In today’s academic research environment, speed and precision are everything. Whether you're analyzing trace organic compounds, processing environmental extracts, or running a high-throughput metabolomics project, one bottleneck continues to slow down even the most well-equipped labs: solvent evaporation.If your lab still relies on aging hot plates or hand-drying methods, you’re not alone. But the consequences are real: inconsistent recovery, lost analytes, and valuable hours wasted each week.<h3>The Hidden Cost of Manual Evaporation</h3>Many academic labs were built on traditional sample prep methods. But as research needs evolve and sample volumes increase, these outdated tools can no longer keep up.Manual evaporation doesn’t just slow workflows—it undermines reproducibility.Hot plates can over-dry samples or introduce uneven heating that degrades sensitive compounds. Open evaporation risks contamination. And when multiple students share equipment, timing differences from sample to sample introduce variability that shows up later as noisy chromatography or inconsistent quantitation.Students and faculty alike often report frustration with drying steps taking far too long, especially when preparing dozens of samples for <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis?hsLang=en">LC-MS</a> or <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-gc-ms/ms-analysis?hsLang=en">GC-MS workflows</a>. In some cases, samples left unattended can be partially lost or require re-preparation entirely.For grant-funded research, that wasted time and material adds up quickly.<h3>A Better Way: Controlled Nitrogen Blowdown</h3>Nitrogen blowdown evaporation replaces guesswork with control. A steady stream of inert nitrogen combined with gentle, regulated heat speeds evaporation while protecting sensitive analytes.<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=362&amp;manufacturerItems=540">Systems from Organomation </a>are designed specifically for sample preparation—not as improvised solutions or general lab accessories, but as purpose-built tools for consistent concentration.The result is straightforward:<ul style="list-style-type:disc;"><li>Faster dry-downs</li><li>Better recoveries</li><li>Improved reproducibility</li><li>Less hands-on time</li></ul>So researchers can focus on generating data instead of babysitting samples.<h3>Why Academic Labs Choose the N-EVAP</h3>Research labs rarely process identical samples all day.One student may be concentrating a small organic extract, another working with aqueous environmental samples, and a third reducing a larger crude matrix—all at the same time. That variability is exactly where many batch systems fall short.The<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=362&amp;manufacturerItems=540&amp;search=n-evap"> N-EVAP</a> transforms sample preparation uncertainty into control through radical flexibility.Unlike systems that force you to work around equipment constraints, the N-EVAP’s individual per-sample valves let you adjust gas flow, temperature exposure, and needle positioning for each sample—simultaneously.This isn’t theoretical flexibility. It means you can:<ul><li>Concentrate a 10 mL aqueous sample</li><li>Reduce a 5 mL organic extract</li><li>Evaporate a 50 mL environmental sample</li></ul>—all in the same run, without compromise.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/manual-to-automated-solvent-drying-is-it-worth-the-switch">Learn how the University of Cincinnati achieved 20x faster sample prep with the N-EVAP evaporator.</a></blockquote><ul><li>For academic programs handling variable matrices, this eliminates the false choice between batch efficiency and analytical precision. Each sample gets exactly the conditions it needs, preserving analyte integrity while maintaining throughput. &nbsp;</li><li>Available in configurations from <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2352">6</a> to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1911">45 </a>positions—with optional digital controls on larger models—the system scales easily from small teaching labs to large research groups without forcing workflow changes. &nbsp;</li><li>It’s built for scientists who want control over their experiments, not workarounds. &nbsp;</li><li>Our evaporators are the <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/why-organomation-is-the-most-cited-blowdown-evaporator-brand-in-u.s.-epa-methods">most cited nitrogen blowdown sample concentrators</a> in standardized EPA methods, making Organomation the trusted, fail proof choice.</li></ul><h3>Built for Chromatography Workflows</h3>Since 1959, Organomation has focused exclusively on sample preparation. That specialization shows in the details that matter most to chromatography labs: uniform heating, consistent gas distribution, compatibility with common vial formats, and rugged construction that stands up to daily use in shared academic spaces.Whether you're preparing samples for LC-MS, GC-MS, or other analytical methods, nitrogen blowdown helps ensure:<ul><li>Faster turnaround between experiments</li><li>Consistent recoveries</li><li>Fewer re-runs</li><li>Less student labor tied up in drying steps</li></ul>Which ultimately means more time spent on analysis, interpretation, and publication.<h3>Prove the Time Savings for Yourself</h3>Upgrading your evaporation workflow can clearly improve efficiency—but how much time would your lab actually save? ➔ Rather than guessing, you can calculate it.Organomation’s free <a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/evaporation-time-calculator-excel-download">Evaporation Time Savings Calculator</a> lets you enter your real lab conditions—sample counts, volumes, current dry-down times, and run frequency—to quantify exactly how much time nitrogen blowdown could save each week, month, or semester.For many academic labs, the results are eye-opening:<ul><li>Hours of student and staff time reclaimed</li><li>Faster LC-MS/GC-MS queues</li><li>Reduced bottlenecks before analysis</li><li>Hard numbers that help justify equipment purchases in grants and budgets</li></ul>In just a few minutes, you’ll have concrete data showing whether flexible evaporation makes financial and workflow sense for your lab.<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/evaporation-time-calculator-excel-download">Download the Evaporation Time Savings Calculator and see what your lab could save.</a></blockquote>

Is Your University Lab Losing Time and Data in Sample Prep? Here’s How to Fix It

<h4>The science behind gummy candies</h4>Who can resist colourful, fruity gummy candies 🍬 with their signature chewy and elastic texture? While they may appear simple, their formulation is actually quite sophisticated. Each gummy is produced using a precisely balanced combination of gelling agents, sugars, acids, flavourings, and colourants, all working together to deliver the desired taste and texture.For instance, the characteristic chewiness of gummy sweets results from the interaction between gelatin and sugars. Even minor adjustments—such as changing the type or concentration of the gelling agent—can significantly alter the final product. In addition, manufacturers must meet regulatory and labeling requirements, including certifications like Halal compliance. This makes accurate and consistent monitoring of ingredients essential throughout production.<h4>The importance of SEC fingerprinting</h4>Size Exclusion Chromatography (SEC), also known as Gel Permeation Chromatography (GPC), offers a fast and reliable way to analyze gummy formulations. By separating molecules according to their hydrodynamic size, SEC generates a unique molecular “fingerprint” for each product.This fingerprint enables manufacturers to:<ul><li>confirm the type and origin of gelling agents (e.g., for Halal verification)</li><li>ensure batch-to-batch consistency and detect production variations</li><li>monitor changes during storage to assess shelf life</li><li>evaluate low-molecular-weight compounds such as sugars in a semi-quantitative manner</li></ul>Overall, SEC fingerprinting supports consistent product quality and regulatory compliance, ensuring that every gummy maintains the same expected characteristics.<h4>Influence of column selection on SEC performance</h4>Column selection plays a crucial role in achieving high-quality separations and detailed molecular fingerprints. To illustrate this, porcine and bovine gelatin standards were analyzed using two different configurations:<ul><li>a single Multipore <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1655">SuperOH-P column</a></li><li>a coupled system of SuperOH-P 350 and SuperOH-P 150 columns</li></ul>Although both setups cover the same molecular weight range (100–1,000,000 Da), the coupled configuration effectively doubles the separation length. This results in improved resolution, which was confirmed experimentally. The coupled columns provided clearer separation between porcine and bovine gelatin, producing more distinct and informative fingerprints.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Fig_1_Overlay_chromatograms_measured_with_DAD_at_230_nm_20_L_d81181cfb4.jpg" alt="KNAUER: Fig. 1 Overlay chromatograms measured with DAD at 230 nm, 20 µL. Dark blue: porcine reference standard; red: bovine reference standard; solid line: measured with column A; dotted line: measured with column set B. Graphic by KNAUER." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Fig_1_Overlay_chromatograms_measured_with_DAD_at_230_nm_20_L_d81181cfb4.jpg 245w," sizes="100vw" width="1024" height="611"><h4>Achieving reliable SEC fingerprints</h4>Reproducibility is key when using SEC for quality control. The process begins with consistent sample preparation—maintaining identical dissolution procedures, concentrations, and filtration steps is essential, as even small variations can influence peak shape and overall results.Beyond the column, the entire system setup is equally important. For example, combining a Refractive Index Detector (RID) with a Diode Array Detector (DAD) allows simultaneous detection of sugars, acids, and polymers within a single analysis.Accurate peak identification further enhances reliability. By analyzing reference standards based on known ingredient compositions, chromatographic peaks can be correctly assigned, enabling detailed interpretation of both high- and low-molecular-weight components.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Fig_2_Zoom_overlay_chromatograms_measured_with_RID_20_L_and_column_set_B_37caf5ac59.jpg" alt="KNAUER: Fig. 2 Zoom overlay chromatograms measured with RID, 20 µL and column set B. Black: Katjes® Yoghurt Gums; turquoise: apple pectin diluted 1:10; dark green: preserving sugar 1:1 (sugar; citric acid; pectin; fully hydrogenated sunflower oil); dark blue: maltodextrin; pink: sodium potassium tartrate; yellow: potassium citrate; red: citric acid; purple: lactic acid; beige: lactose; orange: sucrose; green: glucose; grey: blank. Graphic by KNAUER. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Fig_2_Zoom_overlay_chromatograms_measured_with_RID_20_L_and_column_set_B_37caf5ac59.jpg 245w," sizes="100vw" width="1024" height="611">Additionally, incorporating a flow marker helps correct for system-related variations, such as fluctuations in flow rate, thereby improving retention time stability and peak assignment accuracy. More details on the flow marker and its use in SEC are described in <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VTN_0043_knauer_gpc_sec_data_reproducibility_with_flow_marker_96ee6b3cd9.pdf">this technical note</a>.<h4>Verification of gelatin origin using SEC</h4>Determining the source of gelatin is critical for proper labeling and compliance, particularly for Halal-certified products where porcine gelatin is not permitted.To demonstrate SEC’s capability, two gummy samples with identical formulations but different gelatin sources were analyzed. One sample contained porcine gelatin, while the other used bovine gelatin. The resulting SEC fingerprints showed clear differences in the gelatin region, allowing unambiguous identification. The standard Haribo® Goldbears corresponded to the porcine reference, whereas the Halal version matched the bovine standard.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Fig_3_Overlay_chromatograms_measured_with_DAD_at_230_nm_20_L_and_column_set_B_12e99a43e7.jpg" alt="KNAUER: Fig. 3 Overlay chromatograms measured with DAD at 230 nm, 20 µL and column set B. Solid dark blue line: Haribo® Goldbears; solid red line: Halal Haribo® Goldbears; dotted dark blue line: porcine reference standard; dotted red line: bovine reference standard. Graphic by KNAUER. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Fig_3_Overlay_chromatograms_measured_with_DAD_at_230_nm_20_L_and_column_set_B_12e99a43e7.jpg 245w," sizes="100vw" width="1024" height="611"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_4_Overlay_chromatograms_measured_with_RID_20_L_and_column_set_B_2_c29ea59bc4.jpg" alt="KNAUER: Fig. 4 Overlay chromatograms measured with RID, 20 µL and column set B. Solid dark blue line: Haribo® Goldbears; solid red line: Halal Haribo® Goldbears; dotted dark blue line: porcine reference standard; dotted red line: bovine reference standard. Graphic by KNAUER." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_4_Overlay_chromatograms_measured_with_RID_20_L_and_column_set_B_2_c29ea59bc4.jpg 245w," sizes="100vw" width="1368" height="432">This confirms that SEC is a reliable method for distinguishing gelatin origin.<h4>Role of low-molecular-weight components</h4>In addition to polymers such as gelatin, SEC can also reveal smaller molecules, including sugars and organic acids. While SEC is not a replacement for fully validated HPLC methods, it serves as a rapid screening tool for comparing samples and supporting quality control.Using RID detection, differences in sugar composition become visible. For example, chromatograms showed a significantly higher sucrose signal in preserving sugar compared to gummy candies, reflecting formulation differences.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Knauer_Fig_5_Zoom_overlay_chromatograms_measured_with_RID_20_L_and_column_set_B_06c072e069.jpg" alt="KNAUER: Fig. 5 Zoom overlay chromatograms measured with RID, 20 µL and column set B. Black: sucrose 1mg/ml; blue: Haribo® Goldbears; green: preserving sugar 1:1 (sugar; citric acid; pectin; fully hydrogenated sunflower oil). Graphic by KNAUER." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Knauer_Fig_5_Zoom_overlay_chromatograms_measured_with_RID_20_L_and_column_set_B_06c072e069.jpg 245w," sizes="100vw" width="1024" height="611"><h4>Conclusion</h4>SEC is a powerful analytical technique for monitoring product quality and ensuring process consistency in gummy candy production. By generating detailed molecular fingerprints, it enables manufacturers to verify ingredients, maintain consistency, and comply with regulatory requirements.Importantly, this approach is not limited to gummy candies—it can be adapted to a wide range of products where molecular characterization is essential.<blockquote><ul><li>If you're planning to set up or optimize your GPC/SEC workflow, feel free to contact us at sales@knauer.net. Stay tuned for more exciting insights into the GPC/SEC world in our “GPC/SEC Made Easy” series.</li><li>For more information on the technical details, you can refer to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VFD_0195_sec_for_fingerprint_analysis_of_gummy_candies_ce5349cd95.pdf">this application note.</a></li><li>For further information on this topic, please contact our author: wesolowski@knauer.net</li></ul></blockquote>

GPC/SEC Made Easy – Fingerprint analysis of Gummy Candies

News from LabRulezLCMS Library - Week 17, 2026

Article

Product

Application

Food

Science and research

Laboratories

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Agilent Technologies

Technology Networks

ACD/Labs

RTI International

Anatune

Whether you’re starting a new method or running a routine one, having a checklist to review before starting can help avoid chromatography problems.
In this presentation, we will look at:
<ul>
<li>Your supplies: The role they play in getting the best results possible from your instrument
</li>
<li>Your column: The importance of choice; Why you should benchmark your column with your system
</li>
<li>Your instrument: The importance of maintenance and what to put on your “housekeeping” list
</li>
</ul>
<blockquote>
Presenter: Rita Steed (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rita Steed began supporting the LC column line for Agilent in 1999. As a Chromatography Specialist (first with Chromatography, Inc., then directly for Agilent), Rita worked on-site with researchers in Pharmaceutical and other industries presenting technical seminars and assisting researchers with troubleshooting and method development. Rita has over 20 years of Chromatography experience in the Biotechnology, Chemical, and Pharmaceutical industries. She has held positions in Research, Sales, and Technical Service. Rita has earned degrees in Microbiology and Life Sciences/Biochemistry. In her current position, she is an inside Application Engineer supporting LC columns.
</blockquote>
<blockquote>
Presenter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.
</blockquote>

Agilent Technologies: The Chromatography Checklist

The Chromatography Checklist

Whether you’re starting a new method or running a routine one, having a checklist to review before starting can help avoid chromatography problems.

Whether you’re currently working with biomolecules or are making a transition from working with small molecules to biotherapeutics you will find that size does make a difference in the decisions we make as we’re developing a method.
Some characteristics of biomolecules can make their separations both different from and more challenging than small molecule separations. Of the many different HPLC separation mechanisms and column types, reverse phase is commonly used for both small molecules and biomolecules. This presentation will look at what we typically think about for small molecules and how working with biomolecules may be similar or in some cases quite different.
Areas we’ll discuss are:
<ul>
<li>Method development parameters; similarities and differences
</li>
<li>Column selection
</li>
<li>The matrix and sample prep
</li>
<li>Instrument considerations
</li>
<li>Tips to help identify why your separation doesn’t look like you thought it would
</li>
</ul>
<blockquote>
Presenter: Rita Steed (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rita Steed began supporting the LC column line for Agilent in 1999. As a Chromatography Specialist (first with Chromatography, Inc., then directly for Agilent), Rita worked on-site with researchers in Pharmaceutical and other industries presenting technical seminars and assisting researchers with troubleshooting and method development. Rita has over 20 years of Chromatography experience in the Biotechnology, Chemical, and Pharmaceutical industries. She has held positions in Research, Sales, and Technical Service. Rita has earned degrees in Microbiology and Life Sciences/Biochemistry. In her current position, she is an inside Application Engineer supporting LC columns.
</blockquote>

Agilent Technologies: Making the Leap: Small Molecules to Biomolecules

Making the Leap: Small Molecules to Biomolecules

What we typically think about for small molecules and how working with biomolecules may be similar or in some cases quite different.

Successful chromatography can be like finding your way through a maze. Planning and good habits can help prevent problems that can take you down the wrong path and cause you to lose your chromatography.
In this seminar, we will look at:
<ul>
<li>Method conditions to consider that can make your method robust and rugged. This reduces the chance of method variability and facilitates ease of transfer
</li>
<li>Chemistry, sample prep, and instrument configuration factors that can affect your HPLC separation Careful attention to method development and care of your instrument saves you the time and aggravation of troubleshooting.
</li>
</ul>
<blockquote>
Presenter: Mark Powell (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark Powell is an Applications Engineer located at Agilent’s Little Falls site in Wilmington, DE. Before joining Agilent in 2011, Mark worked in the pharmaceutical industry synthesizing, purifying and analyzing drug candidates. He provides applications assistance and technical support for Agilent’s HPLC columns and consumables.
</blockquote>
<blockquote>
Presenter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.
</blockquote>

Agilent technologies: Surviving Chromatography Part I Preventive Action

Surviving Chromatography Part I Preventive Action

Planning and good habits can help prevent problems that can take you down the wrong path and cause you to lose your chromatography.

Now you’re lost because your chromatography is not where it should be. What do you do?
In this talk we’ll look at ways to troubleshoot what went wrong and discuss things you can do to keep them from happening in the future.
In this talk we’ll discuss:
<ul>
<li>Common chromatography problems including pressure, peak shape issues like tailing, and retention time shifts
</li>
<li>How to isolate the problem and whether it’s related to chemistry or your instrument hardware/software
</li>
<li>Identifying the problem and taking corrective action can help prevent the same thing from happening in the future.
</li>
</ul>
<blockquote>
Presenter: Jean Lane (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Jean has been employed with Agilent since Nov 2010 in technical and applications support and has a primary role supporting Agilent’s full line of LC columns and consumables, which also includes support for Agilent’s GPC/SEC product line. She came to Agilent thru acquisition of Varian and the former Polymer Laboratories. Jean has 20 plus years of technical and applications support for both HPLC and GPC consumable products. In addition to practical chromatography experience in the laboratory, she has had many, many years in her technical role involving customer support providing assistance and troubleshooting for customer chromatography issues.
</blockquote>

Agilent Technologies: Surviving Chromatography Part II Corrective Action

Surviving Chromatography Part II Corrective Action

Ways to troubleshoot what went wrong and things you can do to keep them from happening in the future.

The chromatographic process is described by a few key parameters including resolution, retention factor, and selectivity. A good grasp of the equations that define these parameters can help build your chromatography skill.
In this talk we will discuss:
<ul>
<li>What they are
</li>
<li>Their importance
</li>
<li>The effect they have on our chromatography
</li>
<li>Understanding the fundamental concepts and equations of chromatography helps not only with method development but also with troubleshooting when things go wrong.
</li>
</ul>
<blockquote>
Presenter: Paul Altiero (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Paul Altiero is an Applications Engineer located at the Agilent Little Falls site in Wilmington, DE. Prior to coming to Agilent in 2009, Paul worked in the pharmaceutical industry performing LCMS bioanalysis supporting Drug Discovery DMPK. While at Agilent, Paul has been a field service engineer for LCMS as well as the integrating program manager for the RapidFire high throughput LCMS system. In his current role Paul’s responsibilities include technical support and application assistance for LCMS consumables.
</blockquote>

Agilent Technologies: Why They Matter: An Intro to Chromatography Equations

Why They Matter: An Intro to Chromatography Equations

The chromatographic process is described by a few key parameters including resolution, retention factor, and selectivity.

<h3>Webinar Summary</h3>
Often there is a natural trade-off between IT demands, such as reducing the number of different systems in use (standardization) or leveraging modern technologies (like cloud), and the increased productivity and compliance demands for your laboratory.
This compromise is now over. Learn how Thermo Scientific™ Chromeleon™ 7.3 Chromatography Data System (CDS) is the first CDS to truly meet the needs of both the IT and infrastructure team and the laboratory.
Now you can standardize without compromise with global deployment, system stability and data security, and still realize significant laboratory productivity gains!
<h3>Attend this webinar to learn how Chromeleon™ 7.3 CDS:</h3>
<ul>
<li>Can deliver productivity gains of up to a third</li>
<li>Leverages modern IT technologies to ensures business continuity and streamlining in deployment and leveraging modern IT technologies</li>
<li>Offers new features that will be invaluable to your lab</li>
</ul>
<blockquote>
Presenter: Darren Barrington-Light, Senior Manager Product Marketing, Thermo Fisher Scientific™
</blockquote>

Technology Networks: The New No-compromise Enterprise CDS Solution

The New No-compromise Enterprise CDS Solution

Pharmaceutical impurities, specifically mutagenic impurities in APIs and drug products can significantly affect the stability and efficacy of the drug, and impact safety. Recently, several manufactured lots of Angiotensin II Receptor Blockers (Sartan) and Ranitidine drugs have been recalled due to the presence of high potency mutagenic impurities (nitrosamines) found in these products as a result of a manufacturing process change.
<h3>WHAT WILL YOU LEARN</h3>
<ul>
<li>Understand what mutagenic impurities are and why it&#39;s important to characterize and quantify them, even when present in trace amounts.</li>
<li>Understand the current regulatory guidelines for mutagenic impurity analysis in drug substance and product with an emphasis on nitrosamines in Angiotensin II Receptor Blockers (Sartan) and Ranitidine drug</li>
<li>Learn about approaches for the confident identification and quantification of nitrosamines in APIs and drugs</li>
</ul>
<h3>WHO SHOULD ATTEND</h3>
<ul>
<li>Laboratory managers</li>
<li>Chromatographers</li>
<li>Analytical chemists and scientists</li>
<li>New product developers</li>
</ul>
<blockquote>
Presenter: Chander Mani (Application Engineer, Agilent Technologies)
</blockquote>

Agilent Technologies: LC/MS methods for the accurate determination of nitrosamines produced in the manufacture of APIs and drugs 

LC/MS methods for the accurate determination of nitrosamines produced in the manufacture of APIs and drugs 

Improvements in mass spectrometry have generated an increasing demand for analysis of more complicated samples by mass spectrometry (MS). While liquid chromatography (LC) and gas chromatography (GC) are effective at reducing sample complexity, co-elution of components is still not entirely avoidable. The reality of today&#39;s lab is:
<ul>
<li>A variety of instrument configurations and a multitude of software interfaces</li>
<li>Mountains of complex data for analysis</li>
</ul>
Struggle no more!
Join us to learn how vendor-neutral software can help you deformulate samples more efficiently leveraging knowledge from both the wider scientific community and your organization. See how third-party software enables you to:
<ul>
<li>Separate co-eluting components</li>
<li>Identify known and unknown components</li>
<li>Store, share, and leverage expertise</li>
</ul>
Hear about recent enhancements to these tools and see a sneak-peek of enhancements yet to come.
<h3>Intended Audience</h3>
<ul>
<li>Mass Spectrometrists</li>
<li>Analytical Chemists</li>
<li>Analytical Lab Managers/Directors</li>
</ul>
<blockquote>
Presenter: Anne Marie Smith, Senior Application Scientist at ACD/Lab
</blockquote>
<blockquote>
She received her Ph.D. in Chemical Biology from McMaster University where she developed MALDI-MS based assays for screening aminoglycoside kinases. After graduating she was employed as an Associate Scientist with Gilead Sciences in Alberta where her work focused primarily on impurity identification by LC/MS and LC method development. At ACD/Labs Anne Marie applies her hands-on experience with MS instruments and scientific software packages, plus knowledge of chromatographic method validation, to help customers implement our MS solutions and troubleshoot any technical challenges.
</blockquote>
<blockquote>
Host: Sanji Bhal is the Director of Marketing &amp; Communications at ACD/Labs.
</blockquote>
<blockquote>
Prior to joining ACD/Labs she was a lab-coat wearing medicinal chemist at Signalgene Inc., where she pursued her ongoing interest in cancer research, followed by a stint with the CRO NAEJA Pharmaceuticals. Sanji began her career in the U.K., completing her Ph.D. in synthetic organic chemistry at the University of Reading, and a post-doctoral fellowship at Cancer Research UK. Today Sanji is passionate about understanding the challenges still faced by scientists and R&amp;D organizations, and helping to &#39;match-make&#39; their needs with the tools available to support their innovations.
</blockquote>

Pixabay/Gerd Altmann:  Practical Steps for Efficient Deconvolution of LC/MS and GC/MS Data for Deformulation

 Practical Steps for Efficient Deconvolution of LC/MS and GC/MS Data for Deformulation

From a forensic perspective, a laboratory must answer this question: is the material presented for analysis an illegal product based on its total THC content? This presentation will discuss analytical strategies to answer this question.
The question ‘is this sample illegal based on its psychoactive ∆9-tetrahydrocannabinol content’ has been common in forensic labs for decades. Traditionally, this has been answered in a binary fashion as “yes” or “no” based on the results from a semi-quantitative analysis using GC/MS technologies. Since the passage of the Agriculture Improvement Act, also known as the Farm Bill, this question has become more complicated due in large part to the legalization of hemp as an industrial crop. 
The United States Federal Register defines industrial hemp as any part or derivative (including seeds) of the plant Cannabis sativa L. with a dry weight concentration of “tetrahydrocannabinols” not greater than 0.3% by dry weight of the plant material. Tetrahydrocannabinols specifically refer to salts and isomers of ∆9- tetrahydrocannabinol (THC). Any hemp plant material that exceeds this threshold is defined as marijuana and considered an illegal Schedule I narcotic. 
Recently, the USDA has published guidance for the determination of total THC (0.877*[THCA] + [THC]) in hemp and hemp-derived cannabinoid products. It has been stipulated that this testing must occur in DEA registered labs and that HPLC and or GC technologies are to be used for the quantitative determinations. Here, subject matter experts discuss an orthogonal LC/MS and GC/MS analytical strategy for quantification of total THC in hemp and hemp products. They will also discuss sample preparation of various products and analytical challenges using LC and GC methodologies. 
<h3>Detailed Learning Objectives</h3>
a) Understand the legal definition of hemp and its differentiation from marijuana
b) Learn about HPLC, LC/MS, and GC/MS testing strategies
c) Understand the analytical challenges for the determination of total THC in cannabis, hemp, and cannabinoid products 
<h3>Who should attend:</h3>
Forensic and criminalistic scientists, and laboratory personnel charged with the differentiation of legal help products and illegal cannabis materials.
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Presenter: Anthony Macherone, Ph.D., Sr. Scientist, Strategic Program Manager &amp; Cannabis Applications Technical Leader, Agilent Technologies; Visiting Professor, The Johns Hopkins School of Medicine
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Pixabay/NickyPe: Hemp: A Forensic Perspective

Hemp: A Forensic Perspective

Potential carcinogens N-nitrosamines continue to keep pharmaceutical companies in the crosshairs of health regulators. At every stage of the production process, regulators are demanding increased scrutiny on the presence of nitrosamine and a suite of robust, cost effective techniques are desperately needed to face this issue. The automation that we at Anatune specialise in offers the best chance of meeting the data quality and required throughput.
At this forum, senior scientists from major pharmaceutical companies are coming together to collaborate and solve this problem as quickly as possible. If you work in the pharmaceutical industry or have any interest in the measurement of nitrosamines, this event is for you.
<h3>Agenda:</h3>
09:50 Introduction: Dan Carrier, Anatune
10:00 Regulatory Considerations for Nitrosamine Analysis - Andrew Teasdale AstraZeneca
10:20 The challenge of nitrosamines in drug products and API: how automation can help – Camilla Liscio, Anatune
10:40 Q&amp;A
10:50 Comparison of OMCL Methods for Nitrosamine Impurities in Sartans and Recent Analysis - Mark Harrison, AstraZeneca
11:10 Nitrosamine Analysis with CROs - Tony Taylor, Arch Sciences Group
11:30 Q&amp;A and final discussion.
12:00 Finish

The Anatune Nitrosamine Forum 2020