<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=136&amp;manufacturerItems=50&amp;page=2">Solid phase extraction</a> is routinely selected as a sample preparation technique prior to HPLC and GC analysis. It provides:<ul><li>Clean-up;</li><li>Analyte pre-concentration;</li><li>Solvent switching.</li></ul>This works well for any homogeneous liquid samples, but clearly a solid sample cannot be applied directly to an SPE device. Here we will consider how best to approach the handling of solid samples prior to SPE.The first stage of sample pre-treatment involves homogenising the solid sample with a suitable solvent. The solvent selected for this purpose will:<ul><li>Be effective at solubilising the analyte.</li><li>Be effective at solubilising the sample matrix, although this is not necessary providing the sample is blended well with the solvent.</li><li>Ideally it will be a weak solvent when it comes to the SPE stage. This may not be possible, and it may be necessary to dry down and reconstitute the sample prior to loading on to the SPE cartridge.</li></ul>Having formed a suspension of the sample in a suitable solvent the sample should be vortexed to promote thorough mixing, and then centrifuged to pellet the insoluble components of the matrix. The solvent should then be removed for further treatment.At this point the SPE mechanism needs to be selected:&nbsp;<h3>Reversed Phase SPE Method</h3>Mechanism / Weak Solvent / Strong Solvent<ul><li>Reversed phase – Water/buffer – Acetonitrile/Methanol (hexane strongest)</li><li>Normal phase – Hexane/Heptane – Mid polar organic such as DCM, MTBE, IPA (strongest is water)</li><li>Ion exchange – Aqueous buffer at a pH which promotes ion exchange interactions between analyte and SPE sorbent – Organic solvent, typically methanol with pH adjustment to disrupt the ion exchange interactions.</li></ul>Analyte properties and sample diluent both need to be considered at this point. Reversed phase extractions are effective for moderately polar to moderately hydrophobic analytes, but only if they are dissolved in a weak solvent such as water. If the sample is dissolved in a mid-polar solvent the sample will either need to be diluted, or alternatively dried down and reconstituted. The same is true for normal phase, where samples need to be dissolved in hexane/heptane for analytes to be successfully retained during sample loading onto the SPE device.These examples will hopefully illustrate this concept.<h4>The extraction of PCBs from soil.</h4>PCBs are hydrophobic and will dissolve readily in a non-polar solvent. Soil can be dried, weighed and then extracted using hexane (or heptane). Once thoroughly mixed and centrifuged the resulting solution can be applied directed to a conditioned silica SPE tube allowing for a normal phase extraction to be conducted.<h4>Tylosin from meat.</h4>Tylosin is an antibiotic, with a log P of 1.0. Extracting from meat with a mixture of acetonitrile and water (80:20) will break any hydrophobic interactions releasing the tylosin. After centrifugation the resulting liquid sample will require further dilution with water to reduce the loading solvent strength prior to a reversed phase extraction.<h4>Enilconazole from oranges.</h4>Enilconazole is a fungicide widely used in agriculture and is often used with citrus fruits. It can readily be extracted from oranges using acetonitrile. As enilconazole is basic, the addition of HCl to the acetonitrile extract will promote protonation of the analyte, allowing for it to be directly retained on a strong cation exchange SPE material. This greatly simplifies the extraction process as no dilution of the sample is required (in contrast to reversed phase, or normal phase extraction where 100% acetonitrile would cause the analyte to be unretained during loading).

Considerations when working with solid samples and SPE

ALS recognizes that Climate Change is one of the defining issues of our time and we strive to make Impact through Action in the areas of Sustainability, linked to the ALS core value of Caring.ALS intends to make the world a better place through innovation, science, and commitment to best practice. This year the ALS Board has signed off on a company commitment to Net Zero by 2050 as summarized on our <a target="_blank" rel="noopener noreferrer" href="https://www.alsglobal.com/en/sustainability?utm_source=email-sig-link-ca&amp;utm_medium=email&amp;utm_campaign=sustainability-report-23">annual sustainability report</a>. ALS is pleased to share our milestones and targets with clients.<h3>Background</h3>In 2021, ALS developed a climate change strategy, setting a target of 40% reduction in scope 1 &amp; 2 emissions by 2030. By end of FY23 (March 2023), ALS had achieved a 58% reduction, and achieved carbon neutrality for scope 1 &amp; 2 emissions – well ahead of plan. In the same month, ALS recorded a key milestone with the ALS Board approving our roadmap to reach Net Zero by 2050 (shared at right), with milestones noted and completed actions shaded green.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_Czech_Republic_Enviro_Mail_12_Europe_ALS_Net_Zero_Commitments_and_Roadmap_in_Support_of_our_Staff_Clients_Communities_and_Shareholders_b157904cab.jpg" alt="ALS Czech Republic: EnviroMail™12/Europe: ALS Net Zero Commitments &amp; Roadmap in Support of our Staff, Clients, Communities &amp; Shareholders." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_Czech_Republic_Enviro_Mail_12_Europe_ALS_Net_Zero_Commitments_and_Roadmap_in_Support_of_our_Staff_Clients_Communities_and_Shareholders_b157904cab.jpg 112w," sizes="100vw" width="805" height="1120"><h3>Further detail</h3>Key projects to date have included purchasing Renewable Electricity (RE) from the grid (we utilize greater than 90% RE across all operations), installing &gt;1.8MW of solar photovoltaic (PV) systems across 16 site locations, and continued implementation of our ALS Green Building Standards, which focus on HVAC systems, building insulation, LED lights, energy efficient plant and equipment, moving to electric vehicles (EVs), and staff engagement on adopting climate friendly practices to reduce actual energy demand.This ALS Net Zero commitment will involve reducing absolute scope 1 and 2 emissions by 95% and scope 3 emissions by 90% by 2050, against a 2020 baseline year. This is a challenging task for laboratory operations given requirements for chemical, plastic, and glassware usage, and significant air heating and cooling requirements due to fume hoods which cause frequent cycling of laboratory air.The ALS Roadmap includes a near-term target to reduce absolute scope 1 and 2 greenhouse gas emissions by 78% by 2030 against a 2020 baseline year.Over the next 2 years ALS will measure our scope 3 greenhouse gas inventory to confirm the calculated scope 3 estimate completed in FY2023 and will develop action plans for freight, purchased goods/services, wastes, and employee commutes. A near-term target for 2030 for scope 3 will then be set.Priority actions over the next 5 years will include:<ul><li>purchasing renewable electricity for &gt;95% of our operations</li><li>installing further solar energy PV systems (7 more installed YTD for FY24 with a further 9 systems to be completed in early FY25)</li><li>converting gas ovens and furnaces to electric where possible</li><li>selection of more energy-efficient vehicles; 30% of fleet to be hybrids and EVs by 2030</li><li>upgrading to ALS green building guidelines for new laboratory developments and refurbishments (better insulation, more efficient HVAC, solar PV systems, and upgraded building management systems)</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_Czech_Republic_Enviro_Mail_12_Europe_ALS_Net_Zero_Commitments_and_Roadmap_in_Support_of_our_Staff_Clients_Communities_and_Shareholders_2_91b5e7ebf8.jpg" alt="ALS Czech Republic: EnviroMail™12/Europe: ALS Net Zero Commitments &amp; Roadmap in Support of our Staff, Clients, Communities &amp; Shareholders." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_Czech_Republic_Enviro_Mail_12_Europe_ALS_Net_Zero_Commitments_and_Roadmap_in_Support_of_our_Staff_Clients_Communities_and_Shareholders_2_91b5e7ebf8.jpg 156w," sizes="100vw" width="1089" height="1089"><blockquote>We are pleased to share our commitments with our stakeholders. Please feel free to contact your local ALS representative for further information.</blockquote>

EnviroMail™12/Europe: ALS Net Zero Commitments & Roadmap in Support of our Staff, Clients, Communities & Shareholders

Solid-phase extraction (SPE) is one of the key techniques in modern analytical chemistry for pre-concentrating analytes prior to chromatographic analysis. However, traditional manual SPE procedures are often time-consuming, error-prone, and difficult to reproduce. In response to laboratories’ increasing demand for automation and efficiency, <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky">Watrex Praha</a> introduces the <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/laboratory-automation/streamline-ole-200/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky">Streamline OLE 200</a> – an advanced system for online SPE.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Ole_uvod_oprava_bd77e4d8c2.jpg" alt="Watrex: Streamline™ OLE 200" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Ole_uvod_oprava_bd77e4d8c2.jpg 245w," sizes="100vw" width="1599" height="900"><h4>Comprehensive Automation of SPE&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/laboratory-automation/streamline-ole-200/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky">Streamline OLE 200</a> is a fully automated solid-phase extraction unit designed for direct integration into HPLC systems. It enables efficient pre-concentration of up to eight different samples, minimizes the need for manual handling, and significantly boosts laboratory productivity.<h4>Advantages of SPE Automation with OLE 200&nbsp;</h4><ul><li>Increased laboratory throughput: Automatic processing of up to 8 samples without the need for operator intervention.&nbsp;</li><li>Reduced manual errors and improved result reproducibility.&nbsp;</li><li>Flexible integration: Compatible with any HPLC system, allowing implementation across various laboratory settings.&nbsp;</li><li>Time savings: Eliminates the need to manually transfer samples between the SPE and HPLC steps.&nbsp;</li><li>Multimodal selection of SPE cartridges based on analytes and matrix complexity.&nbsp;</li></ul><h4>Technical Specifications and System Design&nbsp;</h4>At the heart of the system is a high-pressure pump, ensuring precise dosing of both samples and solvents. The system’s design features three key valves:&nbsp;<ul><li>A 10-port selection valve for sample and wash solvent selection.&nbsp;</li><li>A high-pressure SPE cartridge selector, allowing switching between up to five different SPE cartridges.&nbsp;</li><li>A standard injection valve, connecting the device to any HPLC system.</li></ul>This setup ensures that each sample is precisely processed: drawn into an SPE cartridge, washed with one or two eluents, and then eluted directly into the chromatograph.&nbsp;<h4>Functional Diagram&nbsp;</h4><ol><li>The sample is drawn by the pump through the 10-port valve to the selected SPE cartridge.&nbsp;</li><li>The cartridge is washed with one or two eluents to remove interferences.&nbsp;</li><li>Analytes are then eluted with a selected solvent and delivered directly into the HPLC system via the injection valve.&nbsp;</li></ol><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_OLE_clanek_obr_2_36588f90b9.jpg" alt="Watrex: Fig. 2 - Streamline™ OLE 200 Schematic" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_OLE_clanek_obr_2_36588f90b9.jpg 245w," sizes="100vw" width="1700" height="957"><h4>Efficiency, Reproducibility, and Flexibility&nbsp;</h4>Automation of the entire SPE process leads to greater reproducibility and reduces the risk of contamination or human error. The system allows sequential processing of multiple samples, each of which can be analyzed following a specific protocol. Thanks to its open design, the OLE 200 is compatible with any HPLC system, making it easy to integrate into existing lab workflows without major modifications.&nbsp;<h4>Application Potential&nbsp;</h4>The OLE 200 system is particularly suitable for:&nbsp;<ul><li>Pesticide and pharmaceutical residue analysis in water&nbsp;</li><li>Clinical and pharmaceutical analysis of biological fluids&nbsp;</li><li>Food safety and environmental monitoring&nbsp;</li><li>Forensic and toxicological analyses&nbsp;</li></ul>Thanks to its modular design and the ability to select various SPE cartridges based on polarity and interactions, the device can be easily adapted to specific applications.&nbsp;<h4>Operation and Software&nbsp;</h4>The system's user-friendly interface enables easy setup of each SPE step, including cartridge selection, volumes, elution solvents, and wash sequences. The entire process can be fully programmed, minimizing the need for operator involvement during analysis.&nbsp;<h4>Conclusion&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/laboratory-automation/streamline-ole-200/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky">Streamline OLE 200</a> from <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky">Watrex Praha</a> prepresents a modern and powerful tool for automated sample pre-concentration that significantly enhances efficiency, reliability, and accuracy in analytical laboratories. Its flexibility, robust design, and easy integration with existing systems make it an ideal solution for demanding applications in environmental analysis, pharmaceutical research, and routine quality control.&nbsp;<blockquote>Want to learn more? Visit our website at <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=linkedin&amp;utm_medium=propagace&amp;utm_campaign=linkedin_clanky">www.watrex.com</a> or email us at watrex@watrex.com.</blockquote>

Flawless and Effortless: How the Streamline™ OLE 200 Transforms Sample Preparation for HPLC? 

Article

Product

Academy

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Environment

For more than 40 years, ALS has provided testing and technical solutions to clients all over the world in a wide range of industries. We have built our global reputation by embracing the latest technologies and innovative methodologies to deliver high quality testing services to clients. ALS is able to leverage a multifaceted international team while remaining agile enough to provide local expertise and personalized solutions to every one of our clients.

ALS Czech Republic

Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Watrex Praha

Agilent Technologies

Technology Networks

GERSTEL

Thermo Fisher Scientific

C&EN

SCIEX

Waters Corporation

If your goal is to maximize instrument uptime and minimize troubleshooting, then being proactive about your HPLC preventative maintenance is a must. Similar to cars needing regular oil changes, tire pressure adjustments, our HPLC systems also need routine maintenance in order to keep them performing at their best.This presentation will look at several key issues, such as:<ul><li>How often typical preventive maintenance (PM) tasks should be performed.</li><li>What signs to look for that may indicate a need for maintenance.</li><li>Tools for testing the LC systems before and after maintenance.</li></ul>This webinar aims to provide you with the tools to create your own preventative schedule and the skills to implement them effectively.<blockquote>Presenter: Melissa Goodlad (Application Engineer, Agilent Technologies, Inc.)Melissa Goodlad is an Application Engineer providing applications assistance and technical support for Agilent’s HPLC columns and consumables. Before joining Agilent, Melissa was completing her PhD in Physical Chemistry at UC Merced studying nanoparticle self-assemblies.</blockquote>

Agilent Technologies: Becoming a Better Chromatographer - Educational Webinar Series

Preventative and Routine Maintenance for Your HPLC System

This presentation will look at several key issues, such as how often typical preventive maintenance (PM) tasks should be performed.

The Briggs-Rauscher reaction is one of the most captivating demonstrations that a chemist can perform. It is an oscillating reaction that cycles through multiple striking color changes for several minutes, providing a visual example of how chemicals transform in real time. The Briggs-Rauscher reaction involves colored intermediates, with kinetics influenced by temperature. Tracking these color changes is achievable using temperature-controlled UV-Vis spectroscopy. The Agilent Cary 3500 UV-Vis spectrophotometer was used to investigate this reaction at four different temperatures simultaneously. The system's fast data collection and accurate temperature control enabled efficient characterization of complex reaction kinetics<blockquote>Presenter: Marc-Andre Gagnon</blockquote>

Agilent Technologies: Kinetics of an Oscillating Reaction using Temperature-Controlled UV-Vis Spectroscopy

Kinetics of an Oscillating Reaction using Temperature-Controlled UV-Vis Spectroscopy

The Agilent Cary 3500 UV-Vis spectrophotometer was used to investigate Briggs-Rauscher reaction at four different temperatures simultaneously. 

Oscillating Reaction Kinetics via Temp-Controlled UV-Vis

<h5>HPLC purification is powerful and its purpose practical:</h5><ul><li>Recover the target compound</li><li>Obtain desired target purity and yield</li><li>Complete the purification in the least amount of time</li></ul>“Sticky” compounds seemingly hang up in the preparative column and are difficult to effectively detect and collect. When this occurs, prep separations degrade, and the target’s purification success is at risk. In particular, metal-sensitive targets can adsorb to positively charged metal surfaces in the flow path and column. These non-specific adsorbers (NSAs) behave unpredictably and can lead to sample loss, compromised purity or low throughput. Learn how to overcome these issues in LC purifications and improve productivity with a new OBD preparative column technology that is inert to analytes that may be prone to non-specific binding.<h5>Key Objectives:</h5><ul><li>What types of compounds can be NSAs</li><li>What are the chromatographic issues NSAs exhibit and the impact they have on compound purification</li><li>How to mitigate NSA challenges with inert preparative columns</li><li>How to safeguard your purifications even when isolating compounds with unknown structures which may be non-specific adsorbers</li><li>How improving sensitivity can significantly improve outcomes from batch library purifications or for other samples where first-time injection success is paramount to retrieve even low-level targets</li></ul>

C&EN: Next Level Purification Efficiency for Small Molecule Targets and Beyond

Next Level Purification Efficiency for Small Molecule Targets and Beyond

Struggling with “sticky” compounds in prep HPLC? Learn how inert column tech helps overcome NSA issues, boost yield, and protect your sensitive analytes.

Purification Efficiency for Small Molecule Targets

Ensuring the integrity of your data is critical for all life sciences organizations. There is a critical intersection of data integrity and chromatography data systems (CDS). In this session, we explore how Empower Software supports compliance with ALCOA++ principles -- ensuring your data is attributable, legible, contemporaneous, original, accurate, and more.Whether you are an experienced Empower Software user or just beginning your journey, this interactive session is your opportunity to ask questions, gain practical tips, and learn how to leverage Empower Software features to meet regulatory expectations with confidence.From audit trails to secure user access and electronic signatures, we will share insights, best practices, and real-world examples to help you strengthen your lab’s data integrity framework.<h5>Key Takeaways:</h5><ul><li>Understand how Empower Software aligns with ALCOA++ principles</li><li>Learn practical tips for configuring Empower Software for compliance</li><li>Get answers to your most pressing data integrity questions</li><li>Discover tools and features that enhance traceability and accountability</li></ul>Please join us for a lively discussion as we explore this topic. &nbsp;As always, please bring your questions for this exclusive opportunity to ask our experts anything about using Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About ALCOA++ Best Practices in Empower Software

Empower Tips: Ask Me Anything About ALCOA++ Best Practices in Empower Software

We explore how Empower Software supports compliance with ALCOA++ principles -- ensuring your data is attributable, legible, contemporaneous, original, accurate

ALCOA++ Practices in Empower Software

<h4>SCIEX OS software summer school - part 2</h4>Ready to take your SCIEX OS skills to the next level?Join us for part 2 of our live summer school series and continue building your confidence in SCIEX OS software. These short, 30-minute sessions are designed to fit into your day and give you actionable insights, fast.<ul><li>Practical, focused 30-minute sessions</li><li>Live Q&amp;A with SCIEX experts</li><li>Build confidence using SCIEX OS software</li><li>Designed for busy scientists and lab professionals</li></ul><h5>Agenda:</h5><ul><li>23 July, 11:00 am CET: MS tuning</li><li>6 August, 11:00 am CET:&nbsp;Compound optimization</li><li>20 August, 11:00 am CET: Data acquisition (setting up your method)</li><li>3 September, 11:00 am CET: Data processing (quantitation)</li></ul>

SCIEX: SCIEX OS software summer school – part 2 

SCIEX OS software summer school – part 2: Compound optimization

Join us for part 2 of our live summer school series and continue building your confidence in SCIEX OS software. 

SCIEX OS software summer school Compound optimization

Join us for an enlightening webinar series designed to empower academicians and researchers by exploring the latest advancements and opportunities in pharmaceutical sciences. At Agilent, we recognize the unique challenges faced by academicians, researchers, and students. At PharmaFrontiers, we have curated a series of content tailored to address your needs and unlock new opportunities.The PharmaFrontiers seminar series is designed to provide you with valuable knowledge, insights, and practical skills.Topics to be covered:<ul><li>Introduction to Unlocking Intelligent Features of the Agilent Infinity III LC Series.&nbsp;</li><li>Advance your lab with the performance and intelligence of next-generation LC-MS detection.</li><li>Achieve More and Uncover Biological Insights Faster: End-to-End LC Platforms, LC/TQ, and LC/QTOF Workflows.</li></ul><blockquote>Presenter: Dr. Nirmal Thakker (Technical Application Support Specialist – Chromatography, Dissolution &amp; Lab Informatics, Agilent Technologies)Dr. Nirmal has done his PhD in quality assurance and pharmacy and his master's in pharmacy from the University of Pune. He has more than 15 years of overall industrial experience working in analytical research &amp; development for renowned multinational pharma companies like Glenmark, Torrent, and Piramal. He has also worked with Spinco Biotech as an application specialist for LC. Presently, he is working with Agilent Technologies as a technical application support specialist for chromatography, dissolution, and lab informatics. He has expertise in chromatography, QbD, method transfer, and mass spectrometry.Presenter: Vinayak AK (Pre-Sales Applications Engineer - LC/MS and Automation, Agilent Technologies)Vinayak AK began his career at Agilent in 2012 as a campus hire working as an application associate. He then transitioned to the segment marketing team as an application scientist, a role he held for 5 years. For the past 8 years, Vinayak has been serving as a pre-sales applications engineer/product specialist for LC and then for LC/MS. His expertise includes method development for MS-based impurity analysis and purification and cleaning validation workflows, utilizing solutions such as the Agilent 6150 Series Single Quadrupole LC/MS. Vinayak has published a total of 13 application notes across various workflow solutions based on Agilent UHPLC and QbD solutions, including 3 specifically on Agilent Single Quadrupole solutions.Presenter: Dr. Ashish Pargaonkar (Biopharma Market Development Specialist, Agilent Technologies)Dr. Ashish Pargaonkar is a Lead for Biopharma Workflow Commercialization team for India and also Manager for Centre of Excellences at Bangalore. A Microbiologist by education with a Ph.D, he holds more than 20 years of experience for Biopharma market applications on Hi Resolution Mass Spectrometry.He has a long record of successful demonstrations and customer engagements on workflows for CQA’s, Intact mass, peptide mapping, HCP and Glycans using Agilent state-of-the art solutions. He has authored ASMS posters on media components and therapeutic peptides. Dr. Ashish has been invited speaker at several conferences and workshops at Biosimilar Congress, ADC 2018, IIT (Mumbai, Delhi), ICT (Mumbai), PSI events.</blockquote>

Agilent Technologies: Pharma Frontiers Live Webinar Series: Analytical Techniques, Advances in Chromatography and Regulatory Compliance

Ensuring Excellence: Cutting-Edge Techniques for Pharmaceutical Analysis [LC/LCMS]

Discover smart LC features and next-gen LC-MS workflows. Learn how LC/TQ and LC/QTOF platforms can accelerate biological insights and lab productivity.

LC/LCMS Pharmaceutical Analysis

Join us for an enlightening webinar series designed to empower academicians and researchers by exploring the latest advancements and opportunities in pharmaceutical sciences. At Agilent, we recognize the unique challenges faced by academicians, researchers, and students. At PharmaFrontiers, we have curated a series of content tailored to address your needs and unlock new opportunities.The PharmaFrontiers seminar series is designed to provide you with valuable knowledge, insights, and practical skills.Topics to be covered:<ul><li>Finding the Perfect Match: Practical Advice on LC Column Selection.</li><li>Modernizing Academic Laboratories with Agilent OpenLab CDS &amp; SLIMS Software.</li></ul><blockquote>Presenter: Dr. Sunil B Lakhmapure (Pre-Sales Application Engineer, Agilent Technologies)Sunil holds 19 year plus experience in the analytical field with major exposure to LC/GC with Single Quad, Triple Quad and high resolution (QToF) mass spectroscopy. Started career in Pharma R&amp;D as a scientist with hands on experience on high end instruments like LC/MS, XRD &amp; NMR. Developed &amp; published application notes using Chromatographic techniques on real world samples/issues at various levels.Presenter: Mr. Venkatesh Vecham (Application Specialist - Lab Informatics, Agilent Technologies)Vecham Venkatesh is an experienced professional in the analytical and pharmaceutical industry. With over 19 years of expertise, he has held various roles, including Lab Informatics Application Specialist at the Centre of Excellence in Bangalore since 2018. His extensive knowledge includes being an instructor for Agilent Chromatography Software products, such as ChemStation edition software, EZChrom edition software, and OpenLab CDS 2.x, for a period of 4 years. Additionally, Vecham has worked closely with the Informatics, CSVC, R&amp;D, and Quality Control departments as a manager in the pharmaceutical industry. Vecham's experience includes handling audits from regulatory bodies like the USFDA, MHRA, ANVISA, and TGA.</blockquote>

Enabling Workflow Solutions for Pharmaceutical Analysis

Expert tips on choosing right LC column. See how Agilent OpenLab CDS & SLIMS can modernize academic labs through digital workflows and smarter data handling.

Join us on Wednesday, July 30, 2 p.m. EST, for a session on how automation is revolutionizing solid phase extraction (SPE) workflows across diverse analytical applications.<h5>Featured Talks:</h5><ul><li>"Optimizing SPE Sample Preparation: Automation Strategies for Diverse Sample Volumes and Matrices" – Sebastian Wierer, Product Manager Robotics, LCTech GmbH</li><li>"Automating Solid Phase Extraction Methods: From Fields to Pharmacy" – Fred Foster, Applications Scientist, GERSTEL, Inc.</li></ul><h5>Topics include:</h5><ul><li>Chloramphenicol in honey</li><li>Psilocin in serum and urine</li><li>PPCPs &amp; 6-PPDQ in water samples</li><li>Acidic pesticides in potable water</li><li>Drugs of abuse in blood</li></ul><blockquote>Presenter: Fred Foster (Applications Scientist, GERSTEL, Inc.)Presenter: Sebastian Wierer (Produt Manager Robotics, R&amp;D, LCTech GmbH)</blockquote>

GERSTEL: Smart Sample Preparation: Automated SPE for All Areas of Analytical Chemistry

Smart Sample Preparation: Automated SPE for All Areas of Analytical Chemistry

Join us for a session on how automation is revolutionizing solid phase extraction (SPE) workflows across diverse analytical applications.

Smart Sample Preparation - Automated SPE

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Join this free best practices webinar under the motto "Successful with Chromeleon Software!". This webinar is specifically designed for users who want to further develop and optimize their skills in handling the Thermo Scientific Chromeleon chromatography data system. Goal of this session is to provide you with practical insights and valuable tips so that you can fully exploit the potential of the Chromeleon CDS.<h5>Topics:</h5>1. The new way of eWorkflows: Discover the latest developments in the field of eWorkflows. We will show you how to optimize and automate your workflows with the latest features of Chromeleon CDS. Learn how to save time, increase accuracy of your analysis, and maximize efficiency of your laboratory processes through the use of eWorkflows.2. Easy peak integration: Peak integration is a central task in data analysis with Chromeleon CDS. In this section of the webinar, you will learn how to integrate peaks quickly and accurately. We will introduce proven methods and techniques that will help you simplify and improve your data analysis processes. Discover how to achieve consistent and reliable results with the integrated tools in Chromeleon software.<h5>Reasons to attend:</h5><ul><li>Receive practical tips and tricks from our Chromeleon experts</li><li>Learn about the latest features and updates of Chromeleon CDS</li><li>Improve your efficiency and accuracy in using Chromeleon software</li><li>Take the opportunity to ask questions</li></ul><h5>Who should attend:</h5>This webinar is aimed to all Chromeleon users who want to deepen their knowledge and optimize their workflows. Whether you are a beginner or experienced user - this webinar offers valuable information for everyone.Can´t attend on July 31? Please register anyway to automatically receive the link to the webinar recording.<blockquote>Presenter: Michele Musu (Technical Sales Specialist for Chromatography and Mass Spectrometry Software, Thermo Fisher Scientific)Presenter: Zoe Julian (Product Marketing Manager, Thermo Fisher Scientific)Zoe Julian is a product marketing manager for chromatography and mass spectrometry software at Thermo Fisher Scientific.With over 12 years' experience of working with chromatography and mass spectrometry techniques with a background in GC and GC-MS(/MS) organic environmental analysis, she has helped many laboratories and industries improve their workflows through a unique understanding of their challenges. Transitioning to a focus on Chromeleon CDS she has shown customers how software solutions can improve their productivity and support their day-to-day operations.</blockquote></div></div></div>

Thermo Fisher Scientific: eWorkflows and peak integration in Chromeleon CDS software

eWorkflows and peak integration in Chromeleon CDS software

Webinar is designed for users who want to further develop and optimize their skills in handling the Thermo Scientific Chromeleon chromatography data system

Modernization of liquid chromatography (LC) methods is critical for lab productivity and sustainability as well as for keeping up to date with regulatory guidelines. This webinar features two expert speakers who will share insights into the latest LC methods and technologies.Rongjie Fu will cover how to modernize method transfers and adjustments based on revisions to the United States Pharmacopeia (USP), exploring how this can improve lab productivity.Dr. Monique Paré Speirs will then demonstrate how inefficient high-performance LC methods can be overhauled with updated technology to enhance lab sustainability without compromising method accuracy and precision.<h5>Attend this webinar to:</h5><ul><li>Learn how to combine classic single-analyte methods to more efficient multi-analyte methods</li><li>Discover the importance of LC-friendly method development for preventative maintenance of columns and instruments</li><li>Gain insights into how to improve lab efficiency and sustainability with modernized column technology</li><li>Understand the difference between newly revised and original version of USP &lt;621&gt;</li></ul><blockquote>Presenter: Rongjie Fu (Application Scientist, Agilent Technologies)Rongjie Fu received a master’s degree in pharmaceutics from Shanghai University of TCM and is currently working at Agilent Technologies as an application scientist. Presenter: Monique Paré Speirs, PhD (Analytical Chemist, Rhyz Analytical Labs)Monique Paré Speirs is a researcher and method developer for Rhyz Analytical Labs (a Nu Skin company). She has collaborated with Agilent on development projects and her appreciation for Agilent LC technology originated from her experience with Agilent LC/MS systems during her graduate work in the John C. Price Lab at Brigham Young University.</blockquote>

Technology Networks: Modernization of Liquid Chromatography Methods

Modernization of Liquid Chromatography Methods

This webinar features two expert speakers who will share insights into the latest LC methods and technologies.