<h3><strong>A Dedicated Solution for Oligonucleotide Analysis</strong></h3><p>Oligonucleotides have become key players in modern pharmaceutical and biological research, particularly in the development of highly targeted and personalized therapies. As increasing numbers of oligonucleotide-based drugs enter clinical trials or receive regulatory approval, analytical laboratories face growing demands for both throughput and data quality. These molecules present unique chromatographic challenges due to their long, highly polar structures and subtle variations in nucleobase sequence or functionalization.</p><h3><strong>Sepapure oliGO – Designed for Oligonucleotide Separations</strong></h3><p>Selecting the optimal chromatographic approach for oligonucleotide analysis can be complex. Many laboratories rely on ion-pair reversed-phase (IP-RP) chromatography because of its speed, robustness, and compatibility with mass spectrometry. However, commonly used ion-pair reagents can degrade conventional silica-based stationary phases.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.knauer.net/columns-oligonucleotide-columns"><strong>Sepapure oliGO</strong></a> addresses this limitation through a hybrid silica matrix combined with specialized surface end-capping, ensuring resistance to aggressive IP-RP reagents. Its functionalized surface enables both strong reversed-phase interactions and controlled ionic contributions, effectively creating a mixed-mode separation mechanism. This design results in improved durability compared with standard mixed-mode columns, making Sepapure oliGO a robust choice for routine oligonucleotide workflows.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_Sepapure_oli_GO_columns_with_laser_etched_column_information_23f545be81.jpg" alt="KNAUER: Figure 1 - Sepapure oliGO columns with laser-etched column information." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_Sepapure_oli_GO_columns_with_laser_etched_column_information_23f545be81.jpg 223w," sizes="100vw" width="1186" height="828"></p><h3><strong>Method Transfer and Comparative Performance</strong></h3><p>In collaboration with BianoGMP GmbH, KNAUER’s application team evaluated Sepapure oliGO against a widely used reference column. The study compared oligonucleotides of varying lengths and purities, including a fully thiolated 43-mer DNA. Particular attention was paid to potential interactions between thiolated oligonucleotides and stainless-steel hardware, which have been reported to cause peak tailing.</p><p>The results demonstrated that direct method transfer between the reference column and Sepapure oliGO was generally feasible without significant adjustment. Chromatographic resolution remained comparable, while retention times were slightly shorter on Sepapure oliGO. Furthermore, the anticipated benefits of expensive bioinert hardware were not confirmed under the tested conditions, suggesting that such effects may primarily influence very fast (U)HPLC separations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Overlayed_chromatogram_of_crude_product_of_a_43mer_thiolate_oligonucleotide_7ae9613efd.jpg" alt="KNAUER: Figure 2: Overlayed chromatogram of crude product of a 43mer thiolate oligonucleotide. Light blue - reference column and dark blue – Sepapure oliGO." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Overlayed_chromatogram_of_crude_product_of_a_43mer_thiolate_oligonucleotide_7ae9613efd.jpg 245w," sizes="100vw" width="1223" height="453"></p><h3><strong>Low Backpressure for Reliable Operation</strong></h3><p>Sepapure oliGO can be applied effectively in both HPLC and (U)HPLC workflows. Its low operating backpressure minimizes risks associated with clogging, excessive system wear, and performance deterioration over time. Typical IP-RP separations using 3 µm particles generated pressures around 200 bar, enabling laboratories without ultra-high-pressure systems to perform high-quality oligonucleotide analysis.</p><h3><strong>Best Practices for Column Performance</strong></h3><p>To maintain optimal performance, users should observe recommended operating conditions, including a broad <strong>pH range of 1.5–10</strong> and <strong>temperatures up to 60 °C.</strong> Employing a <strong>guard column</strong> can prevent coarse synthesis by-products from reaching the analytical column. If pressure increases are observed, backflushing at low flow rates can restore performance.</p><p>When the system is idle, thorough flushing to remove salts is essential. For storage, the column should be kept in a <strong>1:1 mixture of methanol–water</strong> or <strong>acetonitrile–water.</strong> Gradient transitions are recommended when switching between standard RP eluents and IP-RP reagents. Regeneration procedures developed for RP columns are also suitable for Sepapure oliGO.</p><h3><strong>Beyond Analytical Separations</strong></h3><p>For large-scale purification, ion-exchange chromatography (AEX) may offer advantages. Scalable preparative systems are available to support purification workflows, ranging from compact laboratory setups to pilot-scale platforms with flow rates up to 800 mL/min. Bioinert configurations can be integrated where required, allowing laboratories to tailor purification solutions to their specific oligonucleotide applications.</p><blockquote><ul><li>If you're planning to set up or optimize your oligonucleotide workflow, feel free to contact us at <strong>sales@knauer.net</strong>. Stay tuned for more exciting insights into the Oligonucleotide world in our “<strong>Oligos Made Easy</strong>” series.</li><li>For more in-depth discussion or questions, reach out to the author at <strong>folmert@knauer.net&nbsp;</strong></li></ul></blockquote>

Oligos Made Easy - Part 8: Sepapure oliGO

<p><strong>Visit the LabRulez booth at </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871"><strong>analytica 2026</strong></a><strong> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"></p><h3><strong>Would you like to learn how the LabRulez portals work?</strong></h3><p>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/"><strong>LabRulezLCMS</strong></a><br>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/"><strong>LabRulezGCMS</strong></a><br>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/"><strong>LabRulezICPMS</strong></a></p><ul><li>A <strong>unique online solution</strong> for <strong>your marketing</strong></li><li>A <strong>targeted audience</strong> from the <strong>analytical chemistry community</strong></li><li><strong>Modern technologies</strong> and a unique concept</li><li><strong>Design optimized for most smart devices</strong> – PC, mobile, and tablet</li><li><strong>Advanced statistical tools</strong> fully available to users</li></ul><h3><strong>Services Offered</strong></h3><h4><strong>News + Company Updates</strong></h4><ul><li>Publish <strong>news related to your instrumentation, applications, services, events, job openings</strong>, and more</li><li><strong>News is shared</strong> both on our <strong>portals</strong> and across our <strong>social media channels</strong></li></ul><h4><strong>Library – All Documents in One Place</strong></h4><ul><li><strong>Applications, posters, presentations, technical articles, brochures, specifications</strong></li><li><strong>Fas</strong>t and <strong>advanced search</strong> capabilities</li><li>Over <strong>32,000 documents</strong> currently available in our database</li></ul><h4><strong>Webinars</strong></h4><ul><li><strong>Upcoming and on-demand webinars</strong> from the field of analytical chemistry</li><li>More than <strong>5,500 webinars</strong> covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4><strong>Careers</strong></h4><ul><li><strong>Targeted job</strong> listings in <strong>analytical chemistry</strong></li><li>Clear filtering by specialization or location</li><li><strong>Increased visibility for job postings</strong></li></ul><h4><strong>Companies</strong></h4><ul><li><strong>Company profile</strong> with key information and contacts</li><li><strong>Integration of all your activities on our portal:</strong> News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li><strong>Connection to your Products </strong>listed on LabRulez portals</li></ul><h4><strong>Products and Services</strong></h4><ul><li>Comprehensive <strong>overview of instrumental techniques and services</strong></li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4><strong>Marketplace</strong></h4><ul><li><strong>Buying and selling pre-owned analytical equipment</strong></li><li>We purchase analytical instrumentation of all brands and ages</li><li><strong>Sell your equipment through LabRulez</strong></li><li>Request and purchase <strong>complete systems, modules</strong>, or <strong>spare parts</strong> with warranty and service</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"></p><h3><strong>What Will Be on Display at Our Booth?</strong></h3><p>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar"><strong>LabRulezLCMS Marketplace</strong></a></h4><p><strong>Spare parts for LC/MS:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378"><strong>Vacuum turbo pumps for LC/MS</strong></a></li></ul><p><strong>Spare parts for HPLC:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397"><strong>Degassers for HPLC/UHPLC</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve"><strong>Automatic valves for HPLC</strong></a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul><p><strong>Consumables:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377"><strong>HPLC lamps</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48"><strong>HPLC columns</strong></a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar"><strong>LabRulezGCMS Marketplace</strong></a></h4><p><strong>Spare parts for GC/MS:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo"><strong>Turbo pumps for GC/MS</strong></a></li></ul><p><strong>Spare parts for GC:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC"><strong>EPC modules</strong></a></li></ul><p><strong>Sample injection</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432"><strong>Autosampler 7693A for GC</strong></a></li></ul><p><strong>Consumables:</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7"><strong>GC columns </strong></a>and selected accessories</li></ul>

LabRulez at analytica 2026

News from LabRulezLCMS Library - Week 13, 2026

Article

Product

Events

Application

Science and research

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

DataApex

Separation Science

Agilent Technologies

Bruker

Phenomenex

Thermo Fisher Scientific

Evosep Biosystems

SciY/Mestrelab Research

Waters Corporation

<h5><strong>Key Learning Points:</strong></h5><ul><li>Understand best practices upon opening a new LC Column</li><li>Learn how to clean and regenerate an LC Column</li><li>Find out about additional products and practices that can be used to minimize contamination getting onto LC columns</li></ul><h5><strong>Who Should Attend:</strong></h5><ul><li>Any LC user who would like to ensure that their LC columns are properly cared for to make sure to get most life out of it that is possible.</li></ul><blockquote><p><strong>Presenter:</strong> Genevieve Hodson (Senior Manager, Technical Support &amp; Applications, Phenomenex)</p><p>Genevieve graduated from the University of Texas with a BS in Chemistry located in her home town of Austin Texas. She spent 2 years of her undergraduate performing research in an Organic Chemistry Lab synthesizing intermediates. Out of school she spent 4 years as an Analytical Chemist in the QC and R&amp;D Department of Cerilliant (a Sigma Millipore Company). There she worked with many analytical instruments but became an expert at LC by performing purity analysis, customer specific methods, validations, qc testing and stability studies on a wide range of small molecules including pharmaceuticals, pesticides, explosives and illegal substances. From there she moved to Los Angeles California where she worked at Johnson and Johnson and then a small dietary supplement company. After Genevieve spent a year living abroad in Israel raising her first son, she moved back to LA where she got hired as a Technical Specialist at Phenomenex. At Phenomenex she enjoys continuing to learn about chromatography every day through helping customer with all their chromatography needs!</p></blockquote>

Phenomenex: How to Take Care of Your LC Column

How to Take Care of Your LC Column

Learn about the best practices upon opening your new LC Column, how to clean and regenerate, and additional products and practices...

<h3><strong>Key Learning Points</strong></h3><ul><li>Understand the importance of knowing your analyte and how they influence analysis and optimization</li><li>Learn the importance of an analyte’s physicochemical properties</li><li>Gain an understanding of the main chemical interactions during analyte separation</li></ul><h5>Who Should Attend</h5><p>Anyone interested in better understanding the role of an analyte’s physicochemical properties and how these drive chromatographic separations.</p><blockquote><p><strong>Presenter</strong>: Lucia Geis Asteggiante (Senior Technical Specialist, Phenomenex)</p><p>Lucia is a Senior Technical Specialist that has recently joined Phenomenex’s Global Technical Team. She has a broad experience in the field of Analytical Chemistry with a particular focus on LC chromatography coupled with mass spectrometry. Lucia comes from a strong academic and regulatory background with experiences ranging from method development and analysis of small molecules to large protein complexes. She gained her Ph.D. at the University of Maryland - College Park, USA and did her post-doctoral work at the University of Oxford, UK. During her time as a researcher, she has authored/co-authored 23 scientific publications and 2 book chapters.</p></blockquote>

Phenomenex: Knowing your Analyte Properties to Optimize Analysis

Knowing your Analyte Properties to Optimize Analysis

Understand the importance of knowing your analyte and how they influence analysis and optimization

<p><strong>Measuring scattering samples with UV-VIS-NIR can be challenging for basic instruments. These samples will have diffuse reflectance or transmission and less light hitting your detector.</strong></p><p>In this presentation, we will discuss diffuse reflectance accessories (DRAs) for collecting all light in a measurement as well as Agilent's universal measurement accessory (UMA) for measuring the angular distribution of the reflected light.</p><blockquote><p><strong>Presenter:</strong> Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)</p><p>Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.</p></blockquote>

Agilent Technologies: Measuring Diffuse Powders and Films With UV-VIS-NIR

Measuring Diffuse Powders and Films With UV-VIS-NIR

We will discuss diffuse reflectance accessories (DRAs) as well as Agilent's universal measurement accessory (UMA).

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Working with liquid chromatography (LC) brings the constant challenge to deliver clean separations and defensible data. Labs face column variability, drifting retention times, pressure spikes, ion-pairing issues, and the ongoing challenge of designing methods that hold up across instruments, sites, and sample types.</strong></p><p>Join us for our next 'Expert Answers' session in which Jim Grinias, Professor of Chemistry at Rowan University, will tackle your LC questions. Whether you work in research, QC, or regulated environments, this session gives you space to raise the topics that matter most to your lab.</p><h5><strong>By attending this webinar, you will learn:</strong></h5><ul><li>Practical ways to think through LC troubleshooting</li><li>Factors that influence LC performance across instruments and workflows</li><li>Guidance to strengthen everyday method decisions</li><li>Resources that help elevate routine LC work</li></ul><blockquote><p><strong>Presenter: </strong>Dr. James Grinias (Professor, Department of Chemistry &amp; Biochemistry, Rowan University)</p><p>James Grinias is a Professor in the Department of Chemistry &amp; Biochemistry at Rowan University in Glassboro, New Jersey, USA. Dr. Grinias has a number of research interests focused on chemical separations and microfluidics, both at the fundamental level and for the analysis of biological systems. He is the recipient of the 2021 American Chemical Society Satinder Ahuja Award for Young Investigators in Separation Science and the 2022 LCGC Emerging Leader in Chromatography. At Rowan, he teaches courses in general, analytical, and bioanalytical chemistry while also conducting research on UHPLC column performance and instrument miniaturization.</p></blockquote></div></div></div>

SeparationScience: Expert Answers: LC Troubleshooting and Best Practices

Expert Answers: LC Troubleshooting and Best Practices

Tap into expert LC guidance as Jim Grinias answers your questions on troubleshooting, method choices, and performance across workflows.

LC Troubleshooting and Best Practices

<p><strong>Learn incredible tricks and tips for maximizing your experience with </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/products/305"><strong>Clarity Chromatography Software</strong></a><strong>. Dive into advanced functionalities and discover how to elevate your workflows.</strong></p><p><strong>We will closely look at Sequences and Calibrations.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/training_reservation/149189"><strong>Register Here</strong></a></p></blockquote>

DataApex Clarity software Tips & Tricks Webinar

Learn incredible tricks and tips for maximizing your experience with Clarity Chromatography Software

<p><strong>Discover how to boost efficiency and simplify your LC-MS workflows with Evosep.&nbsp;</strong></p><p><strong>Whether you’re just getting started or exploring new ways to streamline your proteomics setup, this session provides practical insights for users at any experience level. Learn how Evosep’s intuitive, automation-driven technology makes LC-MS–based proteomics accessible, reliable, and easy to integrate into your everyday lab routines.</strong></p><h4><strong>Technology introduction and Q&amp;A session</strong></h4><ul><li>hosted by Nicolai Bache, Chief Strategic officer at Evosep</li></ul><h4><strong>Beginner’s guide to Evosep Eno</strong></h4><ul><li>Talk by Djordje Vasiljevic, PhD., Product specialist at Evosep</li></ul>

Evosep Biosystems: Beginner’s guide to Evosep

Beginner’s guide to Evosep

Discover how to boost efficiency and simplify your LC-MS workflows with Evosep.

<div><h4><strong>Unlock the Secrets of Lipid Nanoparticle Characterization</strong></h4><p><strong>Join our exclusive webinar and discover how to overcome the toughest challenges in LNP analysis.</strong></p><p>Are you working with lipid nanoparticles, liposomes, or other lipid-based drug carriers? Whether you’re in discovery, development, QC, or analytical services, or supporting these efforts in a CRO or biotech institute, this session is for you!</p><h4><strong>What you’ll gain:</strong></h4><ul><li><strong>Boost Lab Efficiency: </strong>Learn how automated zeta potential and size measurements for up to 96 samples in a single run free your team to focus on science, not repetitive tasks.</li><li><strong>Master Challenging Samples: </strong>See how Flow Mode preserves sample integrity and delivers precision, even at physiological ionic strength.</li><li><strong>Simplify Your Workflow:</strong> Experience intuitive guided workflows and DYNAMICS Software, fully 21 CFR Part 11–compliant, to ensure data integrity and smooth transition from research to QC.</li></ul><h4><strong>Why attend?</strong></h4><p>Traditional methods struggle with high-salt media, low-charge samples, and regulatory scrutiny. We’ll show you how the DynaPro ZetaStar solves these pain points, delivering accurate, reproducible results with less than 10% RSD, full compliance, and automation that scales with your needs. Plus, discover how DYNAMICS Software and DYNAMICS Touch make complex analyses simple, reliable, and fast, even from microliter volumes.</p><p><strong>Don’t miss this chance to transform your LNP characterization process.</strong></p><p><i>Reserve your spot today and take the first step toward faster, more reliable insights.</i></p><blockquote><p><strong>Presenter:</strong> Richard Chung (Lab Analytics Product Manager, Waters | Wyatt Technology)</p><p>Since joining Wyatt in 2016, he has held key roles, including Application Scientist and Customer Support Manager, where he worked closely with researchers to solve complex analytical challenges. Now, as a Product Manager, Richard bridges the gap between scientists and better instruments - gathering insights from the field and collaborating with internal research teams to develop cutting-edge solutions that empower laboratories worldwide.</p></blockquote></div>

Waters Corporation: Automation, Speed, and Simplicity for Total Lipid Nanoparticle Characterization

Automation, Speed, and Simplicity for Total Lipid Nanoparticle Characterization

Join our exclusive webinar and discover how to overcome the toughest challenges in LNP analysis.

Total Lipid Nanoparticle Characterization

<div><h3><strong>Discover the Future of Lipid Imaging and Multi-Omics Integration</strong></h3><p><strong>We’re excited to partner with the University of Pittsburgh to bring you an exclusive webinar with Dr. Brian Hoffmann from The Jackson Laboratory. Join us as we introduce cutting-edge technologies which combine highly-sensitive LC-MS and spatial mass spectrometry imaging (MSI) capabilities to offer new possibilities for metabolomics and lipidomics research.</strong></p><p>Following an introduction to the timsTOF fleX by the Bruker application team, Dr. Hoffmann will present on how he utilizes traditional LC-MS with MSI at the Jackson Laboratory to target physiological changes across numerous systems. His research integrates lipidomics, metabolomics, and proteomic analyses down to the single cell level to identify specific changes in aging and Alzheimer’s Disease.</p><p>Within these studies, Dr. Hoffmann utilizes MSI (down to 5 micron resolution) on the timsTOF fleX platform to characterize the spatial distribution of diverse molecular classes, with a focus on lipidomics, to reveal critical relationships that drive aging and neurodegenerative processes. As the spatial lipid distribution defines the physiology of the brain across conditions in these studies, he utilizes the MSI lipidomics data to further determine specific regions of interest to follow-up with complementary multi-omics analyses.</p><h4><strong>Key Learning Objectives:</strong></h4><ul><li>Introduce Mass Spectrometry Imaging (MSI)</li><li>Understand the value in combining spatial MSI with traditional bulk LC-MS data</li><li>Explore ways researchers leverage multi-omics studies on the timsTOF fleX to draw new insights from complex disease and biological systems</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>Scientists and researchers interested in expanding their metabolomics and lipidomics workflows to the spatial dimension</li><li>Those interested in multi-omics and next-generation mass spectrometry applications</li><li>Anyone interested in learning more about Mass Spectrometry Imaging</li></ul><p><i>Don’t miss this opportunity to gain expert insights and stay ahead in the field of multi-omics research.</i></p><blockquote><p><strong>Presenter:</strong> Brian R. Hoffmann, Ph.D. (Director of Protein Sciences and Mass Spectrometry Services, The Jackson Laboratory, Bar Harbor, ME, USA)</p><p>Brian Hoffmann, Ph.D., is the Director of Protein Sciences and Mass Spectrometry Services at The Jackson Laboratory. He obtained his doctorate degree from the University of Wisconsin-Madison in Molecular and Cellular Pharmacology, with a focus on protein interactions and modifications in the extracellular matrix. During this time he also received formal and informal mass spectrometry training on a variety of mass spectrometry instruments. This training was then furthered through a postdoctoral position at the Medical College of Wisconsin in stem cell physiology and proteomics. While at the Medical College of Wisconsin he received a NIH NIDDK K01 grant related to the influence of hyperglycemia on the cardiovascular system and transitioned to an Assistant Professor position in the Department of Biomedical Engineering.</p><p>In late 2020, he was recruited to The Jackson Laboratory as a Scientist to build up the mass spectrometry capabilities and has since transitioned to his current position managing the Mass Spectrometry Service. In his laboratory the team utilizes multi-omics mass spectrometry-based approaches for molecular phenotyping of a variety of models.</p></blockquote></div>

Bruker: Lipid Imaging Mass Spectrometry and Multi-Omics Integration

Lipid Imaging Mass Spectrometry and Multi-Omics Integration

Learn how MSI and LC-MS on the timsTOF fleX enable spatial lipidomics and integrated multi-omics studies for aging and neurodegenerative disease research.

Lipid Imaging Mass Spectrometry & Multi-Omics Integration

<p><strong>Pharma teams often face disconnected systems and slow decision-making. Paul Gillham will share how breaking down silos and creating a seamless data flow can transform operations. Discover how intuitive tools and smarter automation help teams work better together, speed up processes, and deliver consistent quality, without adding complexity.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://biopharmawebinars.com/webinars/developing-and-deploying-digital-ai-solutions-in-pharma-the-reality-vs-the-hype/#webinar_embed"><strong>Register for this webinar</strong></a></p></blockquote><h4><strong>What You’ll Learn</strong></h4><ul><li>Easy ways to connect data and workflows for faster, smarter decisions.</li><li>How automation can boost efficiency while keeping people at the center.</li><li>Practical steps to build a future-ready, digital pharma environment.</li></ul><h4><strong>Who Should Join</strong></h4><ul><li>Pharma manufacturing and quality leaders looking for actionable solutions.</li><li>Digital transformation and automation champions.</li><li>Process engineers and Pharma 4.0 advocates.</li><li>Senior managers seeking strategies that deliver measurable results.</li></ul><p>Sponsored by SciY and followed by a live Q&amp;A session.</p><blockquote><p><strong>Presenter:</strong> Paul Gillham (Innovations Director, SciY)</p><p>Paul is the Director of Innovation at SciY where he leads a team of scientists, mathematicians and engineers. He has over twenty years of experience in the implementation of digitalization for life sciences, notably in the field of PAT (Process Analytical Technologies), with a focus on data management, analysis and communication. He read Physics at the University of Bath and has worked in different industries before joining Optimal, to work on the synTQ suite of software. In April 2022 Optimal was purchased and placed into the SciY group of companies, which has a broad portfolio of software applications within its data management platform. His main aim at SciY is to advance data use, analysis and to action control of our customer’s processes, based on understanding and good science.&nbsp;</p></blockquote>

SciY: From Silos to Synergy: How Smarter Data Flow Transforms Pharma

From Silos to Synergy: How Smarter Data Flow Transforms Pharma

Join webinar to learn how pharma teams can connect data, automate intelligently, accelerate decision-making. Practical Pharma 4.0 insights from SciY experts.

How Smarter Data Flow Transforms Pharma

<h3><strong>Achieve reliable, high-performance single-cell proteomics—every day.</strong></h3><p><strong>Join Jeff Op de Beeck (Thermo Fisher Scientific) for a deep dive into a practical single-cell proteomics workflow designed to deliver exceptional sensitivity, precision, and robustness. This session showcases how the Thermo Scientific™ μPAC™ Neo Plus trap-and-elute setup empowers researchers to perform daily single-cell analysis with unmatched depth and reproducibility.</strong></p><h4><strong>What You Will Learn</strong></h4><ul><li>How to achieve reliable low-flow LC-MS performance suited for single-cell studies</li><li>Advantages of μPAC™ micro Pillar Array columns (50 cm) in high-sensitivity workflows</li><li>Implementing trap-and-elute approaches with the Vanquish™ Neo UHPLC</li><li>Maximizing identification depth and quantitative precision using Orbitrap™ Astral­­™ / Exploris™ systems with FAIMS™ interface</li><li>Practical tips for building a robust, daily-use workflow for ultra-low-sample proteomics</li></ul><h4><strong>Topics Covered</strong></h4><ul><li>Low-flow LC-MS</li><li>Single-cell proteomics</li><li>μPAC Neo Plus trap-and-elute workflow</li><li>Variable-flow nano/capillary LC methods</li><li>High-performance MS with Orbitrap Astral/Exploris + FAIMS</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li><strong>Proteomics scientists and mass spectrometrists</strong> seeking higher sensitivity and throughput in single-cell LC-ESI-MS analysis</li><li><strong>Method developers and LC-MS operators</strong> interested in nano/capillary workflows, trap-and-elute strategies, and precise low-nanoliter injections on the Vanquish Neo UHPLC</li><li><strong>Core facility managers and lab leaders </strong>looking to implement robust, reproducible workflows for daily high-productivity operation</li><li><strong>Single-cell biology researchers</strong> working with limited sample material who need consistent, end-to-end workflows from isolation to data interpretation</li></ul><p>We’ll conclude with a live Q&amp;A session—bring your questions!</p><blockquote><p><strong>Presenter: </strong>Jeff Op de Beeck (Staff Scientist R&amp;D, Thermo Fisher Scientific)</p></blockquote>

Thermo Fisher Scientific: Mastering Single Cell Proteomics: Daily Excellence with μPAC Neo Plus Trap-and-Elute Workflow

Mastering Single Cell Proteomics: Daily Excellence with μPAC Neo Plus Trap-and-Elute Workflow

Learn how to achieve robust, high-sensitivity single-cell proteomics using μPAC Neo Plus trap-and-elute LC-MS with Vanquish Neo and Orbitrap systems.