>Compared to traditional LC-MS or GC-MS workflows, the presented approach offers:<div><div><figure class="table"><table><thead><tr><th>Aspect</th><th>Conventional Methods</th><th>SCT + LMJSSP Approach</th></tr></thead><tbody><tr><td>Sample prep</td><td>Multi-step, solvent-intensive</td><td>Minimal, direct surface sampling</td></tr><tr><td>Chromatography</td><td>Required</td><td>Potentially bypassed</td></tr><tr><td>Throughput</td><td>Moderate</td><td>High (automated)</td></tr><tr><td>Sustainability</td><td>Limited</td><td>Significantly improved</td></tr></tbody></table></figure></div></div>While chromatographic methods remain essential for many applications, this approach provides a complementary pathway for rapid screening and targeted analyses.<h4>Green Chemistry and Systems Thinking</h4>A notable aspect of this work is the integration of systems thinking into analytical chemistry. Inspired by engagement with organizations such as the American Chemical Society and green chemistry initiatives, the research emphasizes:<ul><li>Environmental impact reduction</li><li>Resource efficiency</li><li>Lifecycle considerations</li></ul>This perspective expands the role of analytical chemists beyond method performance to broader societal and environmental implications.<h4>Future Outlook and Applications</h4>The research is currently at an early stage but shows strong potential for:<ul><li>Decentralized diagnostics (e.g., remote blood sampling)</li><li>Environmental monitoring</li><li>High-throughput screening workflows</li><li>Field-deployable analytical systems</li></ul>Further advancements are expected in:<ul><li>Substrate engineering</li><li>Automation robustness</li><li>Integration with advanced MS platforms (e.g., triple quadrupole systems)</li></ul><h4>Conclusion</h4>The integration of dried matrix spots, surface energy traps, and automated surface sampling represents a significant step toward more sustainable, efficient, and accessible analytical workflows.By combining innovations in microfabrication, computer vision, and mass spectrometry, the work of Dan Reddy demonstrates how analytical chemistry can evolve toward smarter, greener, and more autonomous systems.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Mass Spectrometry, Surface Sampling and Dried Matrix Spots - Greener Chemistry and 3D Printing

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Interview

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

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LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Metrohm

Agilent Technologies

Bruker

GERSTEL

Thermo Fisher Scientific

SelectScience

C&EN

In recent years, there has been a growing movement to promote alternative methods to animal testing and the EU and a few other countries have even moved to ban the import and sale of cosmetics that have been tested on animals. The Amino acid Derivative Reactivity Assay (ADRA) Method developed by Fujifilm, is an innovative alternative test method for skin sensitization without the use of animals and it was adopted by the OECD in 2022 as a reliable test method.
In this webinar, we will present the technical background of the ADRA method, the use of reagent kits to perform ADRA testing, and our solutions for ADRA analysis that deliver both enhanced selectivity and high-speed testing. Register for this webinar and learn more about how the ADRA method will help you better test the safety of cosmetics and pharmaceuticals. 
<h5>Key Learning Objectives:</h5>
<ul>
<li>Outline of the OECD TG442C (ADRA: Amino acid Derivative Reactivity Assay) </li>
<li>Overview of ADRA kits and related products </li>
<li>How to conduct ADRA testing using HPLC</li>
</ul>
<h5>Who Should Attend:</h5>
<ul>
<li>R&amp;D and Manufacturer of Cosmetics </li>
<li>Companies considering Alternative Methods to Animal Testing </li>
<li>Industries interested in Alternative Methods to Animal Testing</li>
</ul>
<blockquote>
Presenter: Toshihiko Kasahara, Ph.D. (Safety Eval. Center, ESG Div., Senior Expert, Fujifilm Corporation)
</blockquote>
<blockquote>
Presenter: Suguru Kitagawa (International Sales, EU Region, Fujifilm Wako Pure Chemical Corporation)
</blockquote>
<blockquote>
Presenter: Ayako Nomura (Analytical Instr. Div., Application Specialist, Shimadzu Corporation)
</blockquote>
<blockquote>
Presenter: Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)
</blockquote>

Shimadzu: The Newest Alternative to Animal Testing for Skin Sensitization

The Newest Alternative to Animal Testing for Skin Sensitization

In this webinar, we will present the technical background of the ADRA method and how to conduct ADRA testing using HPLC.

The Alternative to Animal Testing for Skin Sensitization

Join us in this webinar to discuss on basics of GPC technology and respective details of instruments, separations, and parameters in GPC analysis. Along with respective principles and uses for various types of large/polymer samples.
In this webinar, we will discuss:
<ul>
<li>Introduction to GPC</li>
<li>Need of fast GPC and its advantages</li>
<li>Considerations for fast GPC analysis and optimization options</li>
<li>Optimization of various method parameters for good resolution, peak shape and response</li>
<li>Column selection criteria for better results with relevant applications</li>
<li>Agilent columns options for fast GPC analysis</li>
</ul>
By attending this webinar you will learn: How to systematically convert traditional GPC methods to fast GPC, optimize your method parameters for fast GPC analysis and increase lab productivity with proper column selection.
*Attend all 3 sessions and get a digital certificate from Agilent
<blockquote>
Presenter: Dr. Ramaprasad Ganni (Technical Support Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Ramaprasad Ganni has 21 years of experience in the field of Chromatography and Column chemistries. Working with Agilent technologies India, since 2008 in Chemistries and Supplies division. Previously Worked for Elsevier GmbH, and Millipore India Pvt, Ltd. Responsible for Workflow solutions development, providing technical support, and trainings. Experienced in Sample prep, HPLC, GC, Mass spec and GPC Chromatography technologies.
</blockquote>

Agilent Technologies: Pace Up with Fast GPC Analysis

Pace Up with Fast GPC Analysis

How to convert traditional GPC methods to fast GPC, optimize method parameters for fast GPC and increase lab productivity with proper column selection.

Join this webinar to learn how to simplify, speed-up, and standardize your proteomics sample preparation for LC-MS.
The PreOmics team will introduce the PreOmics easy-to-use iST technology. This fast 3-step workflow is designed to be a great support for both those new to proteomics and experts alike. The all-in-one iST kits are compatible with a variety of starting materials, including mammalian and plant samples, different types of tissue and cells, as well as various biological fluids in label-free and chemical labelling applications.The protocols promise an incredibly fast processing time (&lt;2.5 hours) and are easily applicable without compromising sample quality or proteomic depth. Furthermore, iST can be fully automated to further increase standardization, reproducibility, and throughput.
The speakers will also introduce PreON, a fully automated sample preparation platform, as well as different levels of automation for established liquid handling platforms. The varying applications for the iST technology ranging from global proteomics to pre-clinical studies will also be discussed.
<h5>Key learning objectives</h5>
<ul>
<li>Discover best practices for proteomics sample preparation with solutions for new users and proteomics experts alike</li>
<li>Learn more about fast, easy, and reliable sample preparation protocols for LC-MS-based proteomics</li>
<li>Explore automation, standardization, and upscaling of proteomics sample preparation</li>
<li>Learn more about the applications of iST sample preparation kits and solutions in global proteomics as well as pre-clinical research</li>
</ul>
<h5>Who should attend?</h5>
<ul>
<li>Users working with proteomics sample preparation for LC-MS:</li>
<li>Researchers, scientists, principal investigators, group leaders and department heads, lab assistants from biotech/pharma industry, CROs, university hospitals as well as academia</li>
<li>Biomedical and clinical scientists in translational and pre-clinical research</li>
<li>Application scientists and technical support</li>
<li>Distributors of sample preparation systems for LC-MS</li>
<li>Scientists looking for a straightforward approach to start with proteomics</li>
</ul>
<blockquote>
Presenter: Dr. Ingrid Albrecht-Walz (PreOmics GmbH)
</blockquote>
<blockquote>
Dr. Ingrid Albrecht-Walz joined PreOmics in 2022 as Product Manager for Kits &amp; Reagents. She received her Ph.D. in Biology from the University of Munich, Germany, working on the interaction of different viruses. For the past 10 years, Dr. Albrecht-Walz has worked in the field of in vitro diagnostics of infectious diseases. Since proteomics is a highly promising tool for preclinical and diagnostic applications, Dr. Albrecht-Walz decided in 2022 to follow this opportunity at PreOmics.
</blockquote>
<blockquote>
Presenter: Dr. Vincenzo Romaniello (PreOmics GmbH)
</blockquote>
<blockquote>
Dr. Vincenzo Romaniello joined PreOmics in 2021 as Product Manager for Automation Systems. He received his Ph.D. in molecular physiology from the University of Göttingen, Germany. During the past 5 years, Dr. Romaniello has worked in both technical and application support roles for automated sample preparation workflows with major biotech and human diagnostics scientific suppliers. As a result, he has experience in PreOmics automation solutions, and Tecan and Eppendorf systems.
</blockquote>
<blockquote>
Presenter: Dr. Zuzana Demianova (PreOmics GmbH)
</blockquote>
<blockquote>
Dr. Demianova joined PreOmics in 2021 as a Market Development Manager BioPharma and scientific advisor. Assessing proceedings and challenges in the pharma and biopharma field Dr. Demianova introduces PreOmics’ solutions in customer workflows to enable scientific discovery. She thereby partakes also in the development and market introduction of new products as well as optimization and application of established solutions. Prior to PreOmics, Dr. Demianova was application support specialist at Sciex, concentrating on customer support and training. Later on, she was promoted to a global leader in proteomics, which finally led up to her new role as a biopharma application scientist with a focus on “-omics” and biopharma applications using CE and LC-MS technologies.
</blockquote>
<blockquote>
Presenter: Blake Forman (SelectScience)
</blockquote>
<blockquote>
Blake studied chemistry at the University of Surrey, UK, and further went on to study a master’s in chemistry at the University of Southampton, UK. Blake has previously worked in the Medicines and Healthcare Products Regulatory Agency (MHRA) lab at LGC and as a technical sales specialist for Waters. As a member of the Editorial team, he now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Next generation solutions for proteomics sample preparation

Next generation solutions for proteomics sample preparation

Join this webinar to learn how to simplify, speed-up, and standardize your proteomics sample preparation for LC-MS.

Titration, as we know it, is almost 200 years old, but has only gained in importance since. To this day, it is a critical technique used to ensure the quality and safety of many products we consume daily. While not a complicated technique, there are some subtleties that can help ensure your titration results are accurate. Simple electrode care and optimization of basic titration parameters can take the guesswork out of your analysis and help you obtain results you can trust.
During this webinar, Eduardo Simões, Product Specialist for Titration at Metrohm USA, will share best practices for accurate titrations and tips that he’s picked up in his 20 years of performing titrations. Dr. Kerri-Ann Blake, Product Manager for Titration at Metrohm USA, will discuss how updated titration software can improve traceability and alert you to results that do not meet quality standards. The live event will conclude with a Q&amp;A, where you’ll get the chance to ask about your specific titrations. 
<blockquote>
Presenter: Eduardo Simões (Titration Product Specialist, Metrohm USA)
</blockquote>
<blockquote>
Eduardo Simões, MSc is the Titration Product Specialist at Metrohm USA in Riverview, Florida. He received his bachelor and masters in analytical chemistry at the University of Campinas, Brazil. He joined Metrohm Brazil as an application specialist in 2003. Over the last 20 years with Metrohm, he specialized in potentiometry and electroanalysis, gaining extensive field experience in applications and instrument installations, technical support and training. Before moving to the US, Eduardo managed the application lab at Metrohm Brazil where he extended his knowledge to other analytical techniques. In addition, Eduardo has experience developing and implementing ISO methods.
</blockquote>
<blockquote>
Presenter: Kerri-Ann Blake (Titration Product Manager, Metrohm USA)
</blockquote>
<blockquote>
Dr. Kerri-Ann Blake is the Titration Product Manager at Metrohm USA in Riverview, Florida. She earned her PhD in Materials Science and Engineering at the University of Florida where she was a researcher at the Particle Engineering Research Center. In her years with Metrohm USA, she has performed proof of concept studies, internal and external trainings and provided applications support. Kerri-Ann plays a key role in product support and product marketing and also has experience developing and implementing ASTM methods.
</blockquote>

Metrohm: Don’t Miss the Endpoint – Titrate It Right the First Time!

Don’t Miss the Endpoint – Titrate It Right the First Time!

We will share best practices for accurate titrations and tips that he’s picked up in his 20 years of performing titrations.

Dear user and other PaSER interested customers,
You are hereby invited to our 2nd Virtual PaSER Workshop. A lot of new possibilities has been introduced since last time – including, but not limited to PaSER Novor for de novo sequencing of dda-PASEF® data on the PaSER Box as well as TIMS DIA-NN 2.0 -which will be demonstrated during this Workshop. Data virtualization has been a requested feature – and this is now possible with Mass Dynamics for PaSER. Not limited to above – stay tuned for even more approaching features, we will discuss as well.
<h3>The tentative agenda looks like this:</h3>
<h5>1:00 – 1:15 pm: Introduction</h5>
<ul>
<li>Willy Bjørklund</li>
</ul>
<h5>1:15 – 1: 35pm: New Applications on the timsTOF Platform</h5>
<ul>
<li>Lars Kristensen (Field Application Specialist)</li>
</ul>
<h5>1:35 – 1:55 pm: PaSER as a bioinformatic platform - what’s new and what’s coming</h5>
<ul>
<li>Jonathan Krieger (Software R&amp;D Department)</li>
</ul>
<h5>5 minute break</h5>
<h5>2:00 – 2:20 pm: Live Demo/workshop of PaSER</h5>
<ul>
<li>Tharan Srikumar (Software R&amp;D Department)</li>
</ul>
<h5>2:20 – 2:50 pm: Mass Dynamics</h5>
<ul>
<li>Mark Condina and Giuseppe Infusini</li>
</ul>
<h5>2:50 – 3:10 pm: Questions and discussions</h5>
<h5>3:10 – 3:15 pm: Conclusion</h5>
<ul>
<li>Willy Bjørklund</li>
</ul>
We aim for a lively interaction so take the timing as an indication. Please feel free to share with colleagues or others you think could benefit from attending this workshop. Looking forward to “meet”

Bruker Virtual PaSER Workshop

Dear user and other PaSER interested customers, You are hereby invited to our 2nd Virtual PaSER Workshop. 

This year we invite you to ignite your mind to Be Curious about what Ion chromatography (IC) can do with its versatility in many detections across the IC application spectrum to improve your workflows and solve challenges.
During this three day virtual event, learn from a panel of experts how the latest IC applications are helping colleagues achieve breakthroughs, and walk away with valuable information on how advancements in IC can increase laboratory analytical capabilities. 
Although each day is convenient for a specific region, you can attend any session on any day. All sessions and workshops will be available for on-demand viewing after the event concludes.
<h3>Day 3 Agenda | April 20 | Asia Pacific</h3>
Expand the world of electrochemistry applications and IC hyphenation with high-resolution mass spectrometry and understand how Inductively Coupled Plasma Spectrometry can speciate isotopes while simplifying Pharmacopeia QC analysis and keeping your IC in top-notch condition.
<h5>11:00 AM SGT: Opening Plenary: Electrochemical Detection and Its Application in Ion Chromatography</h5>
<ul>
<li>Yan Liu (Thermo Fisher Scientific, IC/SP R&amp;D, Sunnyvale)</li>
</ul>
<h5>12:00 PM SGT: Application of Anion Chromatography Coupled High-Resolution Mass Spectrometry to Increase Cellular Metabolite Coverage</h5>
<ul>
<li>Vinzenz Hofferek (McConville Lab, Department of Biochemistry and Pharmacology)</li>
</ul>
<h5>1:00 PM SGT: Analysis of Anhydrosugars and Xylooligosaccharides by Ion Chromatography with Electrospray Lithium Cationisation-Triple Quadrupole Tandem Mass Spectrometry</h5>
<ul>
<li>Dr. Estrella Sanz Rodriguez (Natural Products Analysis, Australian Centre for Research on Separation Science (ACROSS), University of Tasmania)</li>
</ul>
<h5>2:00 PM SGT: You Gotta Keep ‘Em Separated: Novel IC Applications for Subsequent Isotopic Analyses by Rapid and/or Hyphenated Techniques</h5>
<ul>
<li>Dr. Brandon Mahan (College of Science and Engineering, James Cook University)</li>
<li>Grace Manestar (IsoTropics PhD Candidate)</li>
</ul>
<h5>3:00 PM SGT: Use of Ion Chromatography in Pharmaceutical Quality Control</h5>
<ul>
<li>Catherine Frankis and Stella Planou (Reading Scientific Services Ltd., Reading Science Centre, Whiteknights Campus)</li>
</ul>
<h5>4:00 PM SGT: Tips on Keeping Your Ion Chromatography in Top-Notch Condition</h5>
<ul>
<li>Ryan Ong (Thermo Fisher Scientific, IC/SP Application Sales Support, Singapore)</li>
</ul>

Thermo Fisher Scientific: IC Symposium 2023

IC Symposium 2023 - Day 3

Join us for the 2023 Global IC Symposium! Day 3 | Asia Pacific.

Get ready for Nitrosamines - The LC/MS Edge, a series of virtual connect that explores the latest updates, insights, and technical knowledge on nitrosamines in India.
Join us for the first session, focused on the growing concern of nitrosamines in the Indian pharmaceutical industry. Learn about the perspective of Indian Pharmacopoeia on regulation, evolving market landscape, growth opportunities and the role of LC-MS/MS in nitrosamine assessment studies. Experts will discuss the perspectives of evolving regulations and how companies can adapt these solutions, followed by a Q&amp;A discussion. Nitrosamines pose a significant risk to public health, making it crucial for companies to be aware of the latest regulations and market trends. Stay ahead of the curve and ensure compliance with latest regulatory requirements. Don&#39;t miss out on this valuable opportunity. 
Why should you attend?
<ul>
<li>Gain insights into the perspective of Indian Pharmacopoeia on assessment of nitrosamines.</li>
<li>Understand the current market landscape and growth opportunities.</li>
<li>Learn about compliance requirements and how to navigate them.</li>
<li>Stay up-to-date on the latest trends and updates related to nitrosamines in India.</li>
<li>Improve your professional development &amp; scientific understanding by enhancing your knowledge and skills related to nitrosamines assessment workflows and LC/MS.</li>
</ul>
<blockquote>
Presenter: Mr. Arvind Kumar Sharma (Scientific Assistant, Indian Pharmacopoeia Commission, Ministry of Health &amp; Family Welfare - Government of India)
</blockquote>
<blockquote>
With six years of experience as a Scientific Assistant at Indian Pharmacopoeia Commission, he has played a key role in the current development of Indian Pharmacopoeia Reference Substances (IPRS) and Impurity Reference Substances. He has been engaged in the preparation and updating of draft monographs for publishing in Indian Pharmacopoeia (IP). Additionally, he has played a major role in the development of the latest edition of the National Formulary of India 2021 and has been involved in work related to the Pharmacovigilance Programme of India (PvPI). He holds a a M. Pharmacy in Pharmacology from Sinhgad Institute of Pharmaceutical Sciences, Pune and a B. Pharmacy from the College of Pharmacy, IPS Academy Indore. He has authored several articles published in international journals and organized and represented IPC at various national and international conferences and workshops. He has also participated in joint inspections for registration of manufacturing units and testing laboratories.
</blockquote>
<blockquote>
Presenter: Dr Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies India Pvt Ltd)
</blockquote>
<blockquote>
Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.
</blockquote>

Agilent Technologies: Nitrosamines - The LC/MS Edge 1st Edition: Indian Pharmaceutical Industry Perspective & Evolving Regulatory Landscape

Nitrosamines - The LC/MS Edge 1st Edition: Indian Pharmaceutical Industry Perspective & Evolving Regulatory Landscape

Join us for the first session, focused on the growing concern of nitrosamines in the Indian pharmaceutical industry.

Nitrosamines - The LC/MS Edge 1st Edition

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
An easy to follow guide detailing how to set MS scan parameters for an LCMS experiment will be presented. Scan speeds for reproducible quantitation, chromatographic resolution, retention time definition, proper threshold adjustment for optimum datafile size, and how this can result in faster processing times will all be discussed.
<blockquote>
Presenter: Rebecca Glaskin, Ph.D. (LC/MS Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rebecca Glaskin is an LC/MS Application Scientist at Agilent with a focus on BioPharma applications supporting the LC-Q/TOF and IM-QTOF platforms. Prior to joining Agilent, Rebecca received her Ph.D. in analytical chemistry from Indiana University in the lab of Professor David Clemmer. While there she designed and constructed home-built instruments, pushing the limits of the mobility resolution that can be obtained with a circular drift tube for the separation of biomolecules (peptides, proteins, carbohydrates, and metabolites). While there, she also studied hydrogen/deuterium exchange of proteins in the gas-phase as a function of time and pressure. Rebecca then went to Boston University as a Postdoctoral Associate in the lab of Professor Catherine Costello to develop a database containing collision cross section values for glycans, peptides, and glycopeptides utilizing Agilent Technologies 6560 IM-QTOF. This database can be used to determine how the collision cross section is altered with the addition of individual saccharide units. The trendlines obtained from this database will be used to predict collision cross sections for glycopeptides based on the conformation and structure of the specific glycoform.
</blockquote>
<blockquote>
Presenter: Jim Lau, PhD (HRAMS LC/MS Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Jim Lau received his Ph.D. From the University of Colorado. There he worked in the laboratories of Peter Albersheim and Robert Shapiro. This work involved the structure elucidation of plant natural products and, in particular, elucidating the structures of oligosaccharides derived from plant cell wall polysaccharides. This work was done in the early days of LCMS and made use of DLI-LCMS and (at the time) recently invented Thermospray-LCMS.
</blockquote>
<blockquote>
After the completion of his Ph.D., Jim joined Hewlett-Packard to work on LCMS ionization techniques with Paul Goodley during the early days of Electrospray-LCMS. He then moved to work on field applications and collaborations with Hewlett-Packard’s LCMS customers. More than 30 years later, Jim continues to work with Agilent’s customers in High Resolution Accurate Mass applications of LCMS. While involved in many areas of HRAMS LCMS, his recent work has focused on the area of Screening/Qual&amp;Quant of small molecules and on the high throughput confirmation of oligonucleotide synthesis.
</blockquote>

Agilent Technologies: How to set MS Scan Parameters for your LCMS Experiment

How to set MS Scan Parameters for your LCMS Experiment

An easy to follow guide detailing how to set MS scan parameters for an LCMS experiment will be presented.

Learn how to automate your SPE procedures with the LCTech FREESTYLE™ system for various sample types.
Presenter: Fred Foster (Applications Scientist)

GERSTEL: Automation of Solid Phase Extraction Procedures using a Novel Robotic Automation Platform

Automation of Solid Phase Extraction Procedures using a Novel Robotic Automation Platform

Learn how to automate your SPE procedures with the LCTech FREESTYLE™ system for various sample types.

Automation of Solid Phase Extraction - Automation Platform

The solubility of orally administered drugs is highly influenced by the composition of the intestinal fluids, the presence of fatty acids and cholesterol, and the pH. All these factors can be affected by the individual’s diet (food effect). Typical biorelevant studies, however, fail to capture food effects as the experiments are commonly performed on fixed simulated intestinal fluid (SIF) compositions. Consequently, accurate prediction of the food effect observed in clinical studies is hindered due to lack of reliable data for the model.Here, we propose a high-throughput automated workflow for the study of API solubility in complex, ad hoc biorelevant media, and the implementation of the data obtained in vitro into a Physiologically Based Biopharmaceutic Model (PBBM) used to predict the food effect on a BCS IV zwitterionic drug. The automated workflow led to considerable time and material savings, while the model accurately predicted the results of the food effect.Key Learning Objectives:<ul><li>Determination of food effect, through use of complex biorelevant media, to describe and predict clinical data</li><li>Automated preparation of ad hoc complex biorelevant media</li><li>Automated in vitro biorelevant solubility screen of an API</li><li>Integration of in vitro solubility and permeability into a Physiologically</li><li>Based Biopharmaceutic Model (PBBM)</li></ul>Who Should Attend:<ul><li>Scientist, Sr. Scientist, Development Chemist, Formulation Chemist, Process Chemist, (Directors of preceding), Research Fellow, Professor</li><li>Product Development Scientists, Biochemist</li></ul><blockquote>Presenter:&nbsp;Paola Ferrini (Investigator, High-Throughput Automation Team, GSK)Presenter: Konstantinos Stamatopoulos (Biopharmaceutics Investigator, GSK)Presenter: Catherine Dold (Health &amp; Environment Writer, C&amp;EN Media Group)</blockquote>

C&EN: Automated In Vitro Sample Preparation for PBBM to Predict Food Effect on Oral Drugs

Automated In Vitro Sample Preparation for PBBM to Predict Food Effect on Oral Drugs

We propose a high-throughput automated workflow for the study of API solubility in complex, ad hoc biorelevant media.