News from LabRulezLCMS Library - Week 14, 2026

<h3>We're excited to announce that <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity Chromatography Software</a> version 10.1.2 is now available!</h3>This minor update expands Clarity’s portfolio with new control modules.<h4>Newly added Instrument control modules</h4><ul><li>Ecom auxiliary modules</li><li>HTA ICF control modules</li><li>Spark pump</li></ul><h4>Updated Instrument control modules</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/168">Ecom</a> HPLC</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/328">Knauer</a> HPLC</li><li>Spark ICF control modules</li><li>YoungIn Chromass HPLC</li></ul><blockquote>For a complete list of module changes, see the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">Changelog</a>. For more info about exciting new features directly in Clarity, explore what was introduced in the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5622">Clarity 10.1 release highlights</a>.Clarity can control 1000+ instruments; the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/controls">list can be previewed here</a>.</blockquote><h4>Supported Instruments in Clarity (DataApex) — Quick Guide</h4>Clarity Chromatography Software supports a wide range of chromatographs and peripherals via digital control (DD) and analog acquisition (A/D) using the Colibrick module.<h5>Gas Chromatographs (GC)</h5>Digital integration over LAN/RS232 (many via ICF):<ul><li>Agilent: 5890, 6890, 7890, 8860, 8890, Intuvo 9000</li><li>Shimadzu: GC-2010/2014, Nexis GC-2030</li><li>Thermo Fisher: TRACE 1300/1310</li><li>PerkinElmer: Clarus 400–690</li><li>Also supported: Dani, Ellutia, Young In Chromass, Apix, Fuli, GOW-MAC (selected models)</li></ul><blockquote>Note: Most Agilent 6890–8890 and Intuvo use LAN – ICF.</blockquote><h5>HPLC Systems</h5>Full system/module control:<ul><li>Agilent 1100–1290 Infinity II (ICF)</li><li>Shimadzu LC-10/20 and Nexera LC-40</li><li>PerkinElmer Flexar / NexSAR</li><li>Knauer Azura / BlueShadow / Smartline</li><li>Hitachi Chromaster / Primaide</li><li>Young In Chromass ChroZen series</li><li>Sykam S500–S600, Watrex Streamline, Hanon LC7000–7300</li></ul><h5>HPLC Modules (Pumps, Detectors, Ovens, Fraction Collectors)</h5><ul><li>Pumps: Agilent 1100–1290 families, Knauer, Shimadzu, PerkinElmer, Sykam, SSI, Ecom</li><li>Detectors: VWD/DAD(PDA)/RID/FLD/ELSD across Agilent, Shimadzu, Knauer, PerkinElmer, Young In Chromass, Ecom, etc.</li><li>Column Ovens: Agilent G1316x / G7116x, Shimadzu CTO-20/30/40, Knauer CT2.1, PerkinElmer Flexar</li><li>Fraction Collectors: Knauer FC 6.1, Teledyne FOXY series, Ecom ECF 2096, Waters Fraction Collector II</li></ul><h5>Autosamplers</h5><ul><li>Agilent GC ALS (7673/7683/7693/8697), HPLC ALS modules (G1313A–G7167C)</li><li>Shimadzu AOC-20 / AOC-5000+, SIL-10 / SIL-20 / SIL-40 series</li><li>CTC Analytics PAL, HTA autosamplers, Spark Alias/UHPLC, Knauer AS 6.1L</li><li>PerkinElmer Flexar / NexSAR AS</li></ul><h5>Other Devices</h5><ul><li>GC×GC modulators (e.g., Charles University GC×GC Modulator)</li><li>Valves &amp; switch modules (Agilent, Knauer, Shimadzu, VICI-Valco)</li><li>Degassers, flow monitors, managers, interfaces</li><li>LC-MS / GC-MS: Advion Expression CMS, Microsaic 4500 MiD, Markes BenchTOF (and others)</li><li>Balances (EA extension): Mettler Toledo, Sartorius</li></ul><h5>Analog Acquisition (Colibrick)</h5>A/D support for legacy or analog-output devices:<ul><li>GC: Agilent 5880/4890A, Varian 3xxx/3800/3900, PerkinElmer Clarus series, Thermo TRACE, Shimadzu GC-14/9A, Scion 43x/45x/83xx/85xx, etc.</li><li>HPLC Detectors: Waters 2487/2489, ESA Corona, Hitachi L-series, JASCO FP/UV, Ecom LCD series, many others</li><li>Elemental &amp; Amino Acid Analyzers: Carlo Erba/Costech ECS, Biochrom 20/30+</li></ul>If you are interested in a DEMO VERSION, contact us!

DataApex Clarity Chromatography software 10.1.2 just released!

🎤Dan Reddy (PhD candidate in the Department of Chemistry at Queen's University and a recipient of the NSERC Vanier Canada Graduate Scholarship. He was recently named one of the top 35 early-career scientists globally in the 2025 CAS Future Leaders program.)In this episode, we interview Daniel Reddy, 2025 CAS Future Leader and PhD candidate at Queen's University, about his groundbreaking research on automated mass spectrometry and dried matrix spots (DMS).Dan's work combines computer vision, 3D printer automation, and laser micromachining to revolutionize sample preparation—reducing CO₂ emissions by 28-fold and organic solvent use by 21-fold compared to traditional methods.<h4>What You'll Learn:</h4><ul><li>How to give a mass spectrometer "sight" and "taste" using computer vision and the LMJ-SSP (Liquid Microjunction Surface Sampling Probe)</li><li>The breakthrough technology behind Surface Energy Traps (SETs) for confining liquid droplets on paper substrates</li><li>Why dried matrix spots eliminate the need for cold-chain shipping and enable analysis of blood, urine, and saliva samples via standard mail</li><li>How DIY chemists are hacking 3D printers to build cost-effective autosamplers (replacing $10K+ systems)</li><li>The role of green chemistry and systems thinking in modernizing analytical methods</li><li>Why interdisciplinary collaboration (chemistry + computer science) is critical to innovation</li></ul><h4>Key Topics:</h4><ul><li>Dried Matrix Spots (DMS) for automated sample prep</li><li>Laser-micromachined Surface Energy Traps</li><li>Direct surface sampling mass spectrometry</li><li>Sustainability in analytical chemistry</li><li>3D printer customization for laboratory automation</li><li>The importance of science communication and community outreach</li></ul><h3>Video Transcription</h3><h4>Introduction</h4>Recent advances in analytical chemistry increasingly focus on simplifying workflows, improving sustainability, and enabling automation. In this context, the work of Dan Reddy centers on the concept of “bringing mass spectrometry to life” through the integration of automated sampling, computer vision, and dried matrix spot (DMS) methodologies.The primary objective is to enable efficient and reproducible analysis of biological and liquid samples—such as blood, urine, saliva, or other solutions—by depositing them onto substrates, drying them, and extracting meaningful analytical information directly via mass spectrometry.<h4>Conceptual Framework: Enabling “Sight” and “Taste” in Mass Spectrometry</h4>A central innovation in this work is the conceptual transformation of mass spectrometry from a passive analytical tool into an active, semi-autonomous system.<ul><li>“Sight” is introduced through camera-based computer vision, allowing the system to identify predefined patterns on a substrate.</li><li>“Taste” is implemented via a liquid microjunction surface sampling probe (LMJSSP), which enables direct extraction of analytes from surfaces.</li></ul>The LMJSSP consists of two concentric capillaries forming a continuously flowing microdroplet. When brought into contact with the sample surface, this droplet facilitates localized extraction, effectively enabling direct surface analysis without traditional chromatographic separation.Combined with an automated positioning system (adapted from 3D printer mechanics), the platform can autonomously locate sampling sites and perform reproducible measurements.<h4>Dried Matrix Spots as an Analytical Platform</h4><h5>Principle and Advantages</h5>Dried matrix spots involve depositing a small volume of liquid sample onto a substrate (commonly paper), followed by drying. This approach offers several advantages:<ul><li>Reduced need for cold-chain transport</li><li>Simplified sample handling and storage</li><li>Compatibility with remote or decentralized sampling</li><li>Lower solvent consumption</li></ul>These features contribute significantly to greener analytical workflows and improved logistical efficiency.<h5>Sustainability Impact</h5>The implementation of DMS-based workflows has demonstrated:<ul><li>Up to 28-fold reduction in CO₂ emissions</li><li>Up to 21-fold reduction in organic solvent use</li></ul>These improvements arise from eliminating cold-chain logistics and minimizing solvent-intensive preparation steps.<h4>Surface Energy Traps (SCTs): Controlled Micro-Sampling Environments</h4><h5>Definition and Fabrication</h5>Surface Energy Traps (SCTs) are microstructured regions on a substrate designed to confine liquid droplets within defined boundaries.The fabrication process involves:<ol><li>Coating paper with a hydrophobic layer</li><li>Using laser ablation to selectively remove the coating in defined patterns</li><li>Creating hydrophilic circular regions (typically ~0.5 mm diameter)</li></ol>These patterned regions act as micro-wells that confine droplets spatially and prevent lateral diffusion.<h5>Analytical Benefits</h5>SCTs address key limitations of traditional dried matrix spots:<ul><li>Improved spatial confinement of analytes</li><li>Reduced diffusion variability</li><li>Enhanced reproducibility</li><li>Preconcentration effects due to controlled drying</li></ul>Additionally, the SCT diameter is smaller than the sampling probe, enabling near-complete analyte collection during surface extraction.<h4>Drying Dynamics and Analyte Distribution</h4>Traditional dried matrix spots often suffer from the “coffee-ring effect”, where analytes redistribute unevenly during drying. This leads to variability depending on sampling location.The SCT approach mitigates these effects by:<ul><li>Limiting diffusion area</li><li>Maintaining analytes near the surface</li><li>Producing more uniform analyte distribution</li></ul>Preliminary investigations (e.g., via SEM imaging) indicate improved homogeneity, although further studies are needed to fully characterize drying kinetics and their influence on signal intensity.<h4>Integration with Automated Sampling Systems</h4><h5>3D Printer-Based Positioning</h5>A key engineering innovation is the repurposing of 3D printer hardware for automated sample positioning:<ul><li>Provides cost-effective XYZ motion control</li><li>Enables programmable sampling routines</li><li>Supports integration with analytical instrumentation</li></ul>Custom software—developed in collaboration with computer engineers—allows users to define coordinates, dwell times, and sampling parameters.<h5>Computer Vision Integration</h5>The addition of computer vision enables:<ul><li>Pattern recognition (e.g., alignment markers near SCTs)</li><li>Autonomous targeting of sampling locations</li><li>Reduced operator intervention</li></ul>This transforms the system into a semi-autonomous analytical platform.<h4>Comparison with Conventional Workflows</h4>Compared to traditional LC-MS or GC-MS workflows, the presented approach offers:<div><div><figure class="table"><table><thead><tr><th>Aspect</th><th>Conventional Methods</th><th>SCT + LMJSSP Approach</th></tr></thead><tbody><tr><td>Sample prep</td><td>Multi-step, solvent-intensive</td><td>Minimal, direct surface sampling</td></tr><tr><td>Chromatography</td><td>Required</td><td>Potentially bypassed</td></tr><tr><td>Throughput</td><td>Moderate</td><td>High (automated)</td></tr><tr><td>Sustainability</td><td>Limited</td><td>Significantly improved</td></tr></tbody></table></figure></div></div>While chromatographic methods remain essential for many applications, this approach provides a complementary pathway for rapid screening and targeted analyses.<h4>Green Chemistry and Systems Thinking</h4>A notable aspect of this work is the integration of systems thinking into analytical chemistry. Inspired by engagement with organizations such as the American Chemical Society and green chemistry initiatives, the research emphasizes:<ul><li>Environmental impact reduction</li><li>Resource efficiency</li><li>Lifecycle considerations</li></ul>This perspective expands the role of analytical chemists beyond method performance to broader societal and environmental implications.<h4>Future Outlook and Applications</h4>The research is currently at an early stage but shows strong potential for:<ul><li>Decentralized diagnostics (e.g., remote blood sampling)</li><li>Environmental monitoring</li><li>High-throughput screening workflows</li><li>Field-deployable analytical systems</li></ul>Further advancements are expected in:<ul><li>Substrate engineering</li><li>Automation robustness</li><li>Integration with advanced MS platforms (e.g., triple quadrupole systems)</li></ul><h4>Conclusion</h4>The integration of dried matrix spots, surface energy traps, and automated surface sampling represents a significant step toward more sustainable, efficient, and accessible analytical workflows.By combining innovations in microfabrication, computer vision, and mass spectrometry, the work of Dan Reddy demonstrates how analytical chemistry can evolve toward smarter, greener, and more autonomous systems.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Mass Spectrometry, Surface Sampling and Dried Matrix Spots - Greener Chemistry and 3D Printing

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Interview

Science and research

Software

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

New Food magazine

Agilent Technologies

Thermo Fisher Scientific

SelectScience

SCIEX

Waters Corporation

Join this virtual panel to hear experts discuss new liquid chromatography technologies and techniques for separation of dietary supplements.
Health-conscious consumers are increasingly seeking supplements that deliver targeted health benefits. Meeting the demands of this growing market while maintaining consumer trust, cost control, and speed to market presents a host of analytical challenges.
Join us for an informative webinar focused on the evolving landscape of dietary supplements, where industry experts will discuss standard methods, advanced analytical techniques, and quality control. Learn how the standard methods are established and how to navigate common compliance challenges using advanced analytical techniques.
We will explore the latest chromatography technologies that improve the accuracy and reliability of supplement testing. Gain insights into strategies for ensuring product consistency and purity and understand the importance of ingredient verification for consumer safety and trust.
Don’t miss this great opportunity to deepen your understanding of the supplement landscape and stay ahead in the competitive dietary supplement market by leveraging the latest chromatography technologies!
Key learning points
<ul>
<li>Learn how standard methods are developed and how to incorporate new chromatographic techniques to maintain regulatory compliance
</li>
<li>Discover the latest innovations in chromatography and how these technological advancements can revolutionize your analysis
</li>
<li>Gain insights from industry experts to improve workflow efficiency and ensure product consistency and consumer trust
</li>
</ul>
<blockquote>
Presenter: Jinchuan Yang, PhD (Waters Corporation)
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<blockquote>
Dr. Jinchuan Yang is a Principal Scientist at Waters Corporation, and a subject matter expert in food and environmental applications, polymer chromatography, and LC and MS technologies. Since he joined Waters in 2002, his roles at Waters have mainly focused on application development, market development, and support for R&amp;D and training. He is an active participant in technical stakeholder groups at AOAC International and USP, serving as an expert panel member in AOAC SPIFAN and participating in review, recommendation and muti-lab testing of AOAC methods.
</blockquote>

New Food: How innovation has shaped dietary supplement testing for quality and compliance

How innovation has shaped dietary supplement testing for quality and compliance

The evolving landscape of dietary supplements, where industry experts will discuss standard methods, advanced analytical techniques, and quality control.

How innovation has shaped dietary supplement testing

In this webinar, Novartis will show how they are digitalizing and fully automating systems across large molecule R&amp;D. By integrating liquid handling systems, mass spectrometers, and the Genedata Biopharma platform, Novartis has implemented a ‘full-circle’ mass spectrometry (MS) workflow automation for standardized analyses. Their automated MS workflow includes analytics requests by laboratory scientists, barcoding, sample preparation, mass spectrometry, data analysis, and reporting. Automating repetitive tasks increases efficiency and allows scientists to focus on more complex projects and advanced sample analytics.Join Felix Stemmer, Senior Scientist II, and Martin Jockel, Senior Expert in Data Science, from Novartis as they illustrate how they are streamlining processes and accelerating operations.Key learning objectives<ul><li>Discover how Novartis is automating complex MS-based workflows in biopharma R&amp;D</li><li>Learn how Novartis has implemented a ‘full-circle’ MS analytics platform, integrating high quality MS data into an enterprise-level biotherapeutics discovery platform</li><li>Hear how Novartis scientists significantly increased research efficiency by using MS analytics workflows</li></ul>Who should attend?<ul><li>Biopharmaceutical analytical scientists, laboratory leaders, and directors who are looking to develop and automate MS-based analytics in biotherapeutic R&amp;D.</li><li>IT professionals, automation architects, and engineers looking to support organizational-level data platforms for digitalization of complex, multidimensional data streams in biologics discovery workflows.</li></ul>Certificate of attendanceAll webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.<blockquote>Presenter: Martin Jockel (Senior Expert I Data Science, Novartis)Martin Jockel, a bioinformatics graduate from the Technical University of Applied Sciences in Bingen, has worked for Novartis for the past 12 years. His proficiency in crafting custom software solutions has enhanced laboratories’ capabilities in data storage and visualization, leading to optimized workflows and increased efficiency.In recent years, Jockel has further broadened his scope to include lab automation, ensuring these processes are integrated into Novartis’ technical ecosystem. For the past three years, he has been contributing to the Genedata project at Novartis as a developer and as the Scrum Master for the Technical Team.Presenter: Felix Stemmer (Senior Scientist II, Novartis)Felix Stemmer has a background in bioengineering from the Karlsruhe Institute of Technology where his passion for lab automation began. Now working at Novartis, Stemmer is currently working on a collaborative project with Genedata, integrating liquid handling systems and analytical instruments into Genedata’s respective software.Before joining Novartis, Stemmer worked on a series of automation projects including miniaturizing downstream processing and CHO and HEK upstream processing, highlighting his extensive experience in automation.</blockquote>

SelectScience: Full-Circle MS Workflow Automation at Novartis

Full-Circle MS Workflow Automation at Novartis

Novartis will show how they are digitalizing and fully automating systems across large molecule R&D.

Innovating for the future with cutting-edge solutionsGiven the speed and scale of progress with Artificial Intelligence (AI) in today’s world, researchers and professionals across various scientific fields from the Danaher group of companies have stepped up in the game of AI and advanced technology to seek breakthrough solutions to age-old problems.<h3>Agenda</h3><h5>Introduction to Danaher</h5><h5>3D biology and the paradigm shift in next generation drug discovery</h5><ul><li>Presented by Molecular Device</li></ul><h5>AIVIA - introduction to AI based image analysis</h5><ul><li>Presented by Leica Microsystems</li></ul><h5>Analytical advances in the characterization of mRNA</h5><ul><li>Presented by Phenomenex</li></ul><h5>Unlocking the power of data with IDBS</h5><ul><li>Presented by IDBS</li></ul><h5>The power of AI: from planning and the lab to success in life sciences</h5><ul><li>Presented by Abcam</li></ul><h5>Practical approaches to EV characterization and purification: leveraging nano Flow Cytometry and ultracentrifugation for clinical and commercial success</h5><ul><li>Presented by Beckman Coulter Life Sciences</li></ul><h5>AI-MS/MS-AI mass spectrometry application with AI</h5><ul><li>Presented by SCIEX</li></ul><h5>Work smarter, not harder: emerging lessons on data in biopharma R&amp;D</h5><ul><li>Presented by Genedata</li></ul><h5>In silico process development with mechanistic chromatography modelling</h5><ul><li>Presented by Cytiva</li></ul><h5>CRISPR meets NGS: the powerful duo for drug discovery</h5><ul><li>Presented by IDT</li></ul><h3>Presenter:</h3><ul><li>Gokhale, Aarti Arun, Ph.D (Sr Manager, Gene Reading, APAC, IDT)</li><li>Teo Chong Kok Ph.D (Scientific Account Manager, Genedata)</li><li>Edward Lim (General Manager, SEA, Beckman Coulter Life Sciences)</li><li>Taryn Guinan, Ph.D (Sr Applications Specialist, ANZ, Leica Microsystem)</li><li>Edward Wong, Ph.D (Sr Manager, Gene Writing &amp; Editing, APAC, IDT)</li><li>Stephan Waldert, Ph.D (Director, Data Science &amp; AI, Abcam)</li><li>Manish Manakchand (Commercial Director, Asia, IDBS)</li><li>Namrata Saxena (Technical Manager, Phenomenex)</li><li>Hans Lin (Field Application &amp; Market Development Specialist, SCIEX)</li><li>Mok Wei Chuan (Go Silico Sales Specialist, APAC, Cytiva)</li><li>Minho Tak, Ph.D (Sr Application Scientist, JAPAC, Molecular Device)</li></ul>

SCIEX: AI and technology advancements from Danaher

AI and technology advancements from Danaher

In this live webinar, let’s explore how Danaher group of companies leverage AI and technologies in providing advanced solutions.

AQbD Symposium 2024 (Impact of Q14/Q2 on LC Procedures)Analytical Quality by Design (AQbD) is a science and risk-based approach to analytical procedure development that “starts with the end in mind”.The recently adopted quality guidelines Q14 and Q2(R2) leverage AQbD principles. What does that mean for the Pharma LC lab? We are joined by industry thought leaders for an engaging discussion that will encompass strategies and case studies.<p data-ccp-props="{&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559683&quot;:0,&quot;335559685&quot;:0,&quot;335559731&quot;:0,&quot;335559737&quot;:0,&quot;335562764&quot;:2,&quot;335562765&quot;:0.9,&quot;335562766&quot;:4,&quot;335562767&quot;:10,&quot;335562768&quot;:4,&quot;335562769&quot;:0}" lang="EN-US">Each session will feature a panel of forward thinking leaders on the topic who will present their recent work and participate in a round table discussion.&nbsp;<h5>Learning Objectives</h5><ul><li id="isPasted">Understand opportunities and barriers related to the implementation of Q14</li><li id="isPasted">Learn about analytical development strategies for every phase of clinical development</li><li id="isPasted">Explore case studies applying Q14 to today’s analytical challenges</li><li id="isPasted">Engage with pharma industry thought leaders</li></ul><h4>Session 1: Analytical LC Method Strategies in the Q14 Era</h4><ul><li>Tuesday, December 3, 2024 | Time: 10:00am ET | 3:00pm GMT | 4:00pm CET</li></ul>With the Q14 and Q2(R2) guidelines now adopted by FDA and EMA, there is an opportunity to rethink strategies around analytical LC procedure development. Platform analytical procedures, phase-appropriate approaches, future proofing procedures for robustness, sustainability and user-friendliness are top-of-mind topics. Our panelists will discuss opportunities and barriers in the implementation of Q14.<blockquote>Presenter: Timothy Graul, Ph.D. (Director, Global CMC Advisory Office, Pfizer, Inc.)Timothy W. Graul, Ph.D.,is a Director in the CMC Advisory Office within Pfizer at the Groton, CT site. He received his B.S. Degree in Chemistry at James Madison University and then Ph.D. in Analytical Chemistry at The Florida State University. After completing studies, Tim joined Pfizer Analytical R&amp;D and supported the development of drug product formulations and drug substance synthetic routes. During his time at Pfizer, Tim has been recognized as a leader in Quality by Design for analytical procedures. He has collaborated on publications that have been at the forefront of industry in this area. Tim served as the PhRMA Deputy Topic lead on the ICH Q2/Q14 Expert Working Group and is now an Industry Expert on the Implementation Working Group for the revised Q2 Guideline and new guideline, Q14. He has been a member of industry groups including Land O’ Lakes Pharmaceutical Analysis Conference Planning Committee and AAPS Summer Scientific Forum since 2010, IQ groups such as Analytical Leadership, AQbD, Dissolution, Control Strategy Harmonization Metrics, and Worldwide Specification Harmonization; and is the co-lead of the ISPE PQLI group on Analytical Methods. Presenter: Gerald Gellermann, Ph.D. (Associate Director Scientific Office Analytics, Technical Research and Development, Novartis)Gerald currently works as Scientific Officer at Novartis Technical Research and Development (TRD) Biologics. He is member of the Novartis ICHQ12 implementation team and leads the TRD biologics QbD and Control Strategy initiative. Prior to joining Novartis, he gained professional experience in CMC and analytical development during his time at Roche and in neuroscience research and diagnostic division at Abbott/AbbVie. Gerald holds a master’s degree in biology from the University of Constance and a PhD in Molecular Biology from the University of Jena (both Germany). Gerald also represents Novartis in the industry consortia workstreams supporting ICH Q2(R2) and ICH Q14. Presenter: Andrea Gheduzzi (Principal LC Market Dev. Manager, EMEA, Waters Corporation)Andrea Gheduzzi, is a principal LC market development manager for EMEA at Waters Corporation. Andrea Gheduzzi has spent more than 30 years in the chromatography field. Across his career he had various roles, service engineer, chromatography lab manager position, and technical manager for chromatography columns.He has mainly been dealing with pharma accounts, also supporting LC method development activities using DoE/QbD approaches. In his previous role as Pharma Business Development Manager at Waters he has further expanded his expertise in AQbD and related applications.Since 2023 he became principal LC market development manager for EMEA and member of the AQbD working party at the EDQM. Moderated by: Isabelle Vu Trieu (Pharmaceutical Market Development Manager, Americas, Waters Corporation)Isabelle is a business development professional dedicated to delivering benefits to analytical scientists in the life sciences industry. With over 20 years of experience in providing chromatography and mass spectrometry solutions, Isabelle is particularly interested in helping pharmaceutical scientists achieve the data quality and integrity needed to drive decisions for drug quality, safety and efficacy. Isabelle joined Waters in 2009 and currently manages the development of the pharmaceutical market in the Americas. She holds Masters’ degrees in Chemistry from Columbia University and the University Claude Bernard in Lyon, France as well as a Chemical Engineering degree from Ecole Supérieure de Chimie Physique Electronique in Lyon, France. &nbsp;</blockquote>

Waters Corporation: AQbD Symposium 2024 Analytical Quality by Design

AQbD Symposium - Day 1 - Analytical LC Method Strategies in the Q14 Era

Our panelists will discuss opportunities and barriers in the implementation of Q14.

AQbD: Analytical LC Method Strategies in the Q14 Era

In this educational back-to-school webinar, James Grinias (University of Rowan) and Frank Steiner (Thermo Scientific) discuss strategic approaches for development, optimization and transfer of legacy and modern HPLC methods, utilizing gradient elution.Discussion topics and data on how to more easily move to core-shell column technology, how to modify gradient methods effectively, and how to work within the framework of evolving rules for method transfer such as USP 621.We also discuss using the right tool to reduce the impact of method transfer across HPLC platforms. &nbsp;Key learning objectives:<ul><li>&nbsp;Understanding gradient-based LC separations</li><li>Scalable parameters in pharmacopeia method modernization</li><li>&nbsp;Tricks and tips on method development and transfer</li></ul>If you are unable to attend, please register to ensure you will receive the link to the recording.<blockquote>Presenter: James Grinias (Associate Professor, Department of Chemistry &amp; Biochemistry, Rowan University)James P. Grinias, Associate Professor, Rowan University, teaches analytical and bioanalytical chemistry. His research focuses on UHPLC columns and instrument miniaturization. His work has been recognized with recognition from the American Chemical Society Subdivision on Chromatography and Separations Chemistry, LCGC magazine, and The Analytical Scientist magazine. Presenter: Frank Steiner (Sr. Manager of Product Applications and Scientific Advisor, Chromatography and Mass Spectrometry, Analytical Instrument, Thermo Fisher Scientific)Dr. Frank Steiner is Sr. Manager of Product Applications and Scientific Advisor in the HPLC organization of Thermo Fisher Scientific and coordinates scientific collaborations with external partners to advance UHPLC technologies and applications.</blockquote>

Thermo Fisher Scientific: The real impact of HPLC and column parameters

The real impact of HPLC and column parameters

We will discuss strategic approaches for development, optimization and transfer of legacy and modern HPLC methods, utilizing gradient elution.

The research team successfully generated and analyzed proteomics and metabolomics data, sharing these with the scientific community. They developed statistical workflows for single and multi-omics levels, enabling biological interpretation by combining these modalities. Despite the limitation of using only 42 animals, they emphasized the need for more subjects for better cross-validation of predictors and classifiers. Future applications could involve other knockout mice, focusing on specific questions regarding liver or plasma and extending the workflow to larger scales, including mutants, mouse models, or cells.&nbsp;The team published both raw and processed data, along with the code, as part of a premises package. They conducted hypothesis testing to identify significant features in the data sets, finding valuable information at the molecular level. They compared annotated and non-annotated metabolomics data, finding little performance difference, indicating additional information from non-annotated metabolites isn't crucial for prediction.&nbsp;Biological pathway analysis revealed significant impacts on protein synthesis and ribosomes in the liver. The team also explored various classifiers for genotype prediction, noting good predictive performance except in preclinical plasma data, underscoring the value of molecular-level studies.&nbsp;Learning points:<ul><li id="isPasted">Importance of Molecular-Level Analysis&nbsp;</li><li>Effective Data Sharing and Workflow Development &nbsp;</li><li>Challenges and Future Directions &nbsp;</li></ul>Who should attend:<ul><li>Researchers and professionals in the fields of proteomics, genomics, and molecular biology, specifically those involved in the study of knockout mice, biomarker discovery, and the development of statistical workflows for multi-omics data analysis.</li><li>Bioinformaticians, computational biologists, and those working on the integration and interpretation of complex biological data sets.</li></ul><blockquote>Presenter: Etienne Thevenot (CEA Saclay)</blockquote>

Thermo Fisher Scientific: Complementarity between proteomics and metabolomics

Complementarity between proteomics and metabolomics

Statistical workflows for single and multi-omics levels, enabling biological interpretation by combining these modalities.

<div>Join us for the first-ever Semicon e-Symposium, a one-day virtual event featuring expert discussions on crucial topics in the semiconductor industry, including yield improvement, sustainability, PFAS analysis, and advanced analytical techniques.Here’s why you don’t want to miss this:<ul><li>Discover how leading-edge analytical solutions are driving innovation, featuring a plenary talk by Dr. Stefanie Fingerhut from Merck KGaA on transforming semiconductor materials for mobile technology.</li><li>Explore key advancements in vacuum technology and regulatory updates.</li><li>Gain actionable insights from experts in GC-ICP-MS, UV-Vis spectroscopy, and a special talk by Inès Tendero from Technic France on the analysis of silicon in high-purity matrices.</li></ul>This is a must-attend event for anyone looking to stay informed on key trends and cutting-edge advancements in semiconductor manufacturing. Don’t miss out—register today!<h4>Agenda</h4>8:30 a.m. How Analytical Techniques Contribute to Yield Improvement and Environmental Sustainability in the Semiconductor Industry<ul><li>Gernot Hudin, Agilent Technologies</li></ul>9:00 a.m. Plenary Talk: The Hidden Connection: Merck's Advanced Analytical Techniques Transforming Semiconductor Materials for Mobile Technology<ul><li>Dr. Stefanie Fingerhut, Merck KGaA</li></ul>9:45 a.m. Agilent ICP-MS Supplies Selection Tips for the Semiconductor Industry&nbsp;<ul><li>Alain Desprez, Agilent Technologies</li></ul>10:00 a.m. PFAS 'Forever Chemicals'—Forever a Problem?<ul><li>Shifen Xu, Agilent Technologies</li></ul>10:30 a.m. Quantitative Workflow for the Analysis of PFAS in Semiconductor Lubricant with LC-MS (Q-TOF)<ul><li>Peter Kornas, Agilent Technologies</li></ul>11:00 a.m. Agilent Vacuum in Semiconductor Market<ul><li>Fabio Ardissone, Agilent Technologies</li></ul>11:30 a.m. GC, GC/MS, and GC-ICP-MS in Semiconductor: What, Why, and How?<ul><li>Stephane Decouflet, Agilent Technologies</li></ul>12:00 p.m. Lunch break1:00 p.m. Semiconductor Application of Single Particle ICP-MS<ul><li>Yoshinori Shimamura, Agilent Technologies</li></ul>1:30 p.m. Is It Possible to Identify Organic Solvents by ICP-MS?<ul><li>Katsuo Mizobuchi, Agilent Technologies</li></ul>2:00 p.m. Special talk: Analysis of Si in High-Purity Matrix for Semiconductor Application&nbsp;<ul><li>Inès Tendero, Technic France</li></ul>2:30 p.m. Measuring the Band Gap Energy Using UV-Vis Spectroscopy<ul><li>Marcus Schulz, Agilent Technologies</li></ul>2:45 p.m. Recap—closing session<ul><li>Gernot Hudin, Agilent Technologies</li></ul></div>

Semicon e-Symposium 2024

Expert discussions on crucial topics in the semiconductor industry.

Viral vectors continue to be critical in the development of new gene and cell therapies. However, in-depth characterization of these complex systems remains a challenge throughout the development and manufacturing process. Developing robust analytical methodologies to characterize multiple critical quality attributes (CQAs) for large heterogeneous viral vector systems can be challenging.In this webinar, we will discuss how to implement high throughput dynamic light scattering (DLS) and electrophoretic lights scattering (ELS) workflows initial screening, along with and multi-angle light scattering combined with size exclusion chromatography (SEC-MALS) or field-flow fractionation (FFF-MALS) for in-depth simultaneous multiple CQA characterization of AAV, LV, and other gene delivery vectors. Additionally, we will explore how to implement light scattering into bioprocess unit operations for real-time CQA analysis. The CQAs for these techniques include size, size distribution, aggregation, concentration, stability, and capsid content.Key Learning Objectives:<ul><li>How DLS/ELS rapidly characterizes size distribution, aggregation, particle concentration, and stability in a high-throughput workflow.</li><li>How SEC/FFF-MALS characterized heterogeneous samples for high resolution size distribution, payload, titer, and aggregation.</li><li>How real time MALS characterizes and quantifies viral vectors (e.g. AAV, LV) for titer, payload, stability, and purity during TFF, AEX, and other bioprocess unit operations.</li></ul>Who Should Attend:<ul><li>Scientists working in the field of gene therapy characterization, formulation, and process development.</li><li>Casual learner looking to understand more about gene therapy and light scattering solutions.</li><li>Lab Managers who want to learn about state-of-the-art instruments that enhance their lab's analytical capabilities.</li></ul><blockquote>Presenter: Parker Lee, Ph.D. (Waters | Wyatt Technology)Dr. Parker Lee joined Wyatt Technology in 2022 after 5 years of work in macromolecule analytical development for various startups. As a field application scientist he is responsible for working with customers to ensure that they can utilize Wyatt’s light scattering instrumentation most effectively to improve and accelerate their research. &nbsp;</blockquote>

Waters: Robust and high-resolution characterization of viral vector quality from development to release with light scattering techniques

Robust and high-resolution characterization of viral vector quality from development to release with light scattering techniques

We will discuss how to implement high throughput dynamic light scattering (DLS) and electrophoretic light scattering (ELS) workflows in initial screening.

Characterization of viral vector with light scattering

Join Dr. Katie Horton, medical science liaison specialist – EXENT and Dr. Mark Perkins, senior manager, portfolio lifecycle – EXENT, The Binding Site, as they discuss the development and performance of the EXENT® System, a clinical mass spectrometry solution for monoclonal gammopathy assessment.The EXENT System is an automated solution that enables M-protein identification and measurement in serum with enhanced sensitivity beyond conventional methods.The system combines&nbsp;the EXENT&nbsp;Analyzer&nbsp;with the EXENT GAM Assay to&nbsp;provide a fully automated solution&nbsp;to isotype, quantify and track monoclonal&nbsp;proteins throughout the patient journey.​Key learning objectives<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Understand the role of mass spectrometry (MS) in monoclonal protein testing</li><li style="tab-stops:list 36.0pt;">Explore the analytical performance of the EXENT System using MALDI-ToF MS technology</li><li style="tab-stops:list 36.0pt;">Understand the potential clinical impact of mass spectrometry for patients with monoclonal gammopathies</li></ul>Who should attend?Laboratory professionals, hematologists, and primary care professionals who would like to learn more about the latest innovation for monoclonal gammopathy assessment.Certificate of attendance All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes. The EXENT Analyser and Immunoglobulin Isotypes (GAM) for EXENT Analyser are only commercially available in Australia, New Zealand, United Kingdom, Switzerland and the EEA. The products are not commercially available in the USA or China, future commercial availability cannot be guaranteed.Product availability is subject to country specific regulatory requirements. Contact your local representative for availability in your country.<blockquote>Presenter: Dr. Mark Perkins (Senior Manager, Portfolio Lifecycle - EXENT, The Binding Site, part of Thermo Fisher Scientific)Dr. Mark Perkins has over 20 years of experience in the life science and diagnostic industry. He led the team responsible for the design and development of the EXENT solution and currently manages the team responsible for clinical and education evidence generation for the EXENT System.Presenter: Dr Katie Horton (Medical Science Liaison - EXENT, The Binding Site, part of Thermo Fisher Scientific)Dr. Katie Horton has over five years’ experience working in a UK National Health Service (NHS) diagnostic clinic. She now works as a medical science liaison specialist using her mass spectrometry and clinical diagnostics expertise to help drive forward the clinical evidence generation and educational initiatives for the EXENT System.</blockquote>

SelectScience: Transforming M-protein diagnostics with mass spectrometry using the EXENT® System

Transforming M-protein diagnostics with mass spectrometry using the EXENT® System

Join us as we discuss the development and performance of the EXENT® System, a clinical mass spectrometry solution for monoclonal gammopathy assessment.

M-protein diagnostics with MS using the EXENT®

The analysis of biomolecules, with the development of increasingly complex products and the rise in regulatory requirements, is challenging.Our expertise in chromatography, mass spectrometry, and data analysis allows us to combine the most advanced technologies to offer solutions that meet your needs regarding:<ul style="list-style-type:disc;margin-top:0in;" type="disc"><li style="color:rgb(0, 0, 0);">Quality and reliability of your results</li><li style="color:rgb(0, 0, 0);">Productivity</li><li style="color:rgb(0, 0, 0);">Ease of use</li><li style="color:rgb(0, 0, 0);">Compliance with regulatory agency standards</li></ul>In this seminar, we will present some of the&nbsp;most recent and relevant applications in the analysis, quantification, and characterization of biomolecules&nbsp;such as proteins, RNA, peptides, oligonucleotides, nucleic acids, viral vectors, lipid nanoparticles, glycans, or amino acids.Join us to discover how our analytical solutions can help you overcome current and future challenges in the field of biomolecule analysis.<div><div><div dir=""><div><blockquote><div>Presenter: Ben Wilkes (Principal Biologics Market Development Manager, Waters)</div></blockquote></div></div></div><div><blockquote>Since 2022, Ben Wilkes is a Principal Biologics Market Development Manager at Waters where he connects biotech companies with enabling analytical technologies, focusing on liquid chromatography and mass spectrometry. Prior to Waters, Ben worked at Lonza Biologics from 2015 to 2022 as an analytical R&amp;D scientist, supporting all aspects of a products lifecycle with novel analytical methods. He also previously worked at Abzena and Sanofi-Genzyme after graduating from the University of Manchester in 2012Presenter: Alberto Méndez (Chat) (MS Specialist, Spain and Portugal, Waters)Presenter: Pablo de la Iglesia (Chat) (MS Specialist, Spain, Waters)</blockquote></div></div>

Waters Corporation: Advanced Analytical Solutions for Biomolecule Analysis

Advanced Analytical Solutions for Biomolecule Analysis

We will present some of the most recent and relevant applications in the analysis, quantification, and characterization of biomolecules.