News from LabRulezLCMS Library - Week 14, 2026

<h3>We're excited to announce that <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity Chromatography Software</a> version 10.1.2 is now available!</h3>This minor update expands Clarity’s portfolio with new control modules.<h4>Newly added Instrument control modules</h4><ul><li>Ecom auxiliary modules</li><li>HTA ICF control modules</li><li>Spark pump</li></ul><h4>Updated Instrument control modules</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/168">Ecom</a> HPLC</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/328">Knauer</a> HPLC</li><li>Spark ICF control modules</li><li>YoungIn Chromass HPLC</li></ul><blockquote>For a complete list of module changes, see the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">Changelog</a>. For more info about exciting new features directly in Clarity, explore what was introduced in the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5622">Clarity 10.1 release highlights</a>.Clarity can control 1000+ instruments; the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/controls">list can be previewed here</a>.</blockquote><h4>Supported Instruments in Clarity (DataApex) — Quick Guide</h4>Clarity Chromatography Software supports a wide range of chromatographs and peripherals via digital control (DD) and analog acquisition (A/D) using the Colibrick module.<h5>Gas Chromatographs (GC)</h5>Digital integration over LAN/RS232 (many via ICF):<ul><li>Agilent: 5890, 6890, 7890, 8860, 8890, Intuvo 9000</li><li>Shimadzu: GC-2010/2014, Nexis GC-2030</li><li>Thermo Fisher: TRACE 1300/1310</li><li>PerkinElmer: Clarus 400–690</li><li>Also supported: Dani, Ellutia, Young In Chromass, Apix, Fuli, GOW-MAC (selected models)</li></ul><blockquote>Note: Most Agilent 6890–8890 and Intuvo use LAN – ICF.</blockquote><h5>HPLC Systems</h5>Full system/module control:<ul><li>Agilent 1100–1290 Infinity II (ICF)</li><li>Shimadzu LC-10/20 and Nexera LC-40</li><li>PerkinElmer Flexar / NexSAR</li><li>Knauer Azura / BlueShadow / Smartline</li><li>Hitachi Chromaster / Primaide</li><li>Young In Chromass ChroZen series</li><li>Sykam S500–S600, Watrex Streamline, Hanon LC7000–7300</li></ul><h5>HPLC Modules (Pumps, Detectors, Ovens, Fraction Collectors)</h5><ul><li>Pumps: Agilent 1100–1290 families, Knauer, Shimadzu, PerkinElmer, Sykam, SSI, Ecom</li><li>Detectors: VWD/DAD(PDA)/RID/FLD/ELSD across Agilent, Shimadzu, Knauer, PerkinElmer, Young In Chromass, Ecom, etc.</li><li>Column Ovens: Agilent G1316x / G7116x, Shimadzu CTO-20/30/40, Knauer CT2.1, PerkinElmer Flexar</li><li>Fraction Collectors: Knauer FC 6.1, Teledyne FOXY series, Ecom ECF 2096, Waters Fraction Collector II</li></ul><h5>Autosamplers</h5><ul><li>Agilent GC ALS (7673/7683/7693/8697), HPLC ALS modules (G1313A–G7167C)</li><li>Shimadzu AOC-20 / AOC-5000+, SIL-10 / SIL-20 / SIL-40 series</li><li>CTC Analytics PAL, HTA autosamplers, Spark Alias/UHPLC, Knauer AS 6.1L</li><li>PerkinElmer Flexar / NexSAR AS</li></ul><h5>Other Devices</h5><ul><li>GC×GC modulators (e.g., Charles University GC×GC Modulator)</li><li>Valves &amp; switch modules (Agilent, Knauer, Shimadzu, VICI-Valco)</li><li>Degassers, flow monitors, managers, interfaces</li><li>LC-MS / GC-MS: Advion Expression CMS, Microsaic 4500 MiD, Markes BenchTOF (and others)</li><li>Balances (EA extension): Mettler Toledo, Sartorius</li></ul><h5>Analog Acquisition (Colibrick)</h5>A/D support for legacy or analog-output devices:<ul><li>GC: Agilent 5880/4890A, Varian 3xxx/3800/3900, PerkinElmer Clarus series, Thermo TRACE, Shimadzu GC-14/9A, Scion 43x/45x/83xx/85xx, etc.</li><li>HPLC Detectors: Waters 2487/2489, ESA Corona, Hitachi L-series, JASCO FP/UV, Ecom LCD series, many others</li><li>Elemental &amp; Amino Acid Analyzers: Carlo Erba/Costech ECS, Biochrom 20/30+</li></ul>If you are interested in a DEMO VERSION, contact us!

DataApex Clarity Chromatography software 10.1.2 just released!

🎤Dan Reddy (PhD candidate in the Department of Chemistry at Queen's University and a recipient of the NSERC Vanier Canada Graduate Scholarship. He was recently named one of the top 35 early-career scientists globally in the 2025 CAS Future Leaders program.)In this episode, we interview Daniel Reddy, 2025 CAS Future Leader and PhD candidate at Queen's University, about his groundbreaking research on automated mass spectrometry and dried matrix spots (DMS).Dan's work combines computer vision, 3D printer automation, and laser micromachining to revolutionize sample preparation—reducing CO₂ emissions by 28-fold and organic solvent use by 21-fold compared to traditional methods.<h4>What You'll Learn:</h4><ul><li>How to give a mass spectrometer "sight" and "taste" using computer vision and the LMJ-SSP (Liquid Microjunction Surface Sampling Probe)</li><li>The breakthrough technology behind Surface Energy Traps (SETs) for confining liquid droplets on paper substrates</li><li>Why dried matrix spots eliminate the need for cold-chain shipping and enable analysis of blood, urine, and saliva samples via standard mail</li><li>How DIY chemists are hacking 3D printers to build cost-effective autosamplers (replacing $10K+ systems)</li><li>The role of green chemistry and systems thinking in modernizing analytical methods</li><li>Why interdisciplinary collaboration (chemistry + computer science) is critical to innovation</li></ul><h4>Key Topics:</h4><ul><li>Dried Matrix Spots (DMS) for automated sample prep</li><li>Laser-micromachined Surface Energy Traps</li><li>Direct surface sampling mass spectrometry</li><li>Sustainability in analytical chemistry</li><li>3D printer customization for laboratory automation</li><li>The importance of science communication and community outreach</li></ul><h3>Video Transcription</h3><h4>Introduction</h4>Recent advances in analytical chemistry increasingly focus on simplifying workflows, improving sustainability, and enabling automation. In this context, the work of Dan Reddy centers on the concept of “bringing mass spectrometry to life” through the integration of automated sampling, computer vision, and dried matrix spot (DMS) methodologies.The primary objective is to enable efficient and reproducible analysis of biological and liquid samples—such as blood, urine, saliva, or other solutions—by depositing them onto substrates, drying them, and extracting meaningful analytical information directly via mass spectrometry.<h4>Conceptual Framework: Enabling “Sight” and “Taste” in Mass Spectrometry</h4>A central innovation in this work is the conceptual transformation of mass spectrometry from a passive analytical tool into an active, semi-autonomous system.<ul><li>“Sight” is introduced through camera-based computer vision, allowing the system to identify predefined patterns on a substrate.</li><li>“Taste” is implemented via a liquid microjunction surface sampling probe (LMJSSP), which enables direct extraction of analytes from surfaces.</li></ul>The LMJSSP consists of two concentric capillaries forming a continuously flowing microdroplet. When brought into contact with the sample surface, this droplet facilitates localized extraction, effectively enabling direct surface analysis without traditional chromatographic separation.Combined with an automated positioning system (adapted from 3D printer mechanics), the platform can autonomously locate sampling sites and perform reproducible measurements.<h4>Dried Matrix Spots as an Analytical Platform</h4><h5>Principle and Advantages</h5>Dried matrix spots involve depositing a small volume of liquid sample onto a substrate (commonly paper), followed by drying. This approach offers several advantages:<ul><li>Reduced need for cold-chain transport</li><li>Simplified sample handling and storage</li><li>Compatibility with remote or decentralized sampling</li><li>Lower solvent consumption</li></ul>These features contribute significantly to greener analytical workflows and improved logistical efficiency.<h5>Sustainability Impact</h5>The implementation of DMS-based workflows has demonstrated:<ul><li>Up to 28-fold reduction in CO₂ emissions</li><li>Up to 21-fold reduction in organic solvent use</li></ul>These improvements arise from eliminating cold-chain logistics and minimizing solvent-intensive preparation steps.<h4>Surface Energy Traps (SCTs): Controlled Micro-Sampling Environments</h4><h5>Definition and Fabrication</h5>Surface Energy Traps (SCTs) are microstructured regions on a substrate designed to confine liquid droplets within defined boundaries.The fabrication process involves:<ol><li>Coating paper with a hydrophobic layer</li><li>Using laser ablation to selectively remove the coating in defined patterns</li><li>Creating hydrophilic circular regions (typically ~0.5 mm diameter)</li></ol>These patterned regions act as micro-wells that confine droplets spatially and prevent lateral diffusion.<h5>Analytical Benefits</h5>SCTs address key limitations of traditional dried matrix spots:<ul><li>Improved spatial confinement of analytes</li><li>Reduced diffusion variability</li><li>Enhanced reproducibility</li><li>Preconcentration effects due to controlled drying</li></ul>Additionally, the SCT diameter is smaller than the sampling probe, enabling near-complete analyte collection during surface extraction.<h4>Drying Dynamics and Analyte Distribution</h4>Traditional dried matrix spots often suffer from the “coffee-ring effect”, where analytes redistribute unevenly during drying. This leads to variability depending on sampling location.The SCT approach mitigates these effects by:<ul><li>Limiting diffusion area</li><li>Maintaining analytes near the surface</li><li>Producing more uniform analyte distribution</li></ul>Preliminary investigations (e.g., via SEM imaging) indicate improved homogeneity, although further studies are needed to fully characterize drying kinetics and their influence on signal intensity.<h4>Integration with Automated Sampling Systems</h4><h5>3D Printer-Based Positioning</h5>A key engineering innovation is the repurposing of 3D printer hardware for automated sample positioning:<ul><li>Provides cost-effective XYZ motion control</li><li>Enables programmable sampling routines</li><li>Supports integration with analytical instrumentation</li></ul>Custom software—developed in collaboration with computer engineers—allows users to define coordinates, dwell times, and sampling parameters.<h5>Computer Vision Integration</h5>The addition of computer vision enables:<ul><li>Pattern recognition (e.g., alignment markers near SCTs)</li><li>Autonomous targeting of sampling locations</li><li>Reduced operator intervention</li></ul>This transforms the system into a semi-autonomous analytical platform.<h4>Comparison with Conventional Workflows</h4>Compared to traditional LC-MS or GC-MS workflows, the presented approach offers:<div><div><figure class="table"><table><thead><tr><th>Aspect</th><th>Conventional Methods</th><th>SCT + LMJSSP Approach</th></tr></thead><tbody><tr><td>Sample prep</td><td>Multi-step, solvent-intensive</td><td>Minimal, direct surface sampling</td></tr><tr><td>Chromatography</td><td>Required</td><td>Potentially bypassed</td></tr><tr><td>Throughput</td><td>Moderate</td><td>High (automated)</td></tr><tr><td>Sustainability</td><td>Limited</td><td>Significantly improved</td></tr></tbody></table></figure></div></div>While chromatographic methods remain essential for many applications, this approach provides a complementary pathway for rapid screening and targeted analyses.<h4>Green Chemistry and Systems Thinking</h4>A notable aspect of this work is the integration of systems thinking into analytical chemistry. Inspired by engagement with organizations such as the American Chemical Society and green chemistry initiatives, the research emphasizes:<ul><li>Environmental impact reduction</li><li>Resource efficiency</li><li>Lifecycle considerations</li></ul>This perspective expands the role of analytical chemists beyond method performance to broader societal and environmental implications.<h4>Future Outlook and Applications</h4>The research is currently at an early stage but shows strong potential for:<ul><li>Decentralized diagnostics (e.g., remote blood sampling)</li><li>Environmental monitoring</li><li>High-throughput screening workflows</li><li>Field-deployable analytical systems</li></ul>Further advancements are expected in:<ul><li>Substrate engineering</li><li>Automation robustness</li><li>Integration with advanced MS platforms (e.g., triple quadrupole systems)</li></ul><h4>Conclusion</h4>The integration of dried matrix spots, surface energy traps, and automated surface sampling represents a significant step toward more sustainable, efficient, and accessible analytical workflows.By combining innovations in microfabrication, computer vision, and mass spectrometry, the work of Dan Reddy demonstrates how analytical chemistry can evolve toward smarter, greener, and more autonomous systems.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Mass Spectrometry, Surface Sampling and Dried Matrix Spots - Greener Chemistry and 3D Printing

Article

Product

Application

Video

Scientists

Interview

Science and research

Software

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

CEM Corporation

Metrohm

Agilent Technologies

SelectScience

Waters Corporation

Separation of highly polar compounds such as pharmaceuticals, metabolites, and biomarkers can be challenging using traditional reversed-phase methods on regular C18 columns.
In this webinar, we will discuss available alternatives such as ion pairing, use of polar bonded phases, or polar modified columns. We will also discuss the benefits of selecting alternative modes of separation, such as HILIC and Ligand Exchange chromatography.
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Presenter: Golnar Javadi (Application Engineer, Agilent Technologies, Inc.)
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Golnar Javadi is an applications engineer providing online applications assistance and technical support for LC columns and supplies, Sample Preparation products, and Spectroscopy supplies.
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Before joining Varian and then Agilent, Golnar worked in the pharmaceutical and nutraceutical industries on method development and quality control. She also taught college level chemistry courses for a few years.
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Golnar then joined Varian as a technical support specialist, providing customers with method development assistance and technical support on Sample Preparation (SPE, SLE, and Filtration), HPLC, GC, ToxiLab and DAT. After the Varian-Agilent merger, Golnar joined Agilent Technologies as an Applications Engineer. She provides technical support to customers on Sample Preparation products, Liquid Chromatography columns, and Spectroscopy supplies.
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Agilent Technologies: Analysis of Polar Analytes by LC - What are the Options?

Analysis of Polar Analytes by LC - What are the Options?

In this webinar, we will discuss available alternatives such as ion pairing, use of polar bonded phases, or polar modified columns.

The ACQUITY Premier System delivers improvements in chromatographic performance and with the introduction of a fixed loop injector option, you can now add sample injection versatility to the already proven benefits of the ACQUITY Premier System.
Register for this webinar to learn more about how you can confidently migrate methods to this next-generation UHPLC system to tackle ever-increasing sample complexity with increased flexibility and the highest throughput.
Agenda
<ul>
<li>Application Spotlight: Biopharma method migration from Classic to Premier FL</li>
<li>Choosing the best autosampler for your ACQUITY Premier System</li>
<li>Benefits of the ACQUITY Premier Fixed Loop Injector for metal sensitive compounds</li>
</ul>
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Presenter: Robert Birdsall (Principal Scientist, Waters Corporation)
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Robert received his PhD in analytical chemistry from Purdue University, where he developed chromatographic methods in the characterization of proteins using sub-micron silica-based substrates. He joined Waters in 2013 and is currently leading a team of scientists providing analytical support in the development, commercialization, and application of Waters Technology.
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Presenter: Jennifer Simeone (Principal Consulting Scientist, Waters Corporation)
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Jennifer Simeone is a principal consulting scientist within the QA/QC Business Strategy Group at Waters Corporation in Milford, MA. Prior to joining Waters in 2010, Jennifer worked for Charles River Laboratories where she gained extensive knowledge in bioanalytical LC/MS/MS of small molecules. Her current focus at Waters is development and evaluation of Waters and competitive LC and LC/MS instrumentation.
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Presenter: Norris Wong (Evaluation Scientist II, Waters Corporation)
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Norris Wong is an Evaluation Scientist II at Waters Corporation, part of the Evaluations Team in Milford, MA that performs sustaining, verification, and validation testing on instruments and products. He graduated with a degree in Biochemistry from Bowdoin College. Prior to joining Waters in 2021, Norris worked in the pharmaceutical industry, performing extractable and leachable work in R&amp;D and cGMP environments. Norris has experience with a variety of instrumentation including HPLC, LC-MS, GC-FID, GC-MS, HS-GC-MS, and GC-MS-QQQ.
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Presenter: Jim Karafilidis (Principal Product Marketing Manager, Waters Corporation)
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Jim Karafilidis is a Principal Product Marketing Manager for Waters Corporation where he has worked for 6 years in the LC systems group. He is responsible for Performance LC Systems, which include ACQUITY Premier, ACQUITY UPLC H-Class PLUS and ACQUITY UPLC I-Class PLUS systems.
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Waters Corporation: Ultimate Chromatographic Performance with Fixed Loop Injections

Ultimate Chromatographic Performance with Fixed Loop Injections

How you can migrate methods to ACQUITY Premier UHPLC to tackle ever-increasing sample complexity with increased flexibility and the highest throughput.

Chromatographic Performance with Fixed Loop Injections

LC-MS/MS is rapidly becoming the gold standard for quantifying different classes of analytes in endocrinology research. The power of greater selectivity and analytical sensitivity using LC-MS/MS is critical in understanding the status of endocrine biochemical pathways. The enhanced performance observed on these platforms provides increased confidence in the results, enabling you to make better decisions based on more accurate information.
Greater analytical sensitivity is a goal that drives improvements in precision, leading to clearer insights into results down to low physiological concentrations. Here we will discuss the latest introduction to the Waters MassTrak™ IVD system family, which is shown to be analytically sensitive and efficient, helping to reduce cost and improve the quality of your data. 
Learning objectives: 
<ul>
<li>An introduction to the latest addition to Waters MassTrak IVD System for clinical laboratories
</li>
<li>The importance of selectivity in endocrinology research in obtaining high quality data
</li>
<li>How the latest addition to Waters MassTrak IVD System addresses the needs of those key endocrinology research applications, including steroid hormone analysis
</li>
</ul>
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Presenter: Dominic Foley (Principal Scientist, Waters Corporation)
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Dominic is a Principal Scientist working at Waters Mass Spectrometry Headquarters in Wilmslow, UK. Having joined the company in September 2013, he has specialized in the development of LC-MS/MS clinical research applications, with expertise in steroid hormone analysis and protein/peptide quantification. In his role, he also collaborates with clinical customers in the development and implementation of LC-MS/MS methods in their laboratories.
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Dominic has worked in separation sciences for 14 years, following his ambition of improving the quality of healthcare. He started his career with ICON Development Solutions, a CRO in the north of the UK, where he worked as a LC-MS/MS method development and validation scientist supporting DMPK studies in drug discovery. In 2012, he joined Thermo Fisher Scientific to work in their Chromatography R&amp;D team as a Technical Support Specialist, working on the development of new chromatography and sample preparation products.
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Dominic received his BSc (Hons) in Biochemistry from the University of Manchester in 2006. He has presented his work at conferences around the world and has several publications in both the Microchemical Journal and the Journal of Chromatography A.
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Presenter: David Ballantyne (Principal Product Manager, Waters Corporation)
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David Ballantyne is a Principal Product Manager at Waters Corporation, working within the Global Clinical Diagnostics Portfolio Management team. Having joined the company in 2005, he has held multiple roles throughout Manufacturing and R&amp;D. David has a background in Electrical and Mechanical Engineering and began his career at Waters supporting GC-MS/MS technologies including Tandem Quadrupole and Magnetic Sector Mass Spectrometry.
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In 2018 he moved to his role in Product Management where is focus changed to Clinical Diagnostics, with a particular focus on LC – MS/MS Instrumentation and Informatics solutions. Over the last 5 years David has spent much of his time focused on understanding customer problems and translating them into new solutions.
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Waters Corporation: The Evolving Power of LC-MS/MS Technology within Endocrinology

The Evolving Power of LC-MS/MS Technology within Endocrinology

Here we will discuss the latest introduction to the Waters MassTrak™ IVD system family for clinical laboratories.

The Evolving Power of LC-MS/MS within Endocrinology

A key aspect of durable data is staying current with technologies and underlying platforms. With each new release of Empower Software, you have the opportunity to explore new functionality that will support your operations, as you strive to increase productivity and efficiency while also reducing risk across your entire organization. Whether you are a system administrator, scientist, or in quality, the release of Empower 3.8.0 brings you a new set of tools to support your goals.
Key points of discussion will be:
<ul>
<li>Updates to System Suitability</li>
<li>New features to simplify work and streamline workflows</li>
<li>Compliance and quality enhancements</li>
</ul>
Join us for a live discussion as we explore Empower 3.8.0. As always, don’t forget to bring your questions for this exclusive opportunity to ask our experts anything about Empower Software
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Presenter: Neil Lander (Principal Product Manager, Waters Corporation)
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Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.
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Presenter: Sukhdev Bangar (Principal Product Manager – HPLC, Waters Corporation)
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Sukhdev Bangar is a Principal Product Manager at Waters Corporation in Waters QA/QC Divison. He has over 15 years’ experience in the area of LC and LC-MS applications. Starting life in industry at GSK working with OTC treatments of Dermatological ailments, Inhalation drug testing at 3M, followed by DMPK at AstraZeneca. In 2005 he joined Waters in the Global MS product management group working with R&amp;D to evaluate new MS hardware and software features from an end user perspective. In 2010 he joined the Americas MS demo lab and after a few years became the Team Leader for the Pharma group, leading the efforts in Quan/Qual application Demo’s. Since 2019 Sukhdev has held his current role working out of Waters HQ. His responsibilities include Waters next generation HPLC product line.
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Presenter: Lauren Wood (Empower Customer Success Manager, Waters Corporation)
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Lauren is the Empower Customer Success Manager and is an Empower subject matter expert (SME). Lauren’s concentration is customer success through focus on the support process and defect resolution process for issues pertaining to Empower and/or third-party instrument drivers. Lauren liaises between customers and Marketing, Support, Engineering and CXKM to understand impact and to work with internal teams to prioritize, document, communicate, and resolve software issues. Lauren’s previous roles at Waters during her 30-year tenure have included phone support in Technical Service, Empower training in Customer Education, and Empower product management.
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Waters Corporation: Empower Tips Special Edition: Ask Me Anything About Our Newest Empower Release - Empower 3.8.0

Empower Tips Special Edition: Ask Me Anything About Our Newest Empower Release - Empower 3.8.0

Join us for a live discussion as we explore Empower 3.8.0. As always, don’t forget to bring your questions about Empower Software.

Waters Empower Tips: Newest Release - Empower 3.8.0

Chromium content and impurity analysis of plating baths using ion chromatography provide a highly accurate and easily automated solution compared with traditional wet chemistry methods. Quality control of these and similar plating bath sample types is essential for dialing in bath performance.
Attend this session to learn how The Armoloy Corporation recently replaced tedious, manual analysis of their chromium baths with IC to monitor chromium and ionic contaminants. You’ll also learn how to combine this knowledge with the fundamentals of IC so that you can apply this to other sample types. Take part in our live Q&amp;A after the presentation to get your specific questions answered by our experts. 
<h5>Who should attend?</h5>
<ul>
<li>Analysts, technicians, chemists who want to learn how IC can simplify their analysis, eliminating more cumbersome techniques</li>
<li>Quality lab managers considering implementing IC into their lab</li>
</ul>
<h5>Key learning points</h5>
<ul>
<li>Learn how IC can be used to simplify multiparameter analyses and eliminate tedious wet chemistry methods</li>
<li>Understand how IC can be used as an important tool for quality control in industry</li>
<li>Learn the basics of IC from a theoretical and equipment standpoint</li>
</ul>
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Presenter: Kris Johnson (Chemist, Armoloy)
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Kris Johnson is a chemist at Armoloy where he has been for four years and recently completed his CEF. He handles the chemical and metallurgical testing and heads R&amp;D, among other things. Kris graduated from the chemistry program at Northern Illinois University where he was also a researcher and was recognized in three different published articles. He uses his knowledge in the plating industry to participate in the Aerospace Materials Specifications B Committee to review and update several of these specifications used by numerous laboratories worldwide.
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Presenter: Bikash Chouhan (Applications Specialist, Metrohm USA)
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Bikash Chouhan is an Applications Specialist for Ion Chromatography at Metrohm USA. He completed his PhD in Analytical Chemistry from the University of Texas at Arlington (UTA). His area of research during his PhD was in Capillary Scale Ion Chromatography. He has worked as a Post Doc at the Department of Chemistry and Biochemistry, UTA and as a Senior Scientist in IC at Eurofins, before joining Metrohm USA. He is currently involved in expanding IC applications to more unique and challenging sample matrices.
</blockquote>

Metrohm: Analysis of Plating Baths with Ion Chromatography

Analysis of Plating Baths with Ion Chromatography

Learn how The Armoloy Corporation recently replaced tedious, manual analysis of their chromium baths with IC to monitor chromium and ionic contaminants.

Novel dosage forms require novel dissolution techniques and instruments. Drug-eluting stent testing, transdermals, implants, contact lenses, medical devices, and a variety of other products require absolute control over evaporative losses and assurance of analytical sample integrity. The dissolution testing is frequently done using ultralow volumes in the 5–10 mL range.
In this webinar, we will explore tools and techniques that address the challenges of these types of analysis by examining several examples and case studies.
<h5>Key learning objectives</h5>
<ul>
<li>Discover dissolution techniques for novel formulations</li>
<li>Explore case studies for small-volume dissolution testing</li>
<li>Learn about the Agilent 400-DS</li>
</ul>
<h5>Who should attend?</h5>
<ul>
<li>Dissolution users, lab managers in R&amp;D and QC, and drug/device manufacturers</li>
</ul>
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Presenter: Dr. Karen Krauel-Goellner (Product Manager Dissolution Systems, Agilent Technologies)
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Dr. Karen Krauel-Goellner is a registered pharmacist and holds a PhD from the University of Otago, NZ, in the area of formulation development. Krauel-Goellner previously held research positions at universities and Boehringer Ingelheim, and worked as a clinical supply manager at Boehringer Ingelheim Vetmedica. In 2013, Krauel-Goellner joined Agilent Technologies and is currently a Global Product Manager for Agilent Dissolution Systems. 
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Presenter: Georgina Wynne Hughes (Editorial Team, SelectScience)
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Georgina studied at Birmingham University where she gained a BSc in Biomedical Science, and an MSc by Research in Cancer and Genomic Sciences, which focused on defective autophagy in rare neurodegenerative diseases. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

Select Science: Overcoming Dissolution Challenges with Low-Dose Pharmaceuticals and Medical Devices

Overcoming Dissolution Challenges with Low-Dose Pharmaceuticals and Medical Devices

We will explore tools and techniques that address the challenges of these types of analysis by examining several examples and case studies.

Dissolution with Low-Dose Pharmaceuticals and Medical

UV-VIS typical maintenance and some common validation tests will be discussed.
<blockquote>
Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
</blockquote>

Agilent Technologies: Maintaining Your UV-VIS Spectrometer

Maintaining Your UV-VIS Spectrometer

UV-VIS typical maintenance and some common validation tests will be discussed.

Complement your Empower CDS with sample management, equipment inventory and data archiving.
<ul>
<li>How isolated is your Empower CDS network?</li>
<li>Do you manually transcribe sample information?</li>
<li>Do maintain paper logbooks for your system usage?</li>
<li>Do you deal with the life of your data after processing and reporting?</li>
</ul>

Waters Corporation: CDS and LMS integrated to single product

CDS and LMS integrated to single product

Complement your Empower CDS with sample management, equipment inventory and data archiving.

In this webinar, the successful purification of hydrophobic and difficult peptides is demonstrated using elevated temperature preparative HPLC.
Learn how the use of an integrated heating system enables both the direct translation of elevated temperature methods to the preparative scale, as well as improved purity and recovery.
Additionally, the benefits of Waters BEH reversed-phase columns for elevated temperature applications will be described.
<blockquote>
Presenter: Colin L. Simpson (Principal Scientist, CEM Corporation)
</blockquote>
<blockquote>
Colin Simpson is a Principal Scientist at CEM Corporation, and has over 12 years of experience developing and introducing improved technologies that serve the analytical testing and life science markets. In his current role, he is responsible for leading the development of improved approaches for peptide purification with a focus on both workflow solutions and instrumentation. He earned a B.A. in chemistry from UNC-Chapel Hill and a M.S. in bioanalytical chemistry from UNC-Charlotte.
</blockquote>
<blockquote>
Presenter: Kathy Lawrence, M.S., MBA (Sr. Product Marketing Manager Consumables and Lab Automation, Waters Corporation)
</blockquote>
<blockquote>
Kathy Lawrence is the Product Marketing Manager for Waters’ prep column technologies globally. Early on, she worked as both a discovery R&amp;D chemist for ag chem and pharma where she gained valuable experience synthesizing small molecule insecticides and potential medicinal therapies. During this time, she learned to really leverage the power of various liquid chromatographic techniques to purify target bioactives, evaluate physical properties of the same and develop new skills isolating natural products. Later, in a contract research environment, she successfully managed an analytical-services laboratory supporting discovery synthesis. Kathy worked consultatively with labs across numerous industries during her tenure as Waters North American Purification Specialist where she supported the success of Water’s Prep solutions. Since then, Kathy has held increasingly advanced leadership roles in marketing and business development in support of the commercialization of purification solutions including instruments, consumables, lab services, and biotechnologies. Kathy holds a graduate degree in Chemistry, an MBA, and is she is an author of a handful of journal publications in addition to being a patented product inventor.
</blockquote>

CEM Corporation: Using Elevated Temperatures to Enable the Purification of Hydrophobic and Difficult Peptides

Using Elevated Temperatures to Enable the Purification of Hydrophobic and Difficult Peptides

In this webinar, the successful purification of hydrophobic and difficult peptides is demonstrated using elevated temperature preparative HPLC.

Purification of Hydrophobic and Difficult Peptides

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
Electrospray ionization (ESI) is the most common ionization technique used in LC-MS, however not all samples are best analyzed by ESI. Atmospheric Pressure Chemical Ionization (APCI) is a complementary technique that can work well with small molecules that are more non-polar or neutral. Considerations for solvent and mobile phase additives to optimize APCI performance will be discussed.
<blockquote>
Presenter: Emily Parry, PhD (LC/MS Applications Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Emily has been with Agilent for four years. Prior to joining Agilent, Emily developed methods for environmental contaminants in a variety of human and environmental matrices using both targeted and untargeted mass spectrometry techniques. She worked as a researcher at the Environmental Protection Agency (EPA) and Public Health Institute. She received her Ph.D. degree in Environmental Chemistry from the University of California, Davis.
</blockquote>

Agilent Technologies: From Liquid to Ions…. Eliminate your Fears switching from Electrospray ionization (ESI) to Atmospheric Pressure chemical Ionization (APCI)

From Liquid to Ions…. Eliminate your Fears switching from Electrospray ionization (ESI) to Atmospheric Pressure chemical Ionization (APCI)

ESI vs. APCI. Considerations for solvent and mobile phase additives to optimize APCI performance will be discussed.