Meeting EU Drinking Water Standards: The Critical Role of Sample Prep in Trace Contaminant Analysis

Although modern agriculture needs to be based on accurate real-time data on soil, plant, and environmental conditions, affordable, sufficiently sensitive, and robust monitoring devices for this purpose are currently missing. According to scientists, low-cost sensors based on new smart materials and printing technologies offer a suitable solution. The results of multidisciplinary research thus far and proposals for the development of these devices have been presented by researchers from Czechia, Great Britain, Spain, and the USA in a review article in the prestigious journal <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1">Nature Communications</a>.“Sensor technologies for monitoring plant health are still in their infancy. Only simple sensors capable of monitoring basic parameters such as pH, soil moisture, or temperature are commonly available on the market. However, if farmers are to face current challenges, including climate change, and ensure sufficient food for humanity, they need much more effective tools that will enable them to monitor, for example, various pathogens, including bacteria and fungi. In our opinion, a suitable solution is a combination of new smart materials and printing for the production of inexpensive, durable, and scalable materials,” said the article’s first author, David Panáček from CATRIN, who worked on the study during his internship at Imperial College London.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152">Sensors for monitoring plant health, for example, lag behind similar devices used in human medicine. According to the authors, advances in materials science, which will enable the development of scalable sensor technologies, play a key role in this potential shift. “Printing techniques, including inkjet printing, screen printing, aerosol printing, 3D printing, and direct laser writing, offer flexible ways to produce flexible sensors, large-area sensors, and sensors integrated directly into plants. The review article summarizes recent advances in printable low-dimensional materials for agricultural sensors, analyzes their physico-chemical properties in relation to sensor performance, and discusses key challenges and future opportunities requiring interdisciplinary integration,” said one of the corresponding authors, Michal Otyepka.The research brought together materials scientists, chemists, biologists, sensing experts, and printing technology specialists. Materials research and the use of graphene-based smart materials were led by scientists from CATRIN at Palacký University and VŠB-Technical University of Ostrava. Plant biologists from CATRIN contributed their knowledge of plant development, their responses to stress conditions, and the monitoring of their properties. Researchers from Imperial College London took care of the electronics, while representatives from<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/36"> CEITEC – VUT</a> focused on printing technologies. The team also included leading experts in sensing from the Catalan Institute of Nanoscience and Nanotechnology in Barcelona, and Joseph Wang of the University of California San Diego, the “father of sensing and electrochemistry,” also contributed his extensive knowledge.“This is a groundbreaking study on this topic, which has managed to attract some truly big names in their respective fields. Last but not least, the study demonstrates that interdisciplinarity at CATRIN gives rise to completely new and promising research topics, such as plant sensing and its use for studying plant-environment interactions and smart agriculture,” added another corresponding author, Nuria De Diego.

Current sensors are not good enough. Scientists propose a new way to monitor plant health

In this episode of the Concentrating on Chromatography podcast, host David Oliva interviews Ainslie Chen about her cutting-edge research on hemoglobin variant testing using liquid chromatography-high resolution mass spectrometry (LC-HR-MS). Ainslie discusses her novel method for separating and identifying hemoglobin subunits with mass shifts less than 1 Da, overcoming critical limitations in conventional clinical assays.Hear firsthand how her team developed an LC-HR-MS workflow using a C4 reversed-phase column, tackled technical challenges (including why C18 columns fell short), and achieved unprecedented sensitivity for variant detection in both adult and neonatal samples. The conversation touches on the potential of mass spectrometry to revolutionize clinical diagnostics, the importance of reproducibility, barriers to adoption in routine labs, and how teamwork drives scientific innovation.Perfect for analytical chemists, clinical laboratorians, and anyone interested in the future of protein variant analysis, this episode also features Ainslie’s advice for early-career scientists and insights from her first ACS poster presentation.<h4>Key Highlights:</h4><ul><li>Motivation behind improving hemoglobinopathy testing &nbsp;</li><li>Technical advantages of LC-HR-MS over gene sequencing and CE &nbsp;</li><li>The crucial role of the C4 column in resolving challenging samples &nbsp;</li><li>Critical parameters for reproducible LC-HR-MS workflows &nbsp;</li><li>Barriers and outlook for clinical adoption of advanced mass spectrometry &nbsp;</li><li>The value of teamwork and mentorship in scientific research &nbsp;</li><li>Direct insights from recent ACS conference experiences</li></ul><h3>Video transcription</h3>In this interview, Ainslie Chen discusses her research on improving the detection and identification of hemoglobin variants using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). The work addresses limitations of conventional hemoglobinopathy testing, which often struggles to resolve very small mass differences between closely related hemoglobin subunits. Because even a single amino-acid substitution can significantly alter hemoglobin structure and function, high analytical resolution is essential for accurate diagnosis of conditions such as anemia and sickle cell disease.Chen explains why her team selected LC-HRMS over established clinical techniques like capillary electrophoresis and gene sequencing. While sequencing offers excellent accuracy, it is time-consuming, costly, and requires extensive sample preparation, making it impractical for routine clinical workflows. Capillary electrophoresis enables subunit separation but lacks the resolving power needed to distinguish variants differing by less than one Dalton. In contrast, high-resolution mass spectrometry provides both structural specificity and sensitivity, enabling confident identification of subtle hemoglobin variants with minimal sample preparation.A key methodological insight from the project was the use of a C4 reversed-phase LC column instead of the more common C18 column. Chen describes how the shorter carbon chain and larger pore size of C4 columns improved protein elution and reduced denaturation, leading to more reproducible separations. Critical parameters for reproducibility included consistent mobile-phase composition (0.1% formic acid in water and acetonitrile), controlled temperature (60 °C for LC, ~320 °C capillary temperature), and stable chromatographic conditions.Beyond hemoglobin analysis, Chen highlights the broader potential of high-resolution mass spectrometry in proteoform analysis and clinical diagnostics, including emerging applications in cancer detection. She acknowledges current barriers to clinical adoption—such as energy demands and instrument infrastructure—but points to advances like miniaturized mass spectrometers as promising steps toward wider use. The interview concludes with advice for young scientists: don’t hesitate to reach out to mentors, embrace collaboration, and view analytical chemistry as a versatile tool that bridges medicine, biology, environmental science, and beyond.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Unlocking Hemoglobin Variant Detection: LC-HR-MS Breakthrough with Ainslie Chen

Article

Video

Environment

Scientific article

Interview

Science and research

The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Metrohm

Mettler-Toledo

Unchained Labs

Phenomenex

Thermo Fisher Scientific

Shimadzu Corporation

Waters Corporation

<ul>
<li>Learn the various optical performance parameters</li>
<li>Learn which parameters need to be monitored</li>
<li>Benefits of automated performance qualification</li>
<li>Solution for data integrity compliance in optical instrument qualification</li>
<li>Overview of available service offerings from METTLER TOLEDO</li>
</ul>
During the webinar, we will go into depth about these questions and more:
<h5>What certified reference materials (CRMs) are specified for wavelength accuracy and precision tests by both Pharmacopeias?</h5>
USP: Rare earth oxide solutions/glasses (Ce, Ho, Didymium) or Hg/D2 emission lines
Ph. Eur.: Ho(ClO4)3, Ce2(SO4)3 solutions, or Ho/Didymium glasses, or Hg, D2, Ne, Xe lines
<h5>What CRMs are specified for photometric accuracy and precision tests by both Pharmacopeias?</h5>
USP: for UV range, Nicotinic acid in HCl (6 – 60 mg/L, up to 2.5 A, 213 and 261 nm) or K2Cr2O7 in HClO4 (6 – 200 mg/L, up to 3.0 A, 235, 257, 313, 350 nm); for visible range, neutral density glass filters (up to 3.5 A, 440, 465, 546.1, 590, and 635 nm)
Ph. Eur.: Suitable solid and liquid filters such as certified PDC or neutral density filters; or, instead of certified PDC, Nicotinic acid in HCl.
<h5>What CRMs are specified for photometric linearity tests by both Pharmacopeias?</h5>
USP and Ph. Eur., respectively, specify to use the materials for photometric accuracy tests also for photometric linearity tests.
<h5>Target Audience</h5>
Lab Managers, Lab Technicians, System Owners, Quality Assurance Managers, Quality Assurance Operators
<blockquote>
Presenter: Dr. Fabian Müller (Product Manager SPG UV/VIS)
</blockquote>
<blockquote>
Presenter: Dr. Hans-Joachim Muhr (Business Development Manager BioTech)
</blockquote>

METTLER TOLEDO: Pharmacopeia – What to Check on UV Vis Spectrophotometers? 

Pharmacopeia – What to Check on UV Vis Spectrophotometers? 

USP and Ph. Eur. Requirements Placed on UV/Vis Spectrophotometers

Pharmacopeia – What to Check on UV Vis Spectrophotometers?

Learn how Light Scattering can benefit your drug development!
The scientific community aims to enhance transparency and reliability in published research, with a specific focus on the quality of biological reagents, notably recombinant proteins. Concerns have been raised regarding irreproducible results, prompting discussions on common quality issues associated with recombinant proteins and their impact on downstream applications. In response, professionals in protein purification and characterization have collaboratively developed guidelines for improved quality control.
These guidelines include minimal information requirements for protein identity, production parameters, and long-term stability, as well as a minimal set of quality tests for purity, homogeneity, and identity. Additional recommendations cover DNA contamination, “spectral and thermal denaturation signatures”, homogeneity, “competent fraction”, storage conditions, batch-to-batch reproducibility, and other factors based on intended applications. 
Evaluation of these guidelines over a one-year period suggests that their implementation can enhance experimental reliability and optimize protein quality. Investing in protein QC benefits all stakeholders in life sciences, including researchers, editors, and funding agencies, by improving data accuracy and minimizing resource wastage
Key learning topics:
<ul>
<li>The latest guidelines for Quality control of Protein purification and characterisation 
</li>
<li>How these guidelines can enhance reliability and improve protein quality in your labs
</li>
<li>How to reduce wastage and improve data accuracy in protein quality control
</li>
</ul>
Who should attend?
<ul>
<li>Lab Managers and Scientists working in upstream recombinant protein production and QC
</li>
<li>Lab Managers and Scientists working in downstream protein purification QC
</li>
</ul>
<blockquote>
Presenter: Dr. André Matagne (Full Professor, University of Liège, Belgium)
</blockquote>
<blockquote>
Dr. Matange is a Full Professor at the University of Liège, Belgium, where he is the chair at the Centre for Protein Engineering within the Faculty of Sciences.
</blockquote>
<blockquote>
With a background in biochemistry, his research is primarily focused on proteins, particularly exploring their folding, stability, and biological activity. Notably, he has played a pivotal role in the development of Robotein®, an advanced technological platform designed for to high throughput protein expression, purification, formulation, and analysis.
</blockquote>
<blockquote>
Since 2016, Dr.Matagnehas been honored as an elected titular member of the Royal Academy of Sciences in Belgium.
</blockquote>

Waters Corporation: Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Learn how Light Scattering can benefit your drug development.

Quality Control of Purified Proteins to Improve Research

Karl Fischer (KF) titration is renowned for its rapid and precise measurement of water content in a wide variety of samples.
Understanding the factors that can impact the accuracy of your Karl Fischer titration process is crucial for ensuring optimal results.
Join us for an in-depth webinar that will delve into the critical factors affecting the Karl Fischer titration process and provide a comprehensive overview from start to finish. Participants will gain insights into essential procedures such as titer determination and explore critical applications.
This session is designed to enhance your understanding and improve the precision of your titration techniques.
<h4>Program Overview</h4>
<ul>
<li>Exploring the Components of a Volumetric Karl Fischer Titration Apparatus: Gain a detailed understanding of each element in the apparatus to enhance your practical knowledge.
</li>
<li>Introduction to Karl Fischer Reagents &amp; Standards: Familiarize yourself with the variety of reagents &amp; standards used in Karl Fischer titration and their specific applications.
</li>
<li>The Importance of Titer Determination: Learn why accurate titer determination is crucial for reliable results and discover the best practices for conducting it effectively.
</li>
<li>Analyzing Challenging Samples: Delve into practical examples that demonstrate how to handle and accurately analyze complex samples.
</li>
<li>Innovations in Titration Technology: Learn about our advanced titration technology that utilizes SmartChemicals to seamlessly transfer data to the Karl Fischer titrator.
</li>
</ul>
<blockquote>
Presenter: Bettina Straub-Jubb (Global Product Manager, Karl Fischer Titration at the Life Science Business of Merck KGaA, Darmstadt, Germany)
</blockquote>
<blockquote>
Bettina is the Global Product Manager for Karl Fischer titration and general titration within the Analytical Essentials team at Merck KGaA, Darmstadt, Germany. She has over 20 years of experience in various facets of titration, including Karl Fischer titration, instrumental analysis reagents, and reference materials, contributing significant expertise to her position. Bettina is deeply familiar with all steps of the titration process and collaborates closely with the application laboratories and R&amp;D department to continually enhance titration methodologies. She holds a degree in Chemical Technology from the Darmstadt University of Applied Sciences, Germany, and completed an apprenticeship as a medical technical laboratory assistant at the Medical Technical Academy in Esslingen, Germany.
</blockquote>
<blockquote>
Presenter: Thomas Hitz (Application Chemist, METTLER TOLEDO)
</blockquote>
<blockquote>
Thomas currently serves as a technical advisor for product development at METTLER TOLEDO, Nänikon, Switzerland. With over 15 years of experience in application development, sales, and customer training, he provides expert support for complex automation solutions in both general and Karl Fischer titration. He holds a degree in biochemistry from the University of Zürich and completed his PhD in 2003 at the Swiss Federal Institute of Technology Zurich in the Department of Material Sciences.
</blockquote>

Mettler Toledo: Optimize Your Volumetric Karl Fischer Titration

Optimize Your Volumetric Karl Fischer Titration

Critical factors affecting the Karl Fischer titration process and a comprehensive overview from start to finish.

Understanding and measuring pH accurately is crucial in both chemical and biological contexts, affecting a range of applications.
For example, in lithium batteries, precise pH control optimizes its performance and ensures safety. In paint, it determines the color consistency, stability, and product longevity. Similarly, in plant-based proteins, pH influences protein extraction and quality, affecting texture and nutritional value. However, the complex matrices and diverse physical properties of these samples often interfere with pH measurements, posing significant challenges.
Join our webinar to learn how to overcome these challenges and optimize your pH measurement results in both chemical and biological samples. Let our experts guide you through advanced techniques, best practices, and practical solutions tailored to different applications.
<h4>Program Overview</h4>
<ul>
<li>Introduction to pH measurement: Learn about the importance of pH accuracy in fields like chemistry and biology.
</li>
<li>pH in chemicals: Discover how precise pH monitoring ensures chemical stability, reactivity, and shelf life. Learn tips for managing pH-dependent chemical processes for optimal results.
</li>
<li>pH in biological samples: Explore the critical role of pH in physiological functions, enzyme activity, and disease diagnosis.
</li>
<li>Techniques and best practices: Discuss pH measurement techniques, calibration, buffers, and overcoming common challenges.
</li>
<li>Interactive Q&amp;A session
</li>
</ul>
<blockquote>
Presenter: Dr Reena Mascarenhas
</blockquote>
<blockquote>
Dr. Reena is a seasoned electrochemist with over 5 years of dedicated experience at METTLER TOLEDO. Her in-depth knowledge and expertise in the field have made her a sought-after speaker for live webinars. With a strong academic foundation and a passion for electrochemical advancements, Dr. Reena is committed to sharing her insights and contributing to the growth of the scientific community.
</blockquote>

Mettler Toledo: How to Measure pH in Chemicals and Biological Samples

How to Measure pH in Chemicals and Biological Samples

How to overcome these challenges and optimize your pH measurement results in both chemical and biological samples.

Analytical testing in process development for protein therapeutics is demanding for several reasons: large number of samples, tedious and labor-intensive sample prep, and relative long analysis time for LC-MS.
Bioreactor samples also require careful preparation to enable high quality and sensitive profiling of critical quality attributes (CQAs), especially for low level post translational modifications (PTMs). 
In this webinar, we present automated workflows that encompass simplified sample prep (Protein A purification, and/or mAb subunit digestion) to rapid LC-MS analysis through data processing. We share application examples of LC-MS subunit analysis using the Genovis FabRICATOR® (IdeS) enzyme to compare CQAs of biosimilars and innovator mAbs:
<ul>
<li>Automated mAbs CQA assessment of cell culture samples - intact mass analysis and subunit analysis (presented by Andreas Nageli, Genovis)
</li>
<li>**Automated mAbs CQA assessment comparing Biosimilars vs Innovator - Subunit analysis for glycan profile and for modification of unpaired cystines (CQA) with samples from clone selection and from downstream processing (a Similis Bio-Waters Collaboration)
</li>
</ul>
You will learn from this webinar how to make your analytics higher throughput, with less human intervention, all while providing high quality, sensitive and specific characterization data, ultimately leading to better, faster decision making.**
Secure your spot to see the reveal of the latest version of the Waters Bioprocessing Walk-up Solutions. Be the first to learn how Waters is enabling bioprocess teams to acquire high quality LC-MS analytics through better automation at the point of need.
<blockquote>
Presenter: Samantha Ippoliti (Principal Scientist, Discovery &amp; Development- Biopharma, Waters Corporation)
</blockquote>
<blockquote>
Samantha (Sam) joined Waters (Milford, MA) in 2018 and has worked on a variety of applications for LC-MS based biopharmaceutical characterization, including peptide mapping analysis and method development, and intact/subunit analysis via reversed phase (RP) and ion exchange (IEX) -MS. Sam has experience with analysis using BioAccord, Xevo series, Synapt XS, and Cyclic IMS LC-MS instruments. Prior to joining Waters, she was part of the LC-MS characterization group supporting a biopharmaceutical developability assessment group at Novartis in Cambridge, MA. (Sam acquired a BS-MS in Chemistry from Northeastern University in 2012.)
</blockquote>
<blockquote>
Presenter: Andreas Nageli, PhD (Principal Scientist, Genovis)
</blockquote>
<blockquote>
Andreas joined Genovis in 2018. As Principal Scientist he is involved in the development of new SmartEnzyme products and applications as well as supporting customers in introducing Genovis SmartEnzymes into their assays. Andreas also heads business development at Genovis. He holds a PhD in microbiology from ETH in Zurich, Switzerland.
</blockquote>

Waters Corporation: Automated LC-MS Workflow for CQA Assessment of Protein Therapeutics with Speed and Simplicity for Process Development

Automated LC-MS Workflow for CQA Assessment of Protein Therapeutics with Speed and Simplicity for Process Development

Automated workflows that encompass simplified sample prep to rapid LC-MS analysis through data processing.

Automated LC-MS Workflow for CQA Assessment of Protein

Today, tomorrow, and forever – PFAS, the “forever chemical”, have emerged as one of the greatest public health concerns of our time, infiltrating our environment and food supply. Herein, join us on Digital Classrooms for an in-depth exploration of PFAS, tracing their origins in everyday consumer products and examining their potential health implications.Our experts, Dr Yap Siew Qi and Elton Goh, will guide you through this critical topic, exploring the regulatory landscape with insights into EFSA and FDA guidelines. They will also introduce Shimadzu's innovative LC-MS/MS solutions, featuring the latest LCMS-TQ RX series. Discover how their robustness, sensitivity, and accuracy can enable effective detection of PFAS in complex food and environmental samples.Let’s work together to overcome global PFAS challenges. Register now to stay informed on this pressing issue!<h5>Learning Objectives:</h5><ul><li>Understand the implications of PFAS presence in food and environment &nbsp;</li><li>Navigate the evolving regulatory landscape for PFAS &nbsp;</li><li>Discover the capabilities of Shimadzu LCMS-TQ RX to detect PFAS in food and environmental samples</li></ul><blockquote>Presenter: Goh Wan Yu Elton (Market Specialist Food, Shimadzu (Asia Pacific) Pte Ltd)Elton is a dedicated and experienced Food Market Specialist at Shimadzu, bringing over nine years of expertise in food safety and analytical chemistry to his role. His career began at the Singapore Food Regulatory Board, where he spent seven years honing his skills and developing a profound understanding of regulatory standards and testing protocols. With a passion for knowledge and innovation, Elton transitioned to the private sector, contributing significantly to the advancement of analytical techniques and the development of novel food safety solutions during his two-year tenure at a research and development centre.Now at Shimadzu, Elton continues to excel, leveraging his expertise to develop cutting-edge analytical methods for detecting and quantifying various compounds in food products. His commitment to food science is evident in his efforts to enhance safety standards, build consumer trust, and make meaningful contributions to the global food industry.Presenter:&nbsp;Yap Siew Qi (LCMS Product Specialist, Shimadzu (Asia Pacific) Pte Ltd)Yap Siew Qi is an experienced professional in analytical chemistry, with a strong focus on liquid chromatography-mass spectrometry (LCMS). Her career commenced as a Research Assistant at the NUS Life Sciences Institute, where she acquired substantial experience in scientific research and laboratory techniques. This role was pivotal in developing her comprehensive understanding of life sciences, setting the stage for her future contributions to analytical chemistry and instrumentation.In 2022, her journey continued at Shimadzu (Asia Pacific), where she joined as an Application Chemist, focusing on LC/LCMS. In this capacity, she refined her expertise in LCMS technology, delivering prompt application support and technical solutions for the customers. Her exceptional skills and knowledge in LCMS soon led to her advancement to the position of Product Specialist. In this role, she continues to provide specialized knowledge and support, demonstrating her dedication to the progression of analytical chemistry and her proficiency in applying innovative technology within the field.Presenter:&nbsp;Mr. Ramaswamy Parthiban (Assistant Vice President, TUV SUD South Asia)Mr. R Parthiban has a robust background in operations management and quality assurance within the testing, inspection, and certification industry. He currently serves as AVP at TUV SUD South Asia, a position he has held since March 2022. Prior to this, he was the National Head at Prime Certification &amp; Inspection from April 2020 to June 2021. His experience also includes a significant role as Director of Operations at ALS Testing Services India Pvt Ltd from July 2018 to March 2020, where he led strategic initiatives and operational excellence.Earlier in his career, Mr. Parthiban held leadership roles including VP Operations at Merieux NutriSciences and Laboratory Manager for Chemistry at Exova Bahrain/KSA. His extensive experience in the industry is complemented by his earlier positions as Senior Manager at Coca-Cola and Laboratory Manager at SGS India Private Ltd. He began his career as a Research Associate at the John F. Welch Technology Center and ITC R&amp;D Center, eventually progressing to an Executive role in Quality Assurance at Sanmar Speciality Chemicals Ltd. Mr. Parthiban's career is marked by his expertise in quality systems, operational management, and strategic leadership in both national and international contexts.</blockquote>

Shimadzu: Discover The Latest LC-MS/MS Innovations For PFAS Challenges

Discover The Latest LC-MS/MS Innovations For PFAS Challenges

Discover how their robustness, sensitivity, and accuracy can enable effective detection of PFAS in complex food and environmental samples.

Supercritical Fluid Chromatography (SFC), a chromatographic technique using a supercritical CO2 mobile phase, has been known for decades but was seldom used due to the popularity of normal and reverse phase liquid chromatography.Several years ago, SFC found a niche in chiral resolution when it was found that the physical characteristics of supercritical fluids can offer unique separations when compared to traditional liquid chromatography methods. Since then, these unique separations and “greener” aspect of CO2 have sparked new interest broadening SFC applications. Shimadzu, the leader in innovative SFC instrumentation, offers an array of analytical and preparative SFC systems that allow researchers easily access this growing technology. In this webinar, we’ll look at how Shimadzu’s SFC instruments and how our unique features are currently used in a variety of cutting edge applications for small and large molecules.<blockquote>Presenter: Stephen Swartz (Business Development Specialist, Shimadzu Scientific Instruments)Steve has been involved with the pharmaceutical industry for over 33 years. As a medicinal chemist at DuPont, Bayer, and Bristol Myers Squibb, he worked in multiple therapeutic areas supporting early phase discovery. After leaving the lab, Steve worked for several instrumentation companies in scientific support, sales, and business development. Since joining Shimadzu in 2020 as Business Development Specialist, he has worked with customers in the pharma and biopharma markets using his experience to help optimize workflows from early discovery to IND and beyond.Presenter:&nbsp;Kevin Wons (Market Manager - Pharma/BioPharma, Shimadzu Scientific Instruments)Kevin has recently joined Shimadzu as Market Manager for Pharma/BioPharma. He has spent the last 6 years at AstraZeneca in the Analytical Sciences Department for product and process characterization for biologics in the AstraZeneca pipeline. Kevin has applications experience with HPLC and LC-MS to do Tryptic Peptide Mapping, Intact Mass Analysis, Subunit Mass Analysis, and Oligosaccharide Profiling. For his last 3 years, he acted as the Glycan Subject Matter Expert (SME) while at AstraZeneca. His work experience also includes Maryland Psychiatric Research Center, where he prepared animal tissue samples such as Brain, Liver, Blood, and Placenta to measure kynurenine pathway metabolites on GC/MS and HPLC. He has a Master’s degree in Professional Studies (MPS) focused on Biotechnology which prepares science professionals to fill management and leadership roles.</blockquote>

Shimadzu: Shimadzu's Recent Advances in SFC

Shimadzu's Recent Advances in SFC

How Shimadzu’s SFC instruments and how our unique features are currently used in a variety of cutting edge applications for small and large molecules.

Titration is generally considered a fairly simple analytical technique. But what do you do, if your titration results are not what they should be? Enter Robert Tobler, Senior Application Specialist Titration at Metrohm International Headquarters!In his webinar on September 18, Robert will show you what typical errors can occur during a titration – and how to avoid or remedy them. Focusing on troubleshooting, Robert will cover everything from the electrode to the setup of your titrator to titration parameters and calculation of &nbsp; the result. The following questions give you an idea of the scope and practical relevance of this webinar:<ul><li>How important is calibration?</li><li>Do I really need to stir the titration solution – and why?</li><li>What do I do, if several equivalence points are detected – or none at all</li><li>How to clean the electrode properly?</li></ul>These questions and many more will be answered step by step so that everyone can follow and understand. During a Q&amp;A session at the end of the webinar, you can ask Robert any question you may have about titration.<blockquote>Presenter: Robert Tobler (Senior Application Specialist Titration, Metrohm International Headquarters)After his apprenticeship as a chemical laboratory technician and further training as a biomedical analyst, Robert Tobler studied chemistry at the Zurich University of Applied Science in Waedenswil, Switzerland. He joined Metrohm in 2015 as an application specialist titration. Since then, Robert has become an expert in applied titration sharing his expertise through the global network of Metrohm subsidiaries.</blockquote>

Metrohm: Troubleshooting titration: essential know-how for quality results

Troubleshooting titration: essential know-how for quality results

What typical errors can occur during a titration – and how to avoid or remedy them.

Troubleshooting titration: essential know-how for quality

Per- and Polyfluoroalkyl Substances (PFAS) are exceptionally versatile chemicals and have seemingly endless applications that include more than 12,000 different compounds.Due to the persistent nature of these compounds, as well as their ability to be easily transported through the environment, there is a significant concern for the presence of PFAS in the human body. A LC-MS/MS method utilizing microelution SPE for sample cleanup, presented for analysis of seven PFAS, identified significant by National Academies of Sciences, Engineering, and Medicine for clinical research and biomonitoring in public health labs.&nbsp;<h4>Who Should Attend:</h4><ul><li>Any scientists interested in LC-MS/MS and sample preparation or anyone curious about PFAS from biological samples</li></ul><h4>Key Learning Points:</h4><ul><li>Learn key steps to LC-MS/MS and sample preparation of biological samples</li><li>Understand potential Challenges when extracting PFAS from biological samples</li><li>Find advantages of using Micro elution SPE sorbent technology</li></ul><blockquote>Presenter: Shahana W. Huq (Senior Application Scientist, Phenomenex)Shahana is a Senior Application Scientist focusing on emerging technologies and solutions within Clinical Research and Sample Preparation, at the Phenomenex Applications Laboratory since the year 2000. She holds an MS in Biochemistry from California State University, Los Angeles. Her work involves experimental design, analytical method development, optimization, and troubleshooting. &nbsp;Furthermore, she has extensive expertise in R&amp;D product innovation and application development, as well as hands-on experience in sample preparation and LC-MS/MS. Shahana’s drive, and vision of the clinical field has motivated her to participate in various scientific publications and even as a coauthor of Phenomenex patent on sample preparation products. Currently, Shahana works closely with global customers in the applied market, providing technical support and consultation services as well as onsite seminars and webinars to promote peer development. &nbsp;Presenter: Richard Jack, PhD (Global Market Development Manager, Phenomenex)Richard is the global market development manager for the environmental and food markets at Phenomenex. He has over 18 years of experience with chromatography and mass spectrometry for the environmental, food, cannabis, semiconductor, chemical, and pharmaceutical industries. Jack has collaborated with global regulatory agencies to develop validated methods through new applications, instrumentation, column chemistries, and software. He is a former EPA scientific advisor for the EPA’s panel on hydraulic fracturing and a coauthor for EPA 557 and 557.1, ASTM D8001, and updates to D4327 and D6919 methods. He is currently the second vice chairman for the ASTM D19 subcommittee on water analysis. Previously, Jack was a vertical marketing manager with Thermo Fisher Scientific, Dionex, and Hitachi High Technologies, where he designed analytical instrumentation, including IC and HPLC systems, pumps, autosamplers, and a variety of detectors. He received his PhD in biochemistry and anaerobic microbiology from Virginia Tech in Blacksburg, Virginia. He received his master’s degree in ecology from the University of Tennessee in Knoxville.</blockquote>

Phenomenex: LC-MS/MS Analysis of PFAS in Bovine Serum for Clinical Research Using Microelution SPE

LC-MS/MS Analysis of PFAS in Bovine Serum for Clinical Research Using Microelution SPE

A LC-MS/MS method utilizing microelution SPE for sample cleanup, presented for analysis of seven PFAS.

LC-MS/MS Analysis of PFAS in Bovine Serum

As subcutaneous delivery of high-concentration biologics becomes more popular, optimizing their formulations becomes more complicated. Some excipients play better with one antibody, not another, or only help under specific conditions. Testing formulations at high protein concentration makes lower sample consumption and efficient assays a must-have. High-throughput, low volume solutions, designed for biologics, will speed up those formulation studies. Here, we present a case study on how to prepare monoclonal antibodies at high and low concentrations with some common excipients and screen for effects on quality, stability, and viscosity.The case study will illustrate how to produce all this data seamlessly, allowing the researcher to rate and rank formulations for their influence on the analyte and to quickly narrow down the optimal excipients.<blockquote>Presenter: Ross Walton (Senior Application Scientist, Analytics, Unchained Labs)Moderator:&nbsp;Chloe (Oxford Global)</blockquote>

Unchained Labs: Fast track formulation with biologics screening in a snap

Fast track formulation with biologics screening in a snap

Explore how to optimize high-concentration biologic formulations using low-volume, high-throughput tools. Case study shows impact on quality, stability.

Pharmacopeia – What to Check on UV Vis Spectrophotometers?

Fast track formulation with biologics screening in a snap

Shimadzu's Recent Advances in SFC

Automated LC-MS Workflow for CQA Assessment of Protein Therapeutics with Speed and Simplicity for Process Development

Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Troubleshooting titration: essential know-how for quality results

How to Measure pH in Chemicals and Biological Samples

Optimize Your Volumetric Karl Fischer Titration

Discover The Latest LC-MS/MS Innovations For PFAS Challenges

LC-MS/MS Analysis of PFAS in Bovine Serum for Clinical Research Using Microelution SPE

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